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Application of buckling-restrained braces in the seismic control of suspension bridges

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Earthquake Engineering and Engineering Vibration 2022年第2期21卷 543-557页

作者： Long lu College of Environment and Civil Engineering Chengdu University of TechnologyChengdu 610059China

Buckling-restrained braces(BRBs)are widely used to improve the seismic performance of *** paper aims to introduce BRBs to suspension bridges and assess the seismic performance of bridges with *** the Dadu River Bridge as a case study,an FEA model of the bridge is established,and different seismic measures(BRBs between the deck and the tower,BRBs at the middle of the span to replace the inclined suspenders to connect the deck and the main cables,fluid viscous dampers(FVDs)between the deck and the tower,the combination of BRBs to replace the inclined suspenders as well as FVDs between the deck and the tower)are applied to the suspension *** influence of the parameters of BRBs on the seismic response of the suspension bridge is studied,and the performance of the bridge with BRBs is compared with that of the bridge with *** results indicate that the use of BRBs in place of the inclined suspenders is beneficial to reduce the displacement of the deck and limit the shear force and bending moment of the *** seismic performance of the suspension bridge with BRBs and FVDs is better than that of the bridge with BRBs or ***,the application of BRBs is a feasible method to improve the seismic performance of the suspension bridge.

关键词： buckling-restrained braces fluid viscous dampers suspension bridge seismic response earthquake

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

CYP2C19 polymorphism influences Helicobacter pylori eradication

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World Journal of Gastroenterology 2014年第43期20卷 16029-16036页

作者： Chao-hung Kuo Chien-Yu lu Hsiang-Yao Shih Chung-Jung Liu Meng-Chieh Wu Huang-Ming Hu Wen-hung Hsu Fang-Jung Yu Deng-Chyang Wu Fu-Chen Kuo Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Department of Medicine Faculty of MedicineCollege of Medicine and Center for Stem Cell ResearchKaohsiung Medical University Department of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Graduate Institute of Public Health Kaohsiung Medical University School of Medicine College of MedicineE-Da HospitalI-Shou University

The known factors that have contributed to the decline of Helicobacter pylori (H. pylori) eradication rate include antibiotic resistance, poor compliance, high gastric acidity, high bacterial load, and cytochrome P450 2C19 (CYP2C19) polymorphism. Proton pump inhibitor (PPI) is important in the eradication regimen. The principal enzyme implicated in the metabolism of PPIs is CYP2C19. The effects of PPI depend on metabolic enzyme, cytochrome P450 enzymes, and CYP2C19 with genetic differences in the activity of this enzyme (the homozygous EM, heterozygous EM (HetEM), and poor metabolizer). The frequency of the CYP2C19 polymorphism is highly varied among different ethnic populations. The CYP2C19 genotype is a cardinal factor of H. pylori eradication in patients taking omeprazole- based or lansoprazole-based triple therapies. In contrast, the CYP2C19 polymorphism has no significant effect on the rabeprazole-based or esomeprazole-based triple therapies. The efficacy of levofloxacin-based rescue triple therapy might be also affected by the CYP2C19 polymorphism, but CYP2C19 genotypes did not show obvious impact on other levofloxacin-based rescue therapies. Choice of different PPIs and/or increasing doses of PPIs should be individualized based on the pharmacogenetics background of each patient and pharmacological profile of each drug. Other possible factors influencing gastric acid secretion (e.g., IL-1β- 511 polymorphism) would be also under consideration.

关键词： Helicobacter pylori CYP2C19 Polymorphism Eradication Rabeprazole Omeprazole Lansoprazole Pantoprazole Esomeprazole

Leader-following consensus of second-order nonlinear multi-agent systems subject to disturbances

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Frontiers of Information Technology & Electronic Engineering 2019年第1期20卷 88-94页

作者： Mao-bin lu lu LIU School of Automation Beijing Institute of Technology City University of Hong Kong Shenzhen Research Institute Department of Biomedical Engineering City University of Hong Kong

In this study, we investigate the leader-following consensus problem of a class of heterogeneous secondorder nonlinear multi-agent systems subject to disturbances. In particular, the nonlinear systems contain uncertainties that can be linearly parameterized. We propose a class of novel distributed control laws, which depends on the relative state of the system and thus can be implemented even when no communication among agents exists. By Barbalat's lemma, we demonstrate that consensus of the second-order nonlinear multi-agent system can be achieved by the proposed distributed control law. The effectiveness of the main result is verified by its application to consensus control of a group of Van der Pol oscillators.

关键词： Multi-agent systems Leader-following consensus Distributed control

Disturbance observer-based backstepping control for hypersonic flight vehicles without use of measured flight path angle

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Chinese Journal of Aeronautics 2021年第2期34卷 396-406页

作者： Yao lu Beijing Aerospace Automatic Control Institute Beijing 100854China National Key Laboratory of Science and Technology on Aerospace Intelligence Control Beijing 100854China

In this paper a nonlinear control method is proposed for the tracking control of hypersonic flight vehicles. The designed control laws do not utilize the measured flight path angle due to its inferior accuracy in practical engineering. For this, an estimated flight path angle is designed via the measurements of the altitude and velocity. A tracking differentiator is designed for constructing nonlinear disturbance observer which is used to estimate the model uncertainties including the parameter indeterminacies and external disturbances in the channels of velocity and pitch rate. A robust high-order differentiator is introduced to avoid the employment of the measured flight path angle and estimate the lumped disturbance in dynamics of flight path angle. Meanwhile, the possible saturation of the control inputs is considered and compensated by the auxiliary states. The boundness of closed-loop signals is proved through the Lyapunov theory. Comparative simulations are carried out and the results demonstrate the effectiveness of the proposed method.

关键词： Anti-saturation Backstepping Disturbance observer Flight control Hypersonic flight vehicle State estimation

山姜素调节cAMP/PKA/CREB信号通路促进骨质疏松性骨折大鼠骨折愈合

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中国组织工程研究 2025年第12期29卷 2438-2443页

作者：陆飞周静金涛连云港市第一人民医院康复医学科江苏省连云港市222000 南京医科大学康达学院康复医学部江苏省连云港市222000 中国人民解放军东部战区总医院健康医学科江苏省南京市210018

背景:山姜素具有抗炎、抗肿瘤、抗菌等作用,已被证实能够缓解骨质疏松症,但山姜素对骨质疏松性骨折的影响及机制仍不清楚。目的:探讨山姜素调节环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白信号通路对骨质疏松性骨折大鼠的改善作... 详细信息

背景:山姜素具有抗炎、抗肿瘤、抗菌等作用,已被证实能够缓解骨质疏松症,但山姜素对骨质疏松性骨折的影响及机制仍不清楚。目的:探讨山姜素调节环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白信号通路对骨质疏松性骨折大鼠的改善作用。方法:采用双侧卵巢切除手术构建骨质疏松症骨折大鼠模型,将成功造模大鼠依据随机数字表法分为山姜素低、中、高剂量组、抑制剂组和模型组,另选12只大鼠作为假手术组。骨折造模当天,山姜素低、中、高剂量组大鼠灌胃7.5,15,30 mg/kg的山姜素+腹腔注射等量的生理盐水,抑制剂组灌胃30 mg/kg的山姜素+腹腔注射5 mg/kg的H-89(通路抑制剂),模型组与假手术组给予(灌胃+腹腔注射)等量生理盐水,1次/d,连续8周。放射性检查评估大鼠骨折愈合情况并进行愈合评分;骨密度扫描仪测定骨折处骨密度;通过三点弯曲实验和压缩实验评估大鼠股骨生物力学状况;苏木精-伊红染色观察大鼠骨折处病理损伤;酶联免疫吸附(ELISA)法检测血清碱性磷酸酶、骨钙素和Ⅰ型胶原交联C-末端肽、环磷酸腺苷水平的变化;Western blot检测股骨组织中骨形态发生蛋白2和环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白通路蛋白表达。结果与结论:①相较于假手术组,模型组大鼠骨折愈合评分、骨密度、最大负荷、最大应力、碱性磷酸酶、骨钙素、环磷酸腺苷水平、骨形态发生蛋白2、磷酸化蛋白激酶A/蛋白激酶A、磷酸化环磷酸腺苷反应元件结合蛋白/环磷酸腺苷反应元件结合蛋白表达下降,Ⅰ型胶原交联羧基末端肽水平增加(P<0.05);与模型组比较,山姜素各剂量组大鼠上述各项指标呈现相反的变化(P<0.05);与山姜素高剂量组比较,抑制剂组大鼠上述指标变化均被逆转(P<0.05)。②结论:山姜素可能通过激活环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白信号通路加速骨质疏松症骨折大鼠的骨折愈合。

关键词：山姜素环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白骨质疏松骨折愈合大鼠

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论苏轼的纪行组诗

海南大学学报（人文社会科学版） 2025年第1期43卷 8-15页

作者：路成文宋定坤华中科技大学人文学院湖北武汉430074

苏轼纪行组诗一百零六组,在文本形态、内容表现与风格特征三方面有显著的个人特色。这些组诗以记录行旅之间的单个事件为主,除纪行外,频繁叙及游览和社交。在宋诗重说理的风尚影响下,苏轼往往在纪行组诗中抒发一己之情感、阐发深刻的人... 详细信息

苏轼纪行组诗一百零六组,在文本形态、内容表现与风格特征三方面有显著的个人特色。这些组诗以记录行旅之间的单个事件为主,除纪行外,频繁叙及游览和社交。在宋诗重说理的风尚影响下,苏轼往往在纪行组诗中抒发一己之情感、阐发深刻的人生哲理。此外,他的纪行组诗不仅能突破传统纪行组诗对于诗人个体的关注,还能做到“情”“景”“事”“理”四者兼备,为唐宋纪行组诗的创作开辟新途。

关键词：苏轼纪行组诗文本形态内容表现风格特征

Cigarette smoking and alcohol drinking and esophageal cancer risk in Taiwan Residents women

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World Journal of Gastroenterology 2010年第12期16卷 1518-1521页

作者： I-Chen Wu Deng-Chyang Wu hung-Ju Su Hui-Jen Tsai Chien-Yu lu Jang-Ming Lee Ming-Tsang Wu Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Faculty of Medicine College of MedicineKaohsiung Medical University Biomedical Engineering Research Laboratories Industrial Technology Research Institute Division of Hematology and Oncology Department of Internal MedicineKaohsiung Medical University Hospital Department of Surgery National Taiwan University Hospital Department of Family Medicine Kaohsiung Medical University Hospital Graduate Institute of Occupational Safety & Health Kaohsiung Medical University

AIM:To investigate the etiology of esophageal cancer among Taiwan Residents ***:This is a multi-center,hospital-based,case-control *** patients consisted of women who were newly diagnosed and pathology-proven to have esophageal squamous cell carcinoma(ESCC) from three large medical centers(one from Northern and two from Southern Taiwan,respectively)between August 2000 and December *** ESCC patient was matched with 4 healthy women based on age(within 3 years)and hospital of origin,from the Department of Preventive Medicine in each hospital.A total of 51 case patients and 204 controls,all women,were ***:Frequencies of smokers and drinkers among ESCC patients were 19.6%and 21.6%,respectively,which were significantly higher than smokers(4.4%) and drinkers(4.4%)among controls(OR=4.07,95%CI:1.36-12.16,P=0.01;OR=3.55,95%CI:1.03-12.27,P=0.04).Women who drank an amount of alcohol more than 158 g per week had a 20.58-fold greater risk(95%CI:1.72-245.62,P=0.02)of ESCC than those who never drank alcohol after adjusting for other covariates,although the sample size was ***:Cigarette smoking and alcohol drinking,especially heavy drinking,are the major risks for developing ESCC in Taiwan Residents women.

关键词： Esophageal squamous cell carcinoma Taiwan Residents women Cigarette smoking Alcohol drinking

Development of Novel Hybrid Hand Formed by a Parallel Wrist and Three Soft-flexible Fingers

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Journal of Bionic Engineering 2022年第5期19卷 1349-1358页

作者： Yi lu Zefeng Chang Yang lu College of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China Harbin Electric Corporation(Qinhuangdao)Heavy Equipment Company Limited Qinhuangdao 066004China

A prototype of a novel hybrid hand is developed by combing a parallel wrist with three flexible *** dynamics model is established,its grabbed forces are measured,and its grabbing performances are ***,Jacobian and Hessian matrices of the moving platform in the parallel wrist are derived,the kinematics formulas for solving the general velocity and the general acceleration of the moving platform are *** its dynamics model is established for solving the dynamic actuation forces,the dynamic constrained forces of the developed hybrid ***,its simulation mechanism is constructed in Matlab,and the theoretical solutions of the kinematics and the dynamics of the developed hybrid hand are verified to be correct using its simulation ***,when objects with different mass are grabbed by prototype of hybrid hand in different poses,the grabbed forces are measured,and the grabbing performances are discovered and analyzed to verify its merits.

关键词： Hybrid hand Flexible finger mechanism Dynamics Parallel wrist Grabbing performance