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Supramolecular G-quadruplex hydrogels:Bridging fabrication to biomedical application

Journal of Materials Science & Technology 2023年第24期155卷 238-252页

作者： Yuanfeng Li Junjie Chi Pingwei Xu Xing Dong anh-tuan le Keqing Shi Yong Liu Jian Xiao Translational Medicine Laboratory The Center of Wound Healing and Regenerative Medicine the First Affiliated Hospital of Wenzhou Medical University Zhejiang 325035 China School of Pharmaceutical Sciences Key Laboratory of Biotechnology and Pharmaceutical Engineering The Center of Wound Healing and Regenerative Medicine the First Affiliated Hospital Wenzhou Medical University Zhejiang 325035 China Wenzhou Institute University of Chinese Academy of Sciences Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine Vision and Brain Health) Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province Zhejiang 325001 China Phenikaa University Nano Institute (PHENA) Phenikaa University Hanoi 12116 Viet Nam

G-quadruplex hydrogel is a class of self-assembled supramolecular hydrogel formed by guanine *** a biomimetic hydrogel,G-quadruplex hydrogels demonstrate wide biomedical applications,such as drug delivery,tissue engineering,and *** advantages of using G-quadruplex hydrogels include adequate biocompatibility and biodegradability,tunable multifunctionality,and cost-effective and large-scalable fabrication *** this review,we focus on recent progress in the fabrication and characterization of G-quadruplex hydrogels to help readers understand the principles of G-quadruplex hydrogel ***,the applications of G-quadruplex hydrogels in the biomedical area are discussed,aiming to pave the way for downward clinical or industry *** development of G-quadruplex hydrogel is still in its *** hope this review will boost the development of this area and that more applications of G-quadruplex hydrogel will be developed.

关键词： Guanosine DNA hydrogel Self-assembly Drug delivery Tissue engineering

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Dynamic covalent nano-networks comprising antibiotics and polyphenols orchestrate bacterial drug resistance reversal and inflammation alleviation

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Bioactive Materials 2023年第9期27卷 288-302页

作者： Yuanfeng Li Yin-Zi Piao Hua Chen Keqing Shi Juqin Dai Siran Wang Tieli Zhou anh-tuan le Yaran Wang Fan Wu Rujiang Ma Linqi Shi Yong Liu Translational Medicine Laboratory The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325035China Wenzhou Institute University of Chinese Academy of SciencesOujiang LaboratoryZhejiang Lab for Regenerative MedicineVision and Brain HealthWenzhouZhejiang325001China Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China Department of Clinical Laboratory The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325035China Nano Institute Phenikaa UniversityYen NghiaHa DongHa NoiViet Nam

New antimicrobial strategies are urgently needed to meet the challenges posed by the emergence of drug-resistant bacteria and bacterial *** work reports the facile synthesis of antimicrobial dynamic covalent nano-networks(aDCNs)composing antibiotics bearing multiple primary amines,polyphenols,and a cross-linker acylphenylboronic ***,the iminoboronate bond drives the formation of aDCNs,facilitates their stability,and renders them highly responsive to stimuli,such as low pH and high H2O2 ***,the representative A1B1C1 networks,composed of polymyxin B1(A1),2-formylphenylboronic acid(B1),and quercetin(C1),inhibit biofilm formation of drug-resistant Escherichia coli,eliminate the mature biofilms,alleviate macrophage inflammation,and minimize the side effects of free *** bacterial eradication and inflammation amelioration efficiency of A1B1C1 networks are also observed in a peritoneal infection *** facile synthesis,excellent antimicrobial performance,and biocompatibility of these aDCNs potentiate them as a much-needed alternative in current antimicrobial pipelines.

关键词： Biofilms Dynamic covalent bonds On-demand drug release Resistance reversal Biosafety

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Measurement investigation on the feasibility of shallow geothermal energy for heating and cooling applied in agricultural greenhouses of Shouguang City: Ground temperature profiles and geothermal potential

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Information Processing in Agriculture 2021年第2期8卷 251-269页

作者： anh tuan le Liang Wang Yang Wang Daoliang Li National Innovation Center for Digital Fishery China Agricultural UniversityBeijing 100083China Beijing Engineering and Technology Research Centre for Internet of Things in Agriculture Beijing 100083China Key Laboratory of Agricultural Information Acquisition Technology Ministry of AgricultureBeijing 100083China College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China Department of Electronics Nam Dinh University of Technology EducationNam Dinh 07000Viet Nam

The use of electrical energy for heating and cooling systems to control the temperature in greenhouses will lead to high production and product *** solve this problem,shallow geothermal energy as a local source of energy could be *** this study,a measurement model,the distribution profiles of temperature,and a preliminary assessment of the geothermal potential in the shallow zone at depths of 0.1 m to 3.6 m in Shouguang City,Shandong Province,eastern China were *** measurement results showed that the annual average temperature at depths of 0.1–3.6 m ranged from 13.1℃ to 17.6℃.Preliminary assessment results of the geothermal potential showed that the daily average temperature difference between the air and at depths of 1.5–3.6 m was mainly from 10℃ to 25℃ during the winter months and between-15℃ and-5℃ during the summer ***,the heating systems could operate during January,February,November,and *** May,June,and July,the cooling systems could be ***,the measurement model gave good stability results,and it could be used in combination with the monitoring of the groundwater table,a survey of the thermal conductivity of the soil,climate change studies,which helps reduce unnecessary time and costs.

关键词： Ground temperature profile Geothermal energy Ground heat exchanger Measurement model Shouguang

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A Comprehensive Survey of Recent Transformers in Image,Video and Diffusion Models

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Computers, Materials & Continua 2024年第7期80卷 37-60页

作者： Dinh Phu Cuong le Dong Wang Viet-tuan le College of Computer Science and Electronic Engineering Hunan UniversityChangsha410082China Faculty of Information Technology Yersin University of Da LatDa Lat66100Vietnam Faculty of Information Technology Ho Chi Minh City Open UniversityHo Chi Minh City722000Vietnam

Transformer models have emerged as dominant networks for various tasks in computer vision compared to Convolutional Neural Networks(CNNs).The transformers demonstrate the ability to model long-range dependencies by utilizing a self-attention *** study aims to provide a comprehensive survey of recent transformerbased approaches in image and video applications,as well as diffusion *** begin by discussing existing surveys of vision transformers and comparing them to this ***,we review the main components of a vanilla transformer network,including the self-attention mechanism,feed-forward network,position encoding,*** the main part of this survey,we review recent transformer-based models in three categories:Transformer for downstream tasks,Vision Transformer for Generation,and Vision Transformer for *** also provide a comprehensive overview of recent transformer models for video tasks and diffusion *** compare the performance of various hierarchical transformer networks for multiple tasks on popular benchmark ***,we explore some future research directions to further improve the field.

关键词： Transformer vision transformer self-attention hierarchical transformer diffusion models

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EP Aquarii:A New Picture of the Circumstellar Envelope

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Research in Astronomy and Astrophysics 2024年第3期24卷 83-105页

作者： Pham T.Nhung Do T.Hoai Pierre Darriulat Pham tuan-anh Pham N.Diep Nguyen B.Ngoc Tran T.Thai Department of Astrophysics Vietnam National Space CenterVietnam Academy of Science and Technology18Hoang Quoc VietNghia DoCau GiayHa Noivietnam

New analyses of earlier ALMA observations of oxygen-rich AGB star EP Aquarii are presented,which complete a previously published analysis and offer a different interpretation of the morpho-kinematics of the circumstellar *** birth of the equatorial density enhancement(EDE)is shown to occur very close to the star where evidence for rotation has been *** to the star and where outflows have been observed:their interaction with the gas of the nascent EDE is seen to play an important role in the development of the wind and the evolution of its radial velocity from 8 to 10 km s^(-1) on the polar symmetry axis to~2 km s^(-1) at the *** implies complex morpho-kinematics:making reliable interpretations with reasonable confidence is *** particular,it questions an earlier interpretation implying the presence of a white dwarf companion orbiting the star at an angular distance of -0″4 from its *** proposes instead an interpretation in terms of a standard mass ejection associated with a shock wave leaving a void of emission in its *** Doppler velocity wings are seen to consist of two components,the upper velocity end of the global wind,reaching above±12 km s^(-1),and an effective line broadening,confined within 200 mas from the center of the star,reaching above±20 km s^(-1) and interpreted as caused by the pattern of shock waves resulting from the interaction between stellar pulsation and convective cell partition.

关键词： stars AGB and post-AGB-(stars) circumstellar matter-radio lines stars

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TiO₂-PES Fibrous Composite Material for Ammonia Removal Using UV-A Photocatalyst

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Journal of Materials Science and Chemical Engineering 2024年第1期12卷 1-19页

作者： anh Phuong le Thi Masaru Ohshiro Takaomi Kobayashi Department of Science and Technology Innovation Nagaoka University of Technology Nagaoka Japan Kasai Corporation Niigata Japan

This study focused on the development and characterization of TiO2-PES composite fibers with varying TiO2 loading amounts using a phase inversion process. The resulting composite fibers exhibited a sponge-like structure with embedded TiO2 nanoparticles within a polymer matrix. Their photocatalytic performance for ammonia removal from aqueous solutions under UV-A light exposure was thoroughly investigated. The findings revealed that PeTi8 composite fibers displayed superior adsorption capacity compared to other samples. Moreover, the study explored the impact of pH, light intensity, and catalyst dosage on the photocatalytic degradation of ammonia. Adsorption equilibrium isotherms closely followed the Langmuir model, with the results indicating a correlation between qm values of 2.49 mg/g and the porous structure of the adsorbents. The research underscored the efficacy of TiO2 composite fibers in the photocatalytic removal of aqueous under UV-A light. Notably, increasing the distance between the photocatalyst and the light source resulted in de-creased hydroxyl radical concentration, influencing photocatalytic efficiency. These findings contribute to our understanding of TiO2 composite fibers as promising photocatalysts for ammonia removal in water treatment applications.

关键词： Ammonia Removal Photocatalyst TiO2-PES Composite Fiber Fibrous Material

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Ethanol extracts of Scutellaria baicalensis protect against lipopolysaccharide-induced acute liver injury in mice

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Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 733-738页

作者： Hai Nguyen Thanh Hue Pham Thi Minh tuan anh le Huong Duong Thi Ly Tung Nguyen Huu Loi Vu Duc Thu Dang Kim Tung Bui Thanh School of Medicine and Pharmacy Vietnam National University Hanoi University of Pharmacy

Objective: To investigated the protective potential of ethanol extracts of Scutellaria baicalensis(S. baicalensis) against lipopolysaccharide(LPS)-induced liver injury. Methods: Dried roots of S. baicalensis were extracted with ethanol and concentrated to yield a dry residue. Mice were administered 200 mg/kg of the ethanol extracts orally once daily for one week. Animals were subsequently administered a single dose of LPS(5 mg/kg of body weight, intraperitoneal injection). Both protein and m RNA levels of cytokines, such as tumor necrosis factor alpha, interleukin-1β, and interleukin-6 in liver tissues were evaluated by ELISA assay and quantitative PCR. C yclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB protein levels in liver tissues were analyzed by western blotting. Results: Liver injury induced by LPS signifi cantly increased necrosis factor alpha, interleukin-1β, interleukin-6, cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB in liver tissues. Treatment with ethanol extracts of S. baicalensis prevented all of these observed changes associated with LPS-induced injury in liver ***: Our study showed that S. baicalensis is potentially protective against LPS-induced liver injury in mice.

关键词： Scutellaria baicalensis Lipopolysaccharide Liver injury Cytokine Nuclear factor-κB

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Optimal Scheduling of Multiple Rail Cranes in Rail Stations with Interference Crane Areas

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Intelligent Automation & Soft Computing 2024年第1期39卷 15-31页

作者： Nguyen Vu anh Duy Nguyen le Thai Nguyen Huu Tho Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City700000Vietnam

In this paper,we consider a multi-crane scheduling problem in rail stations because their operations directly influence the throughput of the rail *** particular,the job is not only assigned to cranes but also the job sequencing is implemented for each crane to minimize the makespan of cranes.A dual cycle of cranes is used to minimize the number of working cycles of *** rail crane scheduling problems in this study are based on the movement of *** consider not only the gantry moves,but also the trolley moves as well as the rehandle cases are also included.A mathematical model of multi-crane scheduling is *** traditional and parallel simulated annealing(SA)are adapted to determine the optimal scheduling *** examples are conducted to evaluate the applicability of the proposed *** of the proposed parallel SA is done by comparing it to existing previous *** of numerical computation highlighted that the parallel SA algorithm outperformed the SA and gave better solutions than other considered algorithms.

关键词： Multi-crane scheduling logistics containers makespan rail stations

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Prevalence, risk factors, and BRAF mutation of colorectal sessile serrated lesions among Vietnamese patients

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World Journal of Clinical Oncology 2024年第2期15卷 290-301页

作者： Nhu Thi Hanh Vu Huy Minh le Diem Thi-Ngoc Vo Hoang anh Vu Nhan Quang le Dung Dang Quy Ho Duc Trong Quach Department of Internal Medicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam GI Endoscopy Department University Medical Center at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Department of Histology-Embryology and Pathology University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Center for Molecular Biomedicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Department of Endoscopy Cho Ray HospitalHo Chi Minh 700000Viet Nam

BACKGROUND Sessile serrated lesions(SSLs)are considered precancerous colorectal lesions that should be detected and removed to prevent colorectal *** studies in Vietnam mainly investigated the adenoma pathway,with limited data on the serrated *** To evaluate the prevalence,risk factors,and BRAF mutations of SSLs in the Vietnamese *** This is a cross-sectional study conducted on patients with lower gastrointestinal symptoms who underwent colonoscopy at a tertiary hospital in *** were diagnosed on histopathology according to the 2019 World Health Organi-zation *** mutation analysis was performed using the Sanger DNA sequencing *** multivariate logistic regression model was used to determine SSL-associated *** There were 2489 patients,with a mean age of 52.1±13.1 and a female-to-male ratio of 1:*** prevalence of SSLs was 4.2%[95%confidence interval(CI):3.5-5.1].In the multivariate analysis,factors significantly associated with SSLs were age≥40[odds ratio(OR):3.303;95%CI:1.607-6.790],male sex(OR:2.032;95%CI:1.204-3.429),diabetes mellitus(OR:2.721;95%CI:1.551-4.772),and hypertension(OR:1.650,95%CI:1.045-2.605).The rate of BRAF mutations in SSLs was 35.5%.CONCLUSION The prevalence of SSLs was 4.2%.BRAF mutations were present in one-third of *** risk factors for SSLs included age≥40,male sex,diabetes mellitus,and hypertension.

关键词： Colorectal cancer Sessile serrated lesion BRAF mutation Risk factors Diabetes mellitus Hypertension

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Regularization of the Inverse Problem for Time Fractional Pseudo-parabolic Equation with Non-local in Time Conditions

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Acta Mathematica Sinica,English Series 2022年第12期38卷 2199-2219页

作者： Nguyen Duc PHUONG le Dinh LONG anh tuan NGUYEN Dumitru BAleANU Faculty of Fundamental Science Industrial University of Ho Chi Minh CityVietnam Division of Applied Mathematics Science and Technology Advanced InstituteVanLang UniversityHoChi Minh CityVietnam Faculty of Technology Van Lang UniversityHo Chi Minh CityVietnam Department of Mathematics Cankaya UniversityAnkaraTurkey lebanese AmericanUniversity BeirutLebanon Institute of Space Sciences Magurele-BucharestRomania

This paper is devoted to identifying an unknown source for a time-fractional diffusion equation in a general bounded ***,we prove the problem is non-well posed and the stability of the source ***,by using the Modified Fractional Landweber method,we present regularization solutions and show the convergence rate between regularization solutions and sought solution are given under a priori and a posteriori choice rules of the regularization parameter,***,we present an illustrative numerical example to test the results of our theory.

关键词： Source problem fractional pseudo-parabolic problem ill-posed problem convergence estimates regularization

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