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International Journal of Coal Science & Technology 2024年第2期11卷 53-66页

作者： Parviz Enany carsten Drebenshtedt Faculty of Mining and Special Civil Engineering Technische Universitat BergakademieGustav-Zeuner StraBe 1A09599FreibergGermany

In this study,the installation of an airlift pump with inner diameter of 102 mm and length of 5.64 m was utilized to consider the conveying process of non-spherical coal particles with density of 1340 kg/m3 and graining 25-44.5 *** test results revealed that the magnitude of increase in the solid transport rate due to the changes in the three tested parameters between compressed air velocity,submergence ratio,and feeding coal possibility was not the same,which are stand in range of 20%,75%,and 40%,***,creating the optimal airlift pump performance is highly dependent on submergence *** importantly,we measured the solid volume fraction using the method of one-way valves in order to minimize the disadvantages of conventional devices,such as fast speed camera and conductivity ring *** results confirmed that the volume fraction of the solid phase in the transfer process was always less than 12%.To validate present experimental data,the existing empirical correlations together with the theoretical equations related to the multiphase flow was *** overall agreement between the theory and experimental solid delivery results was particularly good instead of the first stage of conveying *** drawback can be corrected by omitting the role of friction and shear stress at low air income *** was also found that the model developed by Kalenik failed to predict the performance of our airlift operation in terms of the mass flow rate of the coal particles.

关键词： Vertical velocity Non-spherical particle Submergence ratio Three-phase flow Churn flow Superficial velocity

2019 ESC-HFA射血分数保留性心力衰竭诊断共识的解读

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心血管病学进展 2019年第9期40卷 1193-1195,1211页

作者：徐俊波黄刚蔡琳 tsch?pe carsten 成都市心血管病研究所成都市第三人民医院心血管内科西南交通大学附属医院重庆医科大学附属成都第二医院柏林夏立特医学院魏尔啸医院内科及心脏内科德国心血管研究中心柏林分中心

心力衰竭(心衰)作为各种心脏疾病的严重临床表现或晚期阶段,有较高的死亡率和再入院率,已成为主要的疾病负担之一。发达国家成人心衰患病率为1%~2%,而70岁以上人群患病率约10%[1],中国35~74岁人群心衰患病率约0.9%[2]。西方国家60岁以... 详细信息

心力衰竭(心衰)作为各种心脏疾病的严重临床表现或晚期阶段,有较高的死亡率和再入院率,已成为主要的疾病负担之一。发达国家成人心衰患病率为1%~2%,而70岁以上人群患病率约10%[1],中国35~74岁人群心衰患病率约0.9%[2]。西方国家60岁以上普通人群射血分数保留性心衰(heart failure with preserved ejection fraction,HFpeF)的患病率约4.9%,而HFpeF占因心衰入院的50%以上[3]。65岁以上人群因劳力性呼吸困难初次就诊,约有1/6心衰未能被识别,其中大部分是HFpeF[1]。2016 ESC心衰指南[1]对HFpeF并未提出具体的诊断流程,而2018中国心衰指南[2]对HFpeF的诊断亦未做具体的叙述和深入的建议。

关键词：诊断流程疾病负担 ESC 普通人群

Unraveling the gut-brain axis:the impact of steroid hormones and nutrition on Parkinson's disease

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Neural Regeneration Research 2024年第10期19卷 2219-2228页

作者： Paula Maria Neufeld Ralf A.Nettersheim Veronika Matschke Matthias Vorgerd Sarah Stahlke carsten Theiss Department of Cytology Institute of AnatomyMedical FacultyRuhr-University BochumBochumGermany Department of Visceral Surgery University Hospital BergmannsheilRuhr-University BochumBochumGermany Department of Neurology Heimer Institute for Muscle ResearchUniversity Hospital BergmannsheilRuhr-University BochumBochumGermany

This comprehensive review explores the intricate relationship between nutrition,the gut microbiome,steroid hormones,and Parkinson's disease within the context of the gut-brain *** gut-brain axis plays a pivotal role in neurodegenerative diseases like Parkinson's disease,encompassing diverse components such as the gut microbiota,immune system,metabolism,and neural *** gut microbiome,profoundly influenced by dietary factors,emerges as a key *** during the first 1000 days of life shapes the gut microbiota composition,influencing immune responses and impacting both child development and adult ***-fat,high-sugar diets can disrupt this delicate balance,contributing to inflammation and immune *** nutritional strategies,the Mediterranean diet's anti-inflammatory and antioxidant properties show promise in reducing Parkinson's disease ***-targeted dietary approaches and the ketogenic diet hold the potential in improving brain *** nutrition,emerging research uncovers potential interactions between steroid hormones,nutrition,and Parkinson's ***,with its anti-inflammatory properties and presence in the nervous system,offers a novel option for Parkinson's disease *** ability to enhance neuroprotection within the enteric nervous system presents exciting *** review addresses the hypothesis thatα-synuclein aggregates originate from the gut and may enter the brain via the vagus *** symptoms preceding motor symptoms support this *** gut-brain signaling during gut dysbiosis contributes to inflammation and neurotransmitter imbalances,emphasizing the potential of microbiota-based *** summary,this review uncovers the complex web of interactions between nutrition,the gut microbiome,steroid hormones,and Parkinson's disease within the gut-brain axis *** these connections not only offers novel therapeutic insi

关键词： diet gut-brain axis microbiome neurodegenerative diseases nutrition Parkinson's disease progesterone steroid hormones

Effect of low concentration electrolytes on the formation and corrosion resistance of peO coatings on AM50 magnesium alloy

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Journal of Magnesium and Alloys 2024年第4期12卷 1386-1405页

作者： peng Xie carsten Blawert Maria Serdechnova Natalia Konchakova Tatsiana Shulha Ting Wu Mikhail L.Zheludkevich Institute of Surface Science Helmholtz-Zentrum HereonMax-Planck Strasse 121502 GeesthachtGermany Institute for Materials Science Faculty of EngineeringKiel UniversityKaiserstrasse 224143 KielGermany

In this paper,the formation process,morphology,and electrochemical performance of peO coatings on AM50 magnesium alloy prepared in low concentration phosphate,aluminate,and phosphate-aluminate electrolytes were systematically *** results show that the coatings prepared from the phosphate electrolytes have a higher thickness and better corrosion resistance properties compared to the other *** coatings prepared from low concentration phosphate-aluminate mixed electrolytes have slightly thinner thickness,a similar coating structure and an order of magnitude lower value of electrochemical impedance compared with phosphate electrolyte *** Coatings prepared from low concentration aluminate electrolytes have the lowest thickness and the worst corrosion resistance properties which gets close to corrosion behavior of the bare AM50 under the same test *** application,coatings prepared from single low concentration phosphate electrolytes and low concentration phosphate-aluminate electrolytes have greater potential than single low concentration aluminate ***,reducing the electrolyte concentrations of coating forming ions too much has negative influence on the coating growth rate.

关键词： Plasma electrolytic oxidation Low concentration electrolytes Corrosion resistance AM50 magnesium alloy

Hypoxia in the pulmonary vein increases pulmonary vascular resistance independently of oxygen in the pulmonary artery

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Animal Models and Experimental Medicine 2024年第2期7卷 156-165页

作者： Sigridur Olga Magnusdottir carsten Simonsen Dan Stieper Karbing Bodil Steen Rasmussen Benedict Kjaergaard Biomedical Research Laboratory Aalborg University HospitalAalborgDenmark Department of Clinical Medicine Aalborg UniversityAalborgDenmark Department of Cardiothoracic Surgery Aalborg University HospitalAalborgDenmark Department of Health Science and Technology Aalborg UniversityAalborgDenmark Department of Anesthesia and Intensive Care Aalborg University HospitalAalborgDenmark

Introduction:Hypoxic pulmonary vasoconstriction(HPV)can be a challenging clinical *** is not fully elucidated where in the circulation the regulation of resistance takes *** is often referred to as if it is in the arteries,but we hypothesized that it is in the venous side of the pulmonary ***:In an open thorax model,pigs were treated with a veno-venous extra corporeal membrane oxygenator to either oxygenate or deoxygenate blood passing through the pulmonary *** the same time the lungs were ventilated with extreme variations of inspired air from 5%to 100%oxygen,making it possible to make combinations of high and low oxygen content through the pulmonary circulation.A flow probe was inserted around the main pulmonary artery and catheters in the pulmonary artery and in the left atrium were used for pressure monitoring and blood *** different combinations of oxygenation,pulmonary vascular resistance(PVR)was ***:With unchanged level of oxygen in the pulmonary artery and reduced inspired oxygen fraction lowering oxygen tension from 29 to 6.7 kPa in the pulmonary vein,PVR was *** more extreme hypoxia PVR suddenly *** with low oxygenation in the pulmonary artery did not systematic influence PVR if there was enough oxygen in the inspired air and in the pulmonary ***:The impact of hypoxia occurs from the alveolar level and forward with the blood *** experiments indicated that the regulation of PVR is mediated from the venous side.

关键词： animal models cardiopulmonary support Hypoxic pulmonary vasoconstriction pulmonary circulation

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铁配合型镁合金缓蚀剂的阴极阻蚀机制

Transactions of Nonferrous Metals Society of China 2024年第5期34卷 1496-1506页

作者：杨俊杰王霖倩 carsten BLAWERT Sviatlana VLAMAKA Christian FEILER Mikhail LZHELUDKEVICH 李卫暨南大学先进耐磨蚀及功能材料研究院广州510632 暨南大学韶关研究院韶关512027 Institute of Surface Science Helmholtz-Zentrum Hereon(Hereon)21502 GeesthachtGermany Faculty of Engineering University of KielKaiserstraße 224143 KielGermany

研究阴极缓蚀剂(3-甲基水杨酸盐,3-MeSA)对含铁纯镁腐蚀性能的影响。高铁杂质颗粒成分、腐蚀表面形貌以及3-MeSA分子结构特征为揭示含铁镁合金的腐蚀行为及3-MeSA的阴极型阻蚀机理提供了实验与理论依据。研究结果表明:含铁杂质颗粒中含... 详细信息

研究阴极缓蚀剂(3-甲基水杨酸盐,3-MeSA)对含铁纯镁腐蚀性能的影响。高铁杂质颗粒成分、腐蚀表面形貌以及3-MeSA分子结构特征为揭示含铁镁合金的腐蚀行为及3-MeSA的阴极型阻蚀机理提供了实验与理论依据。研究结果表明:含铁杂质颗粒中含有固溶态硅,而Fe/Si比可能是导致不同局部腐蚀形态差异的主要原因。虽然3-MeSA能在镁基体上形成吸附层,但其阻蚀机制主要归因于其螯合从富铁颗粒中自腐蚀释放Fe^(2+)/Fe^(3+)的能力,阻止被还原的铁物质再次沉积至腐蚀金属表面。

关键词：镁富铁杂质铁配合剂阴极型缓蚀剂量子化学计算

Diagnostic delay in inflammatory bowel diseases in a German population

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World Journal of Gastroenterology 2024年第29期30卷 3465-3478页

作者： Elisabeth Blüthner Annalena Dehe carsten Büning Britta Siegmund Matthias Prager Jochen Maul Alexander Krannich Jan Preiß Bertram Wiedenmann Florian Rieder Raneem Khedraki Frank Tacke Andreas Sturm Anja Schirbel Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Vivantes Klinikum im FriedrichshainBerlin 10249Germany Department of Internal Medicine Krankenhaus WaldfriedeBerlin 14163Germany Department of Gastroenterology Infectious Diseases and RheumatologyCharité-Universitätsmedizin BerlinBerlin 12203Germany Praxis für Gastroenterologie Berlin Zehlendorf Berlin 14195Germany Gastroenterologie am Bayrischen Platz Berlin 10825Germany Clinical Trial Office Charité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Diabetology and HepatologyVivantes Klinikum NeuköllnBerlin 10117Germany Department of Gastroenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine DRK Kliniken Berlin WestendBerlin 14050Germany Gastroenterologie im Havelland Straße der EinheitFalkensee 14612Germany

BACKGROUND Early diagnosis is key to prevent bowel damage in inflammatory bowel disease(IBD).Risk factor analyses linked with delayed diagnosis in European IBD patients are scarce and no data in German IBD patients *** To identify risk factors leading to prolonged diagnostic time in a German IBD *** Between 2012 and 2022,430 IBD patients from four Berlin hospitals were enrolled in a prospective study and asked to complete a 16-item questionnaire to determine features of the path leading to IBD *** diagnostic time was defined as the time from symptom onset to consulting a physician(patient waiting time)and from first consultation to IBD diagnosis(physician diagnostic time).Univariate and multivariate analyses were performed to identify risk factors for each time *** The total diagnostic time was significantly longer in Crohn’s disease(CD)compared to ulcerative colitis(UC)patients(12.0 vs 4.0 mo;Pperformed gastroscopy(P=0.042)were associated with longer physician diagnostic time in CD *** UC,fever was correlated(P=0.020)with shorter physician diagnostic time,while fatigue(P=0.011)and positive family history(P=0.046)were correlated with longer physician diagnostic *** We demonstrated that CD patients compared to UC are at risk of long diagnostic *** efforts should focus on shortening the diagnostic delay for a better outcome in these patients.

关键词： Diagnostic time Diagnostic delay Crohn’s disease Ulcerative colitis Germany

Chlorination of para-substituted phenols:Formation of α, β-unsaturated C4-dialdehydes and C4-dicarboxylic acids

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Journal of Environmental Sciences 2022年第7期34卷 197-208页

作者： Zhuoyue Zhang carsten Prasse Department of Environmental Health and Engineering Johns Hopkins UniversityBaltimoreMD 21218USA

Despite the widespread occurrence of phenols in anthropogenic and natural compounds, their fate in reactions with hypochlorous acid(HOCl), one of the most common water treatment disinfectants, remains incompletely understood. To close this knowledge gap, this study investigated the formation of disinfection by-products(DBPs) in the reaction of free chlorine with seven para-substituted phenols. Based on the chemical structures of the DBPs and the reaction mechanisms leading to their formation, the DBPs were categorized into four groups: chlorophenols, coupling products, substituent reaction products, and ring cleavage products. In contrast to previous studies that investigated the formation of earlystage chlorophenols, the primary focus of this study was on the elucidation of novel ring cleavage products, in particular α, β-unsaturated C-dialdehydes, and C-dicarboxylic acids, which, for the first time, were identified and quantified in this study. The molar yields of 2-butene-1,4-dial(BDA), one of the identified α, β-unsaturated C-dialdehydes, varied among the different phenolic compounds, reaching a maximum value of 10.4% for bisphenol S. Molar yields of 2-chloromaleic acid(Cl-MA), one of the identified C-dicarboxylic acids, reached a maximum value of 30.5% for 4-hydroxy-phenylacetic acid under given conditions. 2,4,6-trichlorophenol(TCP) was shown to be an important intermediate of the parent phenols and the C-ring cleavage products. Based on the temporal trends of α, β-unsaturated C-dialdehydes and C-dicarboxylic acids, their formation is likely attributable to two separate ring cleavage pathways. Based on the obtained results, an overall transformation pathway for the reaction of para-substituted phenols with free chlorine leading to the formation of novel Cring cleavage products was proposed.

关键词： High-resolution mass spectrometry Ring cleavage products Quantification Transformation pathways Mass balance

Evaluation of airlift pump performance for vertical conveying of coal particles

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International Journal of Coal Science & Technology 2023年第3期10卷 155-166页

作者： Parviz Enany Oleksandr Shevchenko carsten Drebenshtedt Faculty of Mining and Special Civil Engineering Technische Universitat BergakademieGustav-Zeuner StraBe 1A09599 FreibergGermany UTF GmbH ErzstraBe 1509618 Brand-ErbisdorfGermany

One of the crucial aspects of reducing air consumption when conveying particles with an airlift pump is to know the factors that affect the process of particle motion at an initial velocity of *** determine the influence of submer-gence ratio and physical properties of particles(such as size,shape,and mass)on the onset of vertical particle motion,the airlift pump was taken as the research object,and spherical glass together with irregular shaped coal were used as experimental test *** results show that unlike the water-solid environment,the start of particle motion in the water-air mixture does not always occur at a certain value of superficial water velocity and this value also increases with increasing submergence *** the parameters considered,the role of submergence ratio is much more effective than the dimensions and the shape of the particle,because by increasing submergence from 0.3 to 0.8,it is possible to reduce air consumption by up to 8 *** on this study the corresponding theoretical model derived by Fujimoto et *** optimized,wherein the overall agreement between the modified theory and present experimental data is particularly *** to Fujimoto,the minimum superficial water velocity for lifting solids in the air-water mixture is not always smaller than water ambient which indicates on optimum submergence ratio higher than ***,a new criterion was introduced to describe the moment of onset of the particle motion as a function of the superficial fluid velocity ratio for each submergence value.

关键词： Air-water-solid flow Slurry- Coal Submergence ratio Taylor bubble Superficial velocity

Significance of intercellular communication for neurodegenerative diseases

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Neural Regeneration Research 2022年第5期17卷 1015-1017页

作者： Hilal Cihankaya carsten Theiss Veronika Matschke Ruhr University Bochum Medical FacultyInstitute of AnatomyDepartment of CytologyBochumGermany International Graduate School of Neuroscience(IGSN) Ruhr-University BochumBochumGermany

The nervous system is a highly complex organization composed of its basicunit,the neuronal cells,and specialized supporting cells,the glial *** main glial cells in the central nervous system(CNS)are astrocytes,microgl... 详细信息

关键词： cytes diseases degenerative