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ICo Lecture:Invigorating ophthalmic Education in China Through the Strategic Plan to Preserve and Restore Vision of the International Council of ophthalmology

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ICO Lecture:Invigorating Ophthalmic Education in China Throu...

Pollutant emission characteristics of rice husk combustion in a vortexing fluidized bed incinerator

中华医学会第十二届全国眼科学术大会

作者： mark o.m.tso Wilmer Eye Center Peking University Eye Center

The International Council of ophthalmology which represents more then 100 National Societies of oph- thalmology has developed a Strategic Plan to stimulate and coordinate educational programs of approximately 150,000 ...

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Journal of Environmental Sciences 2013年第2期25卷 335-339页

作者： Feng Duan Chiensong Chyang Yucheng Chin Jim tso School of metallurgy and Resource Anhui University of Technology Department of Chemical Engineering Chung Yuan Christian University R&D Center for Environmental Technology Chung Yuan Christian University

Rice husk with high volatile content was burned in a pilot scale vortexing fluidized bed incinerator. The fluidized bed incinerator was constructed of 6 mm stainless steel with 0.45 m in diameter and 5 m in height. The emission characteristics of Co, No, and So2 were studied. The effects of operating parameters, such as primary air flow rate, secondary air flow rate, and excess air ratio on the pollutant emissions were also investigated. The results show that a large proportion of combustion occurs at the bed surface and the freeboard zone. The So2 concentration in the flue gas decreases with increasing excess air ratio, while the Nox concentration shows reverse trend. The flow rate of secondary air has a significant impact on the Co emission. For a fixed primary air flowrate, Co emission decreases with the secondary air flowrate. For a fixed excess air ratio, Co emission decreases with the ratio of secondary to primary air flow. The minimum Co emission of 72 ppm is attained at the operating condition of 40% excess air ratio and 0.6 partition air ratio. The Nox and So2 concentrations in the flue gas at this condition are 159 and 36 ppm, which conform to the EPA regulation of Taiwan.

关键词： incineration rice husk vortexing fluidized bed pollutant emission

Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy

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Neural Regeneration Research 2013年第33期8卷 3148-3158页

作者： Liping Yang Lemeng Wu Dongmei Wang Ying Li Hongliang Dou mark o.m.tso Zhizhong ma Department of ophthalmology Peking University Third HospitalKey Laboratory of Vision Loss and RestorationMinistry of Education Wilmer Eye Institute Johns Hopkins University School of Medicine

Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy. In the present study, a streptozotocin-induced diabetic animal model was given an intraperitoneal injection of tauroursodeoxycholic acid. Results from immunofluorescent co-localization experiments showed that both caspase-12 protein and c-Jun N-terminal kinase 1 phosphorylation levels significantly in- creased, which was associated with retinal ganglion cell death in diabetic retinas. The C/ERB ho- mologous protein pathway directly contributed to glial reactivity, and was subsequently responsible for neuronal loss and vascular abnormalities in diabetic retinopathy. our experimental findings in- dicate that endoplasmic reticulum stress plays an important role in diabetes-induced retinal neu- ronal loss and vascular abnormalities, and that inhibiting the activation of the endoplasmic reticulum stress pathway provides effective protection against diabetic retinopathy.

关键词： neural regeneration peripheral nerve injury endoplasmic reticulum stress diabetic retinopathy injury of retinal ganglion cells m011er cells astrocytes c-Jun N-terminal kinase caspase-12 protein C/ERB homologous protein retinal microcirculation glial fibrillary acidic protein grant-supportedpaper neuroregeneration

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血—视网膜屏障的病理

眼科新进展 1983年第2期 133-136页

作者： mark.o.m.tso 张惠容

血—视网膜屏障主要位于视网膜毛细血管内皮和视网膜色素上皮(RPE)。但这两型细胞截然不同,从胚胎学上,视网膜毛细血管内皮来自中胚叶,而 RPE 来自神经胚叶。从结构上,视网膜毛细血管属于连续型。其内皮细胞顶端直接与血流接触,内皮细... 详细信息

血—视网膜屏障主要位于视网膜毛细血管内皮和视网膜色素上皮(RPE)。但这两型细胞截然不同,从胚胎学上,视网膜毛细血管内皮来自中胚叶,而 RPE 来自神经胚叶。从结构上,视网膜毛细血管属于连续型。其内皮细胞顶端直接与血流接触,内皮细胞的纤毛被

关键词：视网膜晶状体后纤维增生 RPE 感光细胞视网膜下间隙色素上皮

Influence of capsaicin infusion on secondary peristalsis in patients with gastroesophageal reflux disease

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World Journal of Gastroenterology 2016年第45期22卷 10045-10052页

作者： Chih-Hsun Yi Wei-Yi Lei Jui-Sheng Hung tso-Tsai Liu Chien-Lin Chen Fabio Pace Department of medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University Division of Gastroenterology Department of Clinical Sciences L. Sacco University Hospital

AIm To determine whether capsaicin infusion could influence heartburn perception and secondary peristalsis in patients with gastroesophageal reflux disease(GERD). mETHoDS Secondary peristalsis was performed with slow and rapid mid-esophageal injections of air in 10 patients with GERD. In a first protocol, saline and capsaicincontaining red pepper sauce infusions were randomly performed, whereas 2 consecutive sessions of capsaicin-containing red pepper sauce infusions were performed in a second protocol. Tested solutions including 5 m L of red pepper sauce diluted with 15 m L of saline and 20 m L of 0.9% saline were infused into the mid-esophagus via the manometric catheter at a rate of 10 mL /min with a randomized and doubleblind fashion. During each study protocol, perception of heartburn, threshold volumes and peristaltic parameters for secondary peristalsis were analyzed and compared between different *** Infusion of capsaicin significantly increased heartburn perception in patients with GERD(P on significantly reduced heartburn perception(P = 0.003). Acute capsaicin infusion decreased threshold volume of secondary peristalsis(P = 0.001) and increased its frequency(P = 0.01) during rapid air injection. The prevalence of GERD patients with successive secondary peristalsis during slow air injection significantly increased after capsaicin infusion(P = 0.001). Repeated capsaicin infusion increased threshold volume of secondary peristalsis(P = 0.002) and reduced the frequency of secondary peristalsis(P = 0.02) during rapid air injection. CoNCLUSIoN Acute esophageal exposure to capsaicin enhances heartburn sensation and promotes secondary peristalsis in gastroesophageal reflux disease, but repetitive capsaicin infusion reverses these effects.

关键词： Capsaicin Esophageal motility Secondary peristalsis Esophageal manometry Gastroesophageal reflux disease

Proteomic identification and functional characterization of mYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity

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Protein & Cell 2015年第1期6卷 42-54页

作者： Linlin Zhang Shanshan Liu Ningning Liu Yong Zhang min Liu Dengwen Li Edward Seto tso-PangYao Wenqing Shui J-un Zhou State Key Laboratory of medicinal Chemical Biology College of Life Sciences Nankai University Tianjin 300071 China High-throughput molecular Drug Discovery Center Tianjin Joint Academy of Biotechnology and Medicine Tianjin 300457 China molecular oncology Program H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 USA Department of Pharmacology and Cancer Biology Duke University Durham NC 27710 USA

Histone deacetylase 6 （HDAC6）, a predominantly cyto- plasmic protein deacetylase, participates in a wide range of cellular processes through its deacetylase activity. However, the diverse functions of HDAC6 can- not be fully elucidated with its known substrates. In an attempt to explore the substrate diversity of HDAC6, we performed quantitative proteomic analyses to monitor changes in the abundance of protein lysine acetylation in response to HDAC6 deficiency. We identified 107 proteins with elevated acetylation in the liver of HDAC6 knockout mice. Three cytoplasmic proteins, including myosin heavy chain 9 （mYH9）, heat shock cognate pro- tein 70 （HscT0）, and dnaJ homolog subfamily A member 1 （DNAJA1）, were verified to interact with HDAC6. The acetylation levels of these proteins were negatively regulated by HDAC6 both in the mouse liver and in cultured cells. Functional studies reveal that HDAC6- mediated deacetylation modulates the actin-binding ability of mYH9 and the interaction between Hsc70 and DNAJA1. These findings consolidate the notion that HDAC6 serves as a critical regulator of proteinacetylation with the capability of coordinating various cellular functions.

关键词： HDAC6 substrate lysine acetylation,quantitative proteomics interaction

兔眼视网膜下注射N-甲基右旋天冬氨酸诱导视网膜变性的组织病理学研究

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中华眼科杂志 2007年第10期43卷 922-927页

作者：张纯徐永胜王薇曹安民北京大学第三医院北京大学眼科中心 100083

目的研究视网膜下注射兴奋性氨基酸N-甲基右旋天冬氨酸（NmDA）对神经细胞变性的作用。方法取12只1个月龄有色家兔，视网膜下注射10μl（30mmol／L）NmDA（溶剂为DmEm-F12），形成视网膜隆起，在注射12、24、48h及1周后分别处死家兔，... 详细信息

目的研究视网膜下注射兴奋性氨基酸N-甲基右旋天冬氨酸（NmDA）对神经细胞变性的作用。方法取12只1个月龄有色家兔，视网膜下注射10μl（30mmol／L）NmDA（溶剂为DmEm-F12），形成视网膜隆起，在注射12、24、48h及1周后分别处死家兔，取其视网膜组织进行免疫组织化学检测和电镜观察。应用抗Calretinin、Calbindin、PKCα抗体，分别标记视网膜无长突细胞、水平细胞及视杆双极细胞；采用原位缺口末端标记技术（TUNEL）技术标记凋亡细胞。结果损伤早期（12～24h），实验组视网膜可见散在细胞核固缩浓染的光感受器细胞，并有无长突细胞和神经节细胞的早期严重变性；中期（48h）视网膜各层神经元均出现病理性改变；损伤晚期（1周）视网膜各层细胞数目明显减少。损伤早期，TUNEL技术标记的阳性细胞位于视网膜各层。免疫组织化学和形态学计量资料显示视网膜下注射NmDA后，水平细胞、无长突细胞及神经节细胞数目明显减少，视杆双极细胞数目基本无变化。超微结构观察显示有凋亡、坏死、水肿变性及混合型细胞死亡等多种变性形式。结论视网膜下聚集NmDA时，光感受器细胞、水平细胞、视杆双极细胞、无长突细胞及神经节细胞均表现为视网膜兴奋性毒性反应，与以往体内及体外研究结果显示的仅有内核层神经元死亡情况不同。

关键词：视网膜变性 N-甲基天冬氨酸注射,病灶内

Digitalized mirror Array and Its Application in Large Telescope:Principle and Case Studies

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Communications in Theoretical Physics 2009年第10期52卷 750-760页

作者： CHEN Ying-Tian ZHANG Yang HU Sen Ho tso-Hsiu Boon Ham Lim Chen Sin Lim Kok Keong Chong Boon Kok Tan University of Science and Technology of China Department of Astronomy and Applied Physics Hefei 230026 China University of Science and Technology of China Department of Mathematics Hefei 230026 China Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100190 China University of Tunku Abdul Rahman Faculty of Engineering and Science Selangor Malaysia

In this article, we report the principle and conceptual design of a fundamentally different technology in fabricating high precision aberration free optical devices. The tip-tilt of facet in a mirror array is produced by digitally controlled line-tilts of rows and columns. It has not only provided a cost-effective designing methodology in optical physics but also led to a much finer precision of 1 mili arc sec or less. As examples of the application of the proposed digitalised optics, two case studies have been given： a 10 m Schmidt telescope （off-axis） and an 8 m Cassegrain telescope （on-axis）.

关键词： tip-tilting line-tilting Schmidt telescope aberration correction cassegrain telescope

Temperature dependent expression of cdc2 and cyclin B1 in spermatogenic cells during spermatogenesis

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Cell Research 2000年第4期10卷 289-302页

作者： KoNG WEI HUA ZHENG GU JI NING LU JIA KE tso Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China College of Life Science, Shandong University, Jinan 250100, China harmacy.ankara.edu.tr

p34cdc2 and Cyclin B1 are key components of cell cycle controlling machine and are believed to play a fundamental role in gametogenesis. It is also well known that, in scrotal mammals, spermatogenesis depends greatly on the maintenance of comparatively low temperature in the scrotum. To investigate whether the expression of cdc2 and Cyclin B1 in spermatogenic cells during spermatogenesis is actually a temperature dependent event, in situ hybridization, Western blotting and immunohistochemistry analysis were used to study the expression of cdc2 and Cyclin B1 in normal and cryptorchid testis. Results showed that the abdominal temperature had no significant influence on the transcription of cdc2 and Cyclin B1 in the spermatogonia and pachytene/diplotene primary spermatocytes, but it blocked the translation of them. Due to the deficiency of p34cdc2 and Cyclin B1, the spermatogonia and pachytene/diplotene primary spermatocytes were unable to form mPF, hence, they couldn't undergo karyokinesis. The development of primary spermatocytes was arrested at the G2 to m phase transition. We also found that testosterone could regulate the Cyclin B1 expression in spermatogenic cells. muscular injection of testosterone could recover spermatogenesis in the unilateral scrotal testis which was influenced by the contralateral cryptorchid testis, but it could not salvage the spermatogenesis block in the cryptorchid testis.

关键词： Temperature spermatogenesis cdc2 cyclin B8