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DEFIBRILATION-GUIDED RADIOFREQUENCY ABLATION OF ATRIAL FIBRILLATION SECONDART TO AN ATRIAL FOCUS

中国介入心脏病学杂志 1998年第4期6卷 165-165页

作者： Lau CP tse hf Ayers G University of Hong Kong Queen Mary HospitalHong KongChinaInControl Inc.aRedmondUSA

ObJective:We aim to identify a focal source of atrial fibrillnion(AF) by unmasking spontaneouscarly re-initiation AF after transvenous atrial defibrillation(TADF) and descride a method of usingrepeated TADF to map the earlicst focus of spontaneous AF re-initlation,followed by focalradiofrequency(RF)ablation,Baekgromod:AF may develop secondary to a rapidly dischargingatrial focus such the remainder of the atrium cannot follow synchonously,although the incidenceof this occuming in patients with AF is *** and RF ablation of this focus may becurative but is limited if the patient is in *** spontaneous early ne-initiation of AF byatrial ectopic beats have been observed following defibrillation,which we hypothesized mighthave a focal ***:We performed electmphysiology study and TADF onconsecuutive patients with ECG documented,drug refractory AF without structural heart *** was perforrmed using a 3/3ms biphasic wave form delivered using catheter based electrodesin the right atrium and the coronary *** observed reproducible early re-initiation of AF(within 2 minutes)by art atrial focus thai showed a consistent atrial activation pattern and couplingcycle length to preceding sinus beat after repeated defibrillation which also facilitated mapping ofthe earliest site of the *** guided RF ablation was then perfonned at this siteaiming at suppression of early AF re-initiation,Clinical and ambulatory ECG recording were madeto assess recumence,Resultn:44 lone AF patrients(40 men and 4 women)with a mean age of58±13 years underwent *** were 32 persistent and 12 paroxysmal *** patients(20%;paroxysmal AF:5 persistent AF:4)had early re-initiation of AF immediately afterdefibrilation Their mead age was significantly younger than that without a putative focal re-initimtion(40±10 versus 62±9 years,p<0.001).The earliest atrial activation was mapped at the rightsuperior(n=4)and left superior(n=3)pulmonary vein ori

关键词： paroxysmal sinus ablation suppression guided persistent ectopic minutes recurrence earliest

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INITIAL EXOERIENCE OF PACING LEAD EXTRACTION USING MECHANICAL AND LASER-ASSISTED DEVICE

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中国介入心脏病学杂志 1998年第4期6卷 165-165页

作者： Lau CP Leung SK Chiang CS Chung HK NG W tse hf Division of Cardiology Dept of MedicineQueen Mary HospitalKwong Wah HospitalQueen Elizabeth Hospital and Prince of Wales HospitalHong KongChina

Objective:To describe our experience on lead extraction in Hong ***:Pacing lead extraction is required when there is infection,lead fracture with protrudingfiagments and absence of venous access during lead ***:We performedthe first lead extraction in Hong Kong using the Cook sheath on March *** 1996,Spectranetics laser sheath using Excimer Laser System(Model CVX-300)was *** was performed under general anesthesis(Cook sheath)or conscious sedation(Laserextraction).Results:Twenty patients with a total of 26 leads were *** indicationsfor lead extraction were:*** retention wire of Aceufix lead(15 patients)2,Infectedpacing leads(4 patients).*** access problem(1 patient).9 leads were extracted withthe Cook sheath,the remaining 17 leads by larer-assisted *** were 20 atrial leadsand 6 ventricular leads from Telectrontics,*** and Intermedics,with thelongest irnplanted lead of 15 *** extraction eas achieved in 24/26(93%)of leadsIn one patient,fracture of outer insulation of Accutix at the superior vena cava occurred afierusccessful removal of the lead from the atrium,and this requited venotomy for *** of advancement of locking styler occurred in another patient with an uninfectedvetricular lead which was not extractde,There was no mortality nor any other majorcomplictaion,Re-implantation was performed at the same setting except for the 4 infectedcases Conelmslom:Lead extraction can be perfomned effectively and smfely with,either theCook or Lmser extraction method,the latter can be chieved without general *** extraction may be incteasingly used in the young patients to reduce the qumber ofhardwares inside the beart and for the purpose of schieving venous access,lends that areabandoned at the time of pacernaker change should be capped rather than cut to facilitate leadextraction in the futureA.

关键词： sheath anesthesia locking conscious retention latter LASER remaining Fracture outer

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缺血性脑卒中患者诊间血压变异性对长期预后的影响

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中华高血压杂志 2015年第5期23卷 498-498页

作者： Lau KK Wong YK Teo KC Chang RS Chan KH Hon SF Wat KL Cheung RT Li LS Siu CW tse hf

血压变异性（blood pressure variablity，BPV）是动脉粥样硬化疾病发展的新的危险因素。最近研究显示，高BPV能预测腔隙性梗死患者的全因和心血管死亡率。除因小血管阻塞造成的脑卒中患者外，BPV是否对缺血性脑卒中患者的预后产生影响... 详细信息

血压变异性（blood pressure variablity，BPV）是动脉粥样硬化疾病发展的新的危险因素。最近研究显示，高BPV能预测腔隙性梗死患者的全因和心血管死亡率。除因小血管阻塞造成的脑卒中患者外，BPV是否对缺血性脑卒中患者的预后产生影响仍然不清楚。

关键词：脑卒中患者血压变异性长期预后缺血性动脉粥样硬化心血管死亡率腔隙性梗死危险因素

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Impact of SGLT2 inhibitors on major clinical events and safety outcomes in heart failure patients:a meta-analysis of randomized clinical trials

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Journal of Geriatric Cardiology 2021年第10期18卷 783-795页

作者： George Bazoukis Stamatis S.Papadatos Costas Thomopoulos Gary tse Stefanos Cheilidis Konstantinos Tsioufis Dimitrios Farmakis Department of Cardiology Larnaca General HospitalLarnacaCyprus Department of Anatomy Histology and EmbryologyMedical SchoolUniversity of IoanninaIoanninaGreece Department of Cardiology Helena Venizelou HospitalAthensGreece Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjinChina University of Cyprus Medical School NicosiaCyprus First Cardiology Clinic Hippokration HospitalAthens UniversityAthensGreece

BACKGROUND Sodium-glucose co-transporter-2 inhibitors(SGLT2i)significantly reduce the risk of cardiovascular(CV)and renal adverse events in patients with diabetes mellitus,heart failure(hf)and/or chronic kidney *** performed a meta-analysis to explore the impact of several different SGLT2i on all-cause mortality,CV mortality,hf hospitalizations and the combined outcome CV death/hf hospitalization in hf patients across the spectrum of left ventricular ejection fraction(LVEF)*** A systematic search in MEDLINE database and Cochrane library through March 2021 was performed without *** clinical trials that provided data about the impact of SGLT2i on all-cause mortality,CV mortality,hf hospitalizations or the combined outcome of CV death/hf hospitalization in hf patients were included.A random effects model was used for calculating the effect *** Nine studies(n=16,723 patients,mean age:65.9 years,males:70.7%)were included in the quantitative *** to placebo,SGLT2i use was associated with 14%lower risk of all-cause mortality[hazard ratio(HR)=0.86,95%CI:0.78−0.94,I^(2)=0,P=0.0008],32%lower risk of hf hospitalizations(HR=0.68,95%CI:0.62−0.74,I^(2)=0,Phf hospitalization(HR=0.74,95%CI:0.68−0.80,I^(2)=0,Phf,regardless of LVEF phenotype,all SGLT2i had an excellent safety profile and significantly reduced the risk of all-cause mortality,CV mortality,hf hospitalizations and CV deaths/hf hospitalizations compared to placeb

关键词： patients clinical protective

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Electrocardiogram-based artificial intelligence for the diagnosis of heart failure:a systematic review and meta-analysis

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Journal of Geriatric Cardiology 2022年第12期19卷 970-980,1011-1015页

作者： Xin-Mu LI Xin-Yi GAO Gary tse Shen-Da HONG Kang-Yin CHEN Guang-Ping LI Tong LIU Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjinChina Kent and Medway Medical School CanterburyUnited Kingdom National Institute of Health Data Science at Peking University Peking UniversityBeijingChina Institute of Medical Technology Peking University Health Science CenterBeijingChina

BACKGROUND The electrocardiogram(ECG)is an inexpensive and easily accessible investigation for the diagnosis of cardiovascular diseases including heart failure(hf).The application of artificial intelligence(AI)has contributed to clinical practice in terms of aiding diagnosis,prognosis,risk stratification and guiding clinical *** aim of this study is to systematically review and perform a meta-analysis of published studies on the application of AI for hf detection based on the *** We searched Embase,PubMed and Web of Science databases to identify literature using AI for hf detection based on ECG *** quality of included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2(QUADAS-2)***-effects models were used for calculating the effect estimates and hierarchical receiver operating characteristic curves were *** analysis was *** and the risk of bias were also *** A total of 11 studies including 104,737 subjects were *** area under the curve for hf diagnosis was 0.986,with a corresponding pooled sensitivity of 0.95(95%CI:0.86–0.98),specificity of 0.98(95%CI:0.95–0.99)and diagnostic odds ratio of 831.51(95%CI:127.85–5407.74).In the patient selection domain of QUADAS-2,eight studies were designated as high *** According to the available evidence,the incorporation of AI can aid the diagnosis of ***,there is heterogeneity among machine learning algorithms and improvements are required in terms of quality and study design.

关键词： diagnosis assessed specificity

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Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip

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Translational Neurodegeneration 2012年第1期1卷 11-19页

作者： WL Ho Jessica WM Ho Hui-Fang Liu Danny hf So Zero HM tse Koon-Ho Chan David B Ramsden Shu-Leong Ho Division of Neurology Department of MedicineUniversity of Hong KongPokfulamHong Kong SARChina School of Medicine and School of Biosciences University of BirminghamBirminghamUK Research Centre of Heart BrainHormone and Healthy Aging(HBHA)University of Hong KongPokfulamHong Kong SARChina

This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also *** free radical production contributes to oxidative *** have evolved to handle such stress via various endogenous anti-oxidant *** such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner *** are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural *** a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative *** also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in ***,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced *** is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with *** expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease.

关键词： uncoupling proteins mitochondria Parkinson??s disease ATP oxidative stress neuroprotection

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