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Diffusion-weighted MR imaging of normal and abnorma scrotum： preliminary results

Asian Journal of Andrology 2012年第4期14卷 649-654页

作者： Athina C tsili Maria I Argyropoulou Dimitrios Giannakis Stavros Tsampalas Nikolaos Sofikitis Konstantinos Tsampoulas Department of Clinical Radiology University Hospital of Ioannina Ioannina 45500 Greece Department of Urology University Hospital of Ioannina Ioannina 45500 Greece

Magnetic resonance （MR） imaging of the scrotum represents an important supplemental diagnostic tool in the evaluation of scrotal diseases. Diffusion-weighted （DW） MR imaging is a developing technique, proved to improve tissue characterization. We evaluated the feasibility and diagnostic performance of DW MR imaging in the detection and characterization of scrotal lesions. We retrospectively evaluated 31 scrotal lesions （23 intratesticular and 8 extratesticular） in 26 men. All MR examinations were performed on a 1.5-T unit, using a pelvic-phased array coil. DW sequences were obtained using a single shot, multislice spin echo planar diffusion pulse sequence and a b factor of 0 and 900 s mm-2. The DW MR characteristics and the apparent diffusion coefficient （ADC） values of normal scrotal contents and scrotal diseases were evaluated. Comparison between the ADC values of normal scrotum, benign lesions and scrotal malignancies was performed. The accuracy of conventional sequences, DW images alone and DW imaging combined with conventional images in differentiating benign from malignant scmtal lesions was calculated. The ADC values of testicular malignancies were different from those of normal testis and benign intratesticular lesions, and the ADC values of benign extratesticular lesions from those of normal epididymis （P〈0.05）. The overall accuracy of conventional imaging, DW imaging alone and DW MR combined with conventional sequences in the characterization of intratesticular lesions was 91%, 87% and 100%, respectively. Our findings suggest that DW MR imaging and ADC values may provide valuable information in the diagnosis and characterization of scrotal diseases.

关键词： diagnosis epididymis male genital neoplasms scrotum testicular neoplasms testis

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Apparent diffusion coefficient values of normal testis and variations with age

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Asian Journal of Andrology 2014年第3期16卷 493-497页

作者： Athina C tsili Dimitrios Giannakis Anastasios Sylakos Alexandra Ntorkou Loukas G Astrakas Nikolaos Sofikitis Maria I Argyropoulou Department of Clinical Radiology University of Ioannina Ioannina Greece Department of Urology University of Ioannina Ioannina Greece Department of Medical Physics University of Ioannina Ioannina Greece.

The usefulness of diffusion-weighted magnetic resonance imaging （DWI） in the evaluation of scrotal pathology has recently been reported. A standard reference of normal testicular apparent diffusion coefficient （ADC） values and their variations with age is necessary when interpreting normal testicular anatomy and pathology. We evaluated 147 normal testes using DWI, including 71 testes from 53 men aged 20-39years （group 1）, 67 testes from 42 men aged 40-69 years （group 2） and nine testes from six men older than 70years （group 3）. DWI was performed along the axial plane, using a single shot, multislice spin-echo planar diffusion pulse sequence and b-values of 0 and 900 s mm-2. The mean and standard deviation of the ADC values of normal testicular parenchyma were calculated for each age group separately. Analysis of variance （ANOVA） followed by post hoc analysis （Dunnett T3） was used for statistical purposes. The ADC values （x 10-3 mm2s-1） of normal testicular tissue were different among age groups （group 1：1.08 ± 0.13; group 2：1.15 ±0.15 and group 3：1.31± 0.22）. ANOVA revealed differences in mean ADC among age groups （F= 11.391, P〈 0.001）. Post hoc analysis showed differences between groups 1 and 2 （P= 0.008） and between groups 1 and 3 （P= 0.043）, but not between groups 2 and 3 （P= 0.197）. Our findings suggest that ADC values of normal testicular tissue increase with advancing age.

关键词： age apparent diffusion coefficient (ADC) diffusion-weighted magnetic resonance imaging testis

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Advances of multidetector computed tomography in the characterization and staging of renal cell carcinoma

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World Journal of Radiology 2015年第6期7卷 110-127页

作者： Athina C tsili Maria I Argyropoulou Department of Radiology Medical School University of Ioannina

Renal cell carcinoma(RCC) accounts for approximately 90%-95% of kidney tumors. With the widespread use of cross-sectional imaging modalities, more than half of RCCs are detected incidentally, often diagnosed at an early stage. This may allow the planning of more conservative treatment strategies. Computed tomography(CT) is considered the examination of choice for thedetection and staging of RCC. Multidetector CT(MDCT) with the improvement of spatial resolution and the ability to obtain multiphase imaging, multiplanar and threedimensional reconstructions in any desired plane brought about further improvement in the evaluation of RCC. Differentiation of RCC from benign renal tumors based on MDCT features is improved. Tumor enhancement characteristics on MDCT have been found closely to correlate with the histologic subtype of RCC, the nuclear grade and the cytogenetic characteristics of clear cell RCC. Important information, including tumor size, localization, and organ involvement, presence and extent of venous thrombus, possible invasion of adjacent organs or lymph nodes, and presence of distant metastases are provided by MDCT examination. The preoperative evaluation of patients with RCC was improved by depicting the presence or absence of renal pseudocapsule and by assessing the possible neoplastic infiltration of the perirenal fat tissue and/or renal sinus fat compartment.

关键词： Carcinoma Kidney Computed tomography Renal cell carcinoma Staging Multidetector computed tomography

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Potential role of imaging in assessing harmful effects on spermatogenesis in adult testes with varicocele

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World Journal of Radiology 2017年第2期9卷 34-45页

作者： Athina C tsili Olga N Xiropotamou Anastasios Sylakos Vasilios Maliakas Nikolaos Sofikitis Maria I Argyropoulou Department of Clinical Radiology University of Ioannina Medical School University Campus Department of Urology University of Ioannina Medical School University Campus

Varicocele is characterized by an abnormal dilatation and retrograde blood flow in the spermatic veins. Varicocele is the leading correctable cause of male infertility. Although it is highly prevalent in infertile men, it is also observed in individuals with normal fertility. Determining which men are negatively affected by varicocele would enable clinicians to better select those men who will benefit from treatment. To assess the functional status of the testes in men with varicocele, color Doppler sonographic parameters were evaluated. Testicular arterial blood flow was significantly reduced in men with varicocele, reflecting an impairment of spermatogenesis. An improvement in the testicular blood supply was found after varicocelectomy on spectral Doppler analysis. Testicular contrast harmonic imaging and elastography might improve our knowledge about the influence of varicocele on intratesticular microcirculation and tissue stiffness, respectively, providing possible information on the early damage of testicular structure by varicocele. Magnetic resonance imaging(MRI), with measurement of apparent diffusion coefficient has been used to assess the degree of testicular dysfunction and to evaluate the effectiveness of varicocele repair. Large prospective studies are needed to validate the possible role of functional sonography and MRI in the assessment of early defects of spermatogenesis in testes with varicocele.

关键词： Varicocele Spermatogenesis Diagnostic imaging Ultrasonography Doppler ultrasound imaging Magnetic resonance imaging Functional

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睾丸微石症影像和随访:ESUR阴囊成像小组委员会的指南

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国际医学放射学杂志 2015年第2期 196-197页

作者： J.Richenberg J.Belfield P.Ramchandani L.Rocher S.Freeman A.C.tsili 高飞 Royal Sussex County Hospital Brighton and Brighton and Sussex Medical School Brighton Sussex UK

摘要目的阴囊成像小组委员会是由欧洲泌尿生殖放射委员会(ESUR)任命的,对睾丸微石症(TML)的影像和随访制定了指南。方法笔者和一位大学图书管理员独立地用

关键词：阴囊睾丸囊男生殖器睾丸微石症 ESUR 委员会小组

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正常和异常睾丸磁化传递成像的初步结果

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国际医学放射学杂志 2016年第3期 320-320页

作者： A.tsili A.Ntorkou D.Baltogiannis A.Sylakos S.Stavrou L.Astrakas 张其锐 Department of Clinical Radiology Medical SchoolUniversity of Ioannina

摘要目的研究正常睾丸的磁化传递率(MTR),其MTR随年龄的变化,并评估MTR描述不同睾丸病变的可行性。方法纳入86例男性,行3D梯度回波磁化传递成像。MTR计算方式为(SIo-SIm)/(SIo)×100%,SIm和SIo分别代表有和无饱和脉冲的信号强度。被试... 详细信息

摘要目的研究正常睾丸的磁化传递率(MTR),其MTR随年龄的变化,并评估MTR描述不同睾丸病变的可行性。方法纳入86例男性,行3D梯度回波磁化传递成像。MTR计算方式为(SIo-SIm)/(SIo)×100%,SIm和SIo分别代表有和无饱和脉冲的信号强度。被试被分为3组:组1,20～39岁;组

关键词：磁化传递成像正常睾丸 MTR

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关于正常成人睾丸MR波谱及其年龄变化的初步观察

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国际医学放射学杂志 2016年第5期 587-587页

作者： A.C.tsili L.G.Astrakas A.Ntorkou D.Giannakis S.Stavrou V.Maliakas 杨学东 Department of Clinical Radiology Medical School University of Ioannina

摘要目的确定正常成人睾丸氢质子MR(1H-MR)波谱及其年龄变化。方法纳入41个正常睾丸的MR资料,包括20～39岁组(组Ⅰ)16个、40～69岁组(组Ⅱ)25个。采用单体素点解析MR波谱序列(PRESS),TR/TE为2 000 ms/25 ms。兴趣容积包括大部分正常睾... 详细信息

摘要目的确定正常成人睾丸氢质子MR(1H-MR)波谱及其年龄变化。方法纳入41个正常睾丸的MR资料,包括20～39岁组(组Ⅰ)16个、40～69岁组(组Ⅱ)25个。采用单体素点解析MR波谱序列(PRESS),TR/TE为2 000 ms/25 ms。兴趣容积包括大部分正常睾丸实质。评价标准化代谢物浓度(即代谢物与肌酸的比值)与年龄的相关性。结果定量测量

关键词：正常成人波谱 MR 睾丸性腺年龄变化

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