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Analysis of aerodynamic and thermodynamic parameters on the grassy marshland surface of Tibetan Plateau

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Progress in Natural Science:Materials International 2002年第1期 38-42页

作者： tsukamoto osamu,ISHIKAWA Hirohiko,TAMAGAWA Ichiro Faculty of Science Okayama University Okayama 700 Japan Disaster Prevention Research Institute Kyoto University Uji Kyoto 611 Japan Department of Civil Engineering Gifu University Gifu-shi 501-1193 Japan

The aerodynamic roughness z0m, the thermodynamic roughness Z0h and the excess resistance to heat transfer kB-1 are analyzed with the data obtained from Global Energy and Water Cycle Experiment (GEWEX) Asian Monsoon Experiment on Tibetan Plateau (GAME/Tibet) in the Intensive Observation Period (IOP), 1998. Some new concepts on the aerodynamic and thermodynamic parameters over the grassy marshland surface of the Tibetan Plateau are proposed.

关键词： Tibetan Plateau grassy marshland surface aerodynamic roughness thermodynamic roughness excess resistance to heat transfer.

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野外观测用快速响应静压测量仪的研制

气象科技 1990年第3期18卷 87-91页

作者： Tsuyoshi Kataoka Yasushi Mitsuta osamu tsukamoto 颜春亮

1.引言湍流边界层中静压的精确测量对于研究湍流动能收支极为重要(例如,Wyngaard和Coté,1971;Maitani和Seo,1985)。因此需要研制一种对风速和风向变化不敏感的静压测量仪器。研制静压测量仪的主要困难在于如何从气压脉动中消去动压力... 详细信息

1.引言湍流边界层中静压的精确测量对于研究湍流动能收支极为重要(例如,Wyngaard和Coté,1971;Maitani和Seo,1985)。因此需要研制一种对风速和风向变化不敏感的静压测量仪器。研制静压测量仪的主要困难在于如何从气压脉动中消去动压力部分。

关键词：静压差量仪湍流动能风向变化湍流边界层静压误差野外观测气压变化动压力压力传感器

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中国建材 2005年第5期 16-17页

作者：塚本修富田健介日本经济产业省制造产业局

日本经济目前正值好转的关键时期,美国及亚洲经济的好转推动了以民间需求为主导的持续型经济增长.企业收益得到改善,利润增长回升趋势稳定.

关键词：相关产业产业政策日本研讨会建材交流关键时期经济增长亚洲经济利润增长收益企业

藏北高原草甸下垫面近地层能量输送及微气象特征

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大气科学 2000年第5期24卷 715-722页

作者：马耀明塚本修吴晓鸣玉川一郎王介民石川裕彦胡泽勇高洪春中国科学院寒区旱区环境与工程研究所兰州730000 日本冈山大学兰州气象学校兰州730000 日本名古屋大学大气水圈科学研究所日本京都大学防灾研究所

利用ＧＡＭＥ／Ｔｉｂｅｔ１９９８年ＩＯＰ观测资料，分析研究藏北高原草甸下垫面近地层的地面加热场、地表能量平衡、地面阻曳系数ＣＤ及感热通量整体输送系数ＣＨ等特征，得到了一些有关藏北高原草甸下垫面近地层能量输送及微气象... 详细信息

利用ＧＡＭＥ／Ｔｉｂｅｔ１９９８年ＩＯＰ观测资料，分析研究藏北高原草甸下垫面近地层的地面加热场、地表能量平衡、地面阻曳系数ＣＤ及感热通量整体输送系数ＣＨ等特征，得到了一些有关藏北高原草甸下垫面近地层能量输送及微气象特征结构的新认识。

关键词：青藏高原草甸下垫面能量输送微气象特征

Experimental Therapeutic Trial of an Antibody against the Cell Adhesion Molecule Gicerin for Lymphomas Using a Murine Cell Line

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Journal of Cancer Therapy 2018年第10期9卷 807-819页

作者： Yasuhiro tsukamoto Yukiko Miyagawa osamu Maeda Department of Animal Hygiene Graduate School of Environmental & Biological Sciences Kyoto Prefecture University Kyoto Japan

Chemotherapy, occasionally combined with radiotherapy, is a major method for treating lymphoma but frequently produces side-effects in patients. Thus, novel therapeutics should be developed as an alternative the chemotherapy in lymphoma patients. Although the cell adhesion molecule gicerins are almost entirely absent in most mature tissues, except for muscle and endothelial cells, various neoplastic cells strongly express gicerin in their cell membranes. This suggests the potential function of gicerin in the progression of tumors, including tumor growth, invasion and metastasis to distant organs from primary sites. In the present study, we assessed therapeutic effects of anti-gicerin antibodies on the murine lymphoma cell line YAC1. Gicerin was found to be expressed in the cell membrane of YAC1 cells and promoted the cell adhesion activity of the YAC1 cells on HUVECs, an endothelial cell line. In addition, YAC1 cells were implanted sub-cutaneously in mice in order to examine the therapeutic effects of anti-gicerin antibodies on lymphoma progression in vivo. The anti-gicerin antibodies suppressed and reduced the lymphoma tumor growth in the mice, whereas the growth of tumor mass was not inhibited by pre-immune IgG administrations. YAC1 cells were also implanted intravenously in mice in order to examine the effects of anti-gicerin antibodies on the pulmonary metastasis of lymphoma cells. The metastasis of the YAC1 cells to the lungs was inhibited by the injection of anti-gicerin antibodies. These findings indicate that anti-gicerin antibodies inhibit the progression of prednisolone-resistant lymphoma, making this a promising novel therapeutic method for treating refractory lymphoma cases.

关键词： Gicerin Cell Adhesion Molecule Lymphoma Mouse

Ostrich Antibody and Its Application to Skin Diseases, a Review and Case Report

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Health 2018年第10期10卷 1357-1370页

作者： Yasuhiro tsukamoto osamu Maeda Genshi Shigekawa Stuart Greenberg Barry Hendler Department of Animal Sciences Graduate School of Environmental & Biological Sciences Kyoto Prefecture University Kyoto Japan Clinical Studies Zeal Cosmetics Osaka Japan Bioresearch Section Maz World Hong Kong Science Park Hong Kong S.A.R. China Clinical Studies Ostri Gen Holdings West Newton MA USA Microfollicular Hair Transplantation Ambler PA USA

Antibodies are immunoglobulins produced by B cells when antigens such as allergens or pathogens invade an animal’s body. The antibodies remove and inactivate antigens. Antibodies are distributed in internal body and mucosal membrane to protect living animals, but they are excellent proteins that can exert their functions, “antigen-antibody reactions,” even when removed from the body. For that reason, antibodies are being put to practical use in diagnostic kits for conditions such as pregnancy and influenza infection, and as anticancer drugs targeting specific tumor markers. The result has been an increasing use of antibodies for research, diagnosis, and therapeutic purposes. Unfortunately, antibodies from experimental mammals such as mice, rats, and rabbits, are not suited to industrial use because of their high production cost. Moreover, handling of these antibodies is difficult due to their vulnerability to heat, acids and alkalis. Accordingly, there is no adaptability to mass production. Recently, we developed a convenient method for the low-cost, mass-production of antibodies using egg-laying hen ostriches. The ostrich egg is an excellent source of antibodies for industrial purposes. The present report shows that the ostrich antibodies have therapeutic effects in ailments such as atopic dermatitis, acne, pyoderma, and pollen allergies. We have successfully produced and purified ostrich immunoglobulin yolk (IgY) against pollen allergens (Cryj1, Cryj2, Chao1, Chao2) and found that allergic reactions were alleviated in skin patch tests of allergic patients by using the ostrich IgY. In addition, we produced ostrich IgY against the homogenates of Staphylococcus aureus and Propionibacterium acnes, and applied to dermal lesions of atopic dermatitis and acne patients, and then observed the therapeutic effects on the dermatitis of volunteer subjects. Antibody against S. aureus also had the therapeutic effect on canine pyoderma caused by MRSA. A particular advantage in us

关键词： Ostrich Antibody Cosmetics Atopic Dermatitis Acne Pollen Allergy Pyoderma

Regulatory T cells percentage in peripheral blood before and after eradication of <i>Helicobacter pylori</i>

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Health 2014年第4期6卷 236-242页

作者： Yuka Satoh Hatsue Ogawara osamu Kawamura Yasuyuki Shimoyama Motoyasu Kusano Akihiko Yokohama Takayuki Saitoh Hiroshi Handa Norifumi tsukamoto Hirokazu Murakami Department of Blood Transfusion Service Gunma University Hospital Maebashi Japan Department of Endoscopy and Endoscopic Surgery Gunma University Hospital Maebashi Japan Department of Laboratory Sciences Course of Health Sciences Gunma Graduate School of Health Sciences Maebashi Japan Department of Medicine and Clinical Science Gunma Graduate School of Medicine Maebashi Japan Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Maebashi Japan Faculty of Health Sciences Gunma Paz College Takasaki Japan Oncology Center Gunma University Hospital Maebashi Japan

Helicobacter pylori (H. pylori) induces gastroduodenal diseases and vigorous humural and cellular immune abnormalities. In order to clarify the immunological changes before and after eradication of H. pylori, the percentages and ratios of the following cells in the peripheral blood of 32 H. pylori-infected patients and 25 control subjects were analyzed: CD4+ T cells, CD8+ T cells, T helper 1 cells (Th1), T helper 2 cells (Th2), CD4+CD25+ T cells, Foxp3+ regulatory T cells (Treg), CD4/CD8 ratio, and Th1/Th2 ratio. CD4/CD8 ratio was significantly higher in H. pylori-infected patients before (mean ± SD, 2.9 ± 1.9) and after (mean ± SD, 2.8 ± 1.6) eradication of H. pylori than in control subjects (mean ± SD, 2.1 ± 0.9). The percentage of Th2 cells was significantly higher in H. pylori-infected patients (mean ± SD, 2.6 ± 1.1) than in control subjects (mean ± SD, 1.9 ± 1.1;p < 0.02). The percentage of Th2 cells after eradication of H. pylori (mean ± SD, 2.3 ± 1.4) was lower than that before eradication. There was no significant difference between control subjects (mean ± SD, 4.1% ± 1.5%) and patients before H. pylori eradication (mean ± SD, 4.5% ± 2.4%) in the percentage of Tregs, but the percentage was significantly higher in patients after H. pylori eradication (mean ± SD, 5.2% ±2.6%) than in control subjects. The function of peripheral induced Tregs was reported to suppress the excessive immune reaction in chronic inflammation. These data suggest that Tregs may proliferate and be activated to suppress the activation of humoral immunity in H. pylori-infected patients, and these changes continue after 3 months or later of successful eradication of H. pylori.

关键词： Helicobacter pylori Regulatory T Cell Th1 Cell Th2 Cell