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摩擦:英文版 2023年第11期11卷 1974-1986页

作者： Dong Geun kim Hyeongmin JE Ajohn HART Sanha kim Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

Mechanically flexible surface structures with embedded conductive electrodes are attractive in contact-based devices,such as those used in reversible dry/adhesion and tactile *** shapes of the surface structures strongly determine the contact behavior and therefore the resulting adhesion and sensing functionalities;however,available features are often restricted by fabrication ***,we additively manufacture elastomeric structure arrays with diverse angles,shapes,and sizes;this is followed by integration of conductive nanowire *** fabricated flexible three-dimensional(3D)surface electrodes are mechanically compliant and electrically conductive,providing multifunctional ability to sense touch and to switch adhesion via a combined effect of shear-and electro *** designed soft,anisotropic flexible structures to mimic the gecko’s reversible adhesion,which is governed by van der Waals forces;we integrated nanowires to further manipulate the localized electric field among the adjacent flexible 3D surface electrodes to provide additional means to digitally tune the electrostatic attraction at the contact *** addition,the composite surface can sense the contact force via capacitive *** our flexible 3D surface electrodes,we demonstrate a complete soft gripper that can grasp diverse convex objects,including metal,ceramic,and plastic products,as well as fresh fruits,and that exhibits 72%greater electroadhesive gripping force when voltage is applied.

关键词： electroadhesion tactile sensing robotic gripper additive manufacturing dry adhesive

Differentiating Neonatal Dubin johnson Syndrome from Biliary Atresia: Start Simply

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 523-524页

作者： Jaimy Villavicencio kim john Birk Division of Gastroenterology and Hepatology University of Connecticut School of MedicineFarmingtonCTUSA

Dubin johnson syndrome usually appears in the second dec-ade of life, making differentiation from biliary atresia (BA) relatively easy. However, there are rare cases of neonatal Dubin johnson syndrome (nDJS) causing cholestasis in neo-nates that can be easily mistaken for other conditions, in-cluding BA. It is important to make a distinction between the two in neonates because nDJS is typically a benign condition and BA, if left untreated, has a high mortality rate.

关键词： typically rare nates

Enhancing IoT anomaly detection performance for federated learning

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Digital Communications and Networks 2022年第3期8卷 314-323页

作者： Brett Weinger Jinoh kim Alex Sim Makiya Nakashima Nour Moustafa K.john Wu Stony Brook University Stony BrookNYUSA Lawrence Berkeley National Laboratory BerkeleyCAUSA Texas A&M University CommerceTXUSA University of New South Wales CanberraAustralia

Federated Learning (FL) with mobile computing and the Internet of Things (IoT) is an effective cooperative learning approach. However, several technical challenges still need to be addressed. For instance, dividing the training process among several devices may impact the performance of Machine Learning (ML) algorithms, often significantly degrading prediction accuracy compared to centralized learning. One of the primary reasons for such performance degradation is that each device can access only a small fraction of data (that it generates), which limits the efficacy of the local ML model constructed on that device. The performance degradation could be exacerbated when the participating devices produce different classes of events, which is known as the class balance problem. Moreover, if the participating devices are of different types, each device may never observe the same types of events, which leads to the device heterogeneity problem. In this study, we investigate how data augmentation can be applied to address these challenges and improving detection performance in an anomaly detection task using IoT datasets. Our extensive experimental results with three publicly accessible IoT datasets show the performance improvement of up to 22.9% with the approach of data augmentation, compared to the baseline (without relying on data augmentation). In particular, stratified random sampling and uniform random sampling show the best improvement in detection performance with only a modest increase in computation time, whereas the data augmentation scheme using Generative Adversarial Networks is the most time-consuming with limited performance benefits.

关键词： Data augmentation Federated learning Internet of things Anomaly detection Machine learning

Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis

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World Journal of Gastroenterology 2016年第12期22卷 3486-3495页

作者： Li-Jun Du Bin-Rui Chen john J kim Sarah kim Jin-Hua Shen Ning Dai Department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University Hangzhou 310020 Zhejiang Province China Division of Gastroenterology Loma Linda University Loma Linda CA 92354 United States

AIM: To evaluate whether Helicobacter pylori (H. pylori) eradication therapy benefits patients with functional dyspepsia (FD).METHODS: Randomized controlled trials (RCTs) investigating the efficacy and safety of H. pylori eradication therapy for patients with functional dyspepsia published in English (up to May 2015) were identified by searching PubMed, EMBASE, and The Cochrane Library. Pooled estimates were measured using the fixed or random effect model. Overall effect was expressed as a pooled risk ratio (RR) or a standard mean difference (SMD). All data were analyzed with Review Manager 5.3 and Stata ***: This systematic review included 25 RCTs with a total of 5555 patients with FD. Twenty-three of these studies were used to evaluate the benefits of H. pylori eradication therapy for symptom improvement; the pooled RR was 1.23 (95%CI: 1.12-1.36, P < 0.0001). H. pylori eradication therapy demonstrated symptom improvement during long-term follow-up at ≥ 1 year (RR = 1.24; 95%CI: 1.12-1.37, P < 0.0001) but not during short-term follow-up at < 1 year (RR = 1.26; 95%CI: 0.83-1.92, P = 0.27). Seven studies showed no benefit of H. pylori eradication therapy on quality of life with an SMD of -0.01 (95%CI: -0.11 to 0.08, P = 0.80). Six studies demonstrated that H. pylori eradication therapy reduced the development of peptic ulcer disease compared to no eradication therapy (RR = 0.35; 95%CI: 0.18-0.68, P = 0.002). Eight studies showed that H. pylori eradication therapy increased the likelihood of treatment-related side effects compared to no eradication therapy (RR = 2.02; 95%CI: 1.12-3.65, P = 0.02). Ten studies demonstrated that patients who received H. pylori eradication therapy were more likely to obtain histologic resolution of chronic gastritis compared to those who did not receive eradication therapy (RR = 7.13; 95%CI: 3.68-13.81, P < 0.00001).CONCLUSION: The decision to eradicate H. pylori in patients with functional

关键词： Functional dyspepsia Helicobacter pylori eradication Symptom improvement Quality of life Peptic ulceration Meta-analysis

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乐活健康

空中英语教室（高级版．彭蒙惠英语） 2024年第1期 10-11,39,40页

作者： Patrick McCreless john Meyer 不详

03一名医生从自己的中风体验中学到的三件事或许能拯救你的生命当朱利安·金医生正在示范一个小型外科手术时,他走路开始出现异常。他自己没有注意到,但手术室里有人注意到了“当时我脑出血了……和高血压有关,”金医生说,“我甚至不知... 详细信息

03一名医生从自己的中风体验中学到的三件事或许能拯救你的生命当朱利安·金医生正在示范一个小型外科手术时,他走路开始出现异常。他自己没有注意到,但手术室里有人注意到了“当时我脑出血了……和高血压有关,”金医生说,“我甚至不知道我有高血压。”

关键词：外科手术高血压手术室脑出血医生朱利安

Towards smart farming solutions in the *** South Korea:A comparison of the current status

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Geography and Sustainability 2021年第4期2卷 312-327页

作者： Susan A.O’Shaughnessy Minyoung kim Sangbong Lee Youngjin kim Heetae kim john Shekailo USDA-ARS Conservation and Production Research Laboratory2300 Experiment Station RDBushlandTexas USA 79012 R&D Coordination Division Rural Development Administration54875Republic of Korea National Institute of Agricultural Sciences Rural Development Administration54875Republic of Korea USDA-ARS Office of International Research Engagement and CooperationBeltsvilleMD 20705

Smart farming solutions combine information,data software tools,and technology with the intent to improve agricultural *** smart farming concepts are well described in the literature,the potential societal impacts of smart farming are less *** demonstrate how smart farming solutions could influence future agricultural production,agri-business and rural communities and their constituents,this article compares smart farming approaches and reasons behind the pursuit of smart farming solutions by the *** South *** article compares agricultural assets and productivity among the two countries as well as the technical and societal challenges impacting agricultural production as a basis to understanding the motivations behind and pathways for developing smart farming *** doing so,the article compares some of the technological and social advantages and disadvantages of smart farming,dependending on the choice and implementation of smart farming *** South Korean government has implemented a national policy to establish smart farming communities;a concept that addresses the entire agri-food supply *** the U.S.,a national plan to develop smart farming technologies does not ***,discrete smart farming solutions driven mainly by competition in the private sector have resulted in high-tech solutions that are advancing smart farming *** differences in approaches and reporting of successes and failures between the two countries could facilitate the rate of evolution of successful smart farming solutions,and moreover,could provide pathways to facilitate sustainable development goals in developing countries where smart farming activities are currently underway.

关键词： Agri-food Climate change Information technology Sustainable agriculture

Gastrointestinal tract(gut) health in the young pig

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Animal Nutrition 2018年第2期4卷 187-196页

作者： john R.Pluske Diana L.Turpin Jae-Cheol kim School of Veterinary and Life Sciences Murdoch University Pork Innovation Western Australia(Inc.) AB Vista Asia Pte.Ltd

An optimally functioning gastrointestinal tract(GIT) clearly is of importance to the overall metabolism,physiology, disease status and performance of pigs of all stages of growth and ***, the‘health’ of the GIT(‘gut health’) has attracted much attention despite the lack of a clear definition to the term or its aetiology, although in broad terms, ‘gut health’ encompasses a number of physiological and functional features including nutrient digestion and absorption, host metabolism and energy generation, a stable and appropriate microbiota/microbiome, defence mechanisms including barrier function and mucosal immune mechanisms, and the interactions between these components.‘Gut health’ in the newlyweaned(young) pig is of obvious interest due to changes in GIT structure and function associated with the post-weaning transition, and more recently to the upsurge in interest in different feed additives as dietary alternatives/replacements caused by bans/reductions in certain antimicrobial compounds being available in some parts of the *** the presence of enteric disease(s) after weaning, a deterioration in ‘gut health’ may be synonymous to the overall health of the pig, and although some direct relationships can be drawn between pig performance and efficiency and a ‘healthy' GIT, sometimes this connection is subtler and less obvious, especially in the absence of overt enteric disease(s).The factors and conditions involved in ‘gut health’ are multifactorial, complex, often poorly described and sometimes incorrectly interpreted,although it is evident that perturbations of the GIT can cause an imbalance and disturb the generalized *** addition to any enteric diseases or conditions that might arise as a result of these disturbances, other influences will also impact such as the responses occurring in the GIT in the period immediately after weaning, any changes that might occur after a change in diet, and(or) disruptions to meal patterns and hence

关键词： Gastrointestinal tract Gut health Structure and function Pig Piglet Weaning

A strain-isolation design for stretchable electronics

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Acta Mechanica Sinica 2010年第6期26卷 881-888页

作者： Jian Wu Ming Li Wei-Qiu Chen Dae-Hyeong kim Yun-Soung kim Yong-Gang Huang Keh-Chih Hwang Zhan Kang john A.Rogers Departments of Civil and Environmental Engineering and Mechanical EngineeringNorthwestern University EvanstonIL 60208USA Department of Engineering Mechanics Dalian University of TechnologyDalian 116024China Department of Engineering Mechanics Zhejiang University Hangzhou 310058China Materials Research Laboratory Department of Materials Science and EngineeringBeckman Institute.University of Illinois UrbanaIL 61801USA AML Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China Departments of Chemistry Electrical and Computer Engineering and Mechanical Science and EngineeringUniversity of Illinois UrbanaIL 61801USA

Stretchable electronics represents a direction of recent development in next-generation semiconductor *** systems have the potential to offer the performance of conventional wafer-based technologies,but they can be stretched like a rubber band,twisted like a rope, bent over a pencil,and folded like a piece of *** the active devices from strains associated with such deformations is an important aspect of *** strategy involves the shielding of the electronics from deformation of the substrate through insertion of a compliant adhesive layer. This paper establishes a simple,analytical model and validates the results by the finite element *** results show that a relatively thick,compliant adhesive is effective to reduce the strain in the electronics,as is a relatively short film.

关键词： Strain isolation Thin film Substrate Adhesive Stretchable electronics

CIPK9: a calcium sensor-interacting protein kinase required for low-potassium tolerance in Arabidopsis

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Cell Research 2007年第5期17卷 411-421页

作者： Girdhar K Pandey Yong Hwa Cheong Beom-Gi kim john J Grant Legong Li Department of Plant and Microbial Biology University of CaliforniaBerkeley CA 94720USA

Potassium is one of the major macro-nutrients essential for a number of cellular processes in plants. Low potassiumlevel in the soil represents a limiting factor for crop production. Recent studies have identified potassium transporters thatare involved in potassium acquisition, and some of them are critical for potassium nutrition under low potassium condi-tions. However, little is understood on the molecular components involved in low potassium signaling and responses. Wereport here the identification of a calcineurin B-like protein-interacting protein kinase （CIPK9） as a critical regulator oflow potassium response in Arabidopsis. The CIPK9 gene was responsive to abiotic stress conditions, and its transcriptwas inducible in both roots and shoots by potassium deprivation. Disruption of CIPK9 function rendered the mutantplants hypersensitive to low potassium media. Further analysis indicated that K+uptake and content were not affected inthe mutant plants, implying CIPK9 in the regulation of potassium utilization or sensing processes.

关键词： calcium calcineurin-B like protein protein kinase potassium nutrition signal transduction

Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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Cancer Communications 2022年第8期42卷 716-749页

作者： Jang Hee Han Yong Keon kim Hakhyun kim Jooyoung Lee Myung Joon Oh Sang Bum kim Minjee kim Kook Hwan kim Hyun Ju Yoon Myung-Shik Lee john D.Minna Michael A.White Hyun Seok kim Severance Biomedical Science Institute Yonsei University College of MedicineSeoul 03722Korea Department of Medical Science Yonsei University Graduate SchoolSeoul 03722Korea Department of Urology Seoul National University HospitalSeoul 03722Korea Checkmate Therapeutics Inc. Seoul 07207Korea Hamon Center for Therapeutic Oncology Research University of Texas Southwestern Medical CenterDallasTexas 75390USA Department of Cell Biology University of Texas Southwestern Medical CenterDallasTexas 75390USA Graduate School of Medical Science Brain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Korea

Background: Autophagy is elevated in metastatic tumors and is often associatedwith active epithelial-to-mesenchymal transition (EMT). However, the extent towhich EMT is dependent on autophagy is largely unknown. This study aimed toidentify the mechanisms by which autophagy facilitates ***: We employed a liquid chromatography-based metabolomic approachwith kirsten rat sarcoma viral oncogene (KRAS) and liver kinase B1 (LKB1)gene co-mutated (KL) cells that represent an autophagy/EMT-coactivatedinvasive lung cancer subtype for the identification of metabolites linked to autophagy-driven EMT activation. Molecular mechanisms of autophagy-drivenEMT activation were further investigated by quantitative real-time polymerasechain reaction (qRT-PCR), Western blotting analysis, immunoprecipitation,immunofluorescence staining, and metabolite assays. The effects of chemicaland genetic perturbations on autophagic flux were assessed by two orthogonalapproaches: microtubule-associated protein 1A/1B-light chain 3 (LC3) turnoveranalysis by Western blotting and monomeric red fluorescent protein-greenfluorescent protein (mRFP-GFP)-LC3 tandem fluorescent protein quenchingassay. Transcription factor EB (TFEB) activity was measured by coordinatedlysosomal expression and regulation (CLEAR) motif-driven luciferase reporterassay. Experimental metastasis (tail vein injection) mouse models were used toevaluate the impact of calcium/calmodulin-dependent protein kinase kinase 2(CAMKK2) or ATP citrate lyase (ACLY) inhibitors on lung metastasis using IVISluciferase imaging ***: We found that autophagy in KL cancer cells increased acetyl-coenzymeA (acetyl-CoA), which facilitated the acetylation and stabilization of theEMT-inducing transcription factor Snail. The autophagy/acetyl-CoA/acetylSnail axis was further validated in tumor tissues and in autophagy-activatedpancreatic cancer cells. TFEB acetylation in KL cancer cells sustained prometastatic autophagy in a mammalian target o

关键词： snail autophagy acetyl-coenzyme A epithelial-to-mesenchymal transition non-small-cell lung cancer CAMKK2 acetyl-snail pancreatic cancer KRAS inhibitor metastasis ACLY