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Visualizing Meiotic Chromosome Pairing and Segregation in Interspecific Hybrids of Rice by Genomic in situ Hybridization

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Rice science 2021年第1期28卷 69-80页

作者： Liu Mao-Sen tseng shih-hsuan Chen Ting-Chu Chung Mei-Chu Institute of Plant and Microbial Biology Academia SinicaNankangTaipei 11529TaiwanChina

Meiotic disturbances in F1 hybrids and their progenies are still major problems in wide *** investigate the genome affinity reflected in chromosome pairing and segregation,we studied chromosome behaviors during meiosis in two interspecific F1 hybrids[***×***(Om×Oa,BCE genome)and Oa×***(Or,EHJ genome)]by using both traditional staining methods and genomic in situ hybridization(GISH).GISH analysis has been successfully performed on mitotic chromosomes to distinguish different Oryza genomes,but relatively fewer systematic analyses of meiotic chromosomes of interspecific hybrids have been *** the hybrids,highly irregular chromosome behaviors through meiosis resulted in producing microspores with unbalanced *** diakinesis of these two hybrids,most chromosomes present as univalent,with low frequency as bivalents and occasionally as *** a pollen mother cell,2 to 8 bivalents and 0 to 4 trivalents were observed in the hybrid Oa×Or,and 1 to 8 bivalents and 0 to 5 trivalents were observed in the hybrid Om×*** results indicated that 51.52%bivalents in Oa×Or and 79.65%bivalents in Om×Oa involved allosyndetic association,which indicates that recombination and introgression should be possible if viable backcrosses can be recovered even from triploid *** this study,we revealed that the meiotic disturbance due to low affinities between parental genomes is the major reason for the sterility of these two triploid interspecific *** two hybrids showing vigor in reproductive growth are potential genetic resources in future breeding programs.A better understanding of genomic affinities between these distant Oryza species can facilitate planning an effective breeding program by using wide hybridization,and efficient and routine GISH analysis is helpful to monitor alien introgression in the process.

关键词： Oryza wide hybridization genomic affinity allosyndesis autosyndesis pollen viability

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Advancements in Liver Tumor Detection:A Comprehensive Review of Various Deep Learning Models

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 91-122页

作者： Shanmugasundaram Hariharan D.Anandan Murugaperumal Krishnamoorthy Vinay Kukreja Nitin Goyal shih-Yu Chen Deptartment of Artificial Intelligence and Data Science Vardhaman College of EngineeringHyderabad501218India Deptartment of CSE V.S.B College of EngineeringKarur639111India Deptartment of Electrical and Electronics Engineering Vardhaman College of EngineeringHyderabad501218India Centre for Research Impact&Outcome Chitkara UniversityRajpura140401PunjabIndia Department of Computer Science and Engineering School of Engineering and TechnologyCentral University of HaryanaMahendergarh123031HaryanaIndia Department of Computer Science and Information Engineering National Yunlin University of Science and TechnologyYunlin64002Taiwan Intelligence Recognition Industry Service Research Center National Yunlin University of Science and TechnologyYunlin64002Taiwan

Liver cancer remains a leading cause of mortality worldwide,and precise diagnostic tools are essential for effective treatment *** Tumors(LTs)vary significantly in size,shape,and location,and can present with tissues of similar intensities,making automatically segmenting and classifying LTs from abdominal tomography images crucial and *** review examines recent advancements in Liver Segmentation(LS)and Tumor Segmentation(TS)algorithms,highlighting their strengths and limitations regarding precision,automation,and *** metrics are utilized to assess key detection algorithms and analytical methods,emphasizing their effectiveness and relevance in clinical *** review also addresses ongoing challenges in liver tumor segmentation and identification,such as managing high variability in patient data and ensuring robustness across different imaging *** suggests directions for future research,with insights into technological advancements that can enhance surgical planning and diagnostic accuracy by comparing popular *** paper contributes to a comprehensive understanding of current liver tumor detection techniques,provides a roadmap for future innovations,and improves diagnostic and therapeutic outcomes for liver cancer by integrating recent progress with remaining challenges.

关键词： Liver tumor detection liver tumor segmentation image processing liver tumor diagnosis feature extraction tumor classification deep learning machine learning

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超塑性Y-TZP基陶瓷之有限元分析（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第12期17卷 989-999页

作者： hsuan-Teh HU shih-Tsung tseng Alice HU Department of Civil Engineering National Cheng Kung University Department of Mechanical and Biomedical Engineering City University of Hong Kong

目的:通过调整非常精细的颗粒,四方晶氧化锆多晶(TZP)在室温下保持稳态四方相,并且具有优异的塑性。然而,当材料变形时,我们必须对超塑性陶瓷在机械应力分布和断裂机制方面有更多的理解。创新点:1.通过材料弹塑性模型;2.使用胡克定律、... 详细信息

目的:通过调整非常精细的颗粒,四方晶氧化锆多晶(TZP)在室温下保持稳态四方相,并且具有优异的塑性。然而,当材料变形时,我们必须对超塑性陶瓷在机械应力分布和断裂机制方面有更多的理解。创新点:1.通过材料弹塑性模型;2.使用胡克定律、塑性应变硬化及von Mises降伏准则;3.结合等向性硬化规则及相关联的流动规则。方法:1.开发一个高温超塑性材料在不同应变率拉伸条件下具备不同应力-应变关系的组成律模型及有限元分析模型;2.通过有限元法仿真模拟与实验结果比对;3.验证所提方法的可行性和精确性。结论:1.有限元仿真模拟的应力-应变关系与实验数据吻合较好,对于所研究的四种组合物,最大应力和应变的误差均小于1%。2.有限元仿真模拟的最终变形形状(宽度和厚度)与拉伸试验的结果一致;这些验证证实了所提有限元分析模型的可靠性。

关键词：有限元分析 Y-TZP基陶瓷超塑性

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Diabetes and gastric cancer: The potential links

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World Journal of Gastroenterology 2014年第7期20卷 1701-1711页

作者： Chin-Hsiao tseng Farn-hsuan tseng Department of Internal Medicine National Taiwan University College of Medicine Division of Endocrinology and Metabolism Department of Internal MedicineNational Taiwan University Hospital Dana and David Dornsife College of Letters Arts and SciencesDepartment of Biological SciencesUniversity of Southern CaliforniaLos AngelesCA 90007United States

This article reviews the epidemiological evidence linking diabetes and gastric cancer and discusses some of the potential mechanisms,confounders and biases in the evaluation of such an *** from four meta-analyses published from 2011 to 2013 suggest a positive link,which may be more remarkable in females and in the Asian *** mechanisms may involve shared risk factors,hyperglycemia,Helicobacter pylori(***)infection,high salt intake,medications and *** may increase the risk of gastric cancer through shared risk factors including obesity,insulin resistance,hyperinsulinemia and ***,even before the clinical diagnosis of diabetes,may predict gastric cancer in some epidemiological studies,which is supported by in vitro,and in vivo *** with diabetes may also have a higher risk of gastric cancer through the higher infection rate,lower eradication rate and higher reinfection rate of *** salt intake can act synergistically with *** infection in the induction of gastric *** a higher risk of gastric cancer in patients with diabetes may be ascribed to a higher intake of salt due to the loss of taste sensation awaits further *** use of medications such as insulin,metformin,sulfonylureas,aspirin,statins and antibiotics may also influence the risk of gastric cancer,but most of them have not been extensively *** may affect the development of gastric cancer through the use of medications and changes in lifestyle,dietary intake,and the metabolism of ***,a potential detection bias related to gastrointestinal symptoms more commonly seen in patients with diabetes and with multiple comorbidities should be pointed *** into account the inconsistent findings and the potential confounders and detection bias in previous epidemiological studies,it is expected that there are still more to be explored for the clarification of the associa

关键词： Diabetes mellitus Gastric cancer Epidemiology Meta-analysis Literature review

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Herpes simplex virus 2-induced aseptic meningitis presenting with sudden deafness:A case report

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World Journal of Clinical Cases 2025年第8期13卷 22-25页

作者： Yuan-Cheng Liu shih-hsuan Hsiao Peir-Rong Chen Department of Otolaryngology Hualien Tzu Chi HospitalHualien 970TaiwanChina Department of Otolaryngology Hualien Tzu Chi Hospitaland Department of OtolaryngologyHead and Neck SurgerySchool of MedicineTzu Chi UniversityHualien 970TaiwanChina

BACKGROUND Aseptic meningitis is defined as meningeal inflammation caused by various etio-logies with negative cerebrospinal fluid(CSF)bacterial *** most common etiologies are viruses[enteroviruses,arboviruses,and herpes simplex virus type 2(HSV-2)].Aseptic meningitis can have various presentations,including sensori-neural *** sensorineural deafness from mumps meningoencephalitis has been reported,cases of HSV-2-induced hearing loss are ***,we re-port a case of HSV-2-induced meningitis that presented with sudden *** SUMMARY A 68-year-old man experienced a profound sudden onset of left-sided hearing loss for one ***-tone audiograms demonstrated sudden left-sided sensorineural hearing loss(thresholds 80-90 dB).After treatment with high-dose steroids for 1 week,he experienced an acute consciousness change with left *** laboratory data showed no significant *** computed tomography without contrast and magnetic resonance imaging revealed no intracranial hemo-rrhage or obvious brain *** CSF analysis and the Multiplex PCR panels showed HSV-2 ***,under the diagnosis of herpes meningoenceph-alitis,acyclovir was prescribed and his symptoms gradually *** This case report further demonstrates that a viral infection could be a cause of sudden sensorineural hearing loss.

关键词： Aseptic meningitis Type 2 herpes simplex Sudden sensorineural hearing loss Immunocompromised Cerebrospinal fluid Case report

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The Reflection of Normal Incident Waves by Absorbing-Type Breakwaters

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China Ocean Engineering 2009年第4期23卷 729-740页

作者： Ching-Yun YUEH shih-hsuan CHUANG Department of Harbor and River Engineering National Taiwan Ocean University

This paper investigates the reflection of normal incident waves produced by absorbing-type breakwaters. The absorbing-type breakwaters in this study consist of a vertical porous plate, a submerged permeable caisson, and an impermeable back wall. The flow field is divided into four regions： a porous caisson region, and three pure water regions. Under the assumptions of linear wave theory, Darcy＇s law in the perforated wall, and the pore velocity potential theory of Sollitt and Cross （1972） in the porons caisson region, this study creates a 2-D BEM model to calculate the reflection coefficients of water waves using several breakwater properties. This numerical model is calibrated by previous numerical studies and limiting cases for a partially perforated-wall caisson breakwater and a vertical porous breakwater with an impermeable back wall. Generally speaking, the wave dissipation in absorbing-type breakwaters is bigger than that for a partially perforatedwall caisson breakwater. The reflection coefficient values imply the performance of wave absorbers in this study. Therefore, we examine the major factors that affect the reflection coefficient.

关键词： vertical porous plate supmerged permeable caisson BEM Darcy's law reflection

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Helicobacter pylori infection concomitant with metabolic syndrome further increase risk of colorectal adenomas

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World Journal of Gastroenterology 2010年第30期16卷 3841-3846页

作者： Ying-Lung Lin Jui-Kun Chiang shih-Min Lin Chih-En tseng Department of Family Medicine Buddhist Tzu-Chi Dalin General Hospital Department of Biological Sciences University of Waikato Department of Anatomic Pathology Buddhist Dalin Tzu Chi General Hospital School of Medicine Buddhist Tzu Chi University

AIM: To investigate the association of colorectal adenomas with both Helicobacter pylori (H. pylori) infection and metabolic syndrome. METHODS: Using a cross-sectional hospital-based study, we analyzed physical examination data from 9311 healthy subjects with overnight physical examinations performed between January 2004 and December 2006. Examined data included gender, age, life style, anthropometric measurements, blood pressure, biochemical and hematological studies, H. pylori infection detected by esophagogastroduodenoscopy and biopsy urease tests, and colorectal adenomas detected with a complete total colonoscopy. RESULTS: The prevalence values for H. pylori infection, metabolic syndrome, and colorectal adenoma were39.2%, 18.7%, and 20.7%, respectively. Colorectal adenoma risk factors included male gender [odd ratio (OR): 2.005, 95% conf idence interval (CI): 1.740-2.310, P < 0.001], advanced age (OR: 1.046, 95% CI: 1.040-1.052, P < 0.001), smoking (OR: 1.377, 95% CI: 1.146-1.654, P = 0.001), increased body fat (OR: 1.016, 95% CI: 1.007-1.026, P = 0.001), higher white blood cell count (OR: 1.038, 95% CI: 1.005-1.073, P = 0.025), H. pylori infection (OR: 1.366, 95% CI: 1.230-1.517, P < 0.001), and metabolic syndrome (OR: 1.408, 95% CI: 1.231-1.610, P < 0.001). In addition, concomitant H. pylori infection with metabolic syndrome further increased the probability of colorectal adenomas. CONCLUSION: Our study revealed H. pylori infection with concomitant metabolic syndrome might further increase the risk of colorectal adenomas.

关键词： Biopsy urease test Colorectal adenoma Colorectal cancer Helicobacter pylori Metabolic syndrome

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Solitary concomitant endocrine tumor and ductal adenocarcinoma of pancreas

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World Journal of Gastroenterology 2010年第21期16卷 2692-2697页

作者： shih-Tang Yan Chang-Kuo Wei Chih-Wen Lin Chih-En tseng Department of Endocrinology and Metabolism Buddhist Dalin Tzu Chi General HospitalChiayi 622TaiwanChina Department of General Surgery Buddhist Dalin Tzu Chi General HospitalChiayi 622TaiwanChina Department of Medical Imaging Buddhist Dalin Tzu Chi General HospitalChiayi 622TaiwanChina Department of Anatomic Pathology Buddhist Dalin Tzu Chi General HospitalChiayi 622TaiwanChina School of Medicine Tzu Chi UniversityHualien 97004TaiwanChina

Pancreatic tumors with combined exocrine and endocrine features are *** reported cases are classified as mixed exocrine and endocrine carcinoma of the *** report the first case of solitary concomitant endocrine tumor and ductal adenocarcinoma of the pancreas.A 58-year-old patient was admitted for uncontrolled diabetes mellitus and body weight *** tumor was fortuitously discovered in the pancreatic tail after a tumor survey ***,the solitary tumor had a central fibrous band that clearly divided it into two *** microscopic examination,the tumor contained both endocrine and exocrine components distinctly separated by the central fibrous *** exocrine part showed a poorly-differentiated *** endocrine part was strongly immunoreactive to chromogranin,synaptophysin and *** reviewed the literature on pancreatic tumors with combined exocrine and endocrine features.A simple classification for this group of neoplasms is suggested,including five types:amphicrine,mixed,collision,solitary concomitant and multiple concomitant.

关键词： Pancreas Concomitant tumor Collision tumor Mixed tumor Glucagonoma

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Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor:A case report

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World Journal of Gastroenterology 2012年第42期18卷 6172-6176页

作者： Liang-Yu shih Chang-Kuo Wei Chih-Wen Lin Chih-En tseng Department of Anatomic Pathology BuddhistDalin Tzu Chi General Hospital Chiayi 62247 Taiwan Department of General Surgery BuddhistDalin Tzu Chi General Hospital Chiayi 62247 Taiwan Department of Medical Imaging Buddhist Da-lin Tzu Chi General Hospital Chiayi 62247 Taiwan School of Medicine Buddhist Tzu Chi Uni-versity Hualien 97004 Taiwan

Desmoid tumor is a locally invasive,myofibroblastic,nonmetastatic *** pathogenesis remains unclear and it may involve genetic abnormalities,sex hormones and traumatic injury,including *** intra-abdominal desmoid tumor is rare,especially in the *** report a case of postoperative retroperitoneal desmoid tumor that developed 29 mo after the first excision of a gastrointestinal stromal *** trauma-related intraabdominal desmoid tumors reported in the English literature are also *** an extremely low incidence,postoperative desmoid tumor should be considered in the differential diagnosis when a recurrent neoplasm is found at least one year after ***,it is a clinical challenge to distinguish recurrent malignant neoplasms from desmoid tumors,and surgical resection is the treatment option depending on the anatomic location.

关键词： Desmoid tumor Gastrointestinal stromal tumor Recurrence Retroperitoneum Surgery

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EZ-Manipulator:Designing a mobile,fast,and ambiguity-free 3D manipulation interface using smartphones

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Computational Visual Media 2018年第2期4卷 139-147页

作者： Po-Huan Wseng shih-hsuan Hung Pei-Ying Chiang Chih-Yuan Yao Hung-Kuo Chu "National Tsing Hua University" Hsinchu 30013TaiwanChina. "National Taiwan University of Science and Technology" Taipei 10607TaiwanChina. "National Taipei University of Technology" Taipei 10607TaiwanChina.

Interacting with digital contents in 3 D is an essential task in various applications such as modeling packages, gaming, virtual reality, etc. Traditional interfaces using keyboard and mouse or trackball usually require a non-trivial amount of working space as well as a learning process. We present the design of EZ-Manipulator, a new 3 D manipulation interface using smartphones that supports mobile, fast, and ambiguity-free interaction with 3 D objects. Our system leverages the built-in multi-touch input and gyroscope sensor of smartphones to achieve 9 degrees-of-freedom axis-constrained manipulation and free-form *** EZ-Manipulator to manipulate objects in 3 D is easy. The user merely has to perform intuitive singleor two-finger gestures and rotate the hand-held device to perform manipulations at fine-grained and coarse levels respectively. We further investigate the ambiguity in manipulation introduced by indirect manipulations using a multi-touch interface, and propose a dynamic virtual camera adjustment to effectively resolve the ambiguity. A preliminary study shows that our system has significant lower task completion time compared to conventional use of a keyboard–mouse interface, and provides a positive user experience to both novices and experts.

关键词： 3D manipulation interface interaction technique multi-touch gyroscope sensorl mobile device input device

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