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Frontiers of Chemical Science and Engineering 2022年第1期16卷 72-80页

作者： Yui Sasaki Xiaojun Lyu Zhoujie Zhang tsuyoshi minami Institute of Industrial Science The University of TokyoTokyo 153-8505Japan

Chemosensor arrays have a great potential for on-site applications in real-world ***,to fabricate on chemosensor array a number of chemosensors are required to obtain various optical patterns for multianalyte ***,we propose a minimized chemosensor array composed of only two types of carboxylate-functionalized polythiophene derivatives for the detection of eight types of metal *** recognition of the metal ions,the polythiophenes exhibited changes in their fluorescence intensity and various spectral *** both chemosensors have the same polymer backbone and recognition moiety,only the difference in the number of methylene groups contributed to the difference in the fluorescence response ***,the metal ions in aqueous media were successfully discriminated qualitatively and quantitatively by the chemosensor microarray on the glass *** study offers an approach for achieving a minimized chemosensor array just by changing the alkyl chain lengths without the necessity for many receptors and reporters.

关键词： metal ions polythiophene chemosensor array fluorescence pattern recognition

Highly selective detection of copper(Ⅱ) by a “ligand-free” conjugated copolymer in nucleophilic solvents

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 105-111页

作者： Weixing Deng Pengfei Sun Quli Fan Lei Zhang tsuyoshi minami Key Laboratory for Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts&TelecommunicationsNanjing 210023China Institute of Industrial Science The University of TokyoMeguro-kuTokyo 153-8505Japan

The synthesis of N-cyclohexyl carbamate-attached fluorene-alt-phenylene copolymer(PFPNCC)and the use of PFPNCC as a“ligand-free”fluorescent chemosensor for Cu(Ⅱ)are *** of Cu(Ⅱ)can efficiently quench the fluorescence of PFPNCC in nucleophilic solvents such as DMF and DMSO,but not in low nucleophilic solvents such as 1,4-dioxane and ***-visible spectra of the mixture of the conjugated polymer and Cu(Ⅱ)indicate the presence of a reduced Cu(Ⅰ)ion in the ***,fluorescence recovery of PFPNCC observed at low temperature suggests that the quenching and reducing mechanism is most probably due to a photo-induced electron transfer from excited PFPNCC to Cu(Ⅱ).Our findings provide a novel strategy for highly selective conjugated polymer-based chemosensors for various target analytes,albeit“ligand-free”.

关键词： ligand-free fluorescent chemosensor copper photo-induced electron transfer

Design and evaluation of an extended-release matrix tablet formulation; the combination of hypromellose acetate succinate and hydroxypropylcellulose

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Asian Journal of Pharmaceutical Sciences 2017年第2期12卷 149-156页

作者： Sachiko Fukui Hideki Yano Shuichi Yada tsuyoshi Mikkaichi Hidemi minami Formulation Technology Research Laboratories Daiichi Sankyo Co.Ltd.1-2-58HiromachiShinagawa-kuTokyo 140-8710Japan Drug Metabolism&Pharmacokinetics Research Laboratories Daiichi Sankyo Co.Ltd.1-2-58HiromachiShinagawa-kuTokyo 140-8710Japan

The purpose of this study was to develop an extended-release(ER) matrix tablet that shows robust dissolution properties able to account for the variability of pH and mechanical stress in the GI tract using a combination of enteric polymer and hydrophilic polymer. Hypromellose acetate succinate(HPMCAS) and hydroxypropylcellulose(HPC) were selected as ER polymers for the ER matrix tablet(HPMCAS/HPC ER matrix tablet). Oxycodone hydrochloride was employed as a model drug. Dissolution properties of the HPMCAS/HPC ER matrix tablets were evaluated and were not affected by the pH of the test medium or paddle rotating *** a USP apparatus 3(bio-relevant dissolution method), dissolution profiles of the HPMCAS/HPC ER matrix tablets containing oxycodone hydrochloride were similar to that of the reference product(OxyC ontin). Moreover, in vivo performance after oral administration of the HPMCAS/HPC ER matrix tablets to humans was simulated by GastroP lus based on dissolution profiles from the USP apparatus 3. The plasma concentration-time profile simulated was similar to that of the reference product. These results suggest that the combination of HPMCAS and HPC shows a robust dissolution profile against pH and paddle rotating speed and indicates the appropriate extended-release profile in humans.

关键词： Extended-release matrix tablet Hypromellose acetate succinate Hydroxypropylcellulose Robust dissolution USP apparatus 3

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国立竞技场

城市环境设计 2024年第1期147卷 64-68页

作者：横尾实宫原贤次草谷友则原田爽一朗矢田元辉松长知宏神田刚南雅博 Japan Sport Council

这个大型体育场由一些小直径的木头建成。外立面上覆盖了重叠的多层屋檐，每层屋檐的下面是小直径的木百叶窗，通过这种现代的方式表达了日本传统建筑中的屋檐之美。105毫米的雪松木方是日本最常见的尺寸，这里将其分成三块50毫米的木...

这个大型体育场由一些小直径的木头建成。外立面上覆盖了重叠的多层屋檐，每层屋檐的下面是小直径的木百叶窗，通过这种现代的方式表达了日本传统建筑中的屋檐之美。105毫米的雪松木方是日本最常见的尺寸，这里将其分成三块50毫米的木板来制作百叶窗。百叶窗出现在外立面上的频率和密度是变化的，让屋檐的尺度更加人性化。屋顶采用桁架结构，该结构结合了具有中等横截面的钢梁和层压木材，利用木材的轴向刚度来最大限度地减少屋顶桁架因风或地震而产生的变形。

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Microstructure and mechanical properties evolution of 65Cu-35Zn brass tube during cyclic rotating−bending process

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Transactions of Nonferrous Metals Society of China 2022年第11期32卷 3610-3622页

作者： Zi-cheng ZHANG tsuyoshi FURUSHIMA Ken-ichi MANABE School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China Department of Mechanical and Biofunctional Systems Institute of Industrial ScienceThe University of TokyoKomaba 4-6-1MeguroTokyo 153-8505Japan Department of Mechanical Engineering Tokyo Metropolitan University1-1 Minami-OsawaHachioji-shiTokyo 192-0397Japan

The cyclic rotating−bending(CRB)processes under different deformation conditions were carried out to refine the microstructure and improve the mechanical properties of the 65Cu−35Zn brass *** microstructure and the mechanical properties in the axial direction of the tubes after the CRB process were studied with the OM,EBSD and conventional tensile *** obtain the accumulated effective plastic strain of the tube during the CRB process,the FEM simulation was also *** results show that the average grain size decreases with the increase of rotation time at RT,and with the decrease of bending angle at 200℃.With the increase of accumulated effective plastic strain during the CRB process,the reduction rate of average grain size of the brass tube increases,the tensile strength of the brass tube increases in wave shape and the elongation increases first and then sharply decreases.

关键词： brass tube cyclic rotating−bending process severe plastic deformation microstructure mechanical properties

Hepatocellular carcinoma and focal nodular hyperplasia of the liver in a glycogen storage disease patient

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World Journal of Hepatology 2012年第6期4卷 191-195页

作者： Yoshihiro Mikuriya Akihiko Oshita Hirotaka Tashiro Hironobu Amano tsuyoshi Kobayashi Kouji Arihiro Hideki Ohdan Division of Frontier Medical Science Department of Surgery Graduate School of Biomedical Sciences Hiroshima University 1-2-3 Kasumi Minami-ku Hiroshima 734-8551 Japan Department of Pathology Hiroshima University Hospital1-2-3 Kasumi Minami-ku Hiroshima 734-8551 Japan

Glycogen storage disease type Ia (GSD-Ia; also called von Gierke disease) is an autosomal recessive disorder of carbohydrate metabolism caused by glucose-6-phosphatase deficiency. There have been many reports describing hepatic tumors in GSD patients; however, most of these reports were of hepatocellular adenomas, whereas there are only few reports describing focal nodular hyperplasia (FNH) or hepatocellular carcinoma (HCC). We report a case with GSD-Ia who had undergone a partial resection of the liver for FNH at 18 years of age and in whom moderately differentiated HCC had developed. Preoperative imaging studies, including ultrasonography, dynamic computer tomography (CT) and magnetic resonance imaging, revealed benign and malignant features. In particular, fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT revealed the atypical findings that FDG accumulated at high levels in the non-tumorous hepatic parenchyma and low levels in the tumor. Right hemihepatectomy was performed. During the perioperative period, high-dose glucose and sodium bicarbonate were administered to control metabolic acidosis. He had multiple recurrences of HCC at 10 mo after surgery and was followed-up with transcatheter arterial chemoembolization. The tumor was already highly advanced when it was found by chance; therefore, a careful follow-up should be mandatory for GSD-I patients as they are at a high risk for HCC, similar to hepatitis patients.

关键词： Glycogen storage disease type Ia Hepato-cellular carcinoma Focal nodular hyperplasia Hepatectomy Metachronous

Degradation of differently processed Mg-based implants leads to distinct foreign body reactions(FBRs)through dissimilar signaling pathways

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镁合金学报(英文) 2023年第6期11卷 2106-2124页

作者： Xiaosong Liu Guoqiang Chen Xiongxiong Zhong Tianfang Wang Xiaohong He Weipeng Yuan Pingping Zhang Ying Liu Dongming Cao Shu Chen Ken-ichi Manabe Zhengyi Jiang tsuyoshi Furushima Damon Kent Yang Chen Guoying Ni Mingyong Gao Hejie Li Cancer Research Institute First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Rheumatology First People’s Hospital of FoshanFoshanGuangdong 528000China The Second Clinical Medical College of Jinan University Shenzhen People’s HospitalShenzhenGuangdong 510632China Genecology Research Centre University of the Sunshine CoastMaroochydore BCQLD 4558Australia Department of Medical Imaging First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Surgery First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Mechanical Engineering Graduate School of Science and EngineeringTokyo Metropolitan University1-1 Minami-osawaHachiojiTokyo 192-0397Japan School of Mechanical MaterialsMechatronic and Biomedical EngineeringFaculty of Engineering and Information SciencesUniversity of WollongongNorthfields AveWollongong NSW 2522Australia Institute of Industrial Science Department of Mechanical and Biofunctional Systemsthe University of Tokyo4-6-1KomabaMeguroTokyo 153-8505Japan School of Science Technology and EngineeringUniversity of the Sunshine CoastMaroochydore BCQLD 4558Australia

Mg alloys have mechanical properties compatible with human ***,their rapid degradation and associated foreign body reactions in vivo significantly limit their application for human *** this study,three differently processed Mg alloys,pure Mg(PM),cold extruded Mg alloy AZ31(CE AZ31),and fully annealed AZ31 Mg alloy(FA AZ31)were comparatively investigated for their potential as implants using a rat *** three implanted Mg alloys do not show any impact on hepato-and renal function,nor any signs of observable changes to vital *** analysis of tissues directly contacting the implants 2.5 months post implantation revealed that FA AZ31 activates very few inflammation and immune associated signaling pathways;while the CE AZ31 and PM produce more significant inflammatory responses as confirmed by cytokine array ***,FA AZ31 activated pathways for cell organization and development that may improve the recovery of injured ***,EBSD analysis reveals that the FA AZ31 alloy has a higher ratio of first-order pyramidal orientated(10–11){10–1–2}grain texture with a value of 0.25,while PM and CE AZ31 alloys have lower ratios of first-order pyramidal orientated texture with the values of 0.16 and 0.17,*** is associated with recovery and recrystallisation during annealing which promotes grain texture which exhibits enhanced degradation behaviours and induces a more limited immune response in *** conclusion,the FA AZ31 demonstrated better biocompatibility and corrosion resistance and is a promising candidate for metal-based degradable implants which warrants further investigation.

关键词： Toxicity test Proteomics analysis Signaling pathway Biocompatibility and corrosion resistance First-order pyramidal slip system Recovery and recrystallization Foreign body reactions(FBRs)

Application of simple adaptive control to water hydraulic servo cylinder system

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材料与冶金学报 2010年第4期9卷 300-303页

作者： tsuyoshi YAMADA Kazuhisa ITO Shigeru IKEO Masaharu NISHIMURA Graduate School of Engineering Tottori University 4 - 101 Minami Koyama - cho Tottori Japan Department of Machinery ＆ Control Systems College of Systems Engineering and Science Shibaura Institute of Technology 307 Fukasaku Saitama Japan Department of Mechanical Engineering Sophia University 7 - 1 Kioicho Chiyodaku Tokyo Japan

In this research, the positioning control of water hydraulic servo cylinder system with the simple adaptive control (SAC) is discussed. Conventional model reference adaptive control (MRAC) also achieves good tracking performance for cylinder control, but the controller structure was much complicated and was not easy to be realized in application. Compared with MRAC, SAC has simpler and lower order structure, i.e., has higher feasibility. But only few papers concerning with the application of the control performance of SAC to hydraulics and pneumatics are available, especially for water hydraulics. In this paper, we will examine and evaluate the control performance of the SAC strategy and it is confirmed that SAC gives better tracking performance compared with PI control.

关键词： water hydraulics servo cylinder system position control simple adaptive control