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Efficacy of ripasudil in reducing intraocular pressure and medication score for ocular hypertension with inflammation and corticosteroid

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 904-908页

作者： Ryoji Yanai Sho-Hei Uchi Masaaki Kobayashi Tomohiko Nagai Shinichiro teranishi Makiko Wakuta Kazuhiro Kimura Department of Ophthalmology Yamaguchi University Graduate School of MedicineYamaguchi 755-8505Japan

·AIM:To investigate the efficacy of ripasudil,a Rho kinase inhibitor,in reducing intraocular pressure(IOP)and medication scores of anti-glaucoma drugs in patients with ocular hypertension with inflammation and corticosteroid.·METHODS:The study included 11 patients diagnosed with ocular hypertension with inflammation and corticosteroid,all of whom were prescribed ripasudil eye drops and followed up for at least 2y after the initiation of *** was measured using a non-contact tonometer before enrollment and at each follow-up *** medication score of glaucoma eye drops was calculated for each patient.·RESULTS:The mean IOP(26.4±2.9 mm Hg before treatment)significantly decreased after ripasudil therapy(13.7±3.3 mm Hg at 3mo)and remained stable in the low-teens during the 2-year follow-up period(P<0.0001).A significant decrease in the medication score was observed at 12mo or later after the initiation of ripasudil therapy(P<0.05).Both baseline medication scores and glaucomatous optic disc change rates were significantly higher in the five eyes that required glaucoma surgery during the 2-year observation period than the 10 eyes that did not require surgery.·CONCLUSION:Our results demonstrate the efficacy of ripasudil,in reducing IOP and the medication score over a 2-year treatment period in patients with ocular hypertension with inflammation and *** findings also suggest that ripasudil could reduce the IOP in uveitic glaucoma patients with both lower baseline medication score and lower glaucomatous optic disc change rate.

关键词： KEYWORDS:intraocular pressure medication score uveitis glaucoma Rho kinase inhibitor

Increased prevalence of intestinal inflammation in patients with liver cirrhosis

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World Journal of Gastroenterology 1999年第5期5卷 391-396页

作者： Saitoh O Sugi K Lojima K Matsumoto H Nakagawa K Kayazawa M Tanaka S teranishi T Hirata I Katsu Ki K Second Department of Internal Medicine Osaka Medical College Takatsuki Japan Department of Gastroenterology Ijinkai Takeda General Hospital Kyoto Japan

AIM To investigate the pathophysiology of the digestive tract in patients with liver *** In 42 cirrhotic patients and 20control subjects, the following fecal proteinswere measured by enzyme-linkedimmunosorb6nt assay: albumin (Alb ),transferrin (Tf), and al-antitrypsin (a,-AT) as amarker for intestinal protein l0ss, hemoglobin(Hb) for bleeding, PMN-eIastase for intestinalinflammation, and secretory lgA for *** The fecaI concentrations of Hb, Alb,Tf, al-AT, and PMN’eIastase were increased in13 (3l%), 8(19%), l0(24%), 6(14%), and 1l(26%) cases among 42 patients, resPectiveIy.F6cal concentration of secretory IgA wasdecreased in 7 (l7%) of 42 patients. However,these fecal concentrations were not related tothe severity or etiology of liver cirrhosis. Theserum Alb level was significantIy decreased inpatients with intestinal protein Ioss c0mpared tothat in patients without intestinal protein *** These findings suggest that: rob6sides the weIl’known pathological conditions,Such as bleeding and protein loss, intestinaIinflammati0n and decreased intestinaI immunityare found in cirrhotic patients, @ intestinalprotein loss contributes to hypoalbuminemia incirrhotic patients, and @ intestinaI inflammationshouId not b6 0verlooked in cirrhotic patients,since it may contribute to or cause intestinalprotein Ioss and oth6r various pathologicalconditions.

关键词： liver cirrhosis intestinal inflammation secretory IgA fecal proteins

CHARACTERISTICS OF SINGLE ELECTRON TUNNELING IN DOUBLE BARRIER TUNNELING JUNCTIONS WITH ALKANETHIOL TUNNELING BARRIERS

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CHARACTERISTICS OF SINGLE ELECTRON TUNNELING IN DOUBLE BARRI...

Asia Conference on Nanoscience and Nanotechnology Abstracts Book

作者： YUHSUKE YASUTAKE TOSHIHARU teranishi YUTAKA MAJIMA Department of Physical Electronics Tokyo Institute of Technology2-12-1 O-okayamaMeguro-kuTokyo 152-8552Japan Graduate School of Pure and Applied Sciences University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8571Japan Department of Physical Electronics Tokyo Institute of TechnologySolution Oriented Research for Science and Technology （SORST）Japan Science and Technology Agency（JST）2-12-1 O-okayamaMeguro-kuTokyo 152-8552Japan

＜正＞ In the nanomechanical double barrier tunneling junction （DBTJ）, the polarity and the number of electrons on the Coulomb island strongly depend on the tunneling resistance between the Coulomb island and two reservoirs, in which the single electron shuttle will occur if the tunneling resistance ratio of two junctions inverses due to the nanomechanical motion of Coulomb island during the self-excitation process. The control of the tunneling resistances in the nanomechanical single electron system is one of the most basic and important issue to realize the single electron shuttle with self-excitation. As a flexible tunneling barrier, alkanethiol self-assembled monolayer （SAM） is the candidate of the protection group of colloidal Au nanoparticle, since its tunneling resistance can be controlled by selecting the number of methylene *** we demonstrate Coulomb staircases in DBTJ structure consisted of scanning probe/vacuum gap/alkanethiol/Au core/alkanethiol/Au （111） electrode as a function of a set-point current of scanning tunneling spectroscopy. The tunneling resistances of probe-Au nanoparticle （R1） and Au nanoparticle-Au （111） electrode （R2） are estimated by fitting a theoretical Coulomb staircase curve into the experimental tunneling current-voltage characteristic. R2 of octanethiol protected Au nanoparticle, corresponding to the tunneling resistances of alkanethiol itself, has been estimated as one order of magnitude larger than that of hexanethiol protected Au nanoparticle. R1 is inversely proportional to the set point current as R1/R2 larger than 1. The relationship between R1/R2 and the DBTJ structure will be discussed as a function of the set-point current

关键词： Coulomb blockade tunneling current scanning tunneling microscopy.

来源： cnki会议评论

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咖啡的香气成分

热带农业科技 1988年第3期 40-43页

作者： Roy teranishi ,陈建白

大约公元前900年,一位阿拉伯医生Rhazes第一次在文献中提到咖啡。最初,咖啡是一种食物,继而用于酿酒、入药,用作饮料可追溯到700年前。如今它是世界上最普遍的兴奋刺激饮料之一。咖啡是由一种属于茜草科的热带植物的成熟果加工制作而成... 详细信息

大约公元前900年,一位阿拉伯医生Rhazes第一次在文献中提到咖啡。最初,咖啡是一种食物,继而用于酿酒、入药,用作饮料可追溯到700年前。如今它是世界上最普遍的兴奋刺激饮料之一。咖啡是由一种属于茜草科的热带植物的成熟果加工制作而成的。咖啡树的主要品种有小粒种咖啡(Coffea arabica)、中粒种咖啡(***)和大粒种咖啡(***),而小粒种咖啡是主要栽培种。咖啡炒制加工过程概述如图1。

关键词：咖啡化合物炒制香味焙炒油料加工生咖啡豆香气成分

1024元高分辨率线阵IRCCD图像传感器

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光电子技术 1988年第4期 94-97页

作者： Nobukazu teranishi 程开富

元中心间距为14μm 的1024元高分辨率红外电荷耦合器（IRCCD）图像传感器已研制成功。该器件主要用于遥感。IRCCD 传感器探测部分采用 PtSi/Si 肖特基势垒代替了常规的 Pd2Si/Si 肖特基势垒。可用于中波和短波红外成像,其功率为7 mW,因... 详细信息

元中心间距为14μm 的1024元高分辨率红外电荷耦合器（IRCCD）图像传感器已研制成功。该器件主要用于遥感。IRCCD 传感器探测部分采用 PtSi/Si 肖特基势垒代替了常规的 Pd2Si/Si 肖特基势垒。可用于中波和短波红外成像,其功率为7 mW,因而适宜于卫星应用。

关键词：线阵高分辨率高分辨力图像传感器 IRCCD

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战后日本的环境公害及其历史教训

嘉兴学院学报 2015年第1期27卷 5-14页

作者：寺西俊一一桥大学

二战后的日本环境污染事件频发,而中央政府反应迟缓,导致环境公害扩大,因此出现了"革新自治体"这种领先于国家的地方环境治理行动,又相继发生了一系列的环境公益诉讼。日本治理环境的对策中对硫氧化物进行"总量控制"是其较为成功的地方,... 详细信息

二战后的日本环境污染事件频发,而中央政府反应迟缓,导致环境公害扩大,因此出现了"革新自治体"这种领先于国家的地方环境治理行动,又相继发生了一系列的环境公益诉讼。日本治理环境的对策中对硫氧化物进行"总量控制"是其较为成功的地方,其"原料和燃料低硫化"和"排烟脱硫"方案是较为失败的地方。主要经验是"促进能源节约和向污染低的产业结构转型"。但日本的东京湾水质至今仍存在较严重的污染问题,行政分割是其症结,因此,必须进行环境政策整合,才能达到"相互合作"共同协作治理的境界。

关键词：日本二战后环境公害历史教训

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Study of Proton Resonances in ^(22)Mg by Resonant Elastic Scattering of ^(21)Na+p and Its Astrophysical Implication in ^(18)Ne(α,p) ^(21)Na Reaction Rate

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原子核物理评论 2009年第S1期26卷 153-157页

作者： S.Kubono T.teranishi M.Notani H.Baba S.Nishimura J.Y.Moon M.Nishimura S.Michimasa H.Iwasaki Y.Yanagisawa N.Hokoiwa M.Kibe J.H.Lee S.Kato Y.Gono C.S.Lee Center for Nuclear Study University of Tokyo(CNS) Department of Physics Kyushu University RIKEN(The Institute of Physical and Chemical Research) Department of Physics Chung-Ang University Department of Physics Yamagata University

Proton resonant states in 22Mg have been investigated by the resonant elastic scattering of 21Na+p. The 21Na beam with a mean energy of 4.00 MeV/u was separated by the CNS radioactive ion beam separator(CRIB) and bombarded a thick(CH2)n target. The energy spectra of recoiled protons were measured at scattering angles of θcm ≈172° and 146°,respectively. A new state at 7.06 MeV has been observed clearly and another new one at 7.28 MeV is tentatively identified due to its low statistics. The proton resonant parameters were deduced from an R-matrix analysis of the differential cross section data. The astrophysical resonant reaction rate for the 18Ne(α,p)21Na reaction has been estimated,and it is about five times larger than that assumed before.

关键词： nuclear astrophysics reaction rate nuclear structure and property

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Exotic Beam for Direct Measurement of the 22^Mg＋a

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Journal of Physical Science and Application 2013年第2期3卷 83-86页

作者： Nguyen Ngoc Duy Shiregu Kubono Hidetoshi Yamaguchi David Kahl Takashi Hashimoto Shinsuke Ota Yasuo Wakabayashi Takashi teranishi Yoong Hee Kim Joeng Soeg Song L.H. Khiem Jun Hu Department of Physics Dongnai University 04-Le Quy Don Bien Hoa City 71000 Dong Nai Vietnam Institute of Physics Vietnam Academy of Science and Technology Hoang Quoc Viet Hanoi 10000 Vietnam Center for Nuclear Study Graduate School of Science Univ. of Tokyo Hirosawa Wako-shi Saitama 351-0198 Japan Japan Atomic Energy Agency (JAEA) Mukoyama Naka-shi Ibaraki 311-0193 Japan Department of Physics University of Kyushu Hakozaki Higashi Ward Fukuoka 812-8581 Japan Department of Physics Seoul University Gwanak-ro Gwanak-gu Seoul 151-742 Korea Institute of Modern Physics Chinese Academy of Science Lanzhou 730000 China

The scattering and resonance reactions of ^22Mg＋p and ^22Mg＋α play crucial roles for studying deeply not only in the structure of proton-rich nuclei of ^23A1 and ^26Si but also for the interest of astrophysics. It is believed that ^22Mg nucleus is a waiting point in the αp-process of nucleosynthesis in novae. We supposed to perform direct measurement the ^22Mg＋α system in invert kinematics using radioactive ion （RI） beam. The ^22Mg beam of 3.73 MeV/u was produced at CRIB facility of the University of Tokyo located at RIKEN, Japan in 2011. In this paper, we report the results the scattering and resonance reactions with the alpha target. of the ^22Mg beam production used for the direct measurement of

关键词： Radioactive ions stellar reaction CRIB nuclear astrophysics.

二硫桥键钴卟啉二聚体的合成与电催化氧还原性能

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无机化学学报 2020年第12期36卷 2377-2384页

作者：金惠东顾银冬连跃彬薛松林房媛媛邓昭坂本雅典寺西利之彭扬苏州大学能源学院能源与材料创新研究院苏州215006 江苏省先进碳材料与可穿戴能源技术重点实验室苏州215006 江苏大学化学化工学院镇江212013 京都大学化学所京都611-0011日本

成功合成了二硫桥键相连的钴卟啉二聚体2Co。通过循环伏安电化学方法测试,在无水二氯甲烷溶剂中,钴卟啉二聚体展示了3个氧化和2个还原峰,表明此钴卟啉二聚体可以稳定多重负/正电荷。详细研究了在酸性条件下的钴卟啉二聚体的电催化氧还... 详细信息

成功合成了二硫桥键相连的钴卟啉二聚体2Co。通过循环伏安电化学方法测试,在无水二氯甲烷溶剂中,钴卟啉二聚体展示了3个氧化和2个还原峰,表明此钴卟啉二聚体可以稳定多重负/正电荷。详细研究了在酸性条件下的钴卟啉二聚体的电催化氧还原性能。钴卟啉二聚体的电催化氧还原显示了高稳定性和高活性,测得转移电子数为3.5~3.6之间。钴卟啉二聚体的电催化氧还原性能说明通过二硫键对钴卟啉单体二聚化可以提高钴卟啉的电催化氧还原性能。

关键词：钴卟啉二聚体氧气电催化还原

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