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Evaluation of choroidal thickness using spectral-domain optical coherence tomography in patients with severe obstructive sleep apnea syndrome: a comparative study

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 1030-1034页

作者： Aylin Karalezli Fatma Corak Eroglu tulay kivanc Rusina Dogan Department of Ophthalmology School of MedicineBaskent University Department of Pulmonary Medicine School of MedicineBaskent University

AIM: To assess choroidal thickness in patients with severe obstructive sleep apnea syndrome(OSAS) and compare them with healthy controls, using spectral domain optical coherence tomography(OCT).METHODS: In this observational, cross-sectional study,choroidal thicknesses of 23 newly severe OSAS patients and 23 body mass index- age- and sex-matched healthy subjects were measured using a high-speed, high-resolution frequency domain- OCT device( λ = 840 nm,26 000 A-scans/s, 5 μm axial resolution). All patients underwent a complete ophthalmic examination before the measurements. OCT measurements were taken at the same time of day(9:00 a.m.), in order to minimize the effects of diurnal ***: There was a statistically significant difference in median choroidal thickness between the OSAS patients(201 μm; range 145-237 μm) and the controls(324 μm; range 296-383 μm;P <0.001). There were significant differences at all measurement points(P <0.001 for all). The apnea-hypopnea index(AHI)values were more than 30 in all OSAS patients and the mean AHI was 48.57 ±6.54. The interexaminer intraclass correlation coefficient(ICC) for the mean choroidal thickness was 0.938(95% CI, 0.908-0.985) and ICC was greater than 0.90 for all measurement ***: The decreased choroidal thickness of patients with severe OSAS might be related to the the autonomic disregulation associated with this *** studies are needed to evaluate the etiopathologic relationship between choroidal thickness and OSAS.

关键词： choroidal thickness optical coherence tomography obstructive sleep apnea syndrome

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