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Vacuum Insulation and Achievement of 980 keV,185 A/m^2 H-Ion Beam Acceleration at JAEA for the ITER Neutral Beam Injector

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Plasma Science and Technology 2013年第2期15卷 179-183页

作者： Hiroyuki TOBARI Masaki TANIGUCHI Mieko KASHIWAGI Masayuki DAIRAKU Naotaka UMEDA Haruhiko YAMANAKA Kazuki tsuchida Jumpei TAKEMOTO Kazuhiro WATANABE Takashi INOUE Keishi SAKAMOTO Japan Atomic Energy Agency (JAEA) Mukouyama 801-1 Naka Ibaraki 311-1093 Japan

Abstract Vacuum insulation of -1 MV is a common issue for the HV bushing and the accel- erator for the ITER neutral beam injector （NBI）. The HV bushing as an insulating feedthrough has a five-stage structure and each stage consists of double-layered insulators. To sustain -1 MV in vacuum, reduction of electric field at several triple points existing around the double-layered insulators is a critical issue. To reduce electric field simultaneously at these points, three types of stress ring have been developed. In a voltage holding test of a full-scale mockup equipped with these stress rings, 120% of rated voltage was sustained and the voltage holding capability required in ITER was verified. In the MeV accelerator, whose target is the acceleration of a H- ion beam of 1 MeV, 200 A/mS, the gap between the grid support was extended to suppress breakdowns triggered by electric field concentration at the edge and corner of the grid support. This modi- fication improved the voltage holding capability in vacuum, and the MeV accelerator succeeded in sustaining -1 MV stably, b-~rthermore, it appeared that the H- ions beam was deflected and a part of the beam was intercepted at the acceleration grid, This causes high heat load on the grids and breakdowns during beam acceleration. To suppress the direct interception, a new grid was designed with proper aperture displacement based on a three dimensional beam trajectory analysis, As a result, 980 keV, 185 A/ms H- ion beam acceleration has been demonstrated, which is close to the ITER requirement.

关键词： neutral beam injector (NBI) negative ion beam HV bushing vacuum insu-lation

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Detection of Oxidized Ferrocenes by LC-MS with Electrospray Ionization Using Picric Acid as the Counter Ion

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International Journal of Analytical Mass Spectrometry and Chromatography 2019年第1期7卷 1-8页

作者： Yutaka Okada Masako tsuchida Department of Applied Chemistry Ritsumeikan University Kusatsu Japan

Ferrocene is an organometallic compound that readily undergoes oxidation in atmosphere under acidic conditions. However, because of its diamagnetic nature, ferrocene does not lend itself to structural analysis by nuclear magnetic resonance (NMR) spectroscopy. In this work, the oxidation of ferrocene and several of its derivatives were analyzed by liquid chromatography-mass spectrometry (LC-MS). An electrospray ionization (ESI) source was used, with picrate serving as the counter ion. This method is particularly effective for studying oxidation of ferrocenes because their reactivity toward oxygen under ambient conditions is low.

关键词： ESI LC-MS Ferrocene Oxidation Picrate

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The leaf extract of Mallotus japonicus and its major active constituent, rutin,suppressed on melanin production in murine B16F1 melanoma

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Asian Pacific Journal of Tropical Biomedicine 2015年第10期5卷 819-823页

作者： Junsei Taira Eito tsuchida Masatsugu Uehara Natsuko Ohhama Wakana Ohmine Takayuki Ogi Department of Bioresource Technology Okinawa National College of Technology Okinawa Industrial Technology Center

Objective: To find anti-melanogenesis materials used in whitening ***: The ethanolic leaf extract of Mallotus japonicus(M. japonicus) having an anti-melanogenesis activity was separated by a sephadex LH-20 chromatography. Each fraction was measured for its tyrosinase inhibitory activity together with its polyphenol content using the Folin–Ciocalteu method. The anti-melanogenesis activity of the active fractions was determined by the melanin content in the murine B16F1 melanoma. The active fractions were put together due to similar constituents, and then separated by high performance liquid chromatography using a C-18 ODS column. The major antimelanogenesis compound was identified using1 H and13C-NMR and liquid chromatography-mass ***: The ethanolic leaf extract of M. japonicus showed an anti-tyrosinase activity with a high polyphenol content, resulting in suppression of melanin production in the B16F1 melanoma. The extract was separated and the active compound was identical as rutin based on the1 H,13C-NMR and liquid chromatography-mass spectrometry analysis data. In addition, the rutin treatment with cells reduced the melanin content in a concentration dependent manner without any cell toxicity. The leaf extract of M. japonicus containing rutin would be useful in whitening cosmetics for protection from UV-light exposure to be limiting the accumulation of melanin in ***: The leaf extract of M. japonicus and/or rutin isolated from the extract as a key whitening agent would be useful as a whitening cosmetic material for protecting against disorder skin due to melanin accumulation.

关键词： melanin rutin melanoma cosmetics constituent suppr

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Endoscopic removal and trimming of distal self-expandable metallic biliary stents

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World Journal of Gastroenterology 2011年第21期17卷 2652-2657页

作者： Kentaro Ishii Takao Itoi Atsushi Sofuni Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Shujiro Tsuji Nobuhito Ikeuchi Junko Umeda Fuminori Moriyasu Akihiko tsuchida Department of Gastroenterology and Hepatology Tokyo Medical University Third Department of Surgery Tokyo Medical University

AIM:To evaluate the efficacy and safety of endoscopic removal and trimming of self-expandable metallic stents(SEMS).METHODS:All SEMS had been placed for distal biliary ***-seven endoscopic procedures were performed in 19 patients in whom SEMS(one uncovered and 18 covered) removal had been attempted,and 8 patients in whom stent trimming using argon plasma coagulation(APC) had been attempted at Tokyo Medical University *** APC settings were:voltage 60-80 W and gas flow at 1.5 L/***:The mean stent indwelling period for all patients in whom stent removal had been attempted was 113.7 ± 77.6 d(range,8-280 d).Of the 19 patients in whom removal of the SEMS had been attempted,the procedure was successful in 14(73.7%) without procedure-related adverse *** indwelling period in the stent removable group was shorter than that in the unremovable group(94.9 ± 71.5 d vs 166.2 ± 76.2 d,P = 0.08).Stent trimming was successful for all patients with one minor adverse event consisting of self-limited *** time ranged from 11 to 16 ***:Although further investigations on larger numbers of cases are necessary to accumulate evidence,the present data suggested that stent removal and stent trimming is feasible and effective for stent-related complications.

关键词：金属支架修剪时间内镜远端胆道清除 SEMS 支架拆除

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Empirical Research on Risk Literacy and Perception of Undergraduates in China’s mainland-A Case of BSE

Empirical Research on Risk Literacy and Perception of Underg...

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第三届风险分析与危机反应国际学术研讨会

作者： Shoji tsuchida Faculty of Safety Science Kansai University

This paper analyzes the general features at risk literacy and perception of university students in China’s mainland in the case of bovine spongiform encephalopathy （BSE）. The results show that:（1） There seem no obvious relationships between respondents’ knowledge about BSE and their risk identification;（2） Among different groups, the greatest divergence appears in the judgment about probability of risk while the smallest one in the trust in science and technology to avoid BSE;（3） Gender, family location, and the background of college and specialty may have influences on the judgment of hazard probability.

关键词： risk literacy risk perception undergraduate student China BSE American beef

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Prognosis of cancer with branch duct type IPMN of the pancreas

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World Journal of Gastroenterology 2010年第15期16卷 1890-1895页

作者： Nobuhito Ikeuchi Takao Itoi Atsushi Sofuni Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Shujiro Tsuji Junko Umeda Fuminori Moriyasu Akihiko tsuchida Kazuhiko Kasuya Department of Gastroenterology and Hepatology Tokyo Medical University Department of Surgery Tokyo Medical University

AIM:To examine the coexistence of metachronous and synchronous cancer in branch duct intraductal papillary mucinous neoplasms of the pancreas (IPMN).METHODS: We reviewed the records of 145 patients with branch duct IPMN between January 1991 and April 2008 and assessed the relationship between IPMN and intraor extra-pancreatic carcinoma and the outcome of ***: The mean observation period was 55.9 ± 45.3 mo. Among the 145 patients, the frequency of extra-pancreatic cancer was 29.0%. The frequency of gastric cancer, colon cancer, breast cancer, and pan-creatic cancer were 25.5%, 15.7%, 13.7%, and 9.8%, respectively. Twenty (13.8%) of the patients died. The cause of death was extra-pancreatic carcinoma in 40%,pancreatic cancer in 25%, IPMN per se in 20%, and benign disease in 15% of the ***: The prognosis for IPMN depends not on the IPMN per se, but on the presence of intraor extra-pancreatic cancer.

关键词： Intraductal papillary mucinous neoplasms of the pancreas Long-term follow-up Extra-pancreatic cancer Pancreatic cancer Prognosis

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Effects of thermal aging on Fe ion-irradiated Fe–0.6%Cu alloy investigated by positron annihilation

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Nuclear Science and Techniques 2017年第2期28卷 8-11页

作者： Yuan-Chao Hu Xing-Zhong Cao Peng Zhang Hidetsugu tsuchida Qiu Xu Shuo-Xue Jin Er-Yang Lu Yu-Xiao Li Run-Sheng Yu Bao-Yi Wang Long Wei Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China College of Physical Engineering Zhengzhou UniversityZhengzhou 450001 China Quantum Science and Engineering Center Kyoto UniversityUji 6110011 Japan Research Reactor Institute Kyoto UniversityOsaka 5900494 Japan

Thermal aging effects on surface of 2.5 Me V Fe ion-irradiated Fe–0.6%Cu alloy were investigated using positron annihilation techniques. The samples were irradiated at 573 K to a dose of 0.1 dpa. Their thermal aging was performed at 573 K for 5, 50 and 100 h. From the results of Doppler broadening measurement, an obvious trough could be seen in near-surface region from the S parameters and inflection point form at S–W curves. This indicates changes in the annihilation mechanism of positrons in surface region after thermal aging. Coincident Doppler broadening indicates that the density of Cu precipitates in the thermal aged samples decreased, due to recovery of the vacancies.

关键词： Fe–Cu alloy Positron annihilation Irradiation Thermal aging

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Carcinogenesis and chemoprevention of biliary tract cancer in pancreaticobiliary maljunction

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World Journal of Gastrointestinal Oncology 2010年第3期2卷 130-135页

作者： Akihiko tsuchida Takao Itoi the third Department of Surgery Tokyo Medical University the fourth Department of Internal Medicine Tokyo Medical University

Pancreaticobiliary maljunction (PBM) is a high risk factor for biliary tract cancer. In PBM, since the pancreatic duct and bile duct converge outside the duodenal wall beyond the influence of the sphincter of Oddi, pancreatic juice and bile are constantly mixed, producing a variety of harmful substances. Because of this, the biliary mucosa is repeatedly damaged and repaired, which causes an acceleration of cell proliferative activity and multiple gene mutations. Histological changes such as hyperplasia, metaplasia, and dysplasia ultimately result in a high incidence of carcinogenesis. In a nationwide survey by the Japanese Study Group on PBM, coexisting biliary tract cancer was detected in 278 of the 1627 registered cases of PBM (17.1%). Of these cases, in those with dilatation of the extrahepatic bile duct, cancer was often detected not only in the gallbladder but also in the bile ducts. More than 90% of cancer cases without dilatation of the extrahepatic bile duct develop in the gallbladder. Standard treatment for PBM is a cholecystectomy and resection of the extrahepatic bile duct. However, cholecystectomy alone is performed at nearly half of institutions in Japan. Conversely, reports of carcinogenesis in the remnant bile duct or pancreas after diversion surgery are steadily increasing. One of the causes for this is believed to be an accumulation of gene mutations which were present before surgery. Anticancer drugs are ineffective in preventing such carcinogenesis following surgery, thus the postoperative administration of chemopreventive agents may be necessary.

关键词： Chemoprevention Gallbladder cancer Bile duct cancer Carcinogenesis Pancreaticobiliary maljunction

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Surface Characterlstlcs of Hemoglobin-Vesicles:Electrostatic Properties and Interaction with Blood Components

Surface Characterlstlcs of Hemoglobin-Vesicles:Electrostatic...

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第十一届国际人工血液大会

作者： H Sajkai E tsuchida Advanced Research Institute for Science and Engineering Waseda UniversityTokyo Japan. Advanced Research Institute for Science and Engineering Waseda UniversityTokyo Japan.

＜正＞Phospholipid vesicles encapsulating concentrated Hb（HbV）have been developed as artificial oxygen *** safety and efficacy of HbV as a transfusion alternative have been demonstrated in *** present HbV formulatio...

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东亚儒学之基本问题

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辽宁大学学报（哲学社会科学版） 2022年第4期50卷 26-33页

作者： [日]土田健次郎日本早稻田大学

东亚各国的儒学研究倾向于围绕本国所受影响范围进行展开。可是,单单以各国儒学为基轴而扩展的研究是不充分的,还需要从一开始就跟进把握东亚儒学的整体状况。因此有必要存在两种儒学史。一种是以各国为基轴的儒学史,另一种则是一开始... 详细信息

东亚各国的儒学研究倾向于围绕本国所受影响范围进行展开。可是,单单以各国儒学为基轴而扩展的研究是不充分的,还需要从一开始就跟进把握东亚儒学的整体状况。因此有必要存在两种儒学史。一种是以各国为基轴的儒学史,另一种则是一开始便着眼于东亚全体来书写的儒学史。各地的儒学深受中国的影响,即从中国单向地传往各地,而非相互交流影响。各地的儒学之所以独立性强,是受到了各地域国家意识较强的影响。而儒学的“天下”本来是指世界整体,并非某一个国家。在日本有言论称日本为“天下”,把日本看作一个世界,即各个国家是一个个不同的世界,而这多个世界又包含在以中国为中轴的大世界当中。在这里各个国家处于“生态隔离”状态。儒学使用的概念能够包含多样的内容,各国才能利用它的特性来构筑本国特有的思想。日本特有的思想感受性能够获得表达方式,是以中国儒学为基础才得以实现的。值得重视的是,在东亚地区,儒学是基础素养,儒学形成了文化知识的共同基础。现在我们应该做的是:首先,通过系统理论地说明东亚儒学的历史存在意义,使之与西欧思想相对化;其次,要系统理论地说明儒学在多样社会中具有明确的存在意义。

关键词：东亚儒学日本儒学天下观基础素养

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