检索结果-南通市图书馆

Highly anticipated natural diterpenoids as an important source of new drugs in 2013-2023

Chinese Chemical Letters 2025年第1期36卷 119-136页

作者： Yingjie Wang Peng Tang Wenchao tu Qi Gao Cuizhu Wang Luying Tan Lixin Zhao Hongye Han Liefeng ma Kouharu Otsuki Weilie Xiao Wenli Wang Jinping Liu Yong Li Zhajun Zhan Wei Li Xianli Zhou Ning Li School of Traditional Chinese materia medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning provinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110016China Key Laboratory of medicinal Chemistry for Natural Resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Key Laboratory of Research and Development for Natural ProductsSchool of Pharmacy and School of Chemical Science and TechnologyState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanYunnan UniversityKunming 650091China School of Pharmacy Nantong UniversityNantong 226001China School of Pharmaceutical Sciences Jilin UniversityChangchun 130021China State Key Laboratory of Bioactive Substance and Function of Natural medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China College of Pharmaceutical Sciences Zhejiang University of TechnologyHangzhou 310014China Faculty of Pharmaceutical Sciences Toho UniversityFunabashiChiba 274-8510Japan School of Life Science and Engineering Southwest Jiaotong UniversityChengdu 610031China

This review covers the structures of diterpenoids,including chain(72),monocyclic(9),labdane-type(67),clerodane-type(127)abietane-type(716),ent-kaurane-type(89),grayanane-type(331),ingenanetype(55),tigliane-type(154),daphnane-type(237),and aconitine-type diterpene alkaloids(265)with rich biological activities reported in *** the drugs in clinical use or under clinical investigation of diterpenoids and leading compounds were summarized.

关键词： Natural diterpenoids Structures Bioactivities Druggability Leading compounds New drugs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effectiveness of mobile health interventions on management of patients with hypertension:a systematic review of systematic reviews

引用

Frontiers of Nursing 2025年第1期12卷 1-12页

作者： Si-Si Wu Xue-mei tu Gui-Qin mou Chun-Hua Long Sha-Sha Li Department of Cardiovascular medicine Chongqing University Three Gorges HospitalChongqing 404020China

Objective:To systematically evaluate the effectiveness of mobile health(mHealth)interventions on self-management and blood pressure(BP)control in patients with hypertension and to provide recommendations for the clinic and future ***:Databases including Embase,Cochrane Library,CINAHL,CNKI,Sinomed,Wanfang,and Weipu were searched to collect systematic reviews(SRs)and meta-analyses on mHealth interventions for hypertension *** researchers independently screened the articles and extracted data,and the Assessment of multiple Systematic Reviews(AmSTAR 2)was used to evaluate the methodological quality of the included ***:A total of 11 SRs were included:1 review was rated as high quality,3 as low quality,and 7 as critically low *** mobile phone was the most common intervention type,followed by the *** reviews performed meta-analyses and showed that mHealth was associated with a significant reduction in systolic blood pressure(SBP),from 2.28 mmHg(95%CI-3.90 to-0.66;I^(2)=40%)to 14.77 mmHg(95%CI 11.76-17.77;I^(2)=89.7%),and diastolic blood pressure(DBP),from 1.50 mmHg(95%CI-2.20 to-0.08;I^(2)=62%)to 8.17 mmHg(95%CI 5.67-10.67;I^(2)=86%).Self-management behaviors included medication adherence(mA),diet,smoking,alcohol drinking,physical activity,and BP *** were inconsistent results on the effectiveness of mHealth ***:mHealth interventions can improve BP control,mA,diet,and smoking in patients with hypertension,but the evidence for the efficacy of mHealth on physical activity and alcohol drinking improvement is *** methodological quality of existing SRs on the management of BP in patients with hypertension was relatively low,and more well-designed SRs or meta-analyses were needed to provide more *** interventions are useful for improving BP control of patients with hypertension.

关键词： blood pressure hypertension mobile health self-management smartphone systematic review

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Honeycomb-spiderweb-inspired self-similar hybrid cellular structures for impact applications

引用

Defence Technology(防务技术) 2025年第1期43卷 182-200页

作者： K.Tewari m.K.Pandit m.m.mahapatra P.R.Budarapu School of mechanical Sciences Indian Institute of Technology BhubaneswarBhubaneswar752050India

Inspired by nature's self-similar designs,novel honeycomb-spiderweb based self-similar hybrid cellular structures are proposed here for efficient energy absorption in impact *** energy absorption is enhanced by optimizing the geometry and topology for a given *** proposed hybrid cellular structure is arrived after a thorough analysis of topologically enhanced self-similar *** optimized cell designs are rigorously tested considering dynamic loads involving crush and high-velocity bullet ***,the influence of thickness,radial connectivity,and order of patterning at the unit cell level are also *** maximum crushing efficiency attained is found to be more than 95%,which is significantly higher than most existing traditional *** on,the first and second-order hierarchical self-similar unit cell designs developed during crush analysis are used to prepare the cores for sandwich *** tests are performed on the developed sandwich structures using the standard 9-mm *** influence of multistaging on impact resistance is also investigated by maintaining a constant total thickness and mass of the sandwich ***,in order to avoid layer-wise weak zones and hence,attain a uniform out-of-plane impact strength,off-setting the designs in each stage is *** sandwich structures with first and second-order self-similar hybrid cores are observed to withstand impact velocities as high as 170 m/s and 270 m/s,respectively.

关键词： Sandwich structures Honeycomb-spider web inspired Self-similar hierarchy Crush analysis High-velocity impact Strong and weak zones multistaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Discovering causal models for structural,construction and defense-related engineering phenomena

引用

Defence Technology(防务技术) 2025年第1期43卷 60-79页

作者： m.Z.Naser School of Civil&Environmental Engineering and Earth Sciences(SCEEES) Clemson UniversityClemsonSouth Carolina 29634USA The Artificial Intelligence Research Institute for Science and Engineering(AIRISE) Clemson UniversityClemsonSouth Carolina 29634USA

Causality,the science of cause and effect,has made it possible to create a new family of *** models are often referred to as causal *** those of mathematical,numerical,empirical,or machine learning(mL)nature,causal models hope to tie the cause(s)to the effect(s)pertaining to a phenomenon(i.e.,data generating process)through causal *** paper presents one of the first works at creating causal models in the area of structural and construction *** this end,this paper starts with a brief review of the principles of causality and then adopts four causal discovery algorithms,namely,PC(Peter-Clark),FCI(fast causal inference),GES(greedy equivalence search),and GRa SP(greedy relaxation of the sparsest permutation),have been used to examine four phenomena,including predicting the load-bearing capacity of axially loaded members,fire resistance of structural members,shear strength of beams,and resistance of walls against impulsive(blast)*** from this study reveal the possibility and merit of discovering complete and partial causal ***,this study also proposes two simple metrics that can help assess the performance of causal discovery algorithms.

关键词： Causality Causal discovery Directed acyclic graphs machine learning metrics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

数字普惠金融、农业要素配置效率与城乡居民收入差距——来自中国1572个县域的证据

引用

南京农业大学学报(社会科学版) 2025年第1期25卷 182-192页

作者：张玉静涂圣伟中国人民大学农业与农村发展学院北京100038 国家发展和改革委员会产业经济与技术经济研究所北京100038

数字普惠金融在促进农业资本深化、农业全要素生产率提升等方面发挥着积极作用,是缩小城乡居民收入差距的重要手段。利用2016—2022年中国1572个县域的面板数据,定量分析数字普惠金融发展对城乡居民收入差距的影响以及农业要素配置效率... 详细信息

数字普惠金融在促进农业资本深化、农业全要素生产率提升等方面发挥着积极作用,是缩小城乡居民收入差距的重要手段。利用2016—2022年中国1572个县域的面板数据,定量分析数字普惠金融发展对城乡居民收入差距的影响以及农业要素配置效率的中介作用。结果表明:数字普惠金融发展能够显著缩小城乡居民收入差距,农业要素配置效率在其中发挥中介作用。从异质性影响看,相对于非数字试点村,数字普惠金融发展较好的试点村在城乡收入差距收敛方面表现较好,但在短期内存在一定的政策扭曲,影响城乡收入差距收敛效果。从结构性影响看,受数字鸿沟影响,使用深度和数字化程度促进收入差距收敛效果较小。这些发现表明,在强化数字普惠金融赋能作用的同时,还需要关注其异质性、结构性特征对促进城乡收入居民差距有效收敛的影响。

关键词：数字普惠金融城乡居民收入差距农业要素配置效率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

构建高水平社会主义市场经济体制的现实语境、内涵特征与实践方略

引用

经济问题 2025年第2期 12-20页

作者：刘衍峰涂良川华南师范大学马克思主义学院广东广州510631

党的二十届三中全会明确指出要构建高水平社会主义市场经济体制,这是党中央立足新的发展阶段作出的重要战略规划,旨在为经济高质量发展提供良好运行机制。构建高水平社会主义市场经济体制立足于中国式现代化发展需求、国内社会主要矛盾... 详细信息

党的二十届三中全会明确指出要构建高水平社会主义市场经济体制,这是党中央立足新的发展阶段作出的重要战略规划,旨在为经济高质量发展提供良好运行机制。构建高水平社会主义市场经济体制立足于中国式现代化发展需求、国内社会主要矛盾转化、全球化竞争加剧的时空方位。其高水平体现为以人民为中心的价值追求、经济建设与环境保护统一的发展理念、政府调控与市场调节的深度治理、构建高水平开放型经济体制的开放理念、建设现代化流通体系的宏观布局。构建高水平社会主义市场经济体制,必须完善收入分配制度,推动共同富裕实现;推进构建全国统一大市场,激活资源高效流动;科学优化政府职能,提升经济治理能力;进一步完善金融监管与风险防范机制,确保经济稳定运行。

关键词：高水平社会主义市场经济体制市场经济全面深化改革

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

引用

Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImRAN T.ASGHAR Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： analytical solution Cattaneo-Christov heat and mass flux chemical reaction gyrotactic microorganism hybrid nanofluid O368 oscillating curved stretchable sheet

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse model

引用

中华医学杂志(英文版) 2025年第2期138卷 2024 Dec 23页

作者： tu Xing Zou Zixing Li Jiahui Zeng Simiao Luo Zhengchao Li Gen Gao Yuanxu Zhang Kang Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou Guangdong China Guangzhou National Laboratory Guangzhou International Bio Island Guangzhou Guangdong China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou Guangdong China University of Chinese Academy of Sciences Beijing China Guangzhou Women and Children’s medical Center Guangzhou Medical University Guangzhou Guangdong China Department of Big Data and Biomedical AI College of Future Technology Peking University Beijing China Institute for Artificial Intelligence in medicine and Faculty of medicine Macau University of Science and Technology Macao Special Administrative Region China

Background: Retinal ganglion cell (RGC) death caused by acute ocular hypertension is an important characteristic of acute glaucoma. Receptor-interacting protein kinase 3 (RIPK3) that mediates necroptosis is a potential therapeutic target for RGC death. However, the current understanding of the targeting agents and mechanisms of RIPK3 in the treatment of glaucoma remains limited. Notably, artificial intelligence (AI) technologies have significantly advanced drug discovery. This study aimed to discover RIPK3 inhibitor with AI ***: An acute ocular hypertension model was used to simulate pathological ocular hypertensionin vivo. We employed a series of AI methods, including large language and graph neural network models, to identify the target compounds of RIPK3. Subsequently, these target candidates were validated using molecular simulations (molecular docking, absorption, distribution, metabolism, excretion, and toxicity [ADmET] prediction, and molecular dynamics simulations) and biological experiments (Western blotting and fluorescence staining)in vitro andin ***: AI-driven drug screening techniques have the potential to greatly accelerate drug development. A compound called HG9-91-01, identified using AI methods, exerted neuroprotective effects in acute glaucoma. Our research indicates that all five candidates recommended by AI were able to protect the morphological integrity of RGC cells when exposed to hypoxia and glucose deficiency, and HG9-91-01 showed a higher cell survival rate compared to the other candidates. Furthermore, HG9-91-01 was found to protect the retinal structure and reduce the loss of retinal layers in an acute glaucoma model. It was also observed that the neuroprotective effects of HG9-91-01 were highly correlated with the inhibition of PANoptosis (apoptosis, pyroptosis, and necroptosis). Finally, we found that HG9-91-01 can regulate key proteins related to PANoptosis, indicating that this compound exerts neuroprotective e

关键词： Virtual screening AI model PANoptosis acute ocular hypertension HG9-91-01 Glucoma

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

20世纪meuse河枯水流量变化

引用

人民黄河 2005年第11期27卷 71-71页

作者： m.tu P.J.m.deLaat m.J.m.de Wit m.J.Hall 荷兰联合国教科文组织国际水利学院荷兰国家水资源统一管理和废水处理研究所

meuse河是欧洲西北部最大的河流之一，包括法国、卢森堡、比利时、德国和荷兰部分的流域面积约33000km^2。meuse河降雨一蒸发趋势明显。一般而言，洪水发生于冬季，枯水在夏季和秋季。枯水期meuse河重要的河流功能如航运、供水、发电、... 详细信息

meuse河是欧洲西北部最大的河流之一，包括法国、卢森堡、比利时、德国和荷兰部分的流域面积约33000km^2。meuse河降雨一蒸发趋势明显。一般而言，洪水发生于冬季，枯水在夏季和秋季。枯水期meuse河重要的河流功能如航运、供水、发电、生态系统及再生利用等均受到阻碍。

关键词：枯水期流量变化 20世纪河流功能流域面积再生利用生态系统西北部卢森堡比利时

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

20世纪meuse河枯水流量变化

引用

人民黄河 2005年第11期 75-75页

作者： m.tu,P.J.m.deLaat,m.J.m.de Wit,m.J.Hall 荷兰联合国教科文组织国际水利学院荷兰联合国教科文组织国际水利学院荷兰国家水资源统一管理和废水处理研究所荷兰联合国教科文组织国际水利学院

由水利部黄河水利委员会主办的第二届黄河国际论坛,于2005年10月18日21日在郑州召开,来自全球60多个国家和地区的800多名专家学者参加了这次世界水利盛会。本次大会的中心议题是维持河流健康生命,分维持河流健康生命、流域水资源一体化... 详细信息

由水利部黄河水利委员会主办的第二届黄河国际论坛,于2005年10月18日21日在郑州召开,来自全球60多个国家和地区的800多名专家学者参加了这次世界水利盛会。本次大会的中心议题是维持河流健康生命,分维持河流健康生命、流域水资源一体化管理及现代技术应用、河流工程与非工程技术、水环境与水生态保护、跨流域调水技术及水资源配置、水权水价及水市场政策等6个专题,共收到论文400多篇,在大会主会场和66个分会场,与会代表进行了充分的交流。本期杂志在全文刊发黄河国际论坛组委会主席、黄河水利委员会主任、教授级高级工程师李国英的主题报告《维持河流健康生命——以黄河为例》和图片报道的同时,从大会交流的论文中选编40篇论文的文摘,以尽可能多的篇幅介绍本次大会的盛况,希望能对广大读者有所裨益。需要说明的是,刊出的文摘在体例上与往期杂志有所不同,同时由于时间紧迫和篇幅所限,难免挂一漏万或存在差错,请会议论文作者及广大读者鉴谅。

关键词：枯水流量 meuse 流域篇幅文摘检索工具

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：