检索结果-南通市图书馆

资源与人居环境 2008年第19期 38-40页

作者： tsing ye 哲伦

中小型煤矿多是美国煤炭工业的一大特色。美国的小煤矿生产效率高,回采率高,安全事故少,产品质量好。除了得益于优越的开采条件和良好的基础设施以外,政府在资源、安全和环境等方面的有效管理,也起了重要作用。

关键词：小煤矿小矿事故死亡率回采率小煤窑储采比美国美利坚合众国北美洲

PTEN,a general negative regulator of cyclin D expression

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cell Research 2007年第4期17卷 291-292页

作者： Eirong Diao~1 ye-Guang Chen ~1State Key Laboratory of Biomembrane and Membrane Biotechnology,Department of Biological Sciences and Biotechnology tsing-hua Universiry,Beijing 100084,China StateKeyLaboratoryofBiomembraneandMembraneBiotechnology DepartmentofBiologicalSciencesandBiotechnologyTsing-huaUniversityBeijing100084China

The tumor-suppressor phosphatase with tensin homol-ogy(PTEN)is frequently mutated in many malignanciesand is one of the most well studied tumor suppressor genes[1,2].PTEN,a lipid and protein dual phosphatase,plays avital role in embryonic development,cell growth,apoptosisand cell *** well-known function of PTEN isphosphatidylinositol-3(PI)-phosphatase,which functionsas a negative regulator of the PIkinase(PI3K)*** well established that PTEN regulates the G1-S transitionby modulating the expression of cyclin D1 and *** passage of any cell through cell cycles is subtlymodulated by a series of proteins,among which the mainplayers in animal cells include cyclins,CDKs(cyclin-de-pendent kinases,positive regulators)and CDK inhibitors(negative regulators such as p21and *** Dsare key regulators during the G1 phase and there are threetypes of cyclin Ds,D1,D2 and D3 in mammalian cells[3].Although the phenotypic analyses of single cyclin Dknockout mice revealed that each of the D type cyclinsis sufficient to drive normal development of the majority

关键词： PTEN,a general negative regulator of cyclin D expression

Establishment of an adult zebrafish model of retinal neurodegeneration induced by NMDA

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2019年第8期12卷 1250-1261页

作者： Zhi-Wen Luo Han-tsing Wang Ning Wang Wei-Wei Sheng Ming Jin ye Lu Yi-Jiang Bai Su-Qi Zou Yu-Lian Pang Hong Xu Xu Zhang Affiliated Eye Hospital of Nanchang University JiangxiResearch Institute of Ophthalmology&Visual Science Nanchang330006Jiangxi ProvinceChina Queen Mary School of Nanchang University Nanchang330031Jiangxi ProvinceChina Institute of Life Science Nanchang UniversityNanchang330031Jiangxi ProvinceChina Jiangxi Provincial Collaborative Innovation Center forCardiovascular Digestive and Neuropsychiatric DiseasesNanchang330031Jiangxi ProvinceChina

AIM: To establish a model of retinal neurodegeneration induced by N-Methyl-D-aspartic acid(NMDA) in adult ***: We compared the effects of three different NMDA delivery methods on retinal neurodegeneration in adult zebrafish: immersion(I.M.), intravitreal injection(I.V.), and intraperitoneal injection(I.P.), and examined retinal pathology and degeneration by hematoxylin and eosin and TUNEL staining in the treated zebrafish. Effects of the NMDA receptor antagonist MK-801 and the natural product resveratrol on NMDA-induced retinal neurodegeneration were also ***: The thickened inner retina was seen in histology with 100 μmol/L NMDA by I.M. administration. Significant apoptosis in the retinal ganglion cell layer and retinal thickness reduction occurred in 0.5 mol/L NMDA I.P. administration ***-like behavioral changes, but no retinal histological alteration occurred in 16 mg/kg NMDA I.P. administration group. Resveratrol and MK-801 prevented NMDA-induced retinal neurodegeneration in the zebrafish. CONCLUSION: Among the three drug administration methods, I.V. injection of NMDA is the most suitable for establishment of an acute retinal damage model inzebrafish. I.M. with NMDA is likely the best for use as a chronic retinal damage model. I.P. treatment with NMDA causes brain damage. Resveratrol and MK801 may be a clinically valuable treatment for retinal neurodegeneration.

关键词： zebrafish NMDA administration method retinal ganglion cell glaucomatous animal model resveratrol

Long-range Correlations in Iodide Cluster Aggregates

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 1997年第4期13卷 271-273页

作者： Zhang, JZ Yang, XD Li, HD ye, XY tsing HUA UNIV DEPT CHEMBEIJING 100084PEOPLES R CHINA

The morphology of tin iodide deposits grown during gas-solid transformation demonstrated long-range correlations. These iodide deposits include basically two kinds of forms: fractal structure and dendritic-like structure. The fractal structure was a sort of tin iodide cluster aggregation. Each fractal structure was composed of numerous tin iodide clusters that connected or disconnected with each other. The average size of fractal structures is between 10 and 22 mu m. The dendritic-like structure was also composed of many tin iodide clusters. These clusters aggregated and formed a dendritic pattern.

关键词： Iodine compounds

Drug Loading on Microneedles

在线全文

学校读者我要写书评

暂无评论

Advances in Chemical Engineering and Science 2019年第2期9卷 204-222页

作者： Meng-Hsuan Hsiao Hsiu-Feng ye Ta-Jo Liu Jane Wang Department of Chemical Engineering National Tsing Hua University Taiwan

An experimental study was carried out to investigate the amount of drugs loaded on microneedles. The microneedles were made with poly (lactic acid). Aqueous poly (vinyl alcohol) solutions were prepared as drug solutions. Two drug loading approaches, i.e., dropping and dipping, were examined. It was found that capillary number is the only relevant dimensionless group for the two methods. For the dropping approach, dried drugs will spread near the bottom of a microneedle patch provided the surface tension is low. As for the dipping approach, both a single microneedle and an array of nine microneedles were examined. For a single microneedle, high capillary rises before pulling and pulling speed are two key factors to increase the drug loading volume. For an array of microneedles, the effect of capillary rise owing to the interaction between microneedles would increase the drug loading volume several times higher than a single microneedle of the same dimension.

关键词： Microneedle Drug Loading Dropping Dipping Capillary Number Capillary Rise

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于机器视觉技术的桥梁挠度测试方法

浙江大学学报（工学版） 2014年第5期48卷 813-819页

作者：叶肖伟张小明倪一清黄启远樊可清浙江大学建筑工程学院浙江杭州310058 香港理工大学深圳研究院广东深圳518057 五邑大学信息工程学院广东江门529020 香港特别行政区政府路政署

针对大跨桥梁的结构位移/挠度测量,提出基于数字图像处理技术的结构位移测量方法,介绍基于模板匹配算法的结构位移计算流程.研发机器视觉位移测量系统,该系统集成远距离、非接触、实时、低成本和便于实施等优势,实现以毫米级的精度进行... 详细信息

针对大跨桥梁的结构位移/挠度测量,提出基于数字图像处理技术的结构位移测量方法,介绍基于模板匹配算法的结构位移计算流程.研发机器视觉位移测量系统,该系统集成远距离、非接触、实时、低成本和便于实施等优势,实现以毫米级的精度进行结构位移测量.对该系统分别进行实验室和现场标定试验,验证该系统用于结构位移测量的可行性以及测量精度的可靠性.在千米级的工作距离,利用该系统和GPS对青马大桥的跨中挠度进行同步测量,结果表明,两者的位移测量数据在时域和频域上均保持高度一致.该机器视觉位移测量系统在土木工程结构位移/挠度监测中具有广泛的应用前景.

关键词：大跨桥梁挠度测量机器视觉技术数字图像处理方法模板匹配算法

意识形态观照下的译者素养——基于译介学的郭士立翻译活动初探

在线全文

学校读者我要写书评

暂无评论

福建工程学院学报 2015年第2期13卷 125-130页

作者：叶颖林本椿福建工程学院人文学院福建福州350118 福建师范大学外国语学院福建福州350117

对晚清德籍传教士郭士立个人翻译活动进行梳理,从译介学的角度指出"主耀中华"的意识形态是推动郭士立翻译活动的关键力量。以史鉴今,郭士立在翻译活动中种种不当行为表明,在译者素养的形成中,意识形态对译者能力和职业道德可能产生的负... 详细信息

对晚清德籍传教士郭士立个人翻译活动进行梳理,从译介学的角度指出"主耀中华"的意识形态是推动郭士立翻译活动的关键力量。以史鉴今,郭士立在翻译活动中种种不当行为表明,在译者素养的形成中,意识形态对译者能力和职业道德可能产生的负面影响不容小觑。

关键词：郭士立 “创造性叛逆” 意识形态 “主耀中华” 译者素养

CEPC Technical Design Report

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

AhRLK1,a CLAVATA1-like leucine-rich repeat receptor-like kinase of peanut,confers increased resistance to bacterial wilt in tobacco

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

AhRLK1,a CLAVATA1-like leucine-rich repeat receptor-like kin...

钙钛矿型Gd_2CuO_4复合氧化物薄膜的制备

中国作物学会油料作物专业委员会第八次会员代表大会暨学术年会

作者： ZHANG Chong CHEN Hua ZHUANG Rui-rong DENG ye CAI Tie-cheng WANG Shuai-yin LIU Qin-zheng TANG Rong-hua SHAN Shi-hua PAN Rong-long ZHUANG Wei-jian State key laboratory of ecological pest control for Fujian and Taiwan crops Fujian Agriculture and Forestry University Key Laboratory of Crop Molecular and Cell Biology Fujian Agriculture and Forestry University Cash Crops Research Institute Guangxi Academy of Agricultural Sciences Shandong Peanut Research Institute Department of Life Science and Institute of Bioinformatics and Structural Biology College of Life ScienceNational Tsing Hua University

Bacterial wilt caused by Ralstonia solanacearum is a devastating disease that infects hundreds of plant *** factors involved in disease resistance and pathogenesis remain poorly *** up regulated and leucine-rich repeat receptor-like kinase characterized as CLAVATA1 and named AhRLK1 was obtained by microarray analysis in response to *** in *** contained presumably,a signal peptide,ten leucine-rich repeat(LRR) domains and conserved motifs of intracellular *** subcellular localization,the AhRLKl protein was visualized only in plasma *** inoculation with ***,AhRLK1 was constantly up regulated in the susceptible variety Xinhuixiaoli but showed little changed in the resistant cultivar Yueyou *** hormones,including salicylic acid,abscisic acid,methyl jasmonate and ethephon induced expression,but expression was completely down regulated under cold and drought *** overexpression provoked a hypersensitive response(HR) in Nicotiana benthamiana following ***,the resistance to *** increased significantly in transgenic overexpression *** contrast,most representative defense-responsive genes in defence related pathways such as NtHIN1,NtPR2,NtLOX1 and NtACS6,were considerably up regulated in the AhRLK1 transgenic ***,EDS1 and PAD4 in R gene signal were also up regulated in transgenic plants,but NDR1 and NPR1 genes were down ***,we suggest that AhRLK1 increases the defense response to *** via HR and hormone defense signalling,associated with EDS1 pathway of R gene *** results provide new understanding of CLV1 function and will contribute to genetic enhancement of peanut.

关键词： peanut bacterial wilt microarray analysis AhRLK1

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

化学学报 2000年第6期58卷 631-635页

作者：张英侠朱永法邵珂姚文清叶小燕曹立礼清华大学化学系北京100084

采用非晶态多核配合物作为前驱体的方法在单晶硅表面成功地制备了钙钛矿型的复合金属氧化物Gd_2CuO_4薄膜,XPS研究表明所制备出的薄膜由Gd_2CuO_4复合金属氧化物组成.XRD研究表明经600℃热处理形成的复合氧化物薄膜以钙钛矿型晶相结构存... 详细信息

采用非晶态多核配合物作为前驱体的方法在单晶硅表面成功地制备了钙钛矿型的复合金属氧化物Gd_2CuO_4薄膜,XPS研究表明所制备出的薄膜由Gd_2CuO_4复合金属氧化物组成.XRD研究表明经600℃热处理形成的复合氧化物薄膜以钙钛矿型晶相结构存在,也进一步证实了所制备出的薄膜是Gd_2CuO_4复合金属氧化物,其晶粒大小在20nm左右.俄歇电子能谱的深度剖析表明形成的薄膜组成均匀,在界面上有一定程度的扩散作用.运用AES揭示了Gd_2CuO_4薄膜的厚度与前驱体溶液中前驱体的质量分数以及添加剂的影响规律.SEM研究表明前驱体配合物的质量分数越低,形成的薄膜越薄,其表面织构越均匀.当前驱体的质量分数超过一定值后,形成的薄膜具有很多微裂纹.添加剂聚乙二醇对形成的薄膜厚度没有明显的影响,但可以明显改善薄膜的织构,使复合氧化物在衬底上分散得更均匀,抑制微裂纹的产生.

关键词： Gd2CuO4薄膜汽车催化剂非晶态多核配合物制备