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The 15th World Veterinary Poultry Congress

作者： Maaike E.Thomas Annemarie Bouma Dieudonné Klinkenberg twan j.van gerwe Aldert A.Bergwerff jan A.Stegeman Frans van Knapen Veterinary Public Health Division Institute for Risk Assessment SciencesUtrecht UniversityYalelaan 23584 CM UtrechtThe Netherlands. Department of Farm Animal Health Faculty of Veterinary MedicineUtrecht UniversityYalelaan 73584 CL UtrechtThe Netherlands Department of Farm Animal Health Faculty of Veterinary MedicineUtrecht UniversityYalelaan 73584 CL UtrechtThe Netherlands Department of Farm Animal Health Faculty of Veterinary MedicineUtrecht UniversityYalelaan 73584 CL UtrechtThe Netherlands Veterinary Public Health Division Institute for Risk Assessment SciencesUtrecht UniversityYalelaan 23584 CM UtrechtThe Netherlands. Department of Farm Animal Health Faculty of Veterinary MedicineUtrecht UniversityYalelaan 73584 CL UtrechtThe Netherlands Veterinary Public Health Division Institute for Risk Assessment SciencesUtrecht UniversityYalelaan 23584 CM UtrechtThe Netherlands.

＜正＞Salmonella is one of the major causes of bacterial gastro-enteritis in humans,and in the European Union （EU）Salmonella enteritidis（S.e.）was by far the most common serovar detected in layer flocks sampled bet...

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Mitigating osteonecrosis of the jaw(ONj) through preventive dental care and understanding of risk factors

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Bone Research 2020年第1期8卷 14-25页

作者： jason twan Douglas MSheeley Martha jSomerman janice SLee National Institute of Dental and Craniofacial Research National Institutes of HealthBethesdaMDUSA Laboratory for Oral Connective Tissue Biology National Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institutes of HealthBethesdaMDUSA

It is well established that alterations in phosphate metabolism have a profound effect on hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the jaw(ONj) was preceded by phosphorus necrosis of the jaw, ca. 1860. The subsequent removal of yellow phosphorus from matches in the early 20 th century saw a parallel decline in "phossy jaw" until the early 2000 s, when similar reports of unusual jaw bone necrosis began to appear in the literature describing jaw necrosis in patients undergoing chemotherapy and concomitant steroid and bisphosphonate treatment. Today, the potential side effect of ONj associated with medications that block osteoclast activity(antiresorptive) is well known, though the mechanism remains unclear and the management and outcomes are often unsatisfactory. Much of the existing literature has focused on the continuing concerns of appropriate use of bisphosphonates and other antiresorptive medications, the incomplete or underdeveloped research on ONj, and the use of drugs with anabolic potential for treatment of osteoporosis. While recognizing that ONj is a rare occurrence and ONj-associated medications play an important role in fracture risk reduction in osteoporotic patients, evidence to date suggests that health care providers can lower the risk further by dental evaluations and care prior to initiating antiresorptive therapies and by monitoring dental health during and after treatment. This review describes the current clinical management guidelines for ONj, the critical role of dental-medical management in mitigating risks, and the current understanding of the effects of predominantly osteoclast-modulating drugs on bone homeostasis.

关键词： drugs metabolism alterations

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How apparent is the apparent digestibility of plant proteins by a carnivorous marine fish:the use of protein gel analysis to characterize dietary and faecal proteins of turbot,Psetta maxima

How apparent is the apparent digestibility of plant proteins...

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The 14th International Symposium on Fish Nutrition & Feeding

作者： Leon T.N.Heinsbroek Cris Wijnen jan Cordewener twan America Ingrid M.van der Meer johan W.Schrama johan A.j.Verreth Aquaculture and Fisheries Group Wageningen University Plant Research International Wageningen University

With the growth of aquaculture and of aquaculture feed production the need for alternative protein sources becomes ever more urgent.A first step to evaluate the potential of alternative protein sources is the determination of the protein(nitrogen) *** this has to be repeated for the multitude of ingredients and fish species,the objective of the present study was to investigate a more generic method to characterize dietary proteins and how they influence the digestion process.

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