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Evaluation of febrile neutropenic patients hospitalized in a hematology clinic

Asian Pacific Journal of Tropical Biomedicine 2015年第12期5卷 1051-1054页

作者： Mucahit Goruk Mehmet Sinan dal tuba dal Abdullah Karakus Recep Tekin Nida Ozcan Orhan Ayyildiz Department of Internal Medicine Dicle University School of Medicine Department of Medical Microbiology Yildirim Beyazit University School of Medicine Department of Clinical Microbiology and Infectious Diseases Dicle University School of Medicine Department of Medical Microbiology Dicle University School of Medicine

Objective:To evaluate the febrile neutropenic patients with hematological malignancies hospitalized in hematology clinic with poor hygiene ***:A total of 124 patients with hematological malignancies(69 male,55 female)hospitalized in hematology clinic with poor hygiene conditions depending on hospital conditions,between January 2007 and December 2010,were evaluated,***:In this study,250 febrile neutropenia episodes developing in 124 hospitalized patients were *** the patients,69 were men(56%)and 55 women(44%).A total of 40 patients(32%)had acute myeloid leukemia,25(20%)acute lymphoblastic leukemia,19(15%)non-Hodgkin's lymphoma,10(8%)multiple myeloma,and 8(8%)chronic myeloid *** our study,56 patients(22%)were diagnosed as pneumonia,38(15%)invasive aspergillosis,38(15%)sepsis,16(6%)typhlitis,9(4%)mucormycosis,and 4(2%)urinary tract ***-positive cocci were isolated from 52%(n=20),while Gram-negative bacilli 42%(n=16)and yeasts from 6%(n=2)of the sepsis patients,*** most frequently isolated Gram-positive bacteria were methicillin-resistant coagulase-negative staphylococci(n=18),while the most frequently isolated Gram-negative bacteria was Escherichia coli(n=10).Conclusions:Febrile neutropenia is still a problem in patients with hematological *** documentation of the flora and detection of causative agents of infections in each unit would help to decide appropriate empirical *** control procedures should be applied for preventing infections and transmissions.

关键词： Febrile neutropenia Hematological malignancy Leuke Multiple myeloma Infections

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Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey

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Asian Pacific Journal of Tropical Biomedicine 2013年第9期3卷 743-747页

作者： Aysegül Copur Cicek Azer Ozad Düzgün Aysegül Saral tuba Kayman Zeynep Cizmeci Pervin Ozlem Balci tuba dal Mehmet Firat Ismail Tosun Yasemin Ay Alitntop Ahmet Caliskan Yelda Yazici Cemal Sandalli Department of Medical Microbiology Faculty of MedicineRecep Tayyip Erdogan University Department of Genetics and Bioengineering Faculty of Engineering and Natural SciencesGümüshane University Department of Biology Faculty of Arts and SciencesArtvin Coruh University Clinical Microbiology Laboratory Research and Training Hospital Clinical Microbiology Laboratory Kecioren Research and Training Hospital Clinical Microbiology Laboratory General State Hospital Department of Medical Microbiology Faculty of MedicineDicle University Clinic of Infectious Diseases and Clinical Microbiology PrivateOSM Ortadogu Hospital Microbiology Laboratory Kirikkale Highly Specialized Hospital General State Hospital Microbiology Laboratory Necip Fazil City Hospital Clinical Microbiology Laboratory Ahi Evren Chest and Cardiovascular Surgery Research and Training Hospital Department of Biology Faculty of Arts and SciencesRecep Tayyip Erdogan University

Objective:To investigate the antibiotic resistance genes inserted into class I and class 2integrons in Acinetobacler baumannii[***)isolates obtained from nine different cities in ***:A collection of 281 *** clinical isolates were collected from nine diferenl state hospitals in Turkey and were confirmed as *** by conventional biochemical,API testing and bla_(-OXA-51)specific *** isolates were examined by PCR for existence of class I and2 integron gene ***:They were characterized by antimicrobial susceptibility testing and the highest resistance rates were determined for piperacillin(90.03%),ciprofloxacin(87.54%),cefepime and trimethoprim/sulfamethoxazole(81.13%).The lowest resistance rates was for cefotaxime(3.55%).class 1 integrons were detected in 6.4%(18/281)of *** strains and no class 2 integron was *** gene casselles of class 1 inlegrons AacCI-AAC(3)l-aadAI,AacCI-aadA1,AAC(3)-I,AAC(3)-I-AAC(3)-I-aadA1,***(3)-I-aadA1-AAC(3)-I-AAC(3)-I,AAC(3)-I-AAC(3)-I-AAC(3)-I-aadA1,AAC(3)-I-aadA1,AAC(3)-I-AAC(3)-I,AAC(3)-I-aadA1-AAC(3)-I-aadA1,AAC(3)-I-AAC(3)-I-aadA1-AAC(3)-I-aadA1 were detected in eighteen *** aac genes family were most frequently found integrated into the class 1 inlegrons and it was followed by aadA genes and TEM-1 ***:This is an extensive study on the distribulion of class 1 integron among *** in *** addition to these,two new alleles were *** percentage rates of similarity to other cassettes are 95%aadA1(TK A18)and 89%,aadA 1(ANKA3).

关键词： Acinetobacter baumannii Class 1 integron Gene cassette Resistance

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Screening of Class 1 and Class 2 Integrons in Clinical Isolates of Pseudomonas aeruginosa Collected from Seven Hospitals in Turkey:A Multicenter Study

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Open Journal of Medical Microbiology 2013年第4期3卷 227-233页

作者： Aysegul Copur Cicek Aysegul Saral Azer Ozad Duzgun Zeynep Cizmeci tuba Kayman Pervin Ozlem Balci tuba dal Mehmet Firat Yelda Yazici Metin Sancaktar Osman Birol Ozgumus Cemal Sandalli Department of Medical Microbiology Faculty of MedicineRecep Tayyip Erdogan UniversityRizeTurkey Department of Biology Faculty of Arts and SciencesArtvin Coruh UniversityArtvinTurkey Department of Genetics and Bioengineering Faculty of Engineering and Natural SciencesGumushane UniversityGumushaneTurkey Clinical Microbiology Laboratory Kecioren Research and Training HospitalAnkaraTurkey Clinical Microbiology Laboratory Research and Training HospitalKayseriTurkey Clinical Microbiology Laboratory General State HospitalTokatTurkey Department of Medical Microbiology Faculty of MedicineDicle UniversityDiyarbakirTurkey Clinic of Infectious Diseases and Clinical Microbiology Private OSM Ortadogu HospitalSanliurfaTurkey Clinical Microbiology Laboratory Ahi Evren Chest and Cardiovascular Surgery Research and Training HospitalTrabzonTurkey Clinical Microbiology Laboratory Akcaabat Hackali Baba General State HospitalTrabzonTurkey Department of Biology Faculty of Arts and SciencesRecep Tayyip Erdogan UniversityRizeTurkey

Pseudomonas aeruginosa is one of the leading nosocomial pathogens worldwide, and their infections are difficult to treat due to acquired resistance to many antibiotics. This study aimed to detect class 1 and 2 integrons and antibiotic susceptibility of clinical isolates of P. aeruginosa. Two hundred and five P. aeruginosa strains were collected from the seven general state hospitals in Turkey. They were characterized by antimicrobial susceptibility testing, screened for class 1 and class 2 integrons, and evaluated for the association between antibiotic resistance phenotypes and the presence of integrons. intI gene was amplified in 10 isolates (4.87%) by PCR and in seven isolates of them (70%) were found different gene cassettes. The aadA gene integrated into the class 1 integrons was most frequently found and it was followed by aac genes and blaOXA family genes. Sequence analysis of variable regions of the class 1 integrons showed five gene cassette arrays;aadA1(99%), aac(3)-Id(82%)-orf-aac(3”)-Ia(99%), aac(3)-Ie(83%)-blaoxa10(100%)- aadA1 (100%), aadA6(99%, 100%), aac(6’)-I(97%)-orf-aadA2(99%). No class 2 integron was detected. This study is the first multicenter study for class 1 integrons and it indicates the low rate of presence of class 1 gene cassette in P. aeruginosa.

关键词： Pseudomonas aeruginosa Antibiotic Resistance Class 1 Integron AadA Multicenter Study

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Molecular epidemiology of HIV-1 strains in the south-east and east of Turkey

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Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 743-747页

作者： Mustafa Kemal elen Murat Sayan tuba dal Celal Ayaz Alicem Tekin Tuncer zekinci Suda Tekin Koruk Tunga Barcin Recep Tekin Mehmet Sinan dal Sevgi Kalkanl Dicle University Clinical Laboratory Kocaeli University Research Center of Experimental Health Sciences Near East University Yildirim Beyazit University Harran University Kiziltepe State Hospital Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Objective:To detect the subtype characterization and drug-resistant mutations in HIV-1 strains after the refugee movement from Syria to Turkey between 2011 and 2014 in south east border lines. Methods: A total of 65 patients were included in this study, of which 57(88%) patients were antiretroviral therapy-naive patients. HIV-1 RNA was detected and quantii ed by realtime PCR assay. HIV-1 subtypes and circulating recombinant forms(CRFs) were identii ed by phylogenetic analysis(neighbor-joining method), and drug-resistant mutations were ***: Three major HIV groups were indicated. Two of these groups were located in subtype B. The other group showed heterogeneity. Subtype B(48/65, 73.8%), followed by CRFs(12/65, 18.5%) was the most common strain. Subtype of CRFs consisted of CRF01_AE(9/65, 13.8%) and CRF02_AG(3/65, 4.6%). Subtype C(1/65, 1.5%), sub-subtypes A1(2/65, 3.1%) and F1(2/65, 3.1%) were also detected with low prevalence. The rate of overall primary antiretroviral resistance was 4.9%(3/61). Drug-resistant rate for non-nucleoside reverse transcriptase inhibitors was 4.9%. The thymidine analogue mutation rate was 13.1%(8/61).Conclusions: HIV molecular epidemiology studies are necessary to determine transmission patterns and spread. Subtype B and CRF01_AE, CRF02_AG are the most prevalent strains in the south-east of Turkey. However, subtype C, sub-subtypes A1 and F1 are of low prevalence but persist in the south-east of Turkey. In the near future, changing of HIV epidemiology will be possible in Turkey due to migration movement in border lines and resistance testing will play an important role in HIV management.

关键词： HIV-1 Turkey Molecular epidemiology Refugee

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Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the prevention of vertical transmission of HBV infection

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World Journal of Gastroenterology 2013年第48期19卷 9377-9382页

作者： Mustafa Kemal Celen Duygu Mert Müzeyyen Ay tuba dal Safak Kaya Necmettin Yildirim Serda Gulsun Tunga Barcin Sevgi Kalkanli Mehmet Sinan dal Celal Ayaz Department of Infectious Diseases Faculty of Medicine Dicle University 21280 YenisehirDiyarbakir Turkey State Hospital 72000 Merkez Batman Turkey State Hospital Kiziltepe 47500 Mardin Turkey Department of Medical Microbiology Faculty of Medicine Dicle University 21280 Yenisehir Diyarbakir Turkey Department of Infectious Disease Teaching and Research Hospital 21100 Diyarbakir Turkey Department of Infectious Diseases State Hospital 47000 Mardin Turkey Department of Infectious Diseases State Hospital 21100 Diyarbakir Turkey Department of Infectious Diseases Mardin Park Hospital 47000 Mardin Turkey Department of Immunology Faculty of Medicine Dicle University 21280 Yeni?ehir Diyarbakir Turkey Department of Internal Medicine Faculty of Medicine Dicle University 21280 Yenisehir Diyarbakir Turkey

AIM:To evaluate the effects of tenofovir disoproxil fumarate(TDF)use during late pregnancy to reduce hepatitis B virus(HBV)transmission in highly viremic ***:This retrospective study included 45 pregnant patients with hepatitis B e antigen(+)chronic hepatitis B and HBV DNA levels>107copies/mL who received TDF 300 mg/d from week 18 to 27 of gestation(n=21).Untreated pregnant patients served as controls(n =24).All infants received 200 IU of hepatitis B immune globulin(HBIG)within 24 h postpartum and 20μg of recombinant HBV vaccine at 4,8,and 24 *** transmission rate was determined by hepatitis B surface antigen and HBV DNA results in infants at week ***:At week 28,none of the infants of TDFtreated mothers had immunoprophylaxis failure,whereas2(8.3%)of the infants of control mothers had immunoprophylaxis failure(P=0.022).There were no differences between the groups in terms of adverse events in mothers or congenital deformities,gestational age,height,or weight in *** postpartum week 28,significantly more TDF-treated mothers had levels of HBV DNA<250 copies/mL and normalized alanine aminotransferase compared with controls(62%vs none,P<0.001;82%vs 61%,P=0.012,respectively).CONCLUSION:TDF therapy during the second or third trimester reduced perinatal transmission rates of HBV and no adverse events were observed in mothers or infants.

关键词： Hepatitis B Tenofovir Reverse transcriptase inhibitors Vertical transmission Chronic

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