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Evaluation of an oral moisture-checking device for screening dry mouth

Open Journal of Stomatology 2013年第8期3卷 440-446页

作者： Yosuke Fukushima Tetsuya Yoda Shoichiro Kokabu Ryuichiro Araki tsubasa murata Yoshimasa Kitagawa Ken Omura Shuji Toya Kayoko Ito Saori Funayama Hiroshi Iwabuchi Kazuhiro Asano Yutaka Imai Akihide Negishi Satoshi Yokoo Goichi Matsumoto Eiro Kubota Hideki Watanabe Mikio Kusama Kojiro Onizawa Takuya Goto Seiji Nakamura Ryuichi Nakazawa Kiyoshi Harada Takashi Fujibayashi Community Health Science Center Saitama Medical University Saitama Japan Department of Dentistry and Oral Surgery Tochigi National Hospital Tochigi Japan Department of Oral and Maxillofacial Surgery Division of Medicine Interdisciplinary Graduate School of Medicine and Engi- neering Univer-sity of Yamanashi Kofu and Tamaho Japan Department of Oral and Maxillofacial Surgery Dokkyo Medical University School of Medicine Tochigi Japan Department of Oral and Maxillofacial Surgery Faculty of Medicine Sai-tama Medical University Saitama Japan Department of Oral and Maxillofacial Surgery Institute of Clinical Medicine University of Tsukuba Tsukuba Japan Department of Oral and Maxillofacial Surgery Jichi Medical University Tochigi Japan Department of Oral and Maxillofacial Surgery Kanagawa Dental College Yokosuka Japan Department of Stomatology and Oral Surgery Gunma University Graduate School of Medicine Maebashi Japan Division of Gereatric Dentistry Niigata University Medical & Dental Hospital Niigata Japan Oral and Maxillofacial Surgery Dry Mouth Clinic The Nippon Dental University Niigata Hospital Niigata Japan Oral Diagnosis and Medicine Department of Oral Pathobiological Science Graduate School of Dental Medicine Hokkaido University Sapporo Japan Oral Surgery Department of Oral Restitution Division of Oral Health Sciences Graduate School Tokyo Medical and Dental University Tokyo Japan Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical Sciences Faculty of Dental Science Kyushu University Fukuoka Japan

Objective: This multicenter clinical study was to assess the clinical usability of an oral moisture-checking device in detecting the dry mouth patients and evaluating the optimal measurement site. Materials and Methods: The study group comprised 250 patients with dry mouth and 241 healthy volunteer subjects at 13 medical centers. This device was used to measure the moisture degrees of the lingual mucosa and the buccal mucosa. Subjective oral dryness, objective oral dryness, and saliva flow rates were also compared between the two groups. For statistical analysis, receiver-operating characteristic analysis was performed to calculate the area under the curve (AUC). Results: The moisture degree of the lingual mucosa was significantly lower in the dry mouth group (27.2 ± 4.9) than that in the healthy group (29.5 ± 3.1, AUC = 0.653). When a lingual mucosa moisture degree of 31.0 or higher was defined as normal, less than 27.0 as dry mouth, and 27.0 to less than 31.0 as borderline zone of dry mouth, both the sensitivity and the specificity for the diagnosis of dry mouth were close to 80%. Conclusion: These results suggest that the oral moisture-checking device is a usable screening device for dry mouth.

关键词： Dry Mouth Oral Moisture-Checking Device ROC Analysis

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Detecting Communities in K-Partite K-Uniform (Hyper)Networks

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Journal of Computer Science & Technology 2011年第5期26卷 778-791页

作者：刘欣 Tsuyoshi murata Department of Computer Science Tokyo Institute of Technology

In social tagging systems such as Delicious and Flickr,users collaboratively manage tags to annotate ***,a social tagging system can be modeled as a （user,tag,resource） hypernetwork,where there are three different types of nodes,namely users,resources and tags,and each hyperedge has three end nodes,connecting a user,a resource and a tag that the user employs to annotate the *** how can we automatically cluster related users,resources and tags,respectively？ This is a problem of community detection in a 3-partite,3-uniform *** generally,given a K-partite K-uniform （hyper）network,where each （hyper）edge is a K-tuple composed of nodes of K different types,how can we automatically detect communities for nodes of different types？ In this paper,by turning this problem into a problem of finding an efficient compression of the （hyper）network＇s structure,we propose a quality function for measuring the goodness of partitions of a K-partite K-uniform （hyper）network into communities,and develop a fast community detection method based on *** method overcomes the limitations of state of the art techniques and has several desired properties such as comprehensive,parameter-free,and *** compare our method with existing methods in both synthetic and real-world datasets.

关键词： community detection bipartite graph tripartite hypergraph clustering social tagging

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Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases

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Acta Pharmacologica Sinica 2007年第3期28卷 439-445页

作者： Nobuo murata Tatsuo YAMAKAWA Department of Surgery Mini-invasive surgery CenterTeikyo University Mizonokuchi HospitalKawasaki 213-8507Japan

Aim:To provide experimental data for further research on the signal transductionof apoptosis in lung adenocarcinoma cells,we examined the effects of exogenousC2-ceramide administration on several members of the mitogen-activated proteinkinase(MAPK)superfamily and caspase-3 in A549 ***:Cell viabilityand apoptosis were analyzed by cell counting kit-8 assay and flow *** MAPK and caspase-3 proteins were detected by Western ***:C2-ceramide selectively altered the phosphorylation state &members ofthe MAPK superfamily,causing hyperphosphorylation ofmitogen-activated pro-tein kinase kinase(MEK)1/2 and the p38 MAPK,but not affecting the phosphory-lation ofextracellular signal-regulated kinase 1/2 and the c-Jun N-terminal ***-203580(a p38 MAPK inhibitor)and p38 siRNA,but not U0126(a MEKinhibitor),partially rescued cell death induced by C2-ceramide.C2-ceramide promoted theactivation of ***:Exogenous C2-ceramide induced apoptosisin human lung adenocarcinoma A549 *** activation of MAPK and caspase-3were involved in the mechanisms ofC2-ceramide-induced apoptosis in A549 cells.

关键词： ceramide apoptosis mitogen-activated protein kinases A549 cells

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Applicability of LIVE/DEAD BacLight stain with glutaraldehyde fixation for the measurement of bacterial abundance and viability in rainwater

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Journal of Environmental Sciences 2017年第1期29卷 202-213页

作者： Wei Hu Kotaro murata Daizhou Zhang Faculty of Environmental and Symbiotic Sciences Prefectural University of KumamotoKumamoto 862-8502Japan

Rainwater contains substantial bacteria and rain is an efficient pathway for the dissemination of bacteria from the atmosphere to land and water ***,quantitative information on rainwater bacteria is very limited due to the lack of a reliable *** this study,the epifluorescence microscopy enumeration with the LIVE/DEAD BacLight Bacterial Viability Kit stain was verified to quantify the abundance of viable and non-viable bacterial cells in rainwater,with the 4＇,6-diamidino-2-phenylindole（DAPI） stain for the reference of total cell *** showed that the total counts of bacterial cells by LIVE/DEAD BacLight staining were consistent with those by DAPI staining,and the average detection efficiency was（109 ± 29）%.The ratio of cell count with glutaraldehyde fixation to that without fixation was（106 ± 5）%on *** bacterial concentration in negative control was usually an order of magnitude lower than that in rainwater ***,in case of small precipitation,the abundance in negative control could be more than that in rainwater *** results indicate that the enumeration with LIVE/DEAD BacLight bacterial viability assay coupled with glutaraldehyde fixation and careful negative control investigation is an approach applicable to the measurement of the concentration and viability of bacterial cells in rainwater.

关键词： Bacterial abundance Viability Rainwater LIVE/DEAD BacLight stain Fluorescent enumeration

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Physiological significance of Rag1 in retinal ganglion cell death

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Neural Regeneration Research 2015年第2期10卷 192-194页

作者： Takuma Hayashi Toshinori murata Department of Immunology and Infectious Disease Shinshu University Graduate School of Medicine Department of Ophthalmology Shinshu University Graduate School of Medicine

Although the transcription factor, nudear factor-κB （NF-κB） is known to regulate cell death and survival, its precise role in cell death within the central nervous system （CNS） remains unknown. We previously reported that mice with a homozygous deficiency for NF-κBp50 spon- taneously developed optic neuropathy. We examined the expression and activation of pro-apoptotic factor（s） that mediate optic neuropathy in p50-/- mice. Recombination activating gene 1 （Ragl） is known to regulate the recombination of immunoglobulin V（D）J.

关键词： RGCs Physiological significance of Rag1 in retinal ganglion cell death cell

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