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Evaluating the safety of intracameral bevacizumab application using oxidative stress and apoptotic parameters in corneal tissue

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 697-702页

作者： Ali Akal turgay ulas Tugba Goncu Muhammet Emin Guldur Sezen Kocarslan Abdullah Taskin Hatice Sezen Kudret Ozkan Omer Faruk Yilmaz Hakan Buyukhatipoglu Department of Ophthalmology Harran University Faculty of Medicine Department of Internal Medicine Harran University Faculty of Medicine Department of Pathology Harran University Faculty of Medicine Department of Biochemistry Harran University Faculty of Medicine

·AIM: To investigate the possible effects of intracameral bevacizumab on oxidative stress parameters and apoptosis in corneal tissue.·METHODS: In total, 30 rats were assigned randomly into the following three groups of 10 rats each: a sham group(Group 1; n =10), a control group [Group 2;balanced salt solution(BSS) was administered at 0.01 m L;n =10], and a treatment group(Group 3; bevacizumab was administered at 0.25 mg/0.01 m L; n =10). The total antioxidant status(TAS) and the total oxidant status(TOS) in the corneal tissue and blood samples were measured, and the oxidative stress index(OSI) was calculated. Additionally, corneal tissue histopathology was evaluated for caspase-3 and 8 staining and apoptotic activity.·RESULTS: In the blood samples, the TAS, TOS, and OSI levels were not significantly different(all P >0.05).Compared with the sham and control groups, the TOS and OSI levels in the corneal tissues were significantly different in the bevacizumab group(all P 0.05).However, compared with the sham and control groups,greater immunohistochemical staining for caspases-3and 8 and an elevated level of apoptotic activity were observed in the bevacizumab group.·CONCLUSION: This study revealed that intracameral bevacizumab injections seemed to be systemically safe but may have elicited local toxic effects in the corneal tissue, as indicated by the oxidative stress parameters and histopathological evaluations.

关键词： apoptosis cornea intracameral bevacizumab oxidative stress

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