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Cervical inlet patch-optical coherence tomography imaging and clinical significance

World Journal of Gastroenterology 2012年第20期18卷 2502-2510页

作者： Chao Zhou Tejas Kirtane tsung-han tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo Department of Electrical Engineering and Computer Science Research Laboratory of Electronics Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139-4307 United States Gastroenterology Section VA Boston Healthcare System/Harvard School of Medicine 150 S. Huntington Avenue Boston MA 02131 United States Light Lab Imaging-St Jude Medical Inc. Westford MN 55117-9983 United States

AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were *** light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT *** OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)*** hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux *** CIP region appeared as a pink circular lesion in the upper esophagus under white light *** imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum ***,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E *** results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP.

关键词： Cervical inlet patch Heterotopic gastric mucosa Optical coherence tomography Optical biopsy Barrett’s esophagus

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A System Level Integration Design for MPEG Layer Ⅲ Audio Decoder

A System Level Integration Design for MPEG Layer Ⅲ Audio De...

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2000年第16届世界计算机大会

作者： tsung-han tsai Department of Electronic Engineering Fu Jen University

＜正＞MPEG Layer Ⅲ audio decoding algorithms are involved of several complex-coding techniques and therefore difficult to make the efficient dedicated architecture *** this paper,we present a semi-ASIC architecture for the MPEG Layer Ⅲ audio *** MPEG Layer Ⅲ algorithms can be divided into two types of *** an embedded RISC core and the two dedicated processing units,each type of operations can be performed *** decoder is designed based on the approaches of simplicity and low cost while meeting the high-efficiency requirements.

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Development of seismic force requirements for buildings in Taiwan

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Earthquake Engineering and Engineering Vibration 2009年第3期8卷 349-358页

作者： Juin-Fu Chai tsung-Jen Teng Keh-Chyuan tsai Center for Research on Earthquake Engineering

This paper describes static and dynamic procedures to calculate seismic demand specified by the current seismic design code for buildings in Taiwan, which was issued in 2005. For design levels with a return period of 475 years, the design spectral response acceleration can be developed for general sites, near-fault sites and Taipei Basin. In addition, in order to prevent building collapse during extremely large earthquakes and yielding of structural components and elements during frequent small earthquakes, the required seismic demands at the maximum considered earthquake level （MCE, 2%/50 years） and operational level are also included in the new seismic design *** dynamic analysis procedures, both the response spectrum method and time history method are specified in the new seismic design code. Finally, procedures to generate spectrum compatible ground motions for time history analysis are illustrated in this paper.

关键词： building code seismic force requirement design spectrum spectrum compatible design ground motion site effect near-fault basin effect

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Adaptable retinal ganglion cell function: assessing autoregulation of inner retina pathways

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Neural Regeneration Research 2020年第12期15卷 2237-2238页

作者： tsung-han Chou Vittorio Porciatti Bascom Palmer Eye Institute University of Miami Miller School of Medicine

Retinal ganglion cell(RGC)function in health and disease:RGCs are extremely high-maintenance neurons connecting the eye to the brain trough the optic *** order to produce and propagate action potentials along the unmyelinated RGC axons and support axonal transport of materials back and forth from the eye to the brain,RGC require large amounts of ***,RGCs are under considerable metabolic stress when healthy and become particularly vulnerable in disease,resulting in blindness(Morgan,2004).

关键词： assessing function connecting

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Adult sigmoid intussusception resembling rectal prolapse:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1163-1168页

作者： tsung-Jung tsai Yu Shih Liu Department of Surgery Changhua Christian HospitalChanghua 500209Taiwan Department of Colorectal Surgery Changhua Christian HospitalChanghua 500209Taiwan

BACKGROUND Rectal prolapse arises from benign *** symptoms of internal intussusception mirror those of rectal prolapse,a misdiagnosis is possible,especially under limited clinical *** is crucial to recognize and differentiate rectal prolapse from internal intussusception because the two diagnoses have different ***,we describe a case of adult sigmoid intussusception presenting as rectal *** SUMMARY A 64-year-old woman with no known medical history visited a gastrointestinal outpatient department due to hard bloody stool defecation for 1 wk followed by constipation for 3 *** revealed a huge polypoid ulcerated tumor at the sigmoid colon with lumen *** patient was admitted due to postprocedural dull abdominal *** to failed colonoscopy reduction and stent insertion,the patient underwent sigmoid colon resection with primary end-to-end anastomosis,with the transverse colostomy pathological report showing adenocarcinoma,*** recovered well from the operation and was discharged with regular outpatient clinic *** Presentation and manifestation of sigmoid intussusception may resemble that of rectal prolapse,necessitating careful observation due to distinct prognostic implications.

关键词： Sigmoid intussusception Rectal prolapse Endoscopic reduction Adenocarcinoma Case report

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Characterization of crud deposited on fuel rods under HWC environment in Kuosheng Nuclear Power Plant

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Nuclear Science and Techniques 2016年第1期27卷 141-148页

作者： tsuey-lin tsai te-yen su tsung-yuan wang tsen-yu yang Chemistry Division Institute of Nuclear Energy ResearchLongtanTaoyuanTaiwanChina

Under normal water chemistry conditions, the oxygen and hydrogen peroxide produced by water radiolysis in the coolant of boiling water reactors(BWRs) can lead to intergranular stress corrosion cracking in the constituent materials of plant components. This fact has led to the wide-scale adoption of hydrogen water chemistry(HWC) in the nuclear industry to counteract these *** study seeks to characterize the metallic composition and the surface properties of the constituent materials of plant components in order to determine their effects on the accumulation of chalk river unidentified deposits(crud) on fuel rods in the BWR Unit-1 of the Kuosheng Nuclear Power Plant in Taiwan. Inductively coupled plasma-atomic emission spectroscopy was used to calculate the concentrations of surface crud and gamma spectrometry was used to determine the radioactivity of the corrosion products, as well as their axial distribution across the surface of the fuel rods. X-ray diffraction analysis and scanning electron microscopy/energy-dispersive X-ray spectroscopy were used to identify the crystalline phase and morphology of the crud as irregular shapes and flakes. The amount of crud deposited during the fourth fuel cycle exceeded that of the third fuel cycle due to extended burn-up time. Our analytical results indicate that the implementation of HWC had no significant effect on the characteristics of subsequent crud.

关键词：燃料棒核电站电感耦合等离子体原子发射光谱法表征沉积 X射线衍射分析反应堆冷却剂系统扫描电子显微镜

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Platelet-rich plasma enhances adipose-derived stem cell-mediated angiogenesis in a mouse ischemic hindlimb model

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World Journal of Stem Cells 2018年第12期10卷 212-227页

作者： Chia-Fang Chen han-tsung Liao Department of Plastic and Reconstructive Surgery Chang Gung Memorial Hospital Craniofacial Research Center Chang Gung Memorial Hospital College of Medicine Chang Gung University

AIM To evaluate the angiogenic effect of platelet-rich plasma(PRP)-preconditioned adipose-derived stem cells(ADSCs) both in vitro and in a mouse ischemic hindlimb *** ADSCs were divided based on culture medium: 2.5% PRP, 5% PRP, 7.5% PRP, and 10% PRP. Cell proliferation rate was analyzed using the MTS assay. The gene expression of CD31, vascular endothelial growth factor, hypoxia-inducible factors, and endothelial cell nitric oxide synthase was analyzed using reverse transcription polymerase chain reaction. Cell markers and structural changes were assessed through immunofluorescence staining and the tube formation assay. Subsequently, we studied the in vivo angiogenic capabilities of ADSCs by a mouse ischemic hindlimb *** The proliferation rate of ADSCs was higher in the 2.5%, 5%, and 7.5% PRP groups. The expression of hypoxia-inducible factor, CD31, vascular endothelial growth factor, and endothelial cell nitric oxide synthase in the 5% and 7.5% PRP groups increased. The 5%, 7.5%, and 10% PRP groups showed higher abilities to promote both CD31 and vascular endothelial growth factor production and tubular structure formation in ADSCs. According to laser Doppler perfusion scan, the perfusion ratios of ischemic limb to normal limb were significantly higher in 5% PRP, 7.5% PRP, and human umbilical vein endothelial cells groups compared with the negative control and fetal bovine serum(FBS) groups(0.88 ± 0.08, 0.85 ± 0.07 and 0.81 ± 0.06 for 5%, 7.5% PRP and human umbilical vein endothelial cells compared with 0.42 ± 0.17 and 0.54 ± 0.14 for the negative control and FBS, P < 0.01).CONCLUSION PRP-preconditioned ADSCs presented endothelial cell characteristics in vitro and significantly improved neovascularization in ischemic hindlimbs. The optimal angiogenic effect occurred in 5% PRP-and 7.5% PRPpreconditioned ADSCs.

关键词： Platelet-rich plasma Adipose-derived stem cells Mesenchymal stem cell Angiogenesis Endothelial differentiation Mouse ischemic hindlimb model

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Analytical Result on the Supercurrent Through a Superconductor/Quantum-Dot/Superconductor Junction

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Communications in Theoretical Physics 2002年第7期38卷 103-106页

作者： LI Wei ZHU Yu LIN tsung-han State Key Laboratory for Mesoscopic Physics and Department of Physics Peking University Beijing 100871 China State Key Laboratory for Mesoscopic Physics and Department of Physics Peking University Beijing 100871 China State Key Laboratory for Mesoscopic Physics and Department of Physics Peking University Beijing 100871 China

We present an analytical result for the supercurrent across a superconductor/quantum-dot/superconductor junction. By converting the current integration into a special contour integral, we can express the current as a sum of the residues of poles. These poles are real and give a natural definition of the Andreev bound states. We also use the exact result to explain some features of the supercurrent transport behavior.

关键词： supercurrent, superconductor/quantum-dot/superconductor junction

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Effect of Intra-Dot Coulomb Interaction on Andreev Reflection in Normal-Metal/Quantum-Dot/Superconductor System

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Communications in Theoretical Physics 2001年第7期36卷 101-108页

作者： ZHU Yu SUN Qing-Feng LIN tsung-han State Key Laboratory for Mesoscopic Physics and Department of Physics Peking University Beijing 100871 China State Key Laboratory for Mesoscopic Physics and Department of Physics Peking University Beijing 100871 China State Key Laboratory for Mesoscopic Physics and Department of Physics Peking University Beijing 100871 China

We investigate the effect of intra-dot Coulomb interaction on the Andreev reflection in a normalmetal/quantum-dot/superconductor (N-QD-S) system with multiple levels in the quantum dot, in the regime where the intra-dot interacting constant is comparable to the energy gap of superconducting lead. By using nonequilibrium Green function method, the averaged occupation of electrons in the quantum dot and the Andreev reflection (AR) current are studied. Comparing to the case of non-interacting quantum dot, the system shows significant changes for the a two-step-like behavior; and the I-Vg shows two groups of peaks, separated by U and with equal heights, where Vg is the gate voltage and U denotes the intra-dot Coulomb interaction constant. (ii) For finite bias voltage, dips, superposed V ≥ U/2, extra AR current peaks occur between the two groups of the peaks. Besides, the properties of the heights of the AR current peaks are more complicated.

关键词： Coulomb interactions, Andreev reflection, normal-metal/quantum-dot/superconductor system

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Hepatitis B virus infection and renal transplantation

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World Journal of Gastroenterology 2010年第31期16卷 3878-3887页

作者： Ming-Chao tsai Yen-Ta Chen Yu-Shu Chien tsung-Hui Hu Division of Hepato-Gas-troenterology Department of Internal MedicineChang Gung Memorial HospitalKaohsiung Medical CenterChang Gung University College of Medicine123Ta-Pei RoadNiao-Sung HsiangKaohsiung Hsien 833Taiwan China Department of Urology Chang Gung Memorial HospitalKaohsiung Medical CenterChang Gung University College of Medicine123Ta-Pei RoadNiao-Sung HsiangKaohsiung Hsien 833 TaiwanChina Division of Nephrology De-partment of Internal MedicineChang Gung Memorial HospitalKaohsiung Medical CenterChang Gung University College of Medicine123Ta-Pei RoadNiao-Sung HsiangKaohsiung Hsien 833Taiwan China

Although the prevalence of chronic hepatitis B virus (HBV) infection has declined in renal transplant recipients (RTRs), it remains a relevant clinical problem with high morbidity and mortality in long-term follow up. A thorough evaluation, including liver biopsy as well as assessment of HBV replication in serum (i.e. hepatitis B e antigen and/or HBV DNA) is required before transplantation. Interferon should not be used in this setting because of low efficacy and precipitation on acute allograft rejection. The advent of effective antiviral therapies offers the opportunity to prevent the progression of liver disease after renal transplantation. However, as far as we are aware, no studies have compared prophylactic and preemptive strategies. To date, the majority of RTRs with HBV-related liver disease have had a high virological and biochemical response to lamivudine use. However, lamivudine resistance is frequent with a prolonged course of therapy. Considering long-term treatment, antiviral agents with a high genetic barrier to resistance and lack of nephrotoxicity are suggested. The optimal strategy in RTRs with HBV infection remains to be established in the near future.

关键词： Hepatitis B Renal transplantation Lamivudine resistance

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