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Therapeutic effect of Guijiajiao(Colla Carapacis et Plastri) on bone regeneration in rats and zebrafish

Journal of Traditional Chinese Medicine 2018年第2期38卷 197-210页

作者： Su Weiyang Feng Chienwei tseng chungchih Hung Hanchun Chen Zhicheng Lee Hsinpai Jean Yenhsuan Wu Shingyi Sean Wen Zhihong Department of Marine Biotechnology and Resources National Sun Yat-Sen University Division of Dentistry Zuoying Branch of Kaohsiung Armed Forces General Hospital Doctoral Degree Program in Marine Biotechnology Academia Sinica Doctoral Degree Program in Marine Biotechnology National Sun Yat-Sen University The School of Chinese Medicine for Post Baccalaureate I Shou University Section of Orthopedic Surgery PingtungChristian Hospital Section of Orthopedic Surgery Pingtung Christian Hospital

OBJECTIVE:To investigate the effect of Guijiajiao(Colla Carapacis et Plastri, CCP), the glue of tortoise shell, on bone regeneration in zebrafish and male Wistar ***: In this study, we applied in vitro and in vivo models, tissue section analysis, and quantitative polymerase chain reaction to assess the effects of CCP on bone repair. MG-63 cells were used in alkaline phosphatase(ALP) activity and mineralization assays. Zebrafish and male Wistar rats were used to evaluate the effects of CCP on bone repair in ***: A simple preparation of CCP promoted osteogenesis in vivo and in vitro, and promoted MG-63 cell proliferation as well as ALP activity and mineralization. In addition, CCP activated Akt and extracellular signaling-regulated kinase pathways and significantly increased the expression of ossification-related genes and proteins such as runt-related transcription factor-2, osteocalcin, and osteopontin. The in vivo results revealed promotion of osteogenesis by immersing zebrafish in CCP for 72 *** oral dose of 1.25 g/kg CCP significantly improved skull defects in rats, which was accompanied by an increase in serum ALP ***: One of the ingredients of Guilu Erxianjiao(tortoise shell and deer horn formula) pro-vides a practical alternative therapy for bone regeneration.

关键词： Colla Carapacis et Plastri Testudinis Bone regeneration Alkaline phosphatase Rat Zebrafish

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