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Redistribution of nerve strain enables end-to-end repair under tension without inhibiting nerve regeneration

Neural Regeneration Research 2019年第7期14卷 1280-1288页

作者： Holly M.Howarth turki alaziz Brogan Nicolds Shawn O'Connor Sameer B.Shah Department of Bioengineering University of California Department of Orthopaedic Surgery University of California School of Exercise and Nutritional Sciences San Diego State University Research Service VA San Diego Healthcare System

End-to-end repair under no or low tension leads to improved outcomes for transected nerves with short gaps,compared to repairs with a ***,grafts are typically used to enable a tension-free repair for moderate to large gaps,as excessive tension can cause repairs to fail and catastrophically impede *** this study,we tested the hypothesis that unloading the repair interface by redistributing tension away from the site of repair is a safe and feasible strategy for end-to-end repair of larger nerve ***,we tested the hypothesis that such an approach does not adversely affect structural and functional *** this study,we used a rat sciatic nerve injury model to compare the integrity of repair and several regenerative outcomes following end-to-end repairs of nerve gaps of increasing *** addition,we proposed the use of a novel implantable device to safely repair end-to-end repair of larger nerve gaps by redistributing tension away from the repair *** data suggest that redistriubution of tension away from the site of repair enables safe end-to-end repair of larger gap *** addition,structural and functional measures of regeneration were equal or enhanced in nerves repaired under tension – with or without a tension redistribution device – compared to tension-free *** that repair integrity is maintained,end-to-end repairs under tension should be considered as a reasonable surgical *** animal experiments were performed under the approval of the Institutional Animal Care and Use Committee of University of California,San Diego(Protocol S11274).

关键词： tension biomechanics strain end-to-end repair peripheral nerve nerve regeneration

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Trajectory Control: Directional MWD Inversely New Wellbore Positioning Accuracy Prediction Method

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Journal of China University of Geosciences 2004年第4期15卷 425-433页

作者： Ahmed Abd alaziz Ibrahim Tagwa Ahmed Musa Faculty of Engineering China University of Geosciences Wuhan 430074 China Engineering Faculty Sudan University of Science and Technology Sudan Faculty of Earth Resources China University of Geosciences Wuhan 430074 China Engineering Faculty Sudan University of Science and Technology Sudan

The deviation control of directional drilling is essentially the controlling of two angles of the wellbore actually drilled, namely, the inclination and azimuth. In directional drilling the bit trajectory never coincides exactly with the planned path, which is usually a plane curve with straight, building, holding, and dropping sections in succession. The drilling direction is of course dependant on the direction of the resultant forces acting on the bit and it is quite a tough job to hit the optimum target at the hole bottom as required. The traditional passive methods for correcting the drilling path have not met the demand to improve the techniques of deviation control. A method for combining wellbore surveys to obtain a composite, more accurate well position relies on accepting the position of the well from the most accurate survey instrument used in a given section of the wellbore. The error in each position measurement is the sum of many independent root sources of error effects. The relationship between surveys and other influential factors is considered, along with an analysis of different points of view. The collaborative work describes, establishes a common starting point of wellbore position uncertainty model, definition of what constitutes an error model, mathematics of position uncertainty calculation and an error model for basic directional service.

关键词： wellbore trajectory bit trajectory actual/planned path steerable directional tool measurement while drilling (MWD) logging while drilling (LWD) position uncertainty error accuracy prediction weighting function

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Molecular Detection of Carbapenemase Genes in Extensive Drug Resistant Acinetobacter baumannii Clinical Isolates from ICU Patients, Khartoum

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Open Journal of Medical Microbiology 2022年第1期12卷 38-48页

作者： Shirehan M. Ibrahim Elamin M. Ibrahim Omer A. Ibrahim Omnia M. Hamid Hassan A. alaziz Department of Medical Microbiology Faculty of Medical Laboratories Ibn Sina University Khartoum Sudan Department of Medical Microbiology Faculty of Medical Laboratory Sciences University of Khartoum Khartoum Sudan Department of Medical Microbiology Faculty of Medical Laboratory Sciences National Ribbat University Khartoum Sudan Department of Medical Microbiology Faculty of Medical Laboratory sciences University of Medical Sciences & Technology UMST-Khartoum Sudan Faculty of Medicine National Ribbat University Khartoum Sudan

Background: The emergence of carbapenemase producing Acinetobacter baumannii is increasingly reported nowadays and constitutes a major problem to the intensive care unit (ICU) patients with notable extensive-drug resistance ability. The study investigates carbapenemase producing A. baumannii strains exhibiting an extensively drug-resistant (XDR) phenotype, isolated from ICU patients in Khartoum. Methods: A total of 100 nonduplicate Gram-negative coccobacilli strains were obtained from microbiology laboratory of ICU patients’ clinical isolates. Molecular identification of A. baumannii was performed by targeting 16S rRNA gene using specifically designed primers. Then, XDR strains were determined by susceptibility testing (disc diffusion). For detection of carbapenemase genes Polymerase chain reaction (PCR) was carried out. Result: Of 100 ICU clinical isolates, 38 (38.0%) was confirmed A. baumannii strains, those strains showed 100% carbapenem resistance and 60.5% extensive drug resistance to the antibiotics tested. The frequency of carbapenemase producer was 57.9% (22/38) of carbapenem resistance A. baumannii (CRAB). The most common carbapenemase associated with resistance was blaOXA gene followed by blaNDM and blaGES A. baumannii isolates. The co-occurrence of blaOXA-48-like and blaNDM, blaOXA-23-like and blaOXA-51, and blaNDM-1 and blaOXA-51 was detected in 22.7%, 18.2% strains and 4.5% respectively. A unique characteristic of our findings was the coharbouring of the genes blaNDM-1, blaOXA-23-like, blaOXA-51 and blaOXA-143 in 9.1% strains (2/22), and this was the first report in the Khartoum city, Sudan. Conclusion: We have demonstrated for the first time a high prevalence of XDR-carbapenemase producing A. baumannii clinical isolates from ICU patients in Khartoum. Also an emergent blaOXA-143 was reported as High-Risk Clones. This highlights the routine mentoring of XDR-carbapenemase producing A. baumannii to avoid clone dissemination in our region hospitals.

关键词： Carbapenem Producing Acinetobacter baumannii (CPAB) Intensive Care Unit (ICU) Patients Extensive Drug-Resistant (XDR) Colistin

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Synthetic Approaches Towards 2-（4-oxo-4, 5-Dihyd ro-Thiazol-2-yl） Acetamide

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材料科学与工程（中英文A版） 2011年第2X期1卷 228-235页

作者： Ali Khalil Shaban Ibrahim Mohamed Hassan Ahmed Eyada Tarek Ahmed abdel alaziz Gameel Ahmed Mohamed Mohamed El-Hag Ali Chemistry Department Faculty of Science Ain Shams University Cairo Egypt Technonlogy Engeneering Institute Tammoh Giza Egypt Chemistry Department Faculty of Science Al-Azhar University Cairo Egypt

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