检索结果-南通市图书馆

世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 1-2页

作者： Aceng j.R. Byarugaba j.S. tumwine j.k. 黄卫东 Dept. of Paediatr. and Child Health Makerere Medical School PO Box 7072 Kampala Uganda

Objective: To compare the efficacy and safety of rectal artemether with intrav enous quinine in the treatment of cerebral malaria in children. Design: Randomis ed, single blind, clinical trial. Setting: Acute care unit at Mulago Hospital, U ganda’s national referral and teaching hospital in kampala. Participants: 103 ch ildren aged 6 months to 5 years with cerebral malaria. Intervention: Patients we re randomised to either intravenous quinine or rectal artemether for seven days. Main outcome measures: Time to clearance of parasites and fever; time to regain ing consciousness, starting oral intake, and sitting unaided; and adverse effects. Results: The difference in parasitological and clinical outco mes between rectal artemether and intravenous quinine did not reach significance (parasite clearance time 54.2 (SD 33.6) hours v 55.0 (SD 24.3) hours, P = 0.90; fever clearance time 33.2 (SD 21.9) hours v 24.1(SD 18.9 hours, P = 0.08; time to regaining consciousness 30.1 (SD 24.1) hours v 22.67 (SD 18.5) hours, P = 0.1 0; time to starting oral intake 37.9 (SD 27.0) hours v 30.3 (SD 21.1) hours, P = 0.14). Mortality was higher in the quinine group than in the artemether group ( 10/52 v 6/51; relative risk 1.29, 95%confidence interval 0.84 to 2.01). No seri ous immediate adverse effects occurred. Conclusion: Rectal artemether is effecti ve and well tolerated and could be used as treatment for cerebral malaria.

关键词：随机临床研究蒿甲醚意识恢复时间退热时间 rectal clearance intravenous 经口寄生虫学坎帕拉

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

随机临床试验:直肠内给予青蒿素甲醚和静脉滴注奎宁治疗乌干达患儿脑型疟疾的比较

引用

世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 1-1页

作者： Aceng j.R. Byarugaba j.S. tumwine j.k. 李开 Dept.of Paediatr.and Child Health Makerere Medical School PO Box707 kampala Ugan-da

Objective: To compare the efficacy and safety of rectal artemether with intrav enous quinine in the reatment of cerebral malaria in ***: Randomised, single blind, clinical ***: Acute care unit at ulago Hospital, Uganda’s national referral and teaching hospital in ***: 103 children aged 6 onths o 5 years with cerebral ***: Patients were randomised to either intravenous quinine or rectal rtemether for seven *** outcome measures: Time to clearance of parasites and fever; time to regaining onsciousness, starting oral intake, and sitting unaided; and adverse ***: The difference in arasitological nd clinical outcomes between rectal artemether and intravenous quinine did not reach significance (parasite clearance time 54.2 (SD 33.6) hours v 55.0 (SD 24.3) hours, P = 0.90; fever clearance time 33.2 (SD 21.9) hours v 4.1SD 18.9 hours, P = 0.08; time to regaining consciousness 30.1 (SD 24.1) hours v 22.67 (SD 18.5) hours, P = 0.10; ime to starting oral intake 37.9 (SD 27.0) hours v 30.3 (SD 21.1) hours, P = 0.14)－.Mortality was higher in the quinine roup than in the artemether group (10/52 v 6/51; relative risk 1.29, 95％confidence interval 0.84 to 2.01).No serious mmediate adverse effects ***: Rectal artemether is effective and well tolerated and could be used s reatment for cerebral malaria.

关键词：青蒿素甲醚脑型疟疾随机临床试验静脉滴注直肠内退热时间意识恢复时间药物不良反应坎帕拉单盲

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：