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Microarray analysis of gene expression in the liver of transgenic mouse model of HCV infection

Advances in Bioscience and Biotechnology 2012年第8期3卷 1151-1159页

作者： Masoud Ghorbani turaya naas Catalina Soare Rashmi Kothary Francisco Diaz-Mitoma Division of Virology Children’s Hospital of Eastern Ontario (CHEO) Ottawa Canada Infectious Disease and Vaccine Research Centre Children’s Hospital of Eastern Ontario research institute Ottawa Canada

Background: The molecular interactions of hepatitis C virus (HCV) with hepatic tissue have yet to be completely elucidated and understood. The purpose of this study was to compare differential gene expression patterns in the livers of non-transgenic and transgenic mouse model expressing HCV structural proteins Core, Envelope 1 (E1) and Envelope 2 (E2) using complementary DNA (cDNA) microarrays. Results: Total RNA extracted from the livers of HCV transgenic and non-transgenic mice was analyzed with cDNA microarray and differentially expressed genes confirmed by real-time RT-PCR. Relative expression ratios of individual genes were determined by comparing hybridization of Cy5-labelled cDNA from transgenic mouse livers and Cy3-labelled cDNA from non-transgenic mouse livers. The spot array images were quantified using QuantArray software and the outlier spots was normalized and filtered using five different criteria. 15,297 genes were analyzed using three different analytical methods. Depending on these methods, twenty-one genes were found to be differentially expressed at a statistically significant level. From these, 6 genes had a consistent differential expression. Several genes were directly involved in lipid metabolism and lipid β-oxidation. 5-azacytidine induced gene 2 (AZ2), which is involved in the methylation of genes was down regulated in HCV transgenic mice. Altered transcript levels of these 6 genes were confirmed by real-time RT-PCR analysis. Conclusion: Interactions between HCV and hepatocytes not only involve lipid metabolism and redox balance, but this interaction may also influence DNA methylation, indicating a potential association with the development of hepatocellular carcinoma.

关键词： Microarray HCV Hepatocellular Carcinoma

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Plato and the invention of life

Plato and the invention of life

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作者： Michael naas.

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Investigations on the Optimization of Contacts Barrier Height for the Improved Performance of ZnO/CdS/CZTS Solar Cells

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Energy Engineering 2023年第8期120卷 1803-1815页

作者： Fatiha Daoudi Abdelkrim naas Omar Meglali Radia Boudaira Ahmed Gueddim A.M.Saeed Material Science and Informatics Laboratory University of DjelfaDjelfa17000Algeria Faculty of Sciences University of M’silaM’sila28000Algeria Department of Physics University of ConstantineConstantine25000Algeria Department of Physics Division of Science and TechnologyUniversity of EducationLahorePakistan

The numerical simulations were performed using the AMPS-1D simulator to study the effects of the CZTS as an absorber layer and the contacts’barrier height on the performance of four ZnO/CdS/CZTS solar *** obtain the best cell performances,the barrier heights of the back and front contacts were adjusted between 0.01,0.77,0.5,and 1.55 eV,*** simulations,we used the lifetime mode,and the device performances were evaluated under AM1.5 illumination *** found that the efficiency,fill factor,and open-circuit voltage were almost constant at a front contact barrier height of less than 0.31 *** short-current density was not affected by the front contact barrier *** back contact material had a significant impact on the CZTS cells *** best performance was obtained for the CZTS550 cell with JSC=29.53 mA/cm2,VOC=1.07 V,FF=0.88,andη=28.08%at barrier heights of 0.31 and 1.55 eV for front and back contacts,*** conduction band offset at the CZTS550/CdS hetero-junction was found to be spike-like with 0.21 *** obtained conversion efficiency is comparable to those previously reported in the literature.

关键词： CZTS solar cell barrier height AMPS-1D photovoltaic parameters

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Lameness prediction in broiler chicken using a machine learning technique

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Information Processing in Agriculture 2021年第3期8卷 409-418页

作者： Irenilza de Alencar naas Nilsa Duarte da Silva Lima Rodrigo Franco Gonc¸alves Luiz Antonio de Lima Henry Ungaro Jair Minoro Abe Paulista University-Graduate Program in Production Engineering Sao PauloBrazil

Broiler flock welfare is usually assessed through mortality,physiology,behavior,and walk-ing *** possibility of assessing broiler chicken lameness using the bird walking abil-ity was investigated using the machine learning approach for the first *** on broiler walking speed and acceleration,genetic strain,and sex were recorded and input in a *** were classified according to the 6-point gait score(GS0 is a sound bird,and GS5 is a severely lame bird).Decision trees were built initially using all *** confusion matrix of each developed model was *** pruning technique was used,removing from the dataset the variables that did not infer in the classification *** reorganized the dataset and re-arranged the data by grouping the intermediate target class of gait score using the Borda Count ***-processing data,we obtained a new set of decision *** the 3-point gait score(GS0 is a sound bird,and GS2 is a lame bird),we obtained a new model with better accuracy(78%);however,the model had a lower accuracy for classifying lame broilers(GS2,5%).The final decision tree was selected for classifying broilers,either sound or lame,according to their walking *** developed model presented good accuracy(91%),and it ordered properly sound(86%)and lame birds(92%).The novel model might be used to assess broiler lameness on-farm by registering the bird displacement *** developments using the model might allow flock lameness detection automatically.

关键词： Broiler welfare Broiler walking speed Decision tree Confusion matrix Gait score

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基于有限元法的汽车变速器齿轮与轴承优化

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传动技术 2015年第2期29卷 3-13,20页

作者： Thomas Merath Joachim naas Franz Joachim 采埃孚(中国)投资有限公司上海201615

采埃孚集团开发和生产了种类繁多的传动齿轮。对于齿轮的优化和可靠设计,有限元法是尤为适合的。而且,这种方法能容易集成于采埃孚的程序系统。本文展示了在开发过程中如何运用该方法进行齿轮优化。此外,文中多处演示了齿轮和轴承之间... 详细信息

采埃孚集团开发和生产了种类繁多的传动齿轮。对于齿轮的优化和可靠设计,有限元法是尤为适合的。而且,这种方法能容易集成于采埃孚的程序系统。本文展示了在开发过程中如何运用该方法进行齿轮优化。此外,文中多处演示了齿轮和轴承之间的相互作用。这也是采埃孚集团致力于开发轴承计算的原因。文中实例展现了如何优化滚动轴承以达到理想的齿轮接触印痕。当然,这些优化方法也适用于传动齿轮。

关键词：变速器齿轮轴承有限元优化

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<i>In Vitro</i>Antibacterial Activity of Flavonoid Extracts of Two Selected Libyan Algae against Multi-Drug Resistant Bacteria Isolated from Food Products

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Journal of Biosciences and Medicines 2017年第1期5卷 26-48页

作者： Rabia Alghazeer Abdalla Elmansori Moammar Sidati Ftaim Gammoudi Salah Azwai Hesham naas Aboubaker Garbaj Ibrahim Eldaghayes Department of Chemistry Faculty of Sciences University of Tripoli Tripoli Libya Department of Botany Faculty of Sciences University of Tripoli Tripoli Libya Marin Biology Research Center Tajura-East of Tripoli Tripoli Libya Department of Microbiology and Parasitology Faculty of Veterinary Medicine University of Tripoli Tripoli Libya Department of Food Hygiene and Control Faculty of Veterinary Medicine University of Tripoli Tripoli Libya

This study aimed to evaluate the antibacterial activity of flavonoids extracted from two Libyan brown algae namely Cystoseira compressa and Padina pavonica using microwave-assisted extraction method against pathogenic bacteria isolated from meat, meat products, milk and dairy products (Staphylococcus aureus subsp. aureus (5 isolates), Bacillus cereus (3 isolates), Bacillus pumilus (1 isolate), Salmonella enterica subsp. enteric (4 isolates) and Enterohaemor-rhagic Escherichia coli O157 (EHEC O157) (4 isolates)). All of these isolates were muti-drug resistant with high MAR index. The results showed that C. compressa extract exhibited better and stronger antibacterial activities against the seventeen tested isolates with inhibition zones diameter ranged from 14 - 22 mm compared to P. pavonica extract which showed positive effect against 9 isolates with low inhibition zone ranged from 11 - 16.5 mm. Flavonoids extracted from C. compressa also displayed the best spectrum of bactericidal effect with a ratio MBC/MIC ≤ 4 obtained on all susceptible tested bacterial strains. Flavonoids and proanthocyanidins significantly contributed to the antibacterial properties. The mode of action of these active extracts is under investigation.

关键词： Brown Algae Flavonoids Multi-Drug Resistant Bacteria Antibacterial Activity

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应用等离子技术压裂致密地层

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国外油气地质信息 2005年第2期 77-82页

作者： Muftah EI-naas 汪先珍（译）李莉（校）

通常利用各种流体对致密地层进行压裂以改善油井的渗透性，从而提高采收率。本文推荐一种处理致密地层的先进方法，尤其：逢合大型稠油油藏。该方法包括使井筒受到氩气等离子流的作用，确保及时有效地把热量传递到：近井苘地带。等离子... 详细信息

通常利用各种流体对致密地层进行压裂以改善油井的渗透性，从而提高采收率。本文推荐一种处理致密地层的先进方法，尤其：逢合大型稠油油藏。该方法包括使井筒受到氩气等离子流的作用，确保及时有效地把热量传递到：近井苘地带。等离子流产生的高温改变了地层岩石的基本性质，使孔隙度和渗透率大幅增加。本丈研究了高温对碳酸盐岩的孔隙度和渗透率的影响。石灰岩在800℃-1200℃的高温下加热，在600℃以上，碳酸盐分解生成氧化钙和二氧化碳。碳酸盐试样的TGA分析表明：常压下分解速率主要取决于反应温度。低温下反应速率很慢，l小时只有5％碳酸盐转化成氧化钙，而在1000℃时，5分钟就转化完全。还利用扫描电镜（SEM）研究了不同温度下孔隙结构的变化。加热碳酸盐试样分析孔隙度和渗透率结果表明：1000℃时，孔隙度和渗透率分别增加100％和4500％。

关键词：致密地层压裂工艺油井渗透性采收率等离子技术孔隙度

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Testicular Metastasis as an Initial Manifestation of Gastrointestinal Cancer

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Journal of Cancer Therapy 2021年第1期12卷 57-64页

作者： Soumia Berrad Zineb Benbrahim Vincent Lorenga Kazadi Lamiae Nouiakh Hayat Erraichi Rafik naas Lamiae Amaadour Karima Oualla Samia Arifi Hinde El Fatemi Nawfel Mellas Department of Oncology Medical Hassan II University Hospital Fès Morocco Department of Anathomopathology Hassan II University Hospital Fès Morocco

Metastatic small bowel tumors in the testes are uncommon often indicating an advanced stage of sickness with poor prognosis. The route of spread to the scrotal level has not yet been defined. The most of these tumors are diagnosed at autopsy or orchiectomy for metastatic carcinoma. The diagnosis is mainly based on histological and immunohistochemical data. In this paper, we report the case of a 36-year-old patient with a spermatic torsion secondary to a testis metastasis from an adenocarcinoma of the small intestine confirmed histologically, occurring as first clinical manifestation that was taken care in the medical oncology department of CHU Has

关键词： Adenocarcinoma Hail Intestine Metastasis Testes Chemotherapy

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