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Effects of Obesity and Smoking on Survival in Non-Small Cell Lung Cancer

Open Journal of Epidemiology 2016年第2期6卷 128-139页

作者： Damien M. Hansra tulay koru-sengul Wei Zhao Feng Miao Alicia P. Monedero Stacey L. Tannenbaum David J. Lee Judith Hurley Margaret M. Byrne University of Miami/Jackson Memorial Hospital Miami FL USA Department of Public Health Sciences and Sylvester Comprehensive Cancer Center of University of Miami Miller School of Medicine Miami FL USA

Background: Obesity is an emerging leading cause of morbidity and mortality in the US and the relationship between obesity, tobacco, and survival in NSCLC is unclear. Methods: Data (n = 87,631) were obtained from linkage of the 1996-2007 Florida Cancer Data System to the Agency for Health Care Administration database providing procedure and diagnoses codes. Survival time was calculated from date of diagnosis to date of death. Smoking status was categorized as never, current, and former. Obesity (yes/no) = ICD9 code BMI > 30 kg/m2, cachexia = ICD9 code “wasting syndrome”, & non-obese = non-obese & non cachectic. Cox proportional regression models used to predict survival;demographic, clinical, treatment factors, & comorbidities were included in adjusted models with smoking status and obesity as the main factors. Results: The majority of patients (pts) were either former (49%) or current (40%) smokers, & non-obese (88%). 6.8% of pts were obese & 4.8% of pts were cachectic. There were significant differences between survival curves and median survival (months) for obese vs. non-obese vs. cachectic pts. (20 vs 10 vs. 7.9;P < 0.001). Former and current smokers had shorter median survival than never smokers (10.8 & 9.2 vs. 11.9;P < 0.001). Survival rates (%) at 1-yr (60.1 vs. 45.2 vs. 37.7;P < 0.001), 5-yr (30.3 vs. 15.4 vs. 9.5;P < 0.001), 10-yr (18.1 vs. 7.6 vs. 2.7;P < 0.001) were better for obese vs. non-obese and cachectic pts respectively. Independent predictor of worse survival in the unadjusted model was former (HR 1.08;P < 0.001) and current (HR 1.20;P < 0.001) smokers compared to never. Obese and non-obese pts had better survival vs. cachexia pts. (HR 0.52;P < 0.001 and HR 0.80, p < 0.001 respectively) and obese had better survival than Non-obese pts (HR 0.65, p < 0.001). In the adjusted model, controlling for extensive variables and comorbidities, former (HR 1.11;P < 0.001) and current (HR 1.19;P < 0.001) smokers still had significantly worse survival vs. never

关键词： Lung Cancer Non-Small Cell Lung Cancer Tobacco Smoking Obesity

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Internet of Things Supported Airport Boarding System and Evaluation with Fuzzy

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Intelligent Automation & Soft Computing 2023年第3期35卷 2687-2702页

作者： Tolga Memika tulay Korkusuz Polat Sakarya University Sakarya54054Turkey

The existing systems sustained with the investments made require more automation and digital transformation with the continuous advancement of *** aviation industry is a sector that is open to more automation and digi-tal transformation,mainly because of the intense competition and the analysis of a large variety of *** long duration of operations in current airline processes and some processﬂows cause customer dissatisfaction and cost *** this study,the boarding process,which is one of the operational processes of airline transportation and is open to improvement,was *** classical boarding process has been redesigned using Internet of Things technology a model called Boarding 4.0 was *** Boarding 4.0,it is aimed to design a process where passengers can take their time before boarding more efﬁ*** the study,the sub-processes of the Boarding 4.0 model,other processes that the sub-processes interact with,their activities,and data exchange passenger move-ments during the activities are explained in *** to the classical boarding process and Boarding 4.0 with the fuzzy ahp technique,it has been shown that boarding 4.0 is more advantageous and passenger movement times can be reduced during *** a result of the evaluation made with the fuzzy ahp,it was determined that boarding 4.0 is more advantageous than the classical boarding *** addition,when the total time of the sub-activities in the board-ing process is calculated,boarding activities for a passenger take 50 min with the classic boarding process and 20 min with Boarding ***,when Boarding 4.0 is used,the passenger gains 30 ***,when the calculation is made concerning the airport’s current capacity,two passengers are hosted with the clas-sical boarding process,whileﬁve passengers are hosted with Boarding *** acquisition is signiﬁcant for airports in terms of efﬁcient use of resources.

关键词： Intelligent airport internet of things boarding system process management model fuzzy ahp

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Exploring the influence of the built environment on human experience through a neuroscience approach:A systematic review

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Frontiers of Architectural Research 2020年第1期9卷 236-247页

作者： tulay Karakas Dilek Yiidiz Istanbul Technical University Faculty of ArchitectureDepartment of ArchitectureIstanbulTurkey

The built environment provides a habitat for the most sophisticated mammal in our universe,the human *** in science and technology are forcing us to reconsider the priority of human needs in current theories of architecture and the built *** developed theories and methodologies in neuroscience have allowed us to improve and deepen our knowledge of human experience in the built *** potential of the relationship between neuroscience and architecture for knowledge creation generates an increasing interest in theoretical and methodological approaches to explore this ***,a common ground on which to conduct interdisciplinary studies investigating developing and emerging concepts at the intersection must be ***,few reviews in the literature have systematically examined developing and emerging concepts at the intersection of neuroscience and *** present review aims to examine the existing literature systematically to explain the influence of the built environment on human experience by using approaches from neuroscience by examining the conceptualizations in the *** study is conducted as a systematic qualitative review that analyzes and synthesizes the developing and emerging concepts that have appeared in the ever-evolving *** study concludes with an overall discussion about these concepts as a means of deeply understanding the influence of the built environment on human experience,responses to the environment based on approaches from neuroscience,and their potential for providing further directions for future research.

关键词： Architecture Neuroscience Human experience Built environment Cognitive architecture Neuro-architecture

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The role of the perfusion index in patients with thoracic trauma

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World Journal of Emergency Medicine 2022年第5期13卷 390-392页

作者： İsmail Uzkuç Ekim Saglam Gurmen Cumhur Murat tulay Emergency Department Manisa Celal Bayar University School of MedicineManisa 45040Turkey Thoracic Surgery Department Manisa Celal Bayar University School of MedicineManisa 45040Turkey

Traumatic injuries range from simple to complicated multiple *** identification of patients with critical injuries and disrupted organ perfusion is essential to prevent tissue hypoxia.A study estimated that a fast and accurate response to thoracic trauma should reduce the mortality by 30%.[1]The tissue perfusion value is an essential indicator of mortality and morbidity for patients admitted to the hospital with thoracic ***,this study aimed to show the role of the perfusion index(PI)in predicting the prognosis of patients admitted to the emergency department for thoracic trauma.

关键词： injuries perfusion admitted

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Assessment of socio-demographic factors,health status and the knowledge on probiotic dairy products

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Food Science and Human Wellness 2020年第3期9卷 272-279页

作者： Lutfiye Yilmaz-Ersan tulay Ozcan Arzu Akpinar-Bayizit Bursa Uludag University Department of Food EngineeringBursaTurkey

The probiotic dairy products have become the fastest growing in functional foods market in response to the increasing numbers of consumers interested in improving their ***,data collected from 314 participants in the city of Bursa,Turkey,were analyzed with the aim to assess the socio-demographic characteristics and health status as well as the consumer’s knowledge and awareness of probiotic dairy products in order to gain a better understanding of consumers’*** was observed that sociodemographic characteristics of the participants were not significantly associated with the degree of knowledge or awareness and purchasing frequencies of probiotic dairy *** a higher educational level,higher income level and being a woman indicated an increased the awareness,knowledge and purchase probability of probiotic dairy *** study emphasized that consumers should be more informed about the positive relationship between a healthier life and the consumption of probiotic dairy products.

关键词： Socio-demographics Health Knowledge Probiotics

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Evaluation of choroidal thickness using spectral-domain optical coherence tomography in patients with severe obstructive sleep apnea syndrome: a comparative study

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 1030-1034页

作者： Aylin Karalezli Fatma Corak Eroglu tulay Kivanc Rusina Dogan Department of Ophthalmology School of MedicineBaskent University Department of Pulmonary Medicine School of MedicineBaskent University

AIM: To assess choroidal thickness in patients with severe obstructive sleep apnea syndrome(OSAS) and compare them with healthy controls, using spectral domain optical coherence tomography(OCT).METHODS: In this observational, cross-sectional study,choroidal thicknesses of 23 newly severe OSAS patients and 23 body mass index- age- and sex-matched healthy subjects were measured using a high-speed, high-resolution frequency domain- OCT device( λ = 840 nm,26 000 A-scans/s, 5 μm axial resolution). All patients underwent a complete ophthalmic examination before the measurements. OCT measurements were taken at the same time of day(9:00 a.m.), in order to minimize the effects of diurnal ***: There was a statistically significant difference in median choroidal thickness between the OSAS patients(201 μm; range 145-237 μm) and the controls(324 μm; range 296-383 μm;P <0.001). There were significant differences at all measurement points(P <0.001 for all). The apnea-hypopnea index(AHI)values were more than 30 in all OSAS patients and the mean AHI was 48.57 ±6.54. The interexaminer intraclass correlation coefficient(ICC) for the mean choroidal thickness was 0.938(95% CI, 0.908-0.985) and ICC was greater than 0.90 for all measurement ***: The decreased choroidal thickness of patients with severe OSAS might be related to the the autonomic disregulation associated with this *** studies are needed to evaluate the etiopathologic relationship between choroidal thickness and OSAS.

关键词： choroidal thickness optical coherence tomography obstructive sleep apnea syndrome

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Ultrasound biomicroscopy in patients with unilateral pseudoexfoliation

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 754-758页

作者： Erkan ünsal Kadir Eltutar Ilkay Muftuoglu tulay Alpar Akcetin Yildiz Acar Department of Ophthalmology Istanbul Education and Research Hospital Kasap Ilyas Mah Org Abdurrahman Nafiz Gurman CdFatih Istanbul 34098 Turkey

·AIM: To compare the anterior segment morphology evaluated using ultrasound biomicroscopy(UBM) in patients with clinical pseudoexfoliation syndrome(XFS)in one eye and no clinical XFS in the fellow eye.·METHODS: Thirty patients with unilateral XFS were included in the study. All patients underwent evaluation of their anterior segment using UBM with and without dilatation with 1% cyclopentolate. The anterior chamber depth(ACD), lens thickness(LT), anterior chamber angle(ACA), ciliary body thickness(CBT), scleral thickness(ST), trabeculae-ciliary processes distance(T-CPD), and iris-ciliary processes distance(I-CPD) were measured using UBM scans. All results between the eyes with clinical XFS and their fellow eyes without clinical XFS were then compared.·RESULTS: Before dilatation the eyes with XFS(4.350±0.531 mm) were found to have a significantly thicker lens(P =0.002) than the eyes without XFS(4.238 ±0.540 mm).In addition after dilatation, the eyes with XFS(4.310 ±0.500 mm) were found to have a significantly thicker lens than the eyes without XFS(4.160±0.480 mm)(P=0.019).The average ACD, for the group with XFS, comparing pre-dilatation(2.616 ±0.349 mm) and post-dilatation measurements(2.714±0.413) was found to be statistically increased(P =0.014). The average ACD, comparing pre-dilatation to post-dilatation measurements in patients without XFS(2.680±0.360),(2.720±0.500) was found to be statistically unchanged(P =0.450).·CONCLUSION: Crystalline lenses tended to be thicker in the eyes with clinical pseudoexfoliation than their fellow eyes without pseudoexfoliation.

关键词： pseudoexfoliation syndrome ultrasonic biomicroscopy anterior segment morphology

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Obestatin in male reproduction and infertility

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Asian pacific Journal of Reproduction 2019年第5期8卷 239-243页

作者： tulay Irez Ivan Rolland Karkada Sulagna Dutta Pallav Sengupta Department of Histology and Embryology Biruni UniversityTurkey Department of Physiology Faculty of Medicine and Biomedical SciencesMAHSA UniversityMalaysia Department of Oral Biology and Biomedical Sciences Faculty of DentistryMAHSA UniversityMalaysia

Obestatin is a 23-amino acid peptide hormone secreted by the stomach and is found in several tissues all over the body, such as the gastric mucosa, spleen, mammary gland, plasma as well as in the testicular Leydig cells. Obestatin seems to operate as part of the integrated gut-brain network acting as an anorectic hormone, reducing food intake and reversing body weight gain. Besides the expressions of obestatin in male reproductive tissues, it is also shown to increase testosterone secretions, thus ameliorating testicular functions. In the present scenario where the increasing prevalence in obesity is considered as one of the major causatives of worldwide declining trend of semen quality, molecules like obestatin playing roles in both metabolic and reproductive functions find importance in management of obesity-induced male infertility or subfertility. The present review article aims to provide updated concepts on obestatin and its mode of actions, and its role in modulation of male reproductive functions.

关键词： Male infertility Obestatin Testosterone Leydig cell

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Sperm counts in Asian men: Reviewing the trend of past 50 years

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Asian pacific Journal of Reproduction 2018年第2期7卷 87-92页

作者： Pallav Sengupta Sulagna Dutta Maiza Binti Tusimin tulay Irez Elzbieta Krajewska-Kulak Department of Physiology Faculty of MedicineMAHSA UniversityMalaysia Department of Obstetrics and Gynaecology Faculty of Medicine and Health SciencesUniversity Putra MalaysiaMalaysia Department of Histology and Embryology Medical FacultyBiruni UniversityIstanbulTurkey Department of Integrated Medical Care Faculty of Health SciencesMedical University of BialystokBialystokPoland

Objective:To reveal the trend in alterations of sperm counts in Asian men over the past 50 ***:This study reviewed all the published reports to unveil the specific pattern of alterations of sperm concentrations in Asian men from 1965 till 2015. The time-related changes in sperm concentration were studied using linear regression ***:The present study elucidated the trend using the reports from Carlsenet al(1965-1990) and non-Carlsen studies published until 2015, on fertile Asian men. In the reports of Carlsenet al., no overall declining trend in Asian men (r = 0.509,P= 0.760) was observed during this tenure, but non-Carsen reports showed a significant time-dependent decline of sperm concentration (r = -0.754, P = 0.005) in Asian men. This present review also showed a mild time-dependant decline in sperm concentration (-0.44×106/mL/year, 95% CI: -0.65 to -0.23;r = -0.473,P = 0.040) which accounted for an overall 22.17% decrease in past 50 ***:This study brings to the forefront that sperm concentration among Asian men follows a mild declining trend over the period of 50 years, and further studies addressing the causes of this decline are required.

关键词： Asian men Semen quality Sperm concentration Sperm count

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The role of human papillomaviruses in cancer progression

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 201-213页

作者： Pinar tulay Nedime Serakinci Department of Medical Genetics Faculty of MedicineNear East University999058 NicosiaCyprus

The importance of human papillomavirus(HPV)infection and its role in the progress of cancer have been widely *** understanding of HPV association with certain cancers,such as cervical cancer,is very well established.A big step forward in the prevention of HPV associated cancers with the use of early detection by screening strategies has also been *** the last decade,development of HPV vaccination has reduced the number of cases in HPV infections and infection induced *** this report,we review the HPV pathogenesis and highlight the mechanism of HPV involvement in cancer development.

关键词： Human papillomavirus cancer immune response human papillomavirus vaccine

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