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Drug-induced sarcoidosis-like reaction three months after BNT162b2 mRNA COVID-19 vaccination:A case report and review of literature

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World Journal of Clinical Cases 2023年第1期11卷 177-186页

作者： Soo Ryang Kim Soo Ki Kim Takako Fujii Hisato Kobayashi Toyokazu Okuda Takanobu Hayakumo Atsushi Nakai Yumi Fujii Ryuji Suzuki Noriko Sasase Aya Otani Yu-ichiro Koma Motoko Sasaki tsutomu kumabe Osamu Nakashima Department of Gastroenterology Kobe Asahi HospitalKobe 6530801HyogoJapan Department of Radiology Kobe Asahi HospitalKobe 6530801HyogoJapan Department of Clinical Laboratory Kobe Asahi HospitalKobe 6530801HyogoJapan Department of Pharmacy Kobe Asahi HospitalKobe 6530801HyogoJapan Division of Pathology Department of PathologyKobe University Graduate School of MedicineKobe 6530801HyogoJapan Department of Human Pathology Kanazawa University Graduate School of MedicineKanazawa 9208640IshikawaJapan Department of Gastroenterology Kumabe ClinicKumamoto 8611331KumamotoJapan Laboratory Services Center St.Mary's HospitalKurume 830-8543FukuokaJapan

BACKGROUND A 70-year-old man with hepatitis C virus-related recurrent hepatocellular carcinoma was admitted for further diagnosis of a 1 cm iso-hyperechoic nodule in segment(S)*** SUMMARY Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging(EOB-MRI)revealed the nodule in S5 with a defect at the hepatobiliary phase,hyperintensity on diffusion weighted imaging(DWI)and hypointensity on apparent diffusion coefficient(ADC)***-enhanced computed tomography revealed hypervascularity at the early phase,and delayed contrast-enhancement was observed at the late ***-enhanced ultrasound(US)revealed incomplete defect at the late vascular *** liver tumor,lymphoproliferative disease,intrahepatic cholangiocarcinoma(small duct type)and bile duct adenoma were suspected through the imaging *** guided biopsy,however,showed a noncaseating hepatic sarcoid-like epithelioid granuloma(HSEG),and histopathological analysis disclosed spindle shaped epithelioid cells harboring Langhans-type multinucleated giant *** month after admission,EOB-MRI signaled the disappearance of the defect at the hepatobiliary phase,of hyperintensity on DWI,of hypointensity on ADC map,and no stain at the early *** That the patient had received BNT162b2 messenger RNA(mRNA)coronavirus disease 2019 vaccination 3 mo before the occurrence of HSEG,and that its disappearance was confirmed 4 mo after mRNA vaccination suggested that the drug-induced sarcoidosis-like reaction(DISR)might be induced by the mRNA ***,rechallenge of drug-induced DISR with the third mRNA vaccination was not confirmed.

关键词： Drug-induced sarcoidosis-like reaction BNT162b2 mRNA COVID-19 vaccine Noncaseating granuloma Ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging Th1/Th2 profile Case report

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Varicella-zoster virus-associated meningitis,encephalitis,and myelitis with sporadic skin blisters:A case report

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World Journal of Clinical Cases 2022年第2期10卷 717-724页

作者： Ken Takami Tsuneaki Kenzaka Ayako kumabe Megumi Fukuzawa Yoko Eto Shun Nakata Katsuhiro Shinohara Kazunori Endo Department of Internal Medicine Sainokuni Higashiomiya Medical CenterSaitama 331-8577SaitamaJapan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineKobe 652-0032HyogoJapan Department of Neurology Sainokuni Higashiomiya Medical CenterSaitama 331-8577SaitamaJapan Department of Dermatology Sainokuni Higashiomiya Medical CenterSaitama 331-8577SaitamaJapan Emergency Department Sainokuni Higashiomiya Medical CenterSaitama 331-8577SaitamaJapan

BACKGROUND Varicella-zoster virus(VZV)generally causes chickenpox at first infection in childhood and then establishes latent infection in the dorsal root ganglia of the spinal cord or other *** reactivation owing to an impaired immune system causes inflammation along spinal nerves from the affected spinal segment,leading to skin manifestations(herpes zoster).Viremia and subsequent hematogenous transmission and nerve axonal transport of the virus may lead to meningitis,encephalitis,and *** such case is described in this *** SUMMARY A 64-year-old man presented with dysuria,pyrexia,and progressive disturbance in *** had signs of meningeal irritation,and cerebrospinal fluid(CSF)analysis revealed marked pleocytosis with mononuclear predominance and a CSF/serum glucose ratio of *** magnetic resonance imaging revealed hyperintense areas in the frontal *** had four isolated blisters with papules and halos on his right chest,right lumbar region,and left scapular *** giant cells were detected using the Tzanck *** epidermal cells with intranuclear inclusion bodies and ballooning degeneration were present on skin *** VZV antibody titers suggested previous infection,and the CSF tested positive for *** developed paraplegia,decreased temperature perception in the legs,urinary retention,and fecal *** patient was diagnosed with meningitis,encephalitis,and myelitis and was treated with acyclovir for 23 days and prednisolone for 14 *** gradual improvement,the urinary retention and gait disturbances persisted as *** VZV reactivation should be considered in differential diagnoses of patients with sporadic blisters and unexplained central nervous system symptoms.

关键词： Varicella-zoster virus Encephalitis Meningitis Myelitis Central nervous system Case report

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ELASTIN FIBRES IN THE ARTICULAR TISSUE OF THE DEVELOPING MOUSE OSSICULAR,STAPEDIOVESTIBULAR AND MANDIBULAR JOINTS

ELASTIN FIBRES IN THE ARTICULAR TISSUE OF THE DEVELOPING MOU...

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The 4th Asian-Pacific Organization for Cell Biology Congress Cell Biology in the Post-Genomic Era

作者： Shunji kumabe Gi-Suep Kim Yasutomo Iwai-Liao Department of Oral Anatomy Osaka Dental UniversityOsaka 573-1121

The development of the mouse stapediovestibular joint (SVJ) and mandibular joint (MJ) were studied in an attempt to elucidate elastogenesis in the articular tissue;the histology was compared with elastogenesis in the ...

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Influence of Adiponectin and Leptin on the Kinetics of Human Pulp Cells

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Open Journal of Stomatology 2020年第12期10卷 360-371页

作者： Isao Tamura Katsura Ueda Yoshifumi Matsuda Aiko Kamada Yoshihiro Yoshikawa Eisuke Domae Takashi Ikeo Shunji kumabe Department of Oral Anatomy School of Dentistry Osaka Dental University 8-1 Kuzuhahanazono-cho Hirakata-shi Osaka Japan Department of Biochemistry School of Dentistry Osaka Dental University 8-1 Kuzuhahanazono-cho Hirakata-shi Osaka Japan

Adipocytokines, such as adiponectin and leptin, are expressed by adipocytes and are known as anti-metabolic syndrome factors. They are also thought to mediate calcification in mineralized tissue. We investigated the effects of adiponectin and leptin on the kinetics of human pulp cells using ELISA and western blot. After gaining informed consent, we obtained human pulp cells from three patients. After cultivation in Dulbecco’s Modified Eagle Medium (DMEM) without serum, cells from the 4th to 6th passages were incubated with various concentrations of adiponectin (1, 10, or 100 ng/mL) in DMEM or leptin (0.1, 1, or 10 ng/mL) in DMEM for 24 h. We confirmed that human pulp cells expressed adiponectin receptor 1 and leptin receptor. Although the proliferation index of these cells as measured by 5-bromo-2'-deoxyuridine (BrdU) incorporation increased in the presence of adiponectin in a dose-dependent manner, pulp cells stimulated with leptin showed no significant changes in BrdU incorporation. Alkaline phosphatase activity showed no significant changes after stimulation with either adipocytokine. Adiponectin induced expression of BMP-2 and osteopontin more strongly than did leptin. In particular, expression of BMP-2 increased in the presence of adiponectin in a dose-dependent manner. In contrast, the expression of dentin sialoprotein increased after stimulation with leptin. The expression of Runx2 was not observed from the cultured pulp cells stimulated with both molecules. These results indicate that adiponectin and leptin contribute to growth and differentiation of human pulp cells and may consequently affect the formation of secondary dentin or reparative dentin in the dentin-pulp complex.

关键词： Dental Pulp Cells Adiponectin Leptin Bone Morphogenetic Protein-2 Dentin Sialoprotein Osteopontin ECM Formation

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陶瓷的超声叠加振动切削

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微细加工技术 1990年第1期 72-78页

作者： J.kumabe 刘乃谦

陶瓷作为一种新型和高级的材料,已逐渐被人们所注意。但是为了在工业中得到广泛的应用,必需研究一种与金属加工成本相似的精密切削工艺。通常用于金属的高速切削工艺对陶瓷显然是不适宜的。

关键词：陶瓷振动切削

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15mw高温连续工作单模曲形TJS激光器

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半导体光电 1982年第4期 59-63页

作者： Hisao kumabe ,Toshio Tanaka ,何兴仁

一种带有窗口结构的新型大功率AlGaAs激光器,即曲型横向结条形激光器(以下简称曲型TJS激光器)制作成功。该激光器即使在连续输出功率为20mw的条件下仍以基横模工作,其阈值电流通过缩短激光器有源区的弯曲长度可降低到20mA,甚至在80℃以... 详细信息

一种带有窗口结构的新型大功率AlGaAs激光器,即曲型横向结条形激光器(以下简称曲型TJS激光器)制作成功。该激光器即使在连续输出功率为20mw的条件下仍以基横模工作,其阈值电流通过缩短激光器有源区的弯曲长度可降低到20mA,甚至在80℃以上器件仍然振荡,它的最大输出功率几乎比普通TJS的高十倍。在脉冲和连续波(CW)工作下分别获得200和40mw的最大功率。本文叙述了这种激光器的静态特性和长期工作状况。

关键词：激光器输出功率腔长基横模光激射器电子器件 TJS 阈值电流单模不可约模激光模

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Parent’s Perceived Provision of Information Regarding Diagnosis to Children with Brain Tumors

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Open Journal of Nursing 2015年第5期5卷 451-464页

作者： Iori Sato Akiko Higuchi Takaaki Yanagisawa Akitake Mukasa Kohmei Ida Yutaka Sawamura Kazuhiko Sugiyama Nobuhito Saito Toshihiro kumabe Mizuhiko Terasaki Ryo Nishikawa Yasushi Ishida Kiyoko Kamibeppu Department of Family Nursing Division of Health Sciences and Nursing Graduate School of Medicine The University of Tokyo Tokyo Japan Children’s Cancer Association of Japan Tokyo Japan Division of Pediatric Neuro-Oncology Department of Neuro-Oncology/Neurosurgery Comprehensive Cancer Center International Medical Center Saitama Medical University Hidaka Japan Department of Neurosurgery Faculty of Medicine The University of Tokyo Tokyo Japan Department of Pediatrics Teikyo University Mizonokuchi Hospital Kawasaki Japan Sawamura Neurosurgery Clinic Sapporo Japan Department of Clinical Oncology & Neuro-Oncology Program Hiroshima University Hospital Hiroshima Japan Department of Neurosurgery Tohoku University Graduate School of Medicine Sendai Japan Department of Neurosurgery Kurume University School of Medicine Kurume Japan Department of Neuro-Oncology/Neurosurgery Comprehensive Cancer Center International Medical Center Saitama Medical University Hidaka Japan Pediatric Medical Center Ehime Prefectural Central Hospital Matsuyama Japan

Background: The aim of this study was to clarify the degree of information provision to children with brain tumors, factors influencing this provision, and the relationship between this provision and psychosocial consequences. Methods: A total of 157 parents completed a questionnaire on the degree of information provision to their children and sociodemographic and medical characteristics. Parents and their children completed subscales of the Pediatric Quality of Life Inventory (PedsQL) Cancer Module. Relevant factors were investigated using ordinal logistic regression analysis and compared with PedsQL scores by degree of information provision with adjustment for age. Results: The majority of children aged 2 - 4 years received a low level of information only in regard to medical procedure and preparation. The majority of children aged 5 - 11 years were provided information regarding disease symptoms and treatment, but not actual diagnosis. Approximately half of children aged 12 - 18 years were provided detailed information including their actual diagnosis. Older children generally received more information regarding their disease (odds ratio [OR] = 1.3 per 1 year old, P < 0.001), while children with intellectual disability received less (OR = 0.2, P = 0.006). The provision of information did not worsen scores for Procedural Anxiety, Treatment Anxiety, Worry, or Communication. Conclusions: To our knowledge, this is the first report on the degree of information provision to children with brain tumors. Parents of children with brain tumors in Japan provide information dependent on age and intellectual level. The disclosure of information to children regarding their disease might affect their trust of medical and health care professionals.

关键词： Adolescent Brain Neoplasms Child Quality of Life Truth Disclosure

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Expression of Plectin-1 and Trichohyalin in Human Tongue Cancer Cells

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Open Journal of Stomatology 2018年第6期8卷 196-204页

作者： Isao Tamura Katsura Ueda Tetsunari Nishikawa Aiko Kamada Tomoharu Okamura Yoshifumi Matsuda Kentaro Ueno Yoshihiro Yoshikawa Eisuke Domae Kazuya Tominaga Shunji kumabe Takashi Ikeo Akio Tanaka Department of Oral Anatomy School of Dentistry Osaka Dental University Hirakata Japan Department of Innovation in Dental Education School of Dentistry Osaka Dental University Hirakata Japan Department of Biochemistry School of Dentistry Osaka Dental University Hirakata Japan Department of Oral Pathology School of Dentistry Osaka Dental University Hirakata Japan Department of Pathology School of Dentistry Osaka Dental University Hirakata Japan

In basal squamous cells, plectin-1 interacts with intermediate filaments, whereas trichohyalin, which is distributed primarily in the medulla and inner root sheath cells of human hair follicles, plays a role in strengthening cells during keratinization. Although both cytoskeletal proteins occur in trace amounts in human tongue epithelial cells, there are minimal data on their expression in human tongue primary cancer cells. We therefore investigated the expression of plectin-1 and trichohyalin in human tongue epithelial cell line (DOK) and tongue cancer cell line (BICR31) using western blotting and FITC-labeled immunocytochemistry techniques. DOK and BICR31 cells were cultivated to subconfluence in Dulbecco’s Modified Eagle’s Medium containing 0.4 μg/ml of hydrocortisone and 10% fetal bovine serum, and the levels of trichohyalin and plectin-1 were determined by western blot analysis and immunocytochemical staining. Trichohyalin expression was clearly observed, with no differences between DOK and BICR31 cells. Although DOK cells expressed trace levels of plectin-1, obvious plectin-1 bands were detected in western blot analyses of BICR31 cells. Immunocytochemical staining revealed that trichohyalin and plectin-1 localize in the cytoplasm. Trichohyalin was diffusely distributed in both cell lines, and colocalization of trichohyalin and cytokeratin 1/10 was observed in almost all BICR31 cells. There were no correlations between western blot and immunocytochemical data for trichohyalin. Conversely, correlations in immunochemical reactions for plectin-1 were observed. Most DOK cells showed no localization of plectin-1, but strong reactions were detected in the cytoplasm of BICR31 cells. These results indicate that trichohyalin is expressed by cancerous tongue epithelial cells during various stages of malignancy and that plectin-1 provides an index of malignancy.

关键词： Tongue Cancer Plectin-1 Trichohyalin Diagnosis

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体外培养骨髓基质细胞在珊瑚羟磷灰石上生长的表面形态观察

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南方医科大学学报 2007年第5期27卷 705-707页

作者：涂小丽刘宏伟岩井康智隈部俊二相川文子南方医科大学珠江医院口腔科广东广州510282 同济大学口腔医学院上海200072 大阪齿科大学

目的观察体外培养的骨髓基质细胞与珊瑚羟基磷灰石复合后的生长特性,论证珊瑚羟磷灰石作为骨组织工程学载体材料的可行性。方法分离纯化的狗骨髓基质细胞与珊瑚羟基磷灰石复合体体外培养,分别在相差显微镜下、扫描电镜下观察细胞的表面... 详细信息

目的观察体外培养的骨髓基质细胞与珊瑚羟基磷灰石复合后的生长特性,论证珊瑚羟磷灰石作为骨组织工程学载体材料的可行性。方法分离纯化的狗骨髓基质细胞与珊瑚羟基磷灰石复合体体外培养,分别在相差显微镜下、扫描电镜下观察细胞的表面形态结构。结果骨髓基质细胞在珊瑚羟基磷灰石上贴附生长良好,功能正常。结论骨髓基质细胞在珊瑚羟基磷灰石上生长增殖良好,珊瑚羟磷灰石是骨组织工程载体材料的可靠选择。

关键词：骨髓基质细胞珊瑚羟基磷灰石超微结构

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Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305)

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中国神经肿瘤杂志 2013年第1期11卷 21-21页

作者： Shibui S Narita Y Mizusawa J Beppu T Ogasawara K Sawamura Y Kobayashi H Nishikawa R Mishima K Muragaki Y Maruyama T Kuratsu J Nakamura H Kochi M Minamida Y Yamaki T kumabe T Tominaga T Kayama T Sakurada K Nagane M Kobayashi K Nakamura H Ito T Yazaki T Sasaki H Tanaka K Takahashi H Asai A Todo T Wakabayashi T Takahashi J Takano S Fujimaki T Sumi M Miyakita Y Nakazato Y Sato A Fukuda H Nomura K Department of Neurosurgery and Neuro-Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyo 104-0045Japan

Objectives: Glioblastoma(GBM) is one of the worst cancers in terms of *** therapy consists of resection with concomitant *** to nimustine hydrochloride(ACNU),an alkylating agent,has been linked to methylguanine DNA methyltransferase(MGMT).Daily administration of procarbazine(PCZ) has been reported to decrease MGMT *** study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma(AA).Methods: Patients(20-69 years) who had newly diagnosed AA and GBM were randomly assigned to receive radiotherapy with ACNU alone or with ACNU + *** primary endpoint was overall survival(OS).This was designed as a phase Ⅱ/Ⅲ trial with a total sample size of 310 patients and was registered as UMIN-CTR ***: After 111 patients from 19 centers in Japan were enrolled,this study was terminated early because temozolomide was newly approved in *** median OS and median progression-free survival(PFS) with ACNU alone(n = 55) or ACNU + PCZ(n = 56) in the intention-to-treat population were 27.4 and 22.4 months(P = 0.75),and 8.6 and 6.9 months,*** median OS and median PFS of the GBM subgroup treated with ACNU alone(n = 40) or ACNU + PCZ(n = 41) were 19.0 and 19.5 months,and 6.2 and 6.3 months,*** 3/4 hematologic adverse events occurred in more than 40% of patients in both arms,and 27% of patients discontinued treatment because of adverse ***: The addition of PCZ to ACNU was not beneficial,in comparison with ACNU alone,for patients with newly diagnosed AA and GBM.

关键词：星形细胞母细胞随机试验放疗胶质变性化疗 MGMT

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