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Cancer-associated fibroblasts in digestive tumors

World Journal of Gastroenterology 2014年第47期20卷 17804-17818页

作者： Lei Huang A-Man Xu Sha liu Wei liu tuan-jie li Department of Gastrointestinal Surgery The First Affiliated Hospital of Anhui Medical University Guangdong Provincial Key Laboratory of liver Disease Research the Third Affiliated Hospital of Sun Yat-sen University Department of Medical Oncology the First Affiliated Hospital of Anhui Medical University liver Transplantation Center the Third Affiliated Hospital of Sun Yat-sen University

The significant influence of tumor stroma on malignant cells has been extensively investigated in this era of targeted therapy. The tumor microenvironment, as a dynamic system, is orchestrated by various cells including tumor vascular composing cells, inflammatory cells and fibroblasts. As a major and important component in tumor stroma, increasing evidence has shown that spindle-shaped cancer-associated fibroblasts (CAFs) are a significant modifier of cancer evolution, and promote tumorigenesis, tumor invasion and metastasis by stimulating angiogenesis, malignant cell survival, epithelial-mesenchymal transition (EMT) and proliferation via direct cell-to-cell contact or secretion of soluble factors in most digestive solid tumors. CAFs are thought to be activated, characterized by the expression of α-smooth muscle actin, fibroblast activated protein, fibroblast specific protein, vimentin, fibronectin, etc. They are hypothesized to originate from normal or aged fibroblasts, bone marrow-derived mesenchymal cells, or vascular endothelial cells. EMT may also be an important process generating CAFs, and most probably, CAFs may originate from multiple cells. A close link exists between EMT, tumor stem cells, and chemo-resistance of tumor cells, which is largely orchestrated by CAFs. CAFs significantly induce immunosuppression, and may be a prognostic marker in various malignancies. Targeted therapy toward CAFs has displayed promising anticancer efficacy, which further reinforces the necessity to explore the relationship between CAFs and their hosts.

关键词： Cancer-associated fibroblast Tumor progression Epithelial-mesenchymal transition Tumor immunity Targeted therapy

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Should peri-gastrectomy gastric acidity be our focus among gastric cancer patients?

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World Journal of Gastroenterology 2014年第22期20卷 6981-6988页

作者： Lei Huang A-Man Xu tuan-jie li Wen-Xiu Han Jing Xu Department of General Surgery the First Affiliated Hospital of Anhui Medical University Department of General Surgery NanFang Hospital of Southern Medical University

AIM: To investigate the necessity and correctness of acid suppression pre- and post-gastrectomy among gastric carcinoma (GC) patients.

关键词： Gastric carcinoma Gastrectomy Reflux Acidity Gastrointestinal juice

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Morbidity and mortality of elderly patients with advanced gastric cancer after laparoscopy-assisted or open distal gastrectomy:a randomized–controlled trial

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Gastroenterology Report 2018年第4期6卷 317-319,I0003页

作者： Jun Luo Yu Zhu Hao liu Yan-Feng Hu tuan-jie li Tian lin Tao Chen Hao Chen Xin-Hua Chen Jiang Yu Guo-Xin li Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515P.R.China

Laparoscopy-assisted distal gastrectomy(LDG)combined with D2 lymphadenectomy may be safely performed in patients with advanced gastric cancer(AGC)by experienced surgeons at specialized high-volume institutions as shown in the Chinese Laparoscopic Gastrointestinal Surgery Study(CLASS)-***,studies focusing on the use of LDG in patients with gastric cancer older than 65 years are *** study was designed to investigate the morbidity and mortality of elderly patients with gastric cancer who underwent laparoscopic-assisted or open distal gastrectomy(ODG).In this prospective,randomized,open,parallel controlled trial,patients older than 65 years with tumor located at the middle or lower part of the stomach will be enrolled in this *** will be randomly divided into a laparoscopic group and an open surgery *** early post-operative complications,intra-operative complications and post-operative recovery will be compared between the two *** trial will provide valuable clinical evidence for the objective assessment of the feasibility,short-term safety,and potential benefits of LDG compared with ODG for gastric cancer in the elderly *** trial has been registered on ***.(Identifier:NCT02246153.)in September 22,2014.

关键词： Laparoscopic gastrectomy advanced gastric cancer elderly patients morbidity mortality

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A unified stochastic damage model for concrete based on multi-scale energy dissipation analysis

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Science China(Technological Sciences) 2024年第3期67卷 863-877页

作者： GUO ChengGong li jie College of Civil Engineering Tongji UniversityShanghai 200092China State Key Laboratory of Disaster Reduction in Civil Engineering Shanghai 200092China

This work proposes a unified damage model for concrete within the framework of stochastic damage mechanics. Based on the micro-meso stochastic fracture model(MMSF), the nonlinear energy dissipation process of the microspring from nanoscale to microscale is investigated. In nanoscale, the rate process theory is adopted to describe the crack growth rate;therefore, the corresponding energy dissipation caused by a representative crack propagation can be obtained. The scale gap from nanoscale to microscale is bridged by a crack hierarchy model. Thus, the total energy dissipated by all cracks from the nanoscale to the microscale is gained. It is found that the fracture strain of the microspring can be derived from the above multi-scale energy dissipation analysis. When energy dissipation is regarded as some microdamage to the microspring, the constitutive law of the microspring is no longer linearly elastic, as previously assumed. By changing the expression of the damage evolution law from fracture strain to energy dissipation threshold, the new damage evolution model is derived. The proposed model can not only replicate the original static model but also extend to cases of rate dependence. By deriving the fracture strain under different strain rates, the rate sensitivity of concrete materials can be reflected. The model parameters can be conveniently obtained by identifying them with experimental data. Finally, several numerical examples are presented to verify the proposed model.

关键词： concrete damage model stochastic damage rate dependent energy dissipation

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Treatment of polycystic liver disease with resection-fenestration and a new classification

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World Journal of Gastroenterology 2008年第32期14卷 5066-5072页

作者： tuan-jie li Hai-Bin Zhang Jun-Hua Lu Jun Zhao Ning Yang Guang-Shun Yang Eastern Hepatobiliary Hospital Second Military Medical University Shanghai 200438 China

AIM: To evaluate outcomes in patients with autosomal dominant polycyst liver disease (APLD) treated by combined hepatic resection and fenestration. A new classification was recommended to presume postoperative complications and long outcome of patients. METHODS: Twenty-one patients with APLD were treated by a combined hepatic resection and fenestration technique. All patients were reviewed retrospectively, and clinical symptoms, performance status and morbidity were recorded. A new classifi cation of APLD is recommended here. RESULTS: All patients were discharged when free of symptoms. The mean follow-up time was 55.7 mo and three patients had a recurrence of symptoms at 81, 68 and 43 mo after operation, respectively. The overall morbidity rate was 76.2%. Two patients with Type B-Ⅱ and Type B-Ⅰ developed biliary leakage. Four patients had severe ascites, including three with Type B-Ⅲ and one with Type B-Ⅱ, Nine patients had pleural effusion, including one with Type A-Ⅰ; one with Type B-Ⅰ; fi ve with Type B-Ⅱ; one with Type A-Ⅲ and one with Type B-Ⅲ. Three patients with Type B had recurrence of symptoms, while none with Type A had severe complications. CONCLUSION: Combined hepatic resection and fenestration is an acceptable procedure for treatment of APLD. According to our classifi cation, postoperative complications and long outcome can be predicted before surgery.

关键词： Autosomal dominant polycyst liverdisease Autosomal dominant polycyst kidney disease Fenestration

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Experimental study on combustion characteristics of supersonic combustor based on alternating-wedge strut

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Chinese Journal of Aeronautics 2024年第5期37卷 214-227页

作者： jie li Wenyan SONG Yuhang WANG School of Power Energy Northwestern Polytechnical UniversityXi’an 710129China

Acetone Planar Lase-Induced Fluorescence(PliF)and OH-PliF were employed to capture the fuel distribution and OH distribution downstream for the supersonic combustor based on the alternating-wedge *** combustion establishment process and combustion mode in the combustor under different fuel injection methods and different equivalence ratios were *** with the kerosene-PliF and OH-PliF results in the cavity combustor,a comparative analysis was conducted to understand the combustion characteristics and combustion modes between the alternating-wedge strut-based combustor and the cavity-based *** results show that the combustor is in weak combustion mode in the case of low equivalence ratio,and the combustor is in intensive combustion mode in the case of high equivalence *** lower limit of the equivalence ratio of the combustor to maintain the intensive combustion mode varies based on different fuel injection *** OH distribution under reacting condition has a strong correlation with the fuel distribution under non-reacting *** OH fluorescence signal near the injector is weaker when the fuel distribution is more *** injector position located at the base of the strut rear has better mixing performance,enabling the combustor to be in intensive combustion mode at a lower equivalence *** combustion reaction in the alternating-wedge strut-based combustor is not necessarily dominated by mass transfer due to the mixing enhancement and premixed zone downstream of strut,while the combustion reaction process in the cavity-based combustor is mainly influenced by mass transfer.

关键词： Supersonic combustor Alternating-wedge strut Cavity PliF Fuel injection Fuel distribution Combustion characteristics Combustion mode

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SG-NeRF:Sparse-Input Generalized Neural Radiance Fields for Novel View Synthesis

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Journal of Computer Science & Technology 2024年第4期39卷 785-797页

作者： Kuo Xu jie li Zhen-Qiang li Yang-jie Cao School of Cyber Science and Engineering Zhengzhou UniversityZhengzhou 450002China Intelligent Big Data System(iBDSys)Lab Shanghai Jiao Tong UniversityShanghai 200240China School of Computer and Artificial Intelligence Zhengzhou UniversityZhengzhou 450001China

Traditional neural radiance fields for rendering novel views require intensive input images and pre-scene optimization,which limits their practical *** propose a generalization method to infer scenes from input images and perform high-quality rendering without pre-scene optimization named SG-NeRF(Sparse-Input Generalized Neural Radiance Fields).Firstly,we construct an improved multi-view stereo structure based on the convolutional attention and multi-level fusion mechanism to obtain the geometric features and appearance features of the scene from the sparse input images,and then these features are aggregated by multi-head attention as the input of the neural radiance *** strategy of utilizing neural radiance fields to decode scene features instead of mapping positions and orientations enables our method to perform cross-scene training as well as inference,thus enabling neural radiance fields to generalize for novel view synthesis on unseen *** tested the generalization ability on DTU dataset,and our PSNR(peak signal-to-noise ratio)improved by 3.14 compared with the baseline method under the same input *** addition,if the scene has dense input views available,the average PSNR can be improved by 1.04 through further refinement training in a short time,and a higher quality rendering effect can be obtained.

关键词： Neural Radiance Fields(NeRF) multi-view stereo(MVS) new view synthesis(NVS)

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Perspective on new cell-free DNA technologies for early cancer detection

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Cancer Biology & Medicine 2024年第2期21卷 139-143页

作者： jie li Xun Lan Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China MOE Key Laboratory of Bioinformatics Tsinghua UniversityBeijing 100084China Tsinghua-Peking Joint Center for life Sciences Tsinghua UniversityBeijing 100084China

High cancer heterogeneity and aggressiveness are major factors contributing to the poor prognosis of patients with advanced cancer~(1-5).Early detection of cancer can significantly improve the prognosis of patients with early-stage cancer after standard *** traditional cancer detection technologies,such as endoscopy for gastrointestinal cancer,mammography for breast cancer。

关键词： prognosis cancer patients

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Strong Edge Coloring of Outerplane Graphs with Independent Crossings

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 467-477页

作者： Ke-jie li Xin ZHANG School of Mathematics and Statistics Xidian UniversityXi’an 710071China

The strong chromatic index of a graph is the minimum number of colors needed in a proper edge coloring so that no edge is adjacent to two edges of the same *** outerplane graph with independent crossings is a graph embedded in the plane in such a way that all vertices are on the outer face and two pairs of crossing edges share no common end *** is proved that every outerplane graph with independent crossings and maximum degreeΔhas strong chromatic index at most 4Δ-6 if Δ≥4,and at most 8 ifΔ≤*** bounds are sharp.

关键词： outer-1-planar graph IC-planar graph strong edge coloring crossing

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Prediction models of burst strength degradation for casing with considerations of both wear and corrosion

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Petroleum Science 2024年第1期21卷 458-474页

作者： jie-li Wang Wen-Jun Huang De-li Gao MOE Key Laboratory of Petroleum Engineering China University of PetroleumBeijing102249China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China

Casing wear and casing corrosion are serious problems affecting casing integrity failure in deep and ultra-deep *** paper aims to predict the casing burst strength with considerations of both wear and ***,the crescent wear shape is simplified into three categories according to common mathematical ***,based on the mechano-electrochemical(M-E)interaction,the prediction model of corrosion depth is built with worn depth as the initial condition,and the prediction models of burst strength of the worn casing and corroded casing are ***,the accuracy of different prediction models is validated by numerical simulation,and the main influence factors on casing strength are *** last,the theoretical models are applied to an ultra-deep well in Northwest China,and the dangerous well sections caused by wear and corrosion are predicted,and the corrosion rate threshold to ensure the safety of casing is *** results show that the existence of wear defects results in a stress concentration and enhanced M-E interaction on corrosion depth *** accuracy of different mathematical models is different:the slot ring model is most accurate for predicting corrosion depth,and the eccentric model is most accurate for predicting the burst strength of corroded *** burst strength of the casing will be overestimated by more than one-third if the M-E interaction is neglected,so the coupling effect of wear and corrosion should be sufficiently considered in casing integrity evaluation.

关键词： Deep well Casing integrity Casing wear Casing corrosion Burst strength

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