检索结果-南通市图书馆

Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第12期17卷 2643-2648页

作者： Ling-Ping Cen tsz kin ng Wai Kit Chu Chi Pui Pang Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Both inflammation and anti-inflammation are involved in the protection of retinal *** of the hypothalamic growth hormone-releasing hormone receptor(GHRHR)have been shown to possess potent anti-inflammatory properties in experimental disease models of various organs,some with systemic *** effects are also found in ocular inflammatory and neurologic injury *** experimental models of mice and rats,both growth hormone-releasing hormone receptor agonists and antagonists may alleviate death of ocular neural cells under certain experimental *** review explores the properties of growth hormone-releasing hormone receptor agonists and antagonists that lead to its protection against inflammatory responses induced by extrinsic agents or neurologic injures in ocular animal models.

关键词： neuroprotection ocular inflammation optic nerve injury retinal ganglion cells uveitis

Peritoneal macrophages attenuate retinal ganglion cell survival and neurite outgrowth

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第6期16卷 1121-1126页

作者： Jia-Jian Liang Yu-Fen Liu tsz kin ng Ci-Yan Xu Mingzhi Zhang Chi Pui Pang Ling-Ping Cen Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Inflammation is a critical pathophysiological process that modulates neuronal survival in the central nervous system after disease or ***,the effects and mechanisms of macrophage activation on neuronal survival remain *** the present study,we co-cultured adult Fischer rat retinas with primary peritoneal macrophages or zymosan-treated peritoneal macrophages for 7 *** analysis revealed that peritoneal macrophages reduced retinal ganglion cell survival and neurite outgrowth in the retinal explant compared with the control *** addition of zymosan to peritoneal macrophages attenuated the survival and neurite outgrowth of retinal ganglion *** media from peritoneal macrophages also reduced retinal ganglion cell survival and neurite *** result suggests that secretions from peritoneal macrophages mediate the inhibitory effects of these *** addition,increased inflammationand oxidation-related gene expression may be related to the enhanced retinal ganglion cell degeneration caused by zymosan *** summary,this study revealed that primary rat peritoneal macrophages attenuated retinal ganglion cell survival and neurite outgrowth,and that macrophage activation further aggravated retinal ganglion cell *** study was approved by the Animal Ethics Committee of the Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong,Shantou,Guangdong Province,China,on March 11,2014(approval ***20140311(2)-P01).

关键词： in vitro inflammation macrophages model neurite outgrowth optic nerve retinal ganglion cells survival

Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第5期19卷 1112-1118页

作者： Meng Wang Shi-Qi Yao Yao Huang Jia-Jian Liang Yanxuan Xu Shaowan Chen Yuhang Wang tsz kin ng Wai Kit Chu Qi Cui Ling-Ping Cen Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijingChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Intraocular pressure elevation can induce retinal ganglion cell death and is a clinically reversible risk factor for glaucoma,the leading cause of irreversible *** previously demonstrated that casein kinase-2 inhibition can promote retinal ganglion cell survival and axonal regeneration in rats after optic nerve *** investigate the underlying mechanism,in the current study we increased the intraocular pressure of adult rats to 75 mmHg for 2 hours and then administered a casein kinase-2 inhibitor(4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole)by intravitreal *** found that intravitreal injection of 4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole promoted retinal ganglion cell survival and reduced the number of infiltrating *** analysis showed that the mitogen activated protein kinase signaling pathway was involved in the response to intraocular pressure elevation but was not modulated by the casein kinase-2 ***,casein kinase-2 inhibition downregulated the expression of genes(Cck,Htrsa,Nef1,Htrlb,Prph,Chat,Slc18a3,Slc5a7,Scn1b,Crybb2,Tsga10ip,and Vstm21)involved in intraocular pressure *** data indicate that inhibition of casein kinase-2 can enhance retinal ganglion cell survival in rats after acute intraocular pressure elevation via macrophage inactivation.

关键词： casein kinase-2 glaucoma intraocular pressure elevation macrophages retinal ganglion cells

WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Progress of mesenchymal stem cell therapy for neural and retinal diseases

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2014年第2期6卷 111-119页

作者： tsz kin ng Veronica R Fortino Daniel Pelaez Herman S Cheung Geriatric Research Education and Clinical CenterMiami Veterans Affairs Medical Center Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Department of Biomedical Engineering College of EngineeringUniversity of Miami

Complex circuitry and limited regenerative power make central nervous system(CNS)disorders the most challenging and difficult for functional *** elusive disease mechanisms,traditional surgical and medical interventions merely slow down the progression of the neurodegenerative ***,the number of neurons still diminishes in many ***,stem cell therapy has been proposed as a viable *** stem cells(MSCs),a widely-studied human adult stem cell population,have been discovered for more than 20 *** have been found all over the body and can be conveniently obtained from different accessible tissues:bone marrow,blood,and adipose and dental *** have high proliferative and differentiation abilities,providing an inexhaustible source of neurons and glia for cell replacement ***,MSCs also show neuroprotective effects without any genetic modification or *** addition,the extraordinary immunomodulatory properties of MSCs enable autologous and heterologous *** qualities heighten the clinical applicability of MSCs when dealing with the pathologies of CNS ***,we summarize the latest progress of MSC experimental research as well as human clinical trials for neural and retinal *** review article will focus on multiple sclerosis,spinal cord injury,autism,glaucoma,retinitis pigmentosa and age-related macular degeneration.

关键词： Mesenchymal stem cells Stem cell therapy Central nervous system Retina Clinical trial

Cell-to-cell proteome variability:life in a cycle

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第7期6卷 1939-1941页

作者： tsz kin Suen Burcu Al Katarzyna Placek Immunology and Metabolism Life and Medical Sciences InstituteUniversity of BonnBonnGermany

Increasing body of evidence,supported by single-cell transcrip-tomic analysis,points to the heterogeneity of single cells within same cell *** the recent study by Mahdessian et al.1 published in Nature the authors elegantly show the cell-to-cell variability in the protein expression,its(in)dependence on the cell cycle progression and provide with the list of new cycling proteins with a potential role in tumorigenesis.

关键词： population cycle

AIEgen based light-up probes for live cell imaging

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2016年第1期59卷 53-61页

作者： Jing Liang Guangxue Feng Ryan tsz kin Kwok Dan Ding Benzhong Tang Bin Liu Department of Chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4117585Singapore NUS Environmental Research Institute National University of Singapore5A Engineering Drive 1117411Singapore Department of Chemistry Division of Biomedical Engineeringthe Hong Kong University of Science and TechnologyKowloonHong KongChina SCUT-HKUST Joint Research Laboratory Guangdong Innovative Research TeamState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China Institute of Materials Research Engineering Agency for ScienceTechnology and Research3 Research Link117602Singapore

Fluorescent light-up probes comprising a tetraphenylethene unit with aggregation-induced emission(AIE)characteristics and a water-soluble peptide have been designed and synthesized which provide cell membrane and nuclear permeability to live *** strategy has offered new opportunities for the development of probes with light-up ability and good signal-to-noise *** selectivity or targeting specificity is determined by the peptide sequence,i.e.a nuclear localization signal that leads to nucleus imaging and a cell biomarker targeting peptide that offers specific light-up imaging of HT-29 cells.

关键词： aggregation-induced emission(AIE) light-up probe live cell imaging nucleus imaging targeted cell imaging AIE probes

Current resistance status of Aedes aegypti and Aedes albopictus populations in Penang Island,Malaysia

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2024年第10期17卷 445-455页

作者： kin Hoong ng Wan Fatma Zuharah Medical Entomology Laboratory School of Biological SciencesUniversiti Sains MalaysiaMalaysia11900PenangMalaysia

Objective:To determine the current insecticide resistance status of Aedes(Ae.)aegypti and *** to four insecticides,namely 0.05%deltamethrin,0.75%permethrin,5%malathion and 0.25%pirimiphos-methyl using the World Health Organisation(WHO)susceptibility test ***:Adult bioassays were carried out using the standard protocol of the World Health *** F1 generation urban and suburban field strains of *** and *** were tested against pyrethroid and organophosphate insecticides,including the presence of piperonyl butoxide(PBO)in four replicates of 25 non-blood-fed female mosquitoes ranging from 3 to 5 days *** Vector Control Research Unit(VCRU)laboratory strain served as a reference ***:In this study,0.05%deltamethrin demonstrated a lower value of knockdown time when 50%of the mosquito population died(KT50)and knockdown time when 95%of the mosquito population died(KT95),which is significantly more effective compared to 0.75%permethrin against adult female ***(urban and suburban)and ***(urban and suburban)(ANOVA,Png to the shorter KT50 and KT95 compared to 0.25%pirimiphos-methyl against ***(urban and suburban)and ***(urban and suburban).*** urban and *** suburban performed a higher resistance ratio(RR)towards both 0.05%deltamethrin and 0.75%permethrin due to the wide use of permethrin in dengue vector control programs in ***,*** urban and suburban have lower resistance than *** urban and suburban towards 0.05%deltamethrin and 0.75%permethrin at 24 hours *** addition of PBO with these insecticides successfully reduced knockdown time(KT50 and KT95)values of most of the *** and *** field strains except PBO+0.75%permethrin against *** ***:The addition of PBO to insecticides has significantly reduced the knockdown time(KT50

关键词： Aedes Insecticide resistance Mosquito Organophosphates Pyrethroids Vector control

Human periodontal ligament-derived stem cells promote retinal ganglion cell survival and axon regeneration after optic nerve injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human periodontal ligament-derived stem cells promote retina...

Small Molecule Organic Nanostructures—Fabrication and Properties

第十四届中国实验动物科学年会

作者： ng,tsz kin 汕头大学香港中文大学联合汕头眼科眼科中心

Optic neuropathies are the leading cause of irreversible blindness and visual impairment in the developed countries, affecting more than 80 million people worldwide. While most optic neuropathies have no effective treatment, there is intensive research on retinal ganglion cell(RGC) protection and axon regeneration.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2008年第4期24卷 563-568页

作者： A.B.Djurii A.M.C.ng Kai-Yin CHEUng Man-kin FUng Wai-kin CHAN Department of Physics University of Hong KongPokfulam RoadHong KongHong Kong SARChina Department of Chemistry University of Hong KongPokfulam RoadHong KongHong Kong SARChina

Organic materials are of great interest for the development of low cost electronic and optoelectronic devices. Although majority of research on organic materials is concerned with synthesis of novel compounds and organic thin films, organic nanostructures are attracting increasing interest in recent years. We briefly review different growth methods of organic nanostructures, which can be roughly divided into vapor deposition methods and self-assembly techniques in solution. Then we highlight some interesting properties of organic nanostructures, as well as possible applications, includinf field emission, electronic and optoelectronic devices.

关键词： Organic nanostructures Self-assembly Vapor deposition