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Cancer-associated fibroblasts in digestive tumors

World Journal of Gastroenterology 2014年第47期20卷 17804-17818页

作者： Lei Huang A-Man Xu Sha liu Wei liu tuan-jie li Department of Gastrointestinal Surgery The First Affiliated Hospital of Anhui Medical University Guangdong Provincial Key Laboratory of liver Disease Research the Third Affiliated Hospital of Sun Yat-sen University Department of Medical Oncology the First Affiliated Hospital of Anhui Medical University liver Transplantation Center the Third Affiliated Hospital of Sun Yat-sen University

The significant influence of tumor stroma on malignant cells has been extensively investigated in this era of targeted therapy. The tumor microenvironment, as a dynamic system, is orchestrated by various cells including tumor vascular composing cells, inflammatory cells and fibroblasts. As a major and important component in tumor stroma, increasing evidence has shown that spindle-shaped cancer-associated fibroblasts (CAFs) are a significant modifier of cancer evolution, and promote tumorigenesis, tumor invasion and metastasis by stimulating angiogenesis, malignant cell survival, epithelial-mesenchymal transition (EMT) and proliferation via direct cell-to-cell contact or secretion of soluble factors in most digestive solid tumors. CAFs are thought to be activated, characterized by the expression of α-smooth muscle actin, fibroblast activated protein, fibroblast specific protein, vimentin, fibronectin, etc. They are hypothesized to originate from normal or aged fibroblasts, bone marrow-derived mesenchymal cells, or vascular endothelial cells. EMT may also be an important process generating CAFs, and most probably, CAFs may originate from multiple cells. A close link exists between EMT, tumor stem cells, and chemo-resistance of tumor cells, which is largely orchestrated by CAFs. CAFs significantly induce immunosuppression, and may be a prognostic marker in various malignancies. Targeted therapy toward CAFs has displayed promising anticancer efficacy, which further reinforces the necessity to explore the relationship between CAFs and their hosts.

关键词： Cancer-associated fibroblast Tumor progression Epithelial-mesenchymal transition Tumor immunity Targeted therapy

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Should peri-gastrectomy gastric acidity be our focus among gastric cancer patients?

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World Journal of Gastroenterology 2014年第22期20卷 6981-6988页

作者： Lei Huang A-Man Xu tuan-jie li Wen-Xiu Han Jing Xu Department of General Surgery the First Affiliated Hospital of Anhui Medical University Department of General Surgery NanFang Hospital of Southern Medical University

AIM: To investigate the necessity and correctness of acid suppression pre- and post-gastrectomy among gastric carcinoma (GC) patients.

关键词： Gastric carcinoma Gastrectomy Reflux Acidity Gastrointestinal juice

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Morbidity and mortality of elderly patients with advanced gastric cancer after laparoscopy-assisted or open distal gastrectomy:a randomized–controlled trial

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Gastroenterology Report 2018年第4期6卷 317-319,I0003页

作者： Jun Luo Yu Zhu Hao liu Yan-Feng Hu tuan-jie li Tian lin Tao Chen Hao Chen Xin-Hua Chen Jiang Yu Guo-Xin li Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515P.R.China

Laparoscopy-assisted distal gastrectomy(LDG)combined with D2 lymphadenectomy may be safely performed in patients with advanced gastric cancer(AGC)by experienced surgeons at specialized high-volume institutions as shown in the Chinese Laparoscopic Gastrointestinal Surgery Study(CLASS)-***,studies focusing on the use of LDG in patients with gastric cancer older than 65 years are *** study was designed to investigate the morbidity and mortality of elderly patients with gastric cancer who underwent laparoscopic-assisted or open distal gastrectomy(ODG).In this prospective,randomized,open,parallel controlled trial,patients older than 65 years with tumor located at the middle or lower part of the stomach will be enrolled in this *** will be randomly divided into a laparoscopic group and an open surgery *** early post-operative complications,intra-operative complications and post-operative recovery will be compared between the two *** trial will provide valuable clinical evidence for the objective assessment of the feasibility,short-term safety,and potential benefits of LDG compared with ODG for gastric cancer in the elderly *** trial has been registered on ***.(Identifier:NCT02246153.)in September 22,2014.

关键词： Laparoscopic gastrectomy advanced gastric cancer elderly patients morbidity mortality

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Treatment of polycystic liver disease with resection-fenestration and a new classification

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World Journal of Gastroenterology 2008年第32期14卷 5066-5072页

作者： tuan-jie li Hai-Bin Zhang Jun-Hua Lu Jun Zhao Ning Yang Guang-Shun Yang Eastern Hepatobiliary Hospital Second Military Medical University Shanghai 200438 China

AIM: To evaluate outcomes in patients with autosomal dominant polycyst liver disease (APLD) treated by combined hepatic resection and fenestration. A new classification was recommended to presume postoperative complications and long outcome of patients. METHODS: Twenty-one patients with APLD were treated by a combined hepatic resection and fenestration technique. All patients were reviewed retrospectively, and clinical symptoms, performance status and morbidity were recorded. A new classifi cation of APLD is recommended here. RESULTS: All patients were discharged when free of symptoms. The mean follow-up time was 55.7 mo and three patients had a recurrence of symptoms at 81, 68 and 43 mo after operation, respectively. The overall morbidity rate was 76.2%. Two patients with Type B-Ⅱ and Type B-Ⅰ developed biliary leakage. Four patients had severe ascites, including three with Type B-Ⅲ and one with Type B-Ⅱ, Nine patients had pleural effusion, including one with Type A-Ⅰ; one with Type B-Ⅰ; fi ve with Type B-Ⅱ; one with Type A-Ⅲ and one with Type B-Ⅲ. Three patients with Type B had recurrence of symptoms, while none with Type A had severe complications. CONCLUSION: Combined hepatic resection and fenestration is an acceptable procedure for treatment of APLD. According to our classifi cation, postoperative complications and long outcome can be predicted before surgery.

关键词： Autosomal dominant polycyst liverdisease Autosomal dominant polycyst kidney disease Fenestration

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Equilibrium Configurations of a Planar 3-DOF Parallel Robot with Flexural Pivots

Equilibrium Configurations of a Planar 3-DOF Parallel Robot ...

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首届亚洲机械电子学学术会议

作者： tuan-jie li Xiao-Yong Zhou School of Electromechanical Engineering,Xidian University Xi’an 710071,China

All previous research on design of parallel robots relates to analyzing and optimizing the kinematic geometry without regard to the equilibrium configurations of the parallel robot with flexural pivots once the external load is *** article addresses the equilibrium configurations of a planar 3-dof parallel robot with flexural pivots.A system of four coupled transcendental equations with trigonometric functions in four unknowns is derived from the inverse static *** initial configurations of the parallel robot are discussed firstly, then a numerical method is presented based on the Newton’s iterative method,which can find all the real roots of the system of transcendental equations with trigonometric functions without initial value selection in the specified intervals to detect the entire set of the initial configurations and the equilibrium configurations of the parallel robot with flexure ***,a numerical example is provided.

关键词： Planar Parallel Robot Parallel Mechanism Flexural Privot Inverse Static Analysis Equilibrium Configuration Numerical Solution

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Zinc-mediated benzylation of aldehydes under solvent-free conditions

Zinc-mediated benzylation of aldehydes under solvent-free co...

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中国化学会第四届有机化学学术会议

作者： MENG, tuan-jie XIN, li WANG, Jin-Xian Institute of chemistry, Department of Chemistry, Northwest Normal University, Lanzhou, 730070, China

Since the surprising discovery of the direct allylation of aldehydes and ketons by a Zn-Barbier reaction, similar one step procedures using different types of organic halides have attracted growing interest during the past decade. Propargyl halides, α -bromo ketones and esters have been added successfully to aldehydes in the presence of zinc, tin, aluminium or indum.

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Facile and Rapid Green Synthesis of 1,5-Diketones under Solvent-free Conditions

Facile and Rapid Green Synthesis of 1,5-Diketones under Solv...

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中国化学会第四届有机化学学术会议

作者： HUANG, Xian-Qiang JIA, Xue-Feng li, Hong-Xia MENG, tuan-jie XIN, li WANG, Jin-Xian (Institute of Chemistry, Department of Chemistry, Northwest Normal University, Lanzhou 730070)

＜正＞Organic synthesis directed toward "Green Chemistry" have attained increasing interest in recent years which should lead to new environmentally benign procedures to save resources and energy. The development of solvent-free reaction is an especially attractive goal in the context of Green Chemistry. Solvent-free reactions possess some advantages over traditional reactions in organic solvents and make it possible to reduce the consumption of environmentally unfriendly solvent.

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Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi Yu Xi Zheng Xiao-Sheng li Qian-jie Xu Wei Zhang Zhong-li liao Hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model

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Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei Xiao Zhiyong Kan Jing Guo Qiang li Wanqi jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： lifang Zhao Mingkai Zhang Qimeng li Xuemin Wang jie Lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

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