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Influence of capsaicin infusion on secondary peristalsis in patients with gastroesophageal reflux disease

World Journal of Gastroenterology 2016年第45期22卷 10045-10052页

作者： Chih-Hsun Yi wei-Yi Lei Jui-Sheng Hung Tso-Tsai Liu chien-Lin Chen Fabio Pace Department of Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University Division of Gastroenterology Department of Clinical Sciences L. Sacco University Hospital

AIM To determine whether capsaicin infusion could influence heartburn perception and secondary peristalsis in patients with gastroesophageal reflux disease(GERD). METHODS Secondary peristalsis was performed with slow and rapid mid-esophageal injections of air in 10 patients with GERD. In a first protocol, saline and capsaicincontaining red pepper sauce infusions were randomly performed, whereas 2 consecutive sessions of capsaicin-containing red pepper sauce infusions were performed in a second protocol. Tested solutions including 5 m L of red pepper sauce diluted with 15 m L of saline and 20 m L of 0.9% saline were infused into the mid-esophagus via the manometric catheter at a rate of 10 mL /min with a randomized and doubleblind fashion. During each study protocol, perception of heartburn, threshold volumes and peristaltic parameters for secondary peristalsis were analyzed and compared between different *** Infusion of capsaicin significantly increased heartburn perception in patients with GERD(P < 0.001), whereas repeated capsaicin infusion significantly reduced heartburn perception(P = 0.003). Acute capsaicin infusion decreased threshold volume of secondary peristalsis(P = 0.001) and increased its frequency(P = 0.01) during rapid air injection. The prevalence of GERD patients with successive secondary peristalsis during slow air injection significantly increased after capsaicin infusion(P = 0.001). Repeated capsaicin infusion increased threshold volume of secondary peristalsis(P = 0.002) and reduced the frequency of secondary peristalsis(P = 0.02) during rapid air injection. CONCLUSION Acute esophageal exposure to capsaicin enhances heartburn sensation and promotes secondary peristalsis in gastroesophageal reflux disease, but repetitive capsaicin infusion reverses these effects.

关键词： Capsaicin Esophageal motility Secondary peristalsis Esophageal manometry Gastroesophageal reflux disease

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Training gastroenterology fellows to perform gastric polypectomy using a novel ex vivo model

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World Journal of Gastroenterology 2011年第41期17卷 4619-4624页

作者： Ming-Jen Chen Ching-Chung Lin Chia-Yuan Liu Chih-Jen Chen Chen-Wang Chang Ching-wei Chang chien-wei Lee Shou-Chuan Shih Horng-Yuan Wang Division of Gastroenterology Department of Internal MedicineMackay Memorial Hospital Mackay Medicine Nursing and Management College Clinical Skills Training Center Department of Medical EducationMackay Memorial Hospital Mackay Medical College

AIM:To evaluate the effect of hands-on training of gastroenterology fellows in gastric polypectomy using an ex vivo ***:Eight gastroenterology fellows at Mackay Memorial Hospital,Taipei were evaluated in gastricpolypectomy techniques using a pig stomach with artificial polyps created by a rubber band ligation *** performance of four second year(year-2)fellows who had undergone one year of clinical training was compared with that of four f irst year(year-1)fellows both before and after a 4-h workshop using the ex vivo *** workshop allowed for hands-on train-ing in the removal of multiple artif icial polyps and the placement of hemoclips at the excision *** included observation of technical skills,procedure time,and the fellows' conf idence ***:One week after the workshop,the year-1 fellows were re-evaluated and had significantly im-proved mean performance scores(from 17.9 ± 1.8 to 22.5 ± 0.7),conf idence scale(from 4.5 ± 1.0 to 7.8 ± 0.5)and procedure time(from 615.0 ± 57.4 s to 357.5 ± 85.0 s)compared with their baseline *** 4 h of training using the ex vivo simulator,the skills of the year-1 fellows were statistically similar to those of the year-2 ***:Use of this ex vivo simulator significantly improved the endoscopic gastric polypectomy skills of gastroenterology fellows who had not had previous clinical training in gastric polypectomy.

关键词： Ex vivo Animal tissue model Hands-on training Pig stomach Polypectomy

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Severe heterotopic ossification in a seronegative spondyloarthritis patient after cervical Bryan disc arthroplasty: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3047-3054页

作者： Chih-wei Huang chien-Lun Tang Hung-Chuan Pan Chung-Yuh Tzeng Hsi-Kai Tsou Neurological Institute Taichung Veterans General HospitalTaichung 407Taiwan Functional Neurosurgery Division Neurological InstituteTaichung Veterans General HospitalTaichung 407Taiwan Faculty of Medicine School of MedicineNational Yang-Ming UniversityTaipei 112Taiwan Division of Joint Reconstruction Department of OrthopedicsTaichung Veterans General HospitalTaichung 407Taiwan Department of Medicinal Botanicals and Health Applications Da-Yeh UniversityChanghua County 515Taiwan Department of Rehabilitation Jen-Teh Junior College of MedicineNursing and ManagementMiaoli County 356Taiwan

BACKGROUND Cervical disc arthroplasty(CDA)is an alternative treatment to traditional interbody fusion that maintains postoperative cervical spine ***,the CDA postoperative period is impacted by osteolysis,subsidence,metallosis,or heterotopic ossification(HO).We report a case of severe HO in a seronegative spondyloarthritis patient after cervical Bryan disc *** SUMMARY A 34-year-old man received hybrid surgery for C4-C5 and C5-C6 arthroplasty with Bryan discs and C6-C7 arthrodesis with polyetheretherketone cage due to traumatic herniation of the intervertebral disc(HIVD).After four years,cervical spine radiographs revealed severe HO around the Bryan discs over the C4-C5 and C5-C6 *** magnetic resonance image revealed HIVD over the C3-C4 level with spinal cord *** spondyloarthritis was diagnosed after consultation with a rheumatologist.A second CDA for the adjacent segment disease HIVD with Baguera C disc over the C3-C4 level achieved an excellent *** Minimizing intraoperative tissue trauma and achieving postoperative interbody stability avoid soft tissue traction to prevent HO formation after CDA.

关键词： Seronegative spondyloarthritis Disc arthroplasty Heterotopic ossification Case report

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The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： Jun Chen Shuotao Wang Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of *** individuals have made significant contributions to the field of nanoscience and *** the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and *** focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in *** extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions

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Preservation of superior rectal artery in laparoscopically assisted subtotal colectomy with ileorectal anastomosis for slow transit constipation

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World Journal of Gastroenterology 2021年第22期27卷 3121-3129页

作者： chien-wei Wu Ta-wei Pu Jung-Cheng Kang Cheng-Wen Hsiao Chao-Yang Chen Je-Ming Hu Kuan-Hsun Lin Tzu-Chiao Lin Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Colon and Rectal Surgery Department of SurgerySongshan BranchTri-Service General HospitalNational Defense Medical CenterTaipei 10581Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 10556Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Colorectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan

BACKGROUND Slow transit constipation(STC)has traditionally been considered as a functional ***,evidence is accumulating that suggests that most of the motility alterations in STC might be of a neuropathic *** the patient does not meet the diagnosis of pelvic outlet obstruction and poorly response to conservative treatment,surgical intervention with subtotal colectomy may be *** most unwanted complication of the procedure is anastomotic leakage,however,preservation of the superior rectal artery(SRA)may reduce its *** To evaluate the preservation of the SRA in laparoscopically assisted subtotal colectomy with ileorectal anastomosis in STC *** This was a single-center retrospective observational *** was diagnosed after a series of examinations which included a colonic transit test,anal manometry,a balloon expulsion test,and a barium *** patients underwent laparoscopically assisted total colectomy with ileorectal anastomosis and were examined between January 2016 and January *** operation time,blood loss,time to first flatus,length of hospital days,and incidence of minor or major complications were *** A total of 32 patients(mean age,42.6 years)who had received laparoscopic assisted subtotal colectomy with ileorectal artery anastomosis and preservation of the *** patients were diagnosed with STC after a series of *** mean operative time was 151 min and the mean blood loss was 119 *** mean day of first time to flatus was 3.0 d,and the mean hospital stay was 10.6 *** were no any patients conversions to ***-operative minor complications including 1 wound infection and 1 case of *** was no surgical *** anastomosis leakage was noted in any of the *** Laparoscopically assisted subtotal colectomy with ileorectal anastomosis and preservation of the SRA can significantly improve bowel function with careful patient selection

关键词： Slow transit constipation Superior rectal artery Anastomosis leakage Laparoscopic-assisted colorectal surgery Iliorectal anastomosis Colonic transit time

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CONTINUOUS BEAMS WITH NON-UNIFORM STIFFNESS~*

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Science in China,Ser.A 1953年第2期 116-126页

作者： chien wei-ZANG (Tsing HUniversity)

In this paper, the method of continued fraction is used for the determination of bending moments of a continuous beam with non-uniform stiffness. Let us first consider a continuous beam supported on n+1 supports and

关键词： CONTINUOUS BEAMS WITH NON-UNIFORM STIFFNESS

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Association between the elderly frequent attender to the emergency department and 30-day mortality： A retrospective study over 10 years

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World Journal of Emergency Medicine 2018年第1期9卷 20-25页

作者： Yuzeng Shen Yee chien Tay Edward Wee Kwan Too Nan Liu Shao wei Lam Marcus Eng Hock Ong Department of Emergency Medicine Singapore General Hospital Singapore Department of Emergency Medicine Sengkang Health Singapore Business Analytics Program National University of Singapore Singapore Singhealth Health Selvices Research Centre Singapore

BACKGROUND: To determine if elderly frequent attenders are associated with increased 30-day mortality, assess resource utilization by the elderly frequent attenders and identify associated characteristics that contribute to mortality. METHODS: Retrospective observational study of electronic clinical records of all emergency department(ED) visits over a 10-year period to an urban tertiary general hospital in Singapore. Patients aged 65 years and older, with 3 or more visits within a calendar year were identified. Outcomes measured include 30-day mortality, admission rate, admission diagnosis and duration spent at ED. Chi-square-tests were used to assess categorical factors and Student t-test was used to assess continuous variables on their association with being a frequent attender. Univariate and multivariate logistic regressions were conducted on all significant independent factors on to the outcome variable(30-day mortality), to determine factor independent odds ratios of being a frequent ***: 1.381 million attendance records were analyzed. Elderly patients accounted for 25.5% of all attendances, of which 31.3% are frequent attenders. Their 30-day mortality rate increased from 4.0% in the first visit, to 8.8% in the third visit, peaking at 10.2% in the sixth visit. Factors associated with mortality include patients with neoplasms, ambulance utilization, male gender and having attended the ED the previous ***: Elderly attenders have a higher 30-day mortality risk compared to the overall ED population, with mortality risk more marked for frequent attenders. This study illustrates the importance and need for interventions to address frequent ED visits by the elderly, especially in an aging society.

关键词： Frequent attenders Elderly Emergency department Mortality

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Treatment of a rotator cuff tear combined with iatrogenic glenoid fracture and shoulder instability:A rare case report

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World Journal of Orthopedics 2020年第11期11卷 516-522页

作者： Chen-Hao Chiang Ting-chien Tsai Kuan-Kai Tung wei-Hsing Chih Ming-Long Yeh wei-Ren Su Department of Biomedical Engineering National Cheng Kung UniversityTainan 70428Taiwan Department of Orthopaedic Surgery Ditmanson Medical Foundation Chia-Yi Christian HospitalChia-Yi 60002Taiwan Department of Orthopaedic Surgery Taichung Veterans General HospitalTaichung 40705Taiwan Department of Orthopaedic Surgery National Cheng Kung University HospitalTainan 70428Taiwan

BACKGROUND The brisement manipulation is an effective treatment for refractory shoulder *** cuff tears can sometimes exist in combination with adhesive *** capsular release combined with rotator cuff repair has achieved good outcomes in published *** SUMMARY We report the case of a patient with right shoulder pain for more than 1 year that was suspected to have adhesive capsulitis and a rotator cuff tear that was treated with brisement manipulation and arthroscopic *** iatrogenic glenoid fracture with shoulder instability occurred during the *** treatment for fracture fixation,capsular release,and rotator cuff repair was performed,and the functional results are *** Arthroscopic fixation for iatrogenic glenoid fracture and repairing coexisting rotator cuff tear can provide the stability needed for early rehabilitation.

关键词： Frozen shoulder Bursitis Arthroscopy Fracture Glenoid fracture Manipulation Iatrogenic Case report

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Impact of disease severity on gastric residual volume in critical patients

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World Journal of Gastroenterology 2011年第15期17卷 2007-2012页

作者： chien-wei Hsu Shu-Fen Sun David Lin Lee Shoa-Lin Lin Kam-Fai Wong Hsiu-Hua Huang Hung-Ju Li Department of Medicine School of Medicine National YangMing University Taipei Taiwan China Intensive Care Unit Department of Medicine Kaohsiung Veterans General Hospital Kaohsiung City 813 Taiwan China Department of Physical Medicine and Rehabilitation Kaohsiung Veterans General Hospital Kaohsiung City 813 Taiwan China Institute of Statistics National University of Kaohsiung Kaohsiung City 813 Taiwan China Department of Nutrition Kaohsiung Veterans General Hospital Kaohsiung City 813 Taiwan China

AIM: To investigate whether illness severity has an impact on gastric residual volume (GRV) in medical critically ill patients. METHODS: Medical intensive care unit (ICU) patients requiring nasogastric feeding were enrolled. Sequential Organ Failure Assessment (SOFA) score was assessed immediately preceding the start of the study. Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores were recorded on the first, fourth, seventh, and fourteenth day of the study period. GRV was measured every 4 h during enteral feeding. The relationship be-tween mean daily GRV and SOFA scores and the correlation between mean daily GRV and mean APACHE Ⅱ score of all patients were evaluated and compared. RESULTS: Of the 61 patients, 43 patients were survivors and 18 patients were non-survivors. The mean daily GRV increased as SOFA scores increased (P < 0.001, analysis of variance). Mean APACHE Ⅱ scores of all patients correlated with mean daily GRV (P = 0.011, Pearson correlation) during the study period. Patients with decreasing GRV in the first 2 d had better survival than patients without decreasing GRV (P = 0.017, log rank test). CONCLUSION: GRV is higher in more severely ill medical ICU patients. Patients with decreasing GRV had lower ICU mortality than patients without decreasing GRV.

关键词： Critical care Outcome Residual volume Severity of illness index Tube feeding

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Crystallization Behavior and Tensile Property of Poly(trimethyleneterephthalate)/Styrene-Ethylene-Buthylene-Styrene Composites

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Journal of Wuhan University of Technology(Materials Science) 2016年第2期31卷 474-480页

作者： TSOU Chi-Hui SUEN Maw-Cherng WU Wen-Yen KAO Bo-jlyue YANG Ming-chien TSOU Chih-Yuan HUNG wei-Song Department of Materials and Textiles Oriental Institute of Technology New Taipei City Taiwan 22064 China Center for Thin FilmTechnologies and Applications Department of Materials Engineering Ming Chi University of Technology New Taipei City Taiwan 24301China R&D Center for Membrane Technology Department of Chemical Engineering Chung Yuan University Jongli Taoyuan Taiwan 32023 China Department of Creative Fashion Design Taoyuan Innovation Institute of Technology Jhongli Taiwan 32091 China Department of Fashion Design and Merchandising Shih Chien University Kaohsiung Taiwan 84550 China Department of Materials Science and Engineering National Taiwan University of Science and Technology Taipei Taiwan 10607 China

Poly（trimethyleneterephthalate）（PTT）/styrene-ethylene-buthylene-styrene（SEBS）composites were prepared by melt *** opticalmicroscopy was used to observe the spherulitic morphology and the crystalstructure of PTT and PTT/SEBS *** electron microscopy was used to determine the dispersion and the compatibility of fracture surfaces of PTT and *** curves of thermalgravimetric analysis illustrated that the thermo stability decreased with increasing SEBS *** calorimetry was used to investigate the crystallization behavior;and the result showed that the glass transition temperature of the compound increased with the SEBS *** Avramiequation described the isothermalcrystallization ***-strain curves for PTT and PTT/SEBS composites showed that the elongation at break was enhanced with increasing SEBS content.

关键词： poly(trimethyleneterephthalate)(PTT) styrene-ethylene-buthylene-styrene(SEBS) crystallization

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