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Non-volatile dynamically switchable color display via chalcogenide stepwise cavity resonators

Opto-Electronic Advances 2024年第1期7卷 16-27页

作者： Kuan Liu Zhenyuan lin Bing Han Minghui Hong tun Cao School of Optoelectronic Engineering and Instrumentation Science Dalian University of TechnologyDalian 116024China Pen-tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361102China Institute of Laser Engineering Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China

High-resolution multi-color printing relies upon pixelated optical nanostructures,which is crucial to promote color display by producing nonbleaching colors,yet requires simplicity in fabrication and dynamic *** trisulfide(Sb_(2)S_(3))is a newly rising chalcogenide material that possesses prompt and significant transition of its optical characteristics in the visible region between amorphous and crystalline phases,which holds the key to color-varying ***,we proposed a dynamically switchable color printing method using Sb_(2)S_(3)-based stepwise pixelated Fabry-Pérot(FP)cavities with various cavity *** device was fabricated by employing a direct laser patterning that is a less timeconsuming,more approachable,and low-cost *** switching the state of Sb_(2)S_(3) between amorphous and crystalline,the multi-color of stepwise pixelated FP cavities can be actively *** color variation is due to the profound change in the refractive index of Sb_(2)S_(3) over the visible spectrum during its phase ***,we directly fabricated sub-50 nm nano-grating on ultrathin Sb_(2)S_(3) laminate via microsphere 800-nm femtosecond laser irradiation in far *** minimum feature size can be further decreased down to~45 nm(λ/17)by varying the thickness of Sb_(2)S_(3) *** switchable Sb_(2)S_(3) photonic devices can take one step toward the next generation of inkless erasable papers or displays and enable information encryption,camouflaging surfaces,anticounterfeiting,***,our work explores the prospects of rapid and rewritable fabrication of periodic structures with nano-scale resolution and can serve as a guideline for further development of chalcogenide-based photonics components.

关键词： tunable color displays Fabry-Pérot cavity resonators color printing chalcogenide materials

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An integrative approach of digital image analysis and transcriptome profiling to explore potential predictive biomarkers for TGFβblockade therapy

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3594-3601页

作者： Robert Pomponio Qi Tang Anthony Mei Anne Caron Bema Coulibaly Joachim Theilhaber Maximilian Rogers-Grazado Michele Sanicola-Nadel Souad Naimi Reza Olfati-Saber Cecile Combeau Jack Pollard tun tun lin Rui Wang Sanofi Translational Medicine Early Development Cambridge MA 02142USA Sanofi Artificial Intelligence and Deep Analytics Data and Data Sciences CambridgeMA 02142USA Sanofi Translational Science Vitry sur Seine 94403France Sanofi Precision Oncology Cambridge MA 02142USA Sanofi Oncology Early Development Cambridge MA 02142USA

Increasing evidence suggests that the presence and spatial localization and distribution pattern of tumor infiltrating lymphocytes(TILs)is associate with response to *** studies have identified TGFβactivity and signaling as a determinant of T cell exclusion in the tumor microenvironment and poor response to PD-1/PD-L1 *** we coupled the artificial intelligence(AI)-powered digital image analysis and gene expression profiling as an integrative approach to quantify distribution of TILs and characterize the associated TGFβpathway *** of T cell spatial distribution in the solid tumor biopsies revealed substantial differences in the distribution *** digital image analysis approach achieves 74%concordance with the pathologist assessment for tumor-immune *** transcriptomic profiling suggests that the TIL score was negatively correlated with TGFβpathway activation,together with elevated TGFβsignaling activity observed in excluded and desert tumor *** present results demonstrate that the automated digital pathology algorithm for quantitative analysis of CD8 immunohistochemistry image can successfully assign the tumor into one of three infiltration phenotypes:immune desert,immune excluded or immune *** association between“cold”tumor-immune phenotypes and TGFβsignature further demonstrates their potential as predictive biomarkers to identify appropriate patients that may benefit from TGFβblockade.

关键词： Digital pathology Artificial intelligence TGFβ Predictive biomarker Tumor topography T cell infiltration Transcriptomic profiling Machine learning

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Microsphere femtosecond laser sub-50 nm structuring in far field via non-linear absorption

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Opto-Electronic Advances 2023年第6期6卷 8-17页

作者： Zhenyuan lin Kuan Liu tun Cao Minghui Hong Pen-tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361102China School of Optoelectronic Engineering and Instrumentation Science Dalian University of TechnologyDalian 116024China Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3117576Singapore

Creation of arbitrary features with high resolution is critically important in the fabrication of nano-optoelectronic ***,sub-50 nm surface structuring is achieved directly on Sb2S3 thin films via microsphere femtosecond laser irradi-ation in far *** varying laser fluence and scanning speed,nano-feature sizes can be flexibly *** small patterns are attributed to the co-effect of microsphere focusing,two-photons absorption,top threshold effect,and high-repetition-rate femtosecond laser-induced incubation *** minimum feature size can be reduced down to~30 nm(λ/26)by manipulating film *** fitting analysis between the ablation width and depth predicts that the feature size can be down to~15 nm at the film thickness of~10 nm.A nano-grating is fabricated,which demonstrates desirable beam diffraction *** nano-scale resolution would be highly attractive for next-generation laser nano-lithography in far field and in ambient air.

关键词： non-linear effect microsphere femtosecond laser far field

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HEP quantification strategy based on modified CREAM

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Journal of Systems Engineering and Electronics 2019年第4期30卷 815-822页

作者： PAN Xing WANG Huixiong lin Ye LIU tun WANG Xiaoxia School of Reliability and Systems Engineering Beihang University

The accurate quantification of human error probability(HEP) has long been a main pursuit for most human reliability analysis(HRA) methods. This paper proposes a strategy to analyzeand predict human error on the basis of a further modification of theexisting cognitive reliability and error analysis method (CREAM)in HRA. Through providing a broader definition for the key parametersused in the quantification method, this paper produces arelatively flexible strategy to determine the nominal HEP (HEP0).Basing on this strategy, the actual quantification of HEP in CREAMis able to be applied to more verified conditions. To prove the validityof the method proposed, a case study of spacecraft launch isalso introduced, in which the prediction derived from the method isproved consistent with real field data.

关键词： human reliability cognitive reliability and error analysismethod(CREAM) context influence nominal human errorprobability(HEP0)

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Shift work aggravates metabolic syndrome development among early-middle-aged males with elevated ALT

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World Journal of Gastroenterology 2009年第45期15卷 5654-5661页

作者： Yu-Cheng lin tun-Jen Hsiao Pau-Chung Chen Department of Occupational Medicine Tao-Yuan General Hospital Tao-Yuan 330-Taiwan China Institute of Occupational Medicine and industrial Hygiene College of Public Health National Taiwan University No. 17 Xu-Zhou Road Taipei 100 Yaiwan China College of Public Health and Nutrition Taipei Medical University Taipei 110 Taiwan China

AIM: To examine whether shift work accelerates metabolic syndrome (MetS) development among early middle-aged males with elevated alanine aminotransferase (e-ALT).METHODS: A retrospective, observational followup study on MetS development at a 5-year interval was conducted using health examination data. Nine hundred and ninety six male employees not fulfi lling MetS criteria at screening were enrolled. Age, MetScomponents, liver enzymes, serological markers for viral hepatitis, abdominal ultrasound, insulin resistance status, lifestyles, and workplace factors were ***: The prevalence of elevated serum ALT (> 40 U/L, e-ALT) at baseline was 19.1%. There were 381 (38.3%) workers with long-term exposures to day-night rotating shift work (RSW). 14.2% of subjects developed MetS during follow-up. After 5 years, the workers with e-ALT had significantly unfavorable changes in MetS-components, and higher rates of MetS development, vs subjects with normal baseline ALT levels. Workers with both baseline e-ALT and 5-year persistent RSW (pRSW) exposure had the highest rate of MetS development. Also, e-ALT-plus-pRSW workers had a significant increase in MetS-components atfollow-up, compared with the other subgroups. After controlling for potential confounders, e-ALT-plus-pRSW workers posed a signifi cant risk for MetS development (odds ratio, 2.7; 95% confi dence interval, 1.4-5.3, vs workers without baseline e-ALT nor pRSW). CONCLUSION: We suggest that all early middle-aged male employees with e-ALT should be evaluated and managed for MetS. Particularly in terms of job arrangements, impacts of long-term RSW on MetS development should be assessed for all male employees having baseline e-ALT.

关键词：代谢综合征谷丙转氨酶男性中年

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Participation of private general practitioners in disease management of malaria in Myanmar

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Asian Pacific Journal of Tropical Medicine 2009年第5期2卷 71-76页

作者： Thein tun Zaw Win tun Hla Soe Tint Khin lin Thar tun Kyaw Moe Kyaw Myint Department of Medical Research(Upper Myanmar) AnisakhanPyin Oo Lwin 05062Mandalay DivisionMyanmar VBDC Divisional Office 35th StreetMandalayMyanmar

Objective:Myanmar has been trying to improve the disease management of malaria through public health services. The involvement of private general practitioners(GPs) is recognized as one of the key contributory issues in malaria control,but no one has yet made an attempt to study the efficiency of their *** study aimed to assess the participation of GPs in improvement of disease ***:The study was conducted with all 32 GPs practicing at three randomly selected townships with high malaria load situated in Upper Myanmar from June 2006 to March 2007 using a pretest-posttest design to assess their knowledge of the disease management prior to and after *** intervention package consisted of a one-day workshop on diagnosis and treatment of malaria and the supply of facilities for *** filled in before and after tests were compared to assess the change of knowledge after the *** and treatment practice during the study period was analysed by review of registers kept by GPs,together with a follow-up survey of their patients for the reliability of ***:An overall improvement of knowledge was observed and significant changes were apparent for three variables:the criteria for referral of severe malaria,the effect of incomplete treatment and recommended treatment of Plasmodium ***-test results showed that only 65.6%of GPs perceived microscopy or Rapid Diagnostic Test kits(RDTs) for confirmation of malaria necessary,while only 15.6%and 40.6%of the GPs knew the recommended treatments of falciparum and vivax malaria,respectively. However,after intervention 92%of the patients were diagnosed as malaria by RDTs and 3%by microscopy throughout the *** GPs prescribed artemisinin-based combination therapy(ACTs) to 95%of confirmed falciparum cases and treated 82.4%of RDT confirmed falciparum negatives with chloroquine and *** with our study,an international NGO,Population Service In

关键词： Malaria Myanmar Private health services Disease management Private general practitioners

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Mako:A Graph-based Pattern Growth Approach to Detect Complex Structural Variants

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 205-218页

作者： Jiadong lin Xiaofei Yang Walter Kosters tun Xu Yanyan Jia Songbo Wang Qihui Zhu Mallory Ryan Li Guo Chengsheng Zhang The Human Genome Structural Variation Consortium Charles Lee Scott E.Devine Evan E.Eichler Kai Ye School of Automation Science and Engineering Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China MOE Key Lab for Intelligent Networks&Networks Security Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China Genome Institute the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Leiden Institute of Advanced Computer Science Faculty of ScienceLeiden UniversityLeiden 2311EZNetherland School of Computer Science and Technology Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China The Jackson Laboratory for Genomic Medicine FarmingtonCT 06032USA Precision Medicine Center the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Institute for Genome Sciences University of Maryland School of MedicineBaltimoreMD 21201USA Department of Genome Sciences University of Washington School of MedicineSeattleWA 98119USA Howard Hughes Medical Institute University of WashingtonSeattleWA 98195USA The School of Life Science and Technology Xi’an Jiaotong UniversityXi’an 710049China 不详

Complex structural variants(CSVs) are genomic alterations that have more than two breakpoints and are considered as the simultaneous occurrence of simple structural ***,detecting the compounded mutational signals of CSVs is challenging through a commonly used model-match *** a result,there has been limited progress for CSV discovery compared with simple structural ***,we systematically analyzed the multi-breakpoint connection feature of CSVs,and proposed Mako,utilizing a bottom-up guided model-free strategy,to detect CSVs from paired-end short-read ***,we implemented a graph-based pattern growth approach,where the graph depicts potential breakpoint connections,and pattern growth enables CSV detection without pre-defined *** evaluations on both simulated and real datasets revealed that Mako outperformed other ***,validation rates of CSVs on real data based on experimental and computational validations as well as manual inspections are around 70%,where the medians of experimental and computational breakpoint shift are 13 bp and 26 bp,***,the Mako CSV subgraph effectively characterized the breakpoint connections of a CSV event and uncovered a total of 15 CSV types,including two novel types of adjacent segment swap and tandem dispersed *** analysis of these CSVs also revealed the impact of sequence homology on the formation of *** is publicly available at https://***/xjtu-omics/Mako.

关键词： Next-generation sequencing Complex structural variant Pattern growth Graph mining Formation mechanism

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在线固相萃取-超高效液相色谱-三重四级杆质谱法测定地表水中22种磺胺类抗生素

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广东化工 2022年第19期49卷 237-240页

作者：林暾福建省环境监测中心站福建福州350001

建立了在线固相萃取-超高效液相色谱-三重四级杆质谱法测定地表水中22种磺胺类抗生素的方法。水样经滤膜过滤,加入0.1%甲酸混匀后采用在线固相萃取柱富集纯化,超高效液相色谱-三重四级杆质谱测定,外标法定量。优化了液相色谱流动相和质... 详细信息

建立了在线固相萃取-超高效液相色谱-三重四级杆质谱法测定地表水中22种磺胺类抗生素的方法。水样经滤膜过滤,加入0.1%甲酸混匀后采用在线固相萃取柱富集纯化,超高效液相色谱-三重四级杆质谱测定,外标法定量。优化了液相色谱流动相和质谱条件,22种磺胺类抗生素在线性范围内线性良好,相关系数r^(2)大于0.9912;方法检出限为0.04~0.42 ng/L,测定下限为0.16~1.68 ng/L;实际水样低、中、高浓度的平均加标回收率范围为70%~111%;相对标准偏差小于5.7%。该方法与传统离线固相萃取法比较具有简单快速、灵敏度高、样品消耗量小等优点,能用于地表水中22种痕量磺胺类抗生素的测定。

关键词：在线固相萃取超高效液相色谱-三重四级杆质谱法磺胺类抗生素地表水

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树脂塔运行周期的延长

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氯碱工业 2022年第10期58卷 3-6页

作者：林暾万华化学(宁波)氯碱有限公司浙江宁波315812

讨论了二次盐水精制工序螯合树脂塔理论运行周期及其影响因素,分析了树脂塔运行周期由48h延长至72h的可行性及经济效益。运行证明:延长树脂塔运行周期后,盐水中杂质无明显差别。由于减少了树脂塔再生次数,因此降低了再生用高纯盐酸、烧... 详细信息

讨论了二次盐水精制工序螯合树脂塔理论运行周期及其影响因素,分析了树脂塔运行周期由48h延长至72h的可行性及经济效益。运行证明:延长树脂塔运行周期后,盐水中杂质无明显差别。由于减少了树脂塔再生次数,因此降低了再生用高纯盐酸、烧碱和纯水的消耗,达到了节能降耗的目的。

关键词：二次盐水螯合树脂塔运行周期钙离子镁离子

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OLYMPIC VILLAGE:Development of a small town in China as it prepares for 2022

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China Report ASEAN 2020年第1期5卷 36-39页

作者： Si Thu tun Zuo lin 不详

Mst people have not heard of the small town of Chongli in northern China,which will host many events for the 2022 Winter Olympic *** about four hours from Beijing by car,Chongli is a district-level town in Zhangjiakou... 详细信息

关键词： Province. town district

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