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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

Microplastic and nanoplastic exposure and risk of diabetes mellitus

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World Journal of Clinical Cases 2025年第3期13卷 24-29页

作者： Hui-Yi Hsiao Chung-Yi Nien Ruei-Feng Shiu Wei-Chun Chin Tzung-Hai yen Department of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina Center for Tissue Engineering Chang Gung Memorial HospitalLinkouTaoyuan 33305TaiwanChina Department of Life Sciences National Central UniversityZhongli 320317TaoyuanTaiwanChina Center of Excellence for The Oceans Taiwan Ocean UniversityKeelung 20224TaiwanChina Institute of Marine Environment and Ecology Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Chemical and Materials Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalLinkou 33305TaoyuanTaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

The issue of plastic pollutants has become a growing *** microplastics(MPs)(particle size<5 mm)and nanoplastics(NPs)(particle size<1μm)can cause DNA damage,cytotoxicity,and oxidative stress in various *** primary known impacts of microplastic/nanoplastic are observed in the liver and respiratory system,leading to hepatotoxicity and chronic obstructive pulmonary *** research on the effects of MPs and NPs on diabetes is still in its early stages,there are potential *** editorial highlights the risk to diabetics from co-exposure to contaminants and MPs/NPs,supported by evidence from animal studies and the various chemical compositions of MPs/NPs.

关键词： Microplastics Nanoplastics Plastic pollution,Diabetes mellitus Insulin resistance

New Challenges for Biological Text-Mining in the Next Decade

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Journal of Computer Science & Technology 2010年第1期25卷 169-178,F0003页

作者： yen-Ching chang Richard Tzong-Han Tsai Wen-Lian Hsu Institute of Information Science "Academia Sinica" Department of Computer Science and Engineering Yuan Ze University Department of Computer Science "National Tsing-Hua University"

The massive flow of scholarly publications from traditional paper journals to online outlets has benefited biologists because of its ease to access. However, due to the sheer volume of available biological literature, researchers are finding it increasingly difficult to locate needed information. As a result, recent biology contests, notably JNLPBA and BioCreAtIvE, have focused on evaluating various methods in which the literature may be navigated. Among these methods, text-mining technology has shown the most promise. With recent advances in text-mining technology and the fact that publishers are now making the full texts of articles available in XML format, TMSs can be adapted to accelerate literature curation, maintain the integrity of information, and ensure proper linkage of data to other resources. Even so, several new challenges have emerged in relation to full text analysis, life-science terminology, complex relation extraction, and information fusion. These challenges must be overcome in order for text-mining to be more effective. In this paper, we identify the challenges, discuss how they might be overcome, and consider the resources that may be helpful in achieving that goal.

关键词： bioinformatics database mining method and algorithm text mining

Identifying timing and risk factors for early recurrence of resectable rectal cancer: A single center retrospective study

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2842-2852页

作者： tsung-Jung Tsai Kai-Jyun Syu Xuan-Yuan Huang Yu Shih Liu chang-Wei Chen yen-Hang Wu Ching-Min Lin Yu-Yao chang Division of Colon and Rectal Surgery Department of SurgeryChanghua Christian HospitalChanghua 50006TaiwanChina Department of Surgery Changhua Christian HospitalChanghua 50006TaiwanChina Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402202TaiwanChina

BACKGROUND Colorectal cancer is a common malignancy and various methods have been introduced to decrease the possibility of *** recurrence(ER)is related to worse *** date,few observational studies have reported on the analysis of rectal ***,we reported on the timing and risk factors for the ER of resectable rectal cancer at our *** To analyze a cohort of patients with local and/or distant recurrence following the radical resection of the primary *** Data were retrospectively collected from the institutional database from March 2011 to January *** data at diagnosis,perioperative and postoperative data,and first recurrence were collected and *** was defined via receiver operating characteristic *** factors were evaluated using the Kaplan–Meier method and Cox proportional hazards *** We included 131 *** optimal cut off value of recurrence-free survival(RFS)to differentiate between ER(n=55,41.9%)and late recurrence(LR)(n=76,58.1%)was 8 *** median post-recurrence survival(PRS)of ER and LR was 1.4 mo and 2.9 mo,respectively(P=0.008)but PRS was not strongly associated with RFS(R^(2)=0.04).Risk factors included age≥70 years[hazard ratio(HR)=1.752,P=0.047],preoperative concurrent chemoradiotherapy(HR=3.683,P9 d(HR=0.441,P=0.006).CONCLUSION RFS of 8 mo was the optimal cut-off *** ER was not associated with PRS,it was still related to prognosis;thus,intense surveillance is recommended.

关键词： Rectal cancer Early recurrence Prognosis Post-recurrence survival

Effect of annealing temperature on the microstructure and mechanical properties of an as-rolled Mg-9wt.%Li-3wt.%Al-1wt.%Zn alloy sheet

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Frontiers of Materials Science 2014年第3期8卷 271-280页

作者： Meng-chang LIN Shang-Qiu LIN Jun-yen UAN Department of Materials Science and Engineering Chung Hsing University 250 kuo-kuang Rd. Taichung 40277 Taiwan China Green Energy and Environment Research Laboratories Industrial Technology Research Institute 195 Sec. 4 Chung-Hsing Road Hsin-Chu 31040 Taiwan China

This study investigated the effect of annealing temperature on the mechanical properties of an as-rolled Mg-9.26wt.%Li-3,03wt,%Al-1,10wt.%Zn （LAZ931） alloy sheet. The dual-phase （a ＋ 13） LAZ931 alloy plate of 3 mm in thickness were roiled （67% reduction） and then annealed at temperatures at 100℃-350℃. The alloy＇s ductility showed a sharp concave downward tendency as a function of annealing temperature, The elongation of the LAZ931 alloy sheet increased with annealing temperature up to 150℃, followed by a sharp decrease of the alloy＇s ductility as the annealing temperature higher than 150℃. The specimen exhibited an extremely low elongation （only -0,5%） at annealing temperature around 300℃. Formation of brittle AILi particles on boundary resulted in Li depletion zone near by grain boundary, transforming the Li depletion zone into a （hcp） layer. The combined effects including brittle AILi particles on boundary and the hcp α layer on boundary resulted in the brittlement of the high-temperature-annealing sample.

关键词： Mg-Li alloy annealing AILi embrittlement

Intense blue-emitting Ca_2PO_4Cl:Eu^(2+) phosphor for near-ultraviolet converting white light-emitting diodes

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Journal of Rare Earths 2010年第S1期28卷 250-253页

作者： Yi-Chen Chiu Chun-Kuei chang Yao-tsung Yeh Shyue-Ming Jang Material and Chemical Research Laboratories Industrial Technology Research Institute Phosphors Research Laboratory and Department of Applied Chemistry National Chiao Tung University

A blue phosphor Ca2PO4Cl:Eu2+(CAP:Eu2+) was synthesized by solid state *** Ca2PO4Cl:Eu2+ exhibited high quantum efficiency and excellent thermal *** luminescent intensity of Ca2PO4Cl:Eu2+ was found to be 128% under excitation at 380 nm,149% under 400 nm,and 247% under 420 nm as high as that of BaMgAl10O17:Eu2+.The optimal doping concentration was observed to 11 mol.% of CAP:Eu2+.The energy transfer between Eu2+ ions in CAP were occurred via electric multipolar interaction,and the critical transfer distance was estimated to be 1.26 nm.A mixture of blue-emitting Ca2PO4Cl:Eu2+,green-emitting(Ba,Sr)2SiO4:Eu2+ and red-emitting CaAlSiN3:Eu2+ phosphors were selected in conjunction with 400 nm chip to fabricate white LED *** average color-rendering index Ra and correlated color temperature(Tc) of the white LEDs were found to be 93.4 and 4590 K,*** results indicated that it was a promising candidate as a blue-emitting phosphor for the near-UV white light-emitting diodes.

关键词： Ca2PO4Cl:Eu2+ phosphors luminscense rare earths

Addressing Japan’s disposal of nuclear-contaminated water from the perspective of international human rights law

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Chinese Journal of Population,Resources and Environment 2024年第1期22卷 1-9页

作者： yen-Chiang chang Xiaonan Zhao Law School Dalian Maritime UniversityDalian 116026China Institute for Bohai and Yellow Sea Studies Dalian Maritime UniversityDalian 116026China

The discharge of nuclear-contaminated water containing radionuclides into the ocean by Japan will lead to its integration into the entire ecosystem through processes of circulation and biomagnification,eventually entering the human body via the food *** poses a substantial risk of irreversible damage to both the ecosystem and human health,a situation that will worsen with the ongoing discharge of such *** respect and protection of human rights represent an international consensus,and safeguarding fundamental human rights is a substantial obligation that states must undertake in accordance with both international and domestic *** the Fukushima nuclear disaster,Japan has continuously violated its international legal obligations to protect human rights in several areas,including the resettlement of disaster victims,the reduction of nuclear radiation levels,and the handling of contaminated *** actions have compromised and will continue to compromise the basic human rights of not only its citizens but also those of people worldwide,including environmental rights,the right to life,development rights,and food *** the aftermath of the Fukushima meltdown,the public and workers involved in handling nuclear contaminants have been continually exposed to high radiation levels,endangering their rights to life,development,and ***’s inadequate efforts in victim resettlement and environmental restoration have jeopardized the environmental and food rights of its citizens to live healthily and access food in an environment unaffected by nuclear *** release of nuclear-contaminated water poses a risk of Japan’s nuclear pollution to the people of neighboring countries and the global population at *** principle of human rights underpins the theory of a community with a shared future for humanity,and human rights are a crucial area of China’s active participation in United Nations affairs and global *** voicing concerns ove

关键词： Fukushima nuclearcontaminated water Crimes against humanity Remedy for violations of human rights Right to environment Right to life

Advanced materials for aqueous supercapacitors in the asymmetric design

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Progress in Natural Science:Materials International 2015年第6期25卷 527-544页

作者： Muniyandi Rajkumar Chun-tsung Hsu Tzu-Ho Wu Ming-Guan Chen Chi-chang Hu Laboratory of Electrochemistry and Advanced Materials Department of Chemical EngineeringNational Tsing Hua University

Supercapacitors have been recognized as one of the promising energy storage devices in the future energy *** this perspective,rapid progress is made in the development of fundamental and applied aspects of *** techniques have been developed specifically to estimate the specific *** efforts have been made in the literature to increase the specific capacitance of electrode ***,researchers pay more attention on designing supercapacitors of asymmetric type with extending cell voltage and dissimilar materials with complementary working *** try to increase the specific energy of asymmetric supercapacitors(ASCs).Conversely,it is still a challenge to find a suitable operation conditions for ASCs in various designs,especially for the one with battery type *** this review,we describe our recent research works and other reports on the preparation of various nanostructured electrode materials and the performances of both symmetric and asymmetric ***,we demonstrate effects of charge balance on the capacitive performances of ASCs which consist of one electrode material of the battery type and one capacitive *** also demonstrate how to evaluate the charge capacities of both positive and negative electrode materials for this ASC application.

关键词： Transition metal oxides Chemical Synthesis Aqueous electrolyte Super capacitors Asymmetric Design

Landscape structure and bird's diversity in the rural areas of Taiwan

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Journal of Environmental Sciences 2003年第2期15卷 241-248页

作者： Chun-yen-chang (Department of Horticulture, “National Chung Hsing University”, Taichung, Taiwan, China) Department of Horticulture National Chung Hsing University Taichung Taiwan

This study tries to discuss the relationship between landscape structure and organisms in the perspective of landscape architecture. The research hypotheses were then proposed as (1) there are relationships between landscape structure indexes and birds' diversity in the rural areas of Taiwan; (2) the relationships between landscape structure and birds' diversity will be different in different hierarchical levels. In order to increase the bird species, landscape planners could tries to increase the density of water bodies, but decrease the farms and human planted woods. Decrease the density of constructed and human planted grasslands. Increase the area of un-worked acres, natural grasslands, and the area of water bodies and circular the water bodies and natural forest. In order to increase birds' diversity, landscape planners could decrease the concentration of paved areas. Concentrate the human planted trees to increase the core areas of woodlands. Increase the area of natural grassland circular. In order to increase the total number of birds in the planning areas, landscape planners could scattered the paved areas and lengthen the constructed areas. Decreases the core region of the constructed areas. Increase the area of un-worked acres and water bodies. Decrease the disturbance of both the interior area of natural and human planted woodlands and try to increase the density of water bodies.;The analysis results showed that the small grain size indexes are more suitable for the rural areas of Taiwan to capture the influential factors of bird communities. The high fragmentation of land usages in Taiwan lessens the influences of the regional landscape pattern.

关键词： landscape structure bird diversity Taiwan