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Surgical Robot for Intraluminal Access:An Ex Vivo Feasibility Study

Cyborg and Bionic Systems 2020年第1期2020卷 1-9页

作者： Ryu Nakadate tsutomu iwasa Shinya Onogi Jumpei Arata Susumu Oguri Yasuharu Okamoto Tomohiko Akahoshi Masatoshi Eto Makoto Hashizume Center for Advanced Medical Innovation Kyushu UniversityJapan Kitakyushu Municipal Medical Center Kyushu UniversityJapan Institute of Biomaterials and Bioengineering Tokyo Medical and Dental UniversityJapan Department of Mechanical Engineering Kyushu UniversityJapan Department of Advanced Medicine and Innovative Technology Kyushu University HospitalJapan Kyushu Central Hospital Japan Department of Urology Kyushu UniversityJapan Kyushu University Japan

Early-stage gastrointestinal cancer is often treated by endoscopic submucosal dissection(ESD)using a flexible endoscope.Compared with conventional percutaneous surgery,ESD is much less invasive and provides a high quality of life for the patient because it does not require a skin incision,and the organ is preserved.However,the operator must be highly skilled because ESD requires using a flexible endoscope with energy devices,which have limited degrees of freedom.To facilitate easier manipulation of these flexible devices,we developed a surgical robot comprising a flexible endoscope and two articulating instruments.The robotic system is based on a conventional flexible endoscope,and an extrapolated motor unit moves the endoscope in all its degrees of freedom.The instruments are thin enough to allow insertion of two instruments into the endoscope channel,and each instrument has a bending section that allows for up–down,right–left,and forward–backward motion.In this study,we performed an ex vivo feasibility evaluation using the proposed robotic system for ESD in a porcine stomach.The procedure was successfully performed by five novice operators without complications.Our findings demonstrated the feasibility of the proposed robotic system and,furthermore,suggest that even operators with limited experience can use this system to perform ESD.

关键词： Robot Access robot

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Efficacy of hybrid endoscopic submucosal dissection with SOUTEN in gastric lesions:An ex vivo porcine model basic study

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World Journal of Gastrointestinal Surgery 2021年第6期13卷 563-573页

作者： Mitsuru Esaki Eikichi Ihara Norikazu Hashimoto Shuichi Abe Chihoko Aratono Noriko Shiga Yorinobu Sumida Hiroyuki Fujii Kazuhiro Haraguchi Shunsuke Takahashi tsutomu iwasa Kayoko Nakano Masafumi Wada Shinichi Somada Kei Nishioka Yosuke Minoda Haruei Ogino Yoshihiro Ogawa Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Department of Gastroenterology and Metabolism Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Department of Gastroenterology Fukuoka City HospitalFukuoka 811-1394Japan Department of Gastroenterology Harasanshin HospitalFukuoka 812-0033Japan Department of Gastroenterology and Hepatology National Hospital Organization Fukuokahigashi Medical CenterKoga 811-3195Japan Department of Gastroenterology Fukuokaken Saiseikai Futsukaichi HospitalFutsukaichi 811-8516FukuokaJapan Department of Gastroenterology Clinical Research InstituteNational Hospital Organization Kyushu Medical CenterFukuoka 810-8564Japan Department of Gastroenterology Fukuoka Central HospitalFukuoka 805-0050Japan Department of Gastroenterology National Hospital Organization Beppu Medical CenterBeppu 874-0011Japan

BACKGROUND Hybrid endoscopic submucosal dissection(ESD)that comprises mucosal incision and partial submucosal dissection followed by snaring in a planned manner,has been developed for endoscopic resection of gastrointestinal neoplasms to overcome the technical barrier of ESD.Although the superiority of hybrid ESD with SOUTEN,a single multifunctional device,over conventional ESD has been indicated,the actual effect of snaring itself remains unclear since SOUTEN could be applied to hybrid ESD group,but not to the conventional ESD group,due to ethical issue in clinical practice.AIM To determine whether and how hybrid ESD was superior to conventional ESD in the endoscopic treatment of gastric lesions in an ex vivo porcine model basic study.METHODS Sixteen endoscopists participated in this basic study in August 2020 at Kyushu University,performing 32 procedures each for hybrid ESD and conventional ESD.Mock lesions(10-15 mm,diameter)were created in the porcine stomach.The primary outcome was total procedure time and secondary outcomes were en bloc or complete resection,perforation,procedure time/speed for both,mucosal incision,and submucosal dissection.Factors associated with difficulty in ESD including longer procedure time,incomplete resection,and perforation,were also investigated.Categorical and continuous data were analyzed using the chi-square test or Fisher’s exact test and the Mann-Whitney U test,respectively.RESULTS The median total procedure time of hybrid ESD was significantly shorter than that of conventional ESD(median:8.3 min vs 16.2 min,P<0.001).Time,speed,and the amount of hyaluronic acid during submucosal dissection were more favorable in hybrid ESD than conventional ESD(time,5.2 min vs 10.4 min,P<0.001;speed,43.7 mm^(2)/min vs 23.8 mm^(2)/min,P<0.00;injection volume,1.5 mL vs 3.0 mL,P<0.001),although no significant differences in those factors were observed between both groups during mucosal incision.There was also no significant difference between both groups in the en bloc/complete resection rate an

关键词： Endoscopic mucosal resection Hybrid Stomach neoplasms Treatment outcome Animal experimentation Logistic models

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Review of progress and challenges of key mechanical issues in high-field superconducting magnets

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National Science Review 2023年第3期10卷 29-50页

作者： You-He Zhou Dongkeun Park Yukikazu iwasa Key Laboratory of Mechanics on Disaster and Environment in Western China attached to the Ministry of Education of China Lanzhou University Department of Mechanics and Engineering Sciences College of Civil Engineering and Mechanics Lanzhou University The Plasma Science and Fusion Center Francis Bitter Magnet LaboratoryMassachusetts Institute of Technology

The development of modern science and technology requires high magnetic fields exceeding 25 T.Second-generation high-temperature superconducting wires,i.e.REBCO(REBa2Cu3O7-x,RE refers to Y,Gd,Dy,Eu and other rare-earth elements) coated conductors(CCs),have become the first choice for high-field magnet construction because of their high irreversible magnetic field.The mechanical stresses caused by manufacturing,thermal mismatch and Lorenz forces closely influence electromagnetic performance during operation for REBCO CCs.In addition,the recently studied screen currents have effects on the mechanical characteristics of high-field REBCO magnets.In this review,the experimental and main theoretical works on critical current degradation,delamination and fatigue,and shear investigations on REBCO CCs,are reviewed at first.Then,research progress on the screening-current effect in the development of high-field superconducting magnets is introduced.Finally,the key mechanical problems facing the future development of high-field magnets based on REBCO CCs are prospected.

关键词： REBCO second-generation high-temperature superconducting coated conductors (REBCO 2G-HTS CCs) high-field magnets mechanics screening-current effect

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Do bosons always condense?

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National Science Review 2021年第3期8卷 10-11页

作者： Yoshihiro iwasa Quantum Phase Electronics Center (QPEC) and Department of Applied Physics The University of Tokyo RIKEN Center for Emergent Matter Science (CEMS)

We learn in elementary statistical mechanics that bosonic systems undergo a phase change even without interparticle interactions, called Bose-Einstein condensation (BEC). Indeed, almost all bosonic systems in the real world such as4He, cold atoms and photons, exhibit BEC, and even electrons, a representative fermion system, can show similar condensation and superconductivity through the Cooper pair formation.

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Lead becomes a noncentrosymmetric superconductor in 2D limit

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Science Bulletin 2018年第10期63卷 595-596页

作者： Yoshi iwasa Quantam-Phase Electronics Center ( QPEC) and Department of Applied Physics The University of Tokyo Tokyo 113-8656 Japan RIKEN Center for Emergent Matter Science ( CEMS) Wako 351-0198 Japan

Properties of ultrathin materials always stimulate physicists’imaginations because the reduced dimensions often alter the properties of materials dramatically.In the last century,the semiconductor technologies enable... 详细信息

关键词：超导体 2D 铅性质材料

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Analysis for Effects of Temperature Rise of PV Modules upon Driving Distance of Vehicle Integrated Photovoltaic Electric Vehicles

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Energy and Power Engineering 2024年第4期16卷 131-150页

作者： Masafumi Yamaguchi Yasuyuki Ota Taizo Masuda Christian Thiel Anastasios Tsakalidis Arnulf Jaeger-Waldau Kenji Araki Kensuke Nishioka Tatsuya Takamoto Takashi Nakado Kazumi Yamada tsutomu Tanimoto Yosuke Tomita Yusuke Zushi Kenichi Okumura Takashi Mabuchi Akinori Satou Kyotaro Nakamura Ryo Ozaki Nobuaki Kojima Yoshio Ohshita Toyota Technological Institute Nagoya Japan Faculty of Engineering Miyazaki University Miyazaki Japan Toyota Motor Corporation Susono Japan European Commission— Joint Research Centre Ispra Italy Sharp Corporation Nara Japan Toyota Motor Corporation Toyota Japan Nissan Motor Corporation Yokosuka Japan

The development of vehicle integrated photovoltaics-powered electric vehicles (VIPV-EV) significantly reduces CO2 emissions from the transport sector to realize a decarbonized society. Although long-distance driving of VIPV-EV without electricity charging is expected in sunny regions, driving distance of VIPV-EV is affected by climate conditions such as solar irradiation and temperature rise of PV modules. In this paper, detailed analytical results for effects of climate conditions such as solar irradiation and temperature rise of PV modules upon driving distance of the VIPV-EV were presented by using test data for Toyota Prius and Nissan Van demonstration cars installed with high-efficiency InGaP/GaAs/InGaAs 3-junction solar cell modules with a module efficiency of more than 30%. The temperature rise of some PV modules studied in this study was shown to be expressed by some coefficients related to solar irradiation, wind speed and radiative cooling. The potential of VIPV-EV to be deployed in 10 major cities was also analyzed. Although sunshine cities such as Phoenix show the high reduction ratio of driving range with 17% due to temperature rise of VIPV modules, populous cities such as Tokyo show low reduction ratio of 9%. It was also shown in this paper that the difference between the driving distance of VIPV-EV driving in the morning and the afternoon is due to PV modules’ radiative cooling. In addition, the importance of heat dissipation of PV modules and the development of high-efficiency PV modules with better temperature coefficients was suggested in order to expand driving range of VIPV-EV. The effects of air-conditioner usage and partial shading in addition to the effects of temperature rise of VIPV modules were suggested as the other power losses of VIPV-EV.

关键词： Vehicle Integrated Photovoltaics (VIPV) VIPV-Powered Electric Vehicles Driving Distance PV Modules Solar Irradiation Temperature Rise Radiative Cooling

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Impact of prior chemotherapy with two different fluoropyrimidines on the efficacy of capecitabine plus irinotecan or FOLFIRI with or without bevacizumab in metastatic colorectal cancer:a post hoc analysis of the AXEPT study

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Cancer Communications 2023年第4期43卷 519-522页

作者： Satoru iwasa Zi-Xian Wang Kei Muro Satoshi Morita Young Suk Park Dongsheng Zhang Yasuhide Yamada Junichi Sakamoto TaeWon Kim Department of Gastrointestinal Medical Oncology National Cancer Center HospitalTokyoJapan Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdongP.R.China Department of Clinical Oncology Aichi Cancer Center HospitalNagoyaJapan Department of Biomedical Statistics and Bioinformatics Graduate School of MedicineKyoto UniversityKyotoJapan Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Comprehensive Cancer Center National Center for Global Health and MedicineTokyoJapan Department of Medical Oncology Hamamatsu University School of MedicineShizuokaJapan Tokai Central Hospital KakamigaharaJapan Department of Oncology Asan Medical CenterUniversity of UlsanCollege of MedicineSeoulKorea

Dear Editor,Recently,the phase III Asian XELIRI(capecitabine plus irinotecan)ProjecT(AXEPT)study demonstrated the non-inferiority of modified capecitabine plus irinotecan(mXELIRI)±bevacizumab(Bev)to fluorouracil plus leucovorin with irinotecan(FOLFIRI)±Bev in terms of overall survival(OS)as a second-line treatment for patients with metastatic colorectal cancer[1,2].In the past decade,oral prodrugs of fluorouracil-containing regimens have shown similar efficacies to intravenous fluorouracilcontaining regimens.

关键词： FOLFIRI colorectal metastatic

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Evidence of spin density wave of CeOs4Sb12

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Rare Metals 2006年第S1期25卷 550-552页

作者： iwasa Kazuaki SUGAWARA Hitoshi SATO Hideyuki Department of Physics Tohoku University Sendai 980-8578 Japan Department of Physics Tokyo Metropolitan University Tokyo 192-0397 Japan

Elastic neutron diffraction measurements were performed on single crystals to study the ground state below the mysterious exotic transition temperature 0.86 K. An antiferromagnetic order with a tiny moment of 0.027 μB per formula is formed as the ground state for CeOs4Sb12 below the transition point. Our neutron data gives the evidence of spin density wave state for CeOs4Sb12 in this work.

关键词： elastic neutron scattering skutterudite structure antiferromagnetic ordering spin density wave

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A genetic typing method for albino mutation in the Mongolian gerbil by PCR-RFLP analysis

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Integrative Zoology 2021年第3期16卷 429-432页

作者： Takao UKAJI Masahiro A.iwasa Osamu KAI Department of Animal Science and Resources College of Bioresource SciencesNihon UniversityFujisawaJapan

INTRODUCTION The Mongolian gerbil(Meriones unguiculatus)has been used as an animal model for pharmacology(Wu et al.2008),parasitology(Lim et al.2004),and studies of reproduction(Kai et al.1995).The molecular mechanisms of several coat-color phenotypes are known in gerbils(Petrij et al.2001,2007).On the other hand,although albinism in gerbils was first reported by Matsuzaki et al.(1989),its molecular mechanism is still unclear.In a previous study,we reported the establishment of the albino gerbil strain(strain code:MON/Num/c)as a closed colony and the agouti-colored strain(strain code:MON/Num/a)as inbred.Our albino strain had 4 nucleotide substitutions and 2 missense mutations(R77H in exon 1 and Q473R in exon 5)in the tyrosinase(Tyr)gene(Ukaji et al.2016).

关键词： al. colored analysis

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PPARα activator irbesartan suppresses the proliferation of endometrial carcinoma cells via SREBP1 and ARID1A

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Oncology Research 2023年第3期31卷 239-253页

作者： YU LU tsutomu MIYAMOTO HODAKA TAKEUCHI FUMI TSUNODA NAOKI TANAKA TANRI SHIOZAWA Department of Obstetrics and Gynecology School of MedicineShinshu UniversityMatsumoto390-8621Japan Department of Global Medical Research Promotion School of MedicineShinshu University GraduateMatsumotoNagano390-8621Japan International Relations Office School of MedicineShinshu UniversityMatsumotoNagano390-8621Japan Research Center for Social Systems Shinshu UniversityMatsumotoNagano390-8621Japan

Endometrial carcinoma(EMC)is associated with obesity;however,the underlying mechanisms have not yet been elucidated.Peroxisome proliferator-activated receptor alpha(PPARα)is a nuclear receptor that is involved in lipid,glucose,and energy metabolism.PPARαreportedly functions as a tumor suppressor through its effects on lipid metabolism;however,the involvement of PPARαin the development of EMC remains unclear.The present study demonstrated that the immunohistochemical expression of nuclear PPARαwas lower in EMC than in normal endometrial tissues,suggesting the tumor suppressive nature of PPARα.A treatment with the PPARαactivator,irbesartan,inhibited the EMC cell lines,Ishikawa and HEC1A,by down-regulating sterol regulatory element-binding protein 1(SREBP1)and fatty acid synthase(FAS)and up-regulating the tumor suppressor genes p21 and p27,antioxidant enzymes,and AT-rich interaction domain 1A(ARID1A).These results indicate the potential of the activation of PPARαas a novel therapeutic approach against EMC.

关键词： Peroxisome proliferator-activated receptor alpha Sterol regulatory element-binding protein 1 Antioxidant Migration

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