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中华高血压杂志 2010年第12期18卷 1198-1198页

作者： turner st Schwartz GL Chapman AB Beitelshees AL Gums JG Cooper-DeHoff RM Boerwinkle E Johnson JA Bailey KR 黄晓斌

年龄和种族类别或肾素水平已被推荐作为使用8受体阻滞剂或噻嗪类利尿剂进行单药治疗预测血压反应的指标。然而使用B受体阻滞剂或噻嗪类利尿剂与其他抗高血压药物进行联合治疗，上述特征，或其他特征指标的预测作用还不明确。

关键词：噻嗪类利尿剂 β受体阻滞剂血浆肾素活性抗高血压药物预测作用联合治疗单药治疗血压反应

血压有关的基因位点变异解释非洲裔与白人对降压药的反应差异：基因组精准医学可能摒弃种族策略

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中华高血压杂志 2019年第9期27卷 899-899页

作者： Iniesta R Campbell D Venturini C Faconti L Singh S Irvin MR Cooper-DeHoff RM Johnson JA turner st Arnett DK Weale ME Warren H Munroe PB Cruickshank K Padmanabhan S Lewis C Chowienczyk P 赵狄(译) 练桂丽(校) 不详

一些指南推荐根据自身确定的种族选择降压药,但根据个体的基因型可能较种族更好。该研究探讨不同种族的血压反应变异在多大程度上可以用遗传因素(基因确定的血统及已知血压相关位点的基因变异)来解释。研究者分析了进行过基因分型(4696... 详细信息

一些指南推荐根据自身确定的种族选择降压药,但根据个体的基因型可能较种族更好。该研究探讨不同种族的血压反应变异在多大程度上可以用遗传因素(基因确定的血统及已知血压相关位点的基因变异)来解释。研究者分析了进行过基因分型(4696例),且可获得对β受体阻滞剂、血管紧张素转换酶抑制剂、血管紧张素受体拮抗剂、噻嗪或噻嗪类利尿剂及钙拮抗剂治疗反应的5个临床试验数据。

关键词：基因位点精准医学降压药基因组

全基因组和基于基因的荟萃分析识别影响氢氯噻嗪血压反应的新型基因位点

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中华高血压杂志 2016年第11期24卷 1007-1007页

作者：刘莉叶鹏 Salvi E Wang Z Rizzi F Gong Y McDonough CW Padmanabhan S Hiltunen TP Lanzani C Zaninello R Chittani M Bailey KR Sarin AP Barcella M Melander O Chapman AB Manunta P Kontula KK Glorioso N Cusi D Dominiczak AF Johnson JA Barlassina C Boerwinkle E Cooper-DeHoff RM turner st

本研究旨在识别影响氢氯噻嗪单药治疗降压反应的新基因位点。纳入来自国际抗高血压药物基因组学研究联合会的6个临床试验中的白人高血压患者1739例,进行氢氯噻嗪降压反应的全基因组荟萃分析。此外,研究者对先前有证据表明其参与利尿反... 详细信息

本研究旨在识别影响氢氯噻嗪单药治疗降压反应的新基因位点。纳入来自国际抗高血压药物基因组学研究联合会的6个临床试验中的白人高血压患者1739例,进行氢氯噻嗪降压反应的全基因组荟萃分析。此外,研究者对先前有证据表明其参与利尿反应、血压调节或高血压易感性的候选基因进行了基于基因的分析。

关键词：血压调节基因位点荟萃分析抗高血压药物基因组研究抗高血压治疗缝隙连接蛋白叉头 junction 候选基因

The potential of vertebrate microfossils for marine to non-marine correlation in the Late Jurassic

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Progress in Natural Science:Materials International 2007年第6期17卷 655-663页

作者： Detlev Thies Alexander Mudroch Susan turner Institute of Geology und Paleontology University of HannoverD-30167 HannoverGermany Independent Palaeobiologist Bcklinplatz 4D-30177 HannoverGermany School of Geosciences Monash UniversityVictoria 3800AustraliaQueensland MuseumGeology/Palaeontology122 Gerler RoadHendraQueensland 4011Australia

Fish (cartilaginous: elasmobranch and bony: osteichthyan actinopterygian) and reptile (crocodile) microfossils comprising scales and teeth have been examined from a series of limestone samples in the Upper Jurassic of France and Germany to gauge the possibilities of using them for correlation between fully marine and hypo-or hyper-saline (non-marine) deposits.

关键词： Upper Jurassic Kimmeridgian chondrichthyans actinopterygians crocodilians microfossils biostratigraphy

Novel polysaccharide-protein conjugates provide an immunogenic 13-valent pneumococcal conjugate vaccine for ***

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Synthetic and Systems Biotechnology 2017年第1期2卷 49-58页

作者： Allison E.B.turner Jonas E.Gerson Helen Y.So Daniel J.Krasznai Adrienne J.st.Hilaire Donald F.Gerson Vaccine Research and Development PnuVax Incorporated Headquarters134 Albert St.KingstonOntarioK7L 3V2Canada Vaccine Research and Development PnuVax Incorporated Laboratories6000 Royalmount Ave.MontrealQuebecH4P 2T1Canada

Pneumonia remains the single leading cause of childhood death *** the commercial availability of multiple pneumococcal conjugate vaccines(PCVs),high dosage cost and supply shortages prevent PCV delivery to much of the developing *** current work presents high-yield pneumococcal conjugates that are immunogenic in animals and suitable for use in human vaccine *** 13-valent pneumococcal conjugate vaccine(PCV-13)investigated in this research incorporated serotypes 1,3,4,5,6A,6B,7F,9V,14,18C,19A,19F,and *** polysaccharides(PnPSs)and CRM197 carrier protein were produced and purified in-house,and used to prepare PnPS-CRM conjugates using unique,cyanide-free,in vacuo glycation conjugation *** vitro characterization confirmed the generation of higher molecular weight PnPS-CRM conjugates low in free *** vivo animal studies were performed to compare PnuVax's PCV-13 to the commercially available PCV-13,Prevnar®13(Pfizer,USA).A boost dose was provided to all groups post-dose 1 at t?14 ***-dose 2 results at t?28 days showed that all 13 serotypes in PnuVax's PCV-13 were *** serotype IgG GMCs demonstrated that PnuVax's PCV-13 is immunogenic for all 13 serotypes,with 10 of the 13 serotypes statistically the same or higher than Prevnar®13 post-dose *** a result,the novel polysaccharideprotein conjugates developed in this work are highly promising for use in human PCV *** in vacuo conjugation technique applied in this work could also be readily adapted to develop many other conjugate vaccines.

关键词： Pneumonia Vaccine development PCV Pneumococcal conjugate vaccine Polysaccharide Carrier protein In vacuo glycation

Impact Assessments for Urban World Heritage:European Experiences under Scrutiny

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Built Heritage 2018年第4期2卷 58-71页

作者： Dennis Rodwell Michael turner Cultural Heritage and Sustainable Urban Development MelroseScotlandUK Graduate Program in Urban Design Bezalel Academy of Arts and DesignJerusalemIsrael

In the context of the broadening understanding of urban heritage,including the 2011 UNESCO Recommendation on the Historic Urban Landscape and related United Nations agendas such as the 2030 Sustainable Development Goals and the New Urban Agenda,this article questions the relevance of limited-focused impact assessments as a tool for the holistic management of complex urban sites in the 21st *** article identifies pitfalls in the use of such assessments,illustrating this principally with two cases in which retrospective assessments were undertaken post-inscription in an attempt to address conflicting interests:the visual impact study for Dresden Elbe Valley,inscribed on the World Heritage List in 2004 and delisted in 2009;and the three impact assessments for Liverpool Maritime Mercantile World Heritage Site,also inscribed in 2004,and placed on the List of World Heritage in Danger continuously since *** article identifies critical missing elements that are inherent in discrete assessments,and provides indicators for practical tools with relevant applicability.

关键词： assessment reactive proactive World Heritage Historic Urban Landscape sustainable development

Carbon Isotope Discrimination is not Correlated with Transpiration Efficiency in Three Cool-Season Grain Legumes(Pulses)

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Journal of Integrative Plant Biology 2007年第10期49卷 1478-1483页

作者： Neil C.turner Jairo A.Palta Renuka Shrestha Christiane Ludwig Kadambot H.M.Siddique David W.turner Centre for Legumes in Mediterranean Agriculture M080The University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia Centre for Legumes in Mediterranean Agriculture M080The University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia CSIRO Plant IndustryPrivate Mail Bag No.5WembleyWA 6913Australia School of Plant Biology M084Institute of AgricultureThe University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia CSIRO Plant Industry Private Mail Bag No.5WembleyWA 6913Australia Centre for Legumes in Mediterranean Agriculture M080The University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia School of Plant BiologyM084Institute of AgricultureThe University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia

The carbon isotope discrimination （δ^13C） of leaves has been shown to be correlated with the transpiration efficiency of leaves in a wide range of species. This has led to δ^13C being used in breeding programs to select for improved transpiration efficiency. The correlation between δ^13C and transpiration efficiency was determined under well-watered conditions during the vegetative phase in six genotypes of lentil （Lens culinaris Medikus）, six genotypes of chickpea （Cicerarietinum L.） and 10 cultivars of narrow-leafed lupin （Lupinus angustifolius L.）. Biomass （dry matter） accumulation and water use （transpiration） varied among the genotypes in all three species and transpiration efficiency was 40% to 75% higher in the most efficient compared with the least efficient genotypes. However, δ^13C and transpiration efficiency were not significantly correlated in any of the species. This suggests that the δ^13C technique cannot be used in selection for transpiration efficiency in the three grain legumes （pulses） studied.

关键词： biomass accumulation breeding chickpea lupin Cicer anetinum Lens culinans lentil Lupinus angustifofius water use.

Gastroenterology training in a resource-limited setting: Zambia, Southern Africa

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World Journal of Gastroenterology 2013年第25期19卷 3996-4000页

作者： Akwi W Asombang Eleanor turner-Moss Anil Seetharam Paul Kelly Division of Gastroenterology and Hepatology Saint Louis University School of Medicine St. Louis Barts and the London School of Medicine Queen Mary University of London Banner Health Liver Center

AIM: To evaluate need for and efficacy of a structured gastroenterology didactic session in expanding awareness and understanding of digestive disorders. METHODS: A four-day symposium was developed with didactic sessions (days 1, 2) and practical endoscopy (days 3, 4). Didactic sessions included case presentations highlighting pathophysiology and management. One nurse and four practicing gastroenterologists from the United Kingdom led lectures and supervised work-shops with audience participation. Practical endoscopy focused on diagnostic and therapeutic procedures and their application to diagnosis and treatment of ailments of the gastrointestinal tract. Preand post-workshop questionnaires were distributed to participants during didactic sessions. A pre-workshop questionnaire gauged expectations and identified objectives to be met at thesymposium. Post-workshop questionnaires were administered to assess efficacy of each session. Participants graded sessions from 1 (poor) to 5 (excellent) on quality of case presentations, knowledge, clarity and mode of presentation. We assessed if time allotted to each topic was sufficient, value of sessions, impact on practice and interest in future symposiums. RESULTS: There were 46 attendees on day 1: 41% undergraduates, 41% residents, 11% consultants and 4% unspecified. Day 2 (a Saturday) had 24 participants: 17% undergraduates, 71% residents, 9% consultants, 4% unspecified. Primary pre-workshop symposium expectation was to gain knowledge in: general gastroenterology (55.5%), practical endoscopy (13.8%), pediatric gastroenterology (5%), epidemiology of gastrointestinal disorders specific to Zambia (6%), and interaction with international speakers (6%). The post-symposium questionnaire was answered by 19 participants, of whom 95% felt specific aims were met; all would attend future conferences and recommend to others. CONCLUSION: The beneficial effect of a structured symposium in developing countries warrants further attention as

关键词： Gastroenterology training Resource-limited country Zambia Specialist training Postgraduate training Hepatology

Protocoled thrombolytic therapy for frostbite improves phalangeal salvage rates

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Burns & Trauma 2020年第1期8卷 338-346页

作者： Rosemary Elizabeth Paine Elizabeth Noel turner Daniel Kloda Carolyne Falank Bruce Chung Damien Wilson Carter Department of Surgery Maine Medical Center22 Bramhall StPortlandMaine 04102USA Department of Radiology Maine Medical Center22 Bramhall StPortlandMaine 04102USA

Background:Frostbite is a cold injury that has the potential to cause considerable morbidity and long-term *** the complexity of these patients,diagnostic and treatment practices lack *** therapy has emerged as a promising treatment modality,demonstrating impressive digit salvage *** review our experience with thrombolytic therapy for severe upper extremity ***:Retrospective data on all frostbite patients evaluated at our institution from December 2017 to March 2018 was collected.A subgroup of patients with severe frostbite treated with intraarterial thrombolytic therapy(IATT)were ***:Of the 17 frostbite patients treated at our institution,14(82%)were male and the median age was 31(range:19–73).Substance misuse was involved in a majority of the cases(58.8%).Five(29.4%)patients with severe frostbite met inclusion criteria for IATT and the remaining patients were treated *** demonstrated a 74.5%improvement in perfusion after tissue plasminogen activator *** comparing phalanges at risk on initial angiography to phalanges undergoing amputation,the phalangeal salvage rate was 83.3%and the digit salvage rate was 80%.Complications associated with IATT included groin hematoma,pseudoaneurysm and retroperitoneal ***:Thrombolytic therapy has the potential to greatly improve limb salvage and functional recovery after severe frostbite when treated at an institution that can offer comprehensive,protocoled thrombolytic therapy.A multi-center prospective study is warranted to elucidate the optimal treatment strategy in severe frostbite.

关键词： Frostbite Tissue plasminogen activator Amputation Digit salvage Thrombolysis

The problem and promise of scale in multilayer animal social networks

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Current Zoology 2021年第1期67卷 113-123页

作者： Alec L.ROBITAILLE Quinn M.R.WEBBER Julie W.turner Vander WAL ERIC Department of Biology Memorial University of NewfoundlandSt.John'sNLA1B 3X9Canada Cognitive and Behavioural Ecology Interdisciplinary Program Memorial University of NewfoundlandSt.John'sNLA1B 3X9Canada

Scale remains a foundational concept in *** scale,for instance,has become a central consideration in the way we understand landscape ecology and animal space ***,scale-dependent social processes can range from fine scale interactions to co-occurrence and overlapping home ***,sociality can vary within and across *** networks promise the explicit integration of the social,spatial,and temporal *** the complex interplay of sociality and animal space use in heterogeneous landscapes,there remains an important gap in our understanding of the influence of scale on animal social *** an empirical case study,we discuss ways of considering social,spatial,and temporal scale in the context of multilayer caribou social *** integration of social and spatial processes,including biologically meaningful scales,within the context of animal social networks is an emerging area of *** incorporate perspectives that link the social environment to spatial processes across scales in a multilayer context.

关键词： caribou habitat selection landscape ecology Rangifer social network analysis space use