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Liver resection for hepatocellular carcinoma larger than 10 cm: A multi-institution long-term observational study

World Journal of Gastrointestinal Surgery 2021年第5期13卷 476-492页

作者： Chao-Wei Lee Ming-Chin Yu Chih-Chi Wang Wei-Chen Lee Hsin-I tsai Feng-Che Kuan Chun-Wei Chen Yi-Chung hsieh Hsing-Yu Chen Division of General Surgery Department of SurgeryLinkou Chang Gung Memorial HospitalGuishan 333TaoyuanTaiwan College of Medicine Chang Gung UniversityGuishan 333TaoyuanTaiwan Graduate Institute of Clinical Medical Sciences Chang Gung UniversityGuishan 333TaoyuanTaiwan Department of Surgery New Taipei Municipal Tu-Cheng Hospital(Built and Operated by Chang Gung Medical Foundation)Tu-Cheng 236017New Taipei CityTaiwan Division of General Surgery Department of SurgeryKaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Division of General Surgery Department of SurgeryChiayi Chang Gung Memorial HospitalChiayi 613Taiwan Department of Anesthesiology Linkou Chang Gung Memorial HospitalGuishan 333TaoyuanTaiwan Department of Hematology and Oncology Chiayi Chang Gung Memorial HospitalChiayi 613Taiwan Department of Gastroenterology and Hepatology Linkou Chang Gung Memorial HospitalGuishan 333TaoyuanTaiwan Division of Chinese Internal Medicine Center for Traditional Chinese MedicineTaoyuan Chang Gung Memorial HospitalGuishan 33378TaoyuanTaiwan School of Traditional Chinese Medicine College of MedicineChang Gung UniversityGuishan 333TaoyuanTaiwan

BACKGROUND The treatment of hepatocellular carcinoma(HCC)≥10 cm remains a *** To consolidate the role of surgical resection for HCC larger than 10 *** Eligible HCC patients were identified from the Chang Gung Research Database,the largest multi-institution database,which collected medical records of all patients from Chang Gung Memorial *** surgical outcome of HCC≥10 cm(L-HCC)was compared to that of HCC<10 cm(S-HCC)(model 1).The survival of L-HCC after either liver resection or transarterial chemoembolization(TACE)was also analyzed(model 2).The long-term risks of all-cause mortality and recurrence were assessed to consolidate the role of surgery for *** From January 2004 to July 2015,a total of 32403 HCC patients were identified from the Chang Gung Research *** 3985 patients who received liver resection,3559(89.3%)had S-HCC,and 426 had *** L-HCC patients had a worse disease-free survival(0.27 for L-HCC vs 0.40 for S-HCC)and overall survival(0.18 for L-HCC vs 0.45 for S-HCC)than the S-HCC after liver resection(both P<0.001).However,the surgical and long-term outcome of resected L-HCC had improved dramatically in the recent *** adjusting for covariates,surgery could provide a better outcome for L-HCC than TACE(adjusted hazard ratio of all-cause mortality:0.46,95%confidence interval:0.38-0.56 for surgery).Subgroup analysis stratified by different stages showed similar trend of survival benefit among L-HCC patients receiving *** Our study demonstrated an improving surgical outcome for HCC larger than 10 *** selected conditions,surgery is better than TACE in terms of disease control and survival and should be *** to inferior survival,a subclassification within T1 stage should be *** studies are mandatory to confirm our findings.

关键词： Hepatocellular carcinoma 10 cm Liver resection Transarterial chemoembolization Chang Gung Research Database

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AXIAL HEAT CONDUCTION MODEL TO PREDICT MAXIMUM HEAT REMOVE OF MINIATURE HEAT PIPE BASED ON GREY MODEL THEORY

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Chinese Journal of Mechanical Engineering 2005年第4期18卷 477-481页

作者： tsai Mengchang Chang Shinhsing Kang Shungwen Department of Mechanical and Electro- Mechanical Engineering Tamkang University 151 Ying-Chuan Rd. Tamsui Taiwan 25137 China Department of Industrial Management Vanung UniversityNo.1 Van-Nung Rd. Chung-Li Tao-Yuan Taiwan 32061. China Department of Mechanical and Electro- Mechanical Engineering Tamkang University 151 Ying-Chuan Rd. Tamsui Taiwan 25137. China

Computer chip is always accompanied by the increase of heat dissipation and miniaturization. The miniature heat pipes are widely used in notebook computer to resolve the heat dissipation problems. Maximum heat removed model of miniature heat pipes building by grey model is presented. In order to know the foundation for modeling, the smooth grade of error examination is inquired and the accuracy of grey relational grade is verified. The model can be used to select a suitable heat pipes to solve electric heat problems in the future. Final results show that the grey model only needs four experiment data and its error value is less than 10%, further, it is better than computational fluid dynamics （CFD） model.

关键词： Maximum heat removed model Miniature heat pipe Grey model theory Computational fluid dynamics (CFD) Grey relational grade

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Recently acquired hepatitis C virus infection among people living with human immunodeficiency virus at a university hospital in Taiwan

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World Journal of Gastroenterology 2021年第37期27卷 6277-6289页

作者： Miao-Hui Huang Hsin-Yun Sun Shu-yuan Ho Sui-yuan Chang Szu-Min hsieh Wang-Huei Sheng Yu-Chung Chuang Yu-Shan Huang Li-Hsin Su Wen-Chun Liu Yi-Ching Su Chien-Ching Hung Department of Internal Medicine Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical Foundation and Tzu Chi UniversityHualien 970410Taiwan Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of MedicineTaipei 100008Taiwan Department of Laboratory Medicine National Taiwan University Hospital and National Taiwan University College of MedicineTaipei 100008Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of MedicineTaipei 100233Taiwan Department of Tropical Medicine and Parasitology National Taiwan University College of MedicineTaipei 100233Taiwan Department of Medical Research China Medical University Hospital and China Medical UniversityTaichung 404394Taiwan

BACKGROUND Little is known about the engagement in hepatitis C virus(HCV)care and completion of HCV treatment in people living with human immunodeficiency virus(HIV)(PLWH)who have HCV coinfection in the Asia-Pacific *** the HCV care cascade can identify barriers to the completion of HCV treatment and facilitate achievement of HCV micro-elimination in *** To investigate the care cascade of incident HCV infections among PLWH in *** PLWH with incident HCV infections,defined as HCV seroconversion,were retrospectively identified by sequential anti-HCV testing of all archived blood samples at National Taiwan University Hospital between 2011 and *** PLWH with incident HCV infections were followed until December 31,*** care cascade of HCV examined included all incident HCV-infected patients,the percentages of anti-HCV antibodies detected by HIV-treating physicians in clinical care,plasma HCV RNA load tested,HCV RNA positivity diagnosed,referral to treatment assessment made,anti-HCV treatment initiated,and sustained virologic response *** who had HCV seroconversion during the interferon(IFN)era(2011–2016)and the direct-acting antiviral(DAA)era(2017–2018)were analyzed *** duration of HCV viremia—from the date of seroconversion to viral clearance by treatments or until the end of observation—and the incidence of sexually transmitted infections(STIs)during the HCV viremic period were *** During the study period,287 of 3495(8.2%)PLWH(92.3%being men who have sex with men)who were HCV-seronegative at baseline developed HCV seroconversion by retrospective testing of all archived blood *** the 287 incident HCV infections,277(96.5%)had anti-HCV antibodies detected by HIV-treating physicians,270(94.1%)had plasma HCV RNA determined and 251(87.5%)tested positive for HCV *** those with HCV viremia,226(78.7%)were referred to treatment assessment,215(74.9%)initiated anti-HCV treatment,and 202(70.4%)achieve

关键词： Recent hepatitis C virus infection Cascade of care Direct-acting antivirals People living with human immunodeficiency virus Sustained virologic response Sexually transmitted infections

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Fatigue behavior of high-entropy alloys： A review

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Science China(Technological Sciences) 2018年第2期61卷 168-178页

作者： CHEN PeiYong LEE Chanho WANG Shao-Yu SEIFI Mohsen LEWANDOWSKI John J DAHMEN Karin A JIA HaoLing XIE Xie CHEN BiLin YEH Jien-Wei tsai Che-Wei yuan Tao LIAW Peter K Department of Materials Science and Engineering The University of TennesseeKnoxville 37996 USA Department of Materials Science and Engineering Case Western UniversityCleveland 44106USA Department of Physics University of IllinoisUrbana 61801USA Department of Materials Science and Engineering 'National' Tsing Hua UniversityHsinchu 30013 Taiwan China Department of Industry and System Engineering Ohio UniversityAthens 45701 USA

Fatigue failures cost approximately 4% of the United States' gross domestic product(GDP). The design of highly fatigue-resistant materials is always in demand. Different from conventional strategies of alloy design, high-entropy alloys(HEAs) are defined as materials with five or more principal elements, which could be solid solutions. This locally-disordered structure is expected to lead to unique fatigue-resistant properties. In this review, the studies of the fatigue behavior of HEAs during the last five years are summarized. The four-point-bending high-cycle fatigue coupled with statistical modelling, and the fatigue-crack-growth behavior of HEAs, are reviewed. The effects of sample defects and nanotwins-deformation mechanisms on four-point-bending high-cycle fatigue of HEAs are discussed in detail. The influence of stress ratio and temperature on fatigue-crack-growth characteristics of HEAs is also discussed. HEAs could exhibit comparable or greater fatigue properties, relative to conventional materials. Finally,the possible future work regarding the fatigue behavior of HEAs is suggested.

关键词：疲劳行为合金设计评论熵疲劳性质 HEA 国内产品统计建模

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The aqueous extract of brucea javanica reduces tumorigenicity of human lung cancer tumorspheres

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Cancer Drug Resistance 2021年第4期4卷 866-880页

作者： Seung-Hun Kim Po-Wei Fan Chang-Heng hsieh Hsuan-yuan Lin Wen-Hsin Wang Ming-Chung Lee Kang Fang School of Life Science Department of Life ScienceNational Taiwan Normal UniversityTaipei 116Taiwan Brion Research Institute of Taiwan New Taipei City 231Taiwan

Aim:Therapy to overcome drug resistance by modulating epidermal growth factor receptor(EGFR)is a viable approach to suppress the proliferation of human non-small cell lung cancer(NSCLC)cells.A previous study demonstrated that the seeds of an aqueous Brucea javanica(BJ)(L.)Merr(Simaroubaceae)extract containing quassinoid mixtures effectively inhibited the growth and alleviated tumorigenesis in H1975 cells of NSCLC by targeting T790M/L858R *** study aimed to further determine whether the aqueous BJ extract affects the enriched H1975 spheroids in suspension culture and mouse xenograft tumor ***:The spheroids of NSCLC adenocarcinoma H1975 cells were enriched in a serum-free *** growth rate of sphere propagation by aqueous BJ extract was determined in suspended culture and in colony-formation *** extract was fed orally to nude mice bearing xenograft *** resected tumors were analyzed by hematoxylin and eosin staining,terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay,and proliferating cell nuclear antigen *** markers were used to determine the pluripotency of tumors from mice treated with different concentrations of BJ ***:BJ extract was demonstrated to be effective against the propagation of the enriched *** animal models,oral administration of the aqueous BJ extract reduced spheroid *** alleviated growth of the established xenograft tumors can be attributed to the reduced drug resistance and induced apoptosis without distinct adverse *** evidence supports activated apoptotic death attenuated spheroid stemness of ***:As an effective treatment regime to assuage lung cancer,the indigenous BJ extract promises to obliterate drug resistance and the growth of cancer stem cell tumors from NSCLC cells harboring T790M/L858R EGFR.

关键词： Brucea javanica cancer stem cells drug resistance epidermal growth factor receptor lung cancer apoptosis

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Outcomes of neoadjuvant chemoradiotherapy followed by radical resection for T4 colorectal cancer

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World Journal of Gastrointestinal Oncology 2020年第12期12卷 1428-1442页

作者： Chun-Ming Huang Ching-Wen Huang Cheng-Jen Ma Hsiang-Lin tsai Wei-Chih Su Tsung-Kun Chang Ming-Yii Huang Jaw yuan Wang Department of Radiation Oncology Kaohsiung Medical University HospitalKaohsiung 80145Taiwan Department of Surgery Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 80145Taiwan Division of Colorectal Surgery Department of SurgeryKaohsiung Medical University HospitalKaohsiung 80145Taiwan Department of Surgery and Cancer Center Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 80708Taiwan

BACKGROUND Patients with clinical T4 colorectal cancer(CRC)have a poor prognosis because of compromised surgical *** therapy may be effective in downstaging tumors,thereby rendering possible radical resection with clear *** To evaluate tumor downsizing and resection with clear margins in T4 CRC patients undergoing neoadjuvant concurrent chemoradiotherapy followed by *** This study retrospectively included 86 eligible patients with clinical T4 CRC who underwent neoadjuvant concurrent chemoradiotherapy followed by radical *** therapy consisted of radiation therapy at a dose of 45-50.4 Gy and chemotherapy agents,either FOLFOX or capecitabine.A circumferential resection margin(CRM)of<1 mm was considered to be a positive *** defined pathological complete response(p CR)as the absence of any malignant cells in a specimen,including the primary tumor and lymph nodes.A multivariate logistic regression model was used to identify independent predictive factors for p *** For 86 patients who underwent neoadjuvant chemoradiotherapy and surgery,the rate of p CR was 14%,and the R0 resection rate was 91.9%.Of the 61 patients with rectal cancer,7(11.5%)achieved p CR and 5(8.2%)had positive *** the 25 patients with colon cancer,5(20%)achieved p CR and 2(8%)had positive *** observed that the FOLFOX regimen was an independent predictor of p CR(P=0.046).After a median follow-up of 47 mo,the estimated 5-year overall survival(OS)and disease-free survival(DFS)rates were 70.8%and 61.4%,*** analysis revealed that a tumor with a negative resection margin was associated with improved DFS(P=0.014)and OS(P=0.001).Patients who achieved p CR exhibited longer DFS(P=0.042)and OS(P=0.003)than those who did *** Neoadjuvant concurrent chemoradiotherapy engenders favorable p CR and R0 resection rates among patients with T4 *** R0 resection rate and p CR are independent prognostic factors for pat

关键词： T4 Chemoradiotherapy Pathological complete response R0 resection Colorectal cancer Survival

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A Distribution Management System for Relational Databases in Cloud Environments

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Journal of Electronic Science and Technology 2013年第2期11卷 169-175页

作者： Sze-Yao Li Chun-Ming Chang yuan-Yu tsai Seth Chen Jonathan tsai Wen-Lung tsai Department of Applied Informatics and Multimedia Asia University Department of Applied Informatics and Multimedia Asia University Institute for Information Industry

For a transaction processing system to operate effectively and efficiently in cloud environments, it is important to distribute huge amount of data while guaranteeing the ACID （atomic, consistent, isolated, and durable） properties. Moreover, database partition and migration tools can help transplanting conventional relational database systems to the cloud environment rather than rebuilding a new system. This paper proposes a database distribution management （DBDM） system, which partitions or replicates the data according to the transaction behaviors of the application system. The principle strategy of DBDM is to keep together the data used in a single transaction, and thus, avoiding massive transmission of records in join operations. The proposed system has been implemented successfully. The preliminary experiments show that the DBDM performs the database partition and migration effectively. Also, the DBDM system is modularly designed to adapt to different database management system （DBMS） or different partition algorithms.

关键词： Data migration database partition distributed database relational database.

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New Challenges for Biological Text-Mining in the Next Decade

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Journal of Computer Science & Technology 2010年第1期25卷 169-178,F0003页

作者： Yen-Ching Chang Richard Tzong-Han tsai Wen-Lian Hsu Institute of Information Science "Academia Sinica" Department of Computer Science and Engineering Yuan Ze University Department of Computer Science "National Tsing-Hua University"

The massive flow of scholarly publications from traditional paper journals to online outlets has benefited biologists because of its ease to access. However, due to the sheer volume of available biological literature, researchers are finding it increasingly difficult to locate needed information. As a result, recent biology contests, notably JNLPBA and BioCreAtIvE, have focused on evaluating various methods in which the literature may be navigated. Among these methods, text-mining technology has shown the most promise. With recent advances in text-mining technology and the fact that publishers are now making the full texts of articles available in XML format, TMSs can be adapted to accelerate literature curation, maintain the integrity of information, and ensure proper linkage of data to other resources. Even so, several new challenges have emerged in relation to full text analysis, life-science terminology, complex relation extraction, and information fusion. These challenges must be overcome in order for text-mining to be more effective. In this paper, we identify the challenges, discuss how they might be overcome, and consider the resources that may be helpful in achieving that goal.

关键词： bioinformatics database mining method and algorithm text mining

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A Critical Eigenvalues Tracing Method for the Small Signal Stability Analysis of Power Systems

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Energy and Power Engineering 2013年第4期5卷 677-682页

作者： Shao-Hong tsai yuan-Kang Wu Ching-Yin Lee Department of Electrical Engineering Hwa Hsia Institute of Technology Department of Electrical Engineering National Chung Cheng University Department of Electrical Engineering Tungnan University

The continuation power flow method combined with the Jacobi-Davidson method is presented to trace the critical eigenvalues for power system small signal stability analysis. The continuation power flow based on a predictor- corrector technique is applied to evaluate a continuum of steady state power flow solutions as system parameters change;meanwhile, the critical eigenvalues are found by the Jacobi-Davidson method, and thereby the trajectories of the critical eigenvalues, Hopf bifurcation and saddle node bifurcation points can also be found by the proposed method. The numerical simulations are studied in the IEEE 30-bus test system.

关键词： Critical Eigenvalue Trajectory Continuation Power Flow Hopf bifurcation Saddle Node Bifurcation Small Signal Stability Jacobi-Davidson Method

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FANCA D1359Y mutation in a patient with gastric polyposis and cancer susceptibility: A case report and review of literature

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World Journal of Gastroenterology 2018年第38期24卷 4412-4418页

作者： Jeffrey Peng Huang Johnson Lin Chi-yuan Tzen Wen-Yu Huang Chia-Chi tsai Chih-Jen Chen Yen-Jung Lu Kuei-Fang Chou Ying-Wen Su Division of Hematology and Medical Oncology Department of Internal Medicine Mackay Memorial Hospital Department of Pathology Mackay Memorial Hospital Laboratory of Good Clinical Research Center Mackay Memorial Hospital Tamsui Branch Department of General Surgery Mackay Memorial Hospital Division of Gastroenterology Department of Internal Medicine Mackay Memorial Hospital ACT Genomics Co. Ltd.

Gastric polyposis is a rare disease. Not all polyps progress to cancer. Monoallelic mutation in Fanconi anemia(FA) genes, unlike biallelic gene mutations that causes typical FA phenotype, can increase risks of cancers in a sporadic manner. Aberrations in the FA pathway were reported in all molecular subtypes of gastric cancer. We studied a patient with synchronous gastric cancer from gastric polyposis by conducting a 13-year long-term follow up. Via pathway-driven massive parallel genomic sequencing, a germline mutation at FANCA D1359Y was identified. We identified several recurrent mutations in DNA methylation(TET1, V873I), the β-catenin pathway(CTNNB1, S45F) and RHO signaling pathway(PLEKHG5, R203C) by comparing the genetic events between benign and malignant gastric polyps. Furthermore, we revealed gastric polyposis susceptible genes and genetic events promoting malignant transformation using pathway-driven targeted gene sequencing.

关键词： Gastric polyposis Gastric cancer Adenocarcinoma Fanconi’s anemia Malignant transformation

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