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Adult sigmoid intussusception resembling rectal prolapse:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1163-1168页

作者： Tsung-jung tsai Yu Shih Liu Department of Surgery Changhua Christian HospitalChanghua 500209Taiwan Department of Colorectal Surgery Changhua Christian HospitalChanghua 500209Taiwan

BACKGROUND Rectal prolapse arises from benign *** symptoms of internal intussusception mirror those of rectal prolapse,a misdiagnosis is possible,especially under limited clinical *** is crucial to recognize and differentiate rectal prolapse from internal intussusception because the two diagnoses have different ***,we describe a case of adult sigmoid intussusception presenting as rectal *** SUMMARY A 64-year-old woman with no known medical history visited a gastrointestinal outpatient department due to hard bloody stool defecation for 1 wk followed by constipation for 3 *** revealed a huge polypoid ulcerated tumor at the sigmoid colon with lumen *** patient was admitted due to postprocedural dull abdominal *** to failed colonoscopy reduction and stent insertion,the patient underwent sigmoid colon resection with primary end-to-end anastomosis,with the transverse colostomy pathological report showing adenocarcinoma,*** recovered well from the operation and was discharged with regular outpatient clinic *** Presentation and manifestation of sigmoid intussusception may resemble that of rectal prolapse,necessitating careful observation due to distinct prognostic implications.

关键词： Sigmoid intussusception Rectal prolapse Endoscopic reduction Adenocarcinoma Case report

Value Function Mechanism in WSNs-Based Mango Plantation Monitoring System

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Computers, Materials & Continua 2024年第9期80卷 3733-3759页

作者： Wen-tsai Sung Indra Griha Tofik Isa Sung-jung Hsiao Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung411030TaiwanChina Department of Informatics Management Politeknik Negeri SriwijayaPalembang30139Indonesia Department of Information Technology Takming University of Science and TechnologyTaipei City11451TaiwanChina

Mango fruit is one of the main fruit commodities that contributes to Taiwan’s *** implementation of technology is an alternative to increasing the quality and quantity of mango plantation product *** this study,a Wireless Sensor Networks(“WSNs”)-based intelligent mango plantation monitoring system will be developed that implements deep reinforcement learning(DRL)technology in carrying out prediction tasks based on three classifications:“optimal,”“sub-optimal,”or“not-optimal”conditions based on three parameters including humidity,temperature,and soil *** key idea is how to provide a precise decision-making mechanism in the real-time monitoring system.A value function-based will be employed to perform DRL model called deep Q-network(DQN)which contributes in optimizing the future reward and performing the precise decision recommendation to the agent and system *** WSNs experiment result indicates the system’s accuracy by capturing the real-time environment parameters is 98.39%.Meanwhile,the results of comparative accuracy model experiments of the proposed DQN,individual Q-learning,uniform coverage(UC),and NaÏe Bayes classifier(NBC)are 97.60%,95.30%,96.50%,and 92.30%,*** the results of the comparative experiment,it can be seen that the proposed DQN used in the study has themost optimal *** with 22 test scenarios for“optimal,”“sub-optimal,”and“not-optimal”conditions was carried out to ensure the system runs well in the real-world *** accuracy percentage which is generated from the real-world data reaches 95.45%.Fromthe resultsof the cost analysis,the systemcanprovide a low-cost systemcomparedtothe conventional system.

关键词： Intelligent monitoring system deep reinforcement learning(DRL) wireless sensor networks(WSNs) deep Q-network(DQN)

Electric-field-controlled highly regioselective thiocyanation of N-containing heterocycles

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Science China Chemistry 2024年第4期67卷 1263-1269页

作者： Ming Gong Qian wu jung Keun Kim Mengmeng Huang Yabo Li Yangjie wu Jong Seung Kim Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan UniversitiesCollege of ChemistryZhengzhou UniversityZhengzhou 450052China Department of Chemistry Korea UniversitySeoul 02841Korea

Achieving highly regioselective synthesis in organic chemistry is challenging due to the uncontrollable orientation between reacting *** electric fields(EEFs)can influence the reactivity and selectivity of the substrate by causing directional ***,scalable and efficient techniques for using EEFs as“smart catalysts”have been lacking,hindering their *** this study,we present a novel method for modifying the regioselectivity of quinoxaline-2(1H)-ones by functionalizing their C7-position using the electric double layer(EDL)*** approach led to moderate to good yields of the corresponding C7-thiocyanation *** calculations and control experiments demonstrated that EEFs could reverse the regioselectivity of quinoxaline-2(1H)-ones,allowing the C7-thiocyanation to proceed via a radical reaction ***,the resulting 7-thiocyano-1-methylquinoxaline-2(1H)-ones exhibited promising AIE *** work showcases a promising strategy for achieving highly regioselective functionalization by aligning the electric field with the desired reaction/bond axis.

关键词： electric fields reaction-axis rule electric double layer C7-thiocyanation C-S bond formation

Long-term Integration Ability of the Submillimeter Wave Astronomy Satellite(SWAS)Spectral Line Receivers

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Research in Astronomy and Astrophysics 2024年第6期24卷 315-322页

作者： Bing-Ru Wang Di Li Paul F.Goldsmith Jingwen wu Chao-Wei tsai Rudolf Schieder Gary J.Melnick National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311100China Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA 91109USA Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China KOSMA I.Physik.InstitutUniversität zu KölnZülpicher Str.7750937 KölnGermany Center for Astrophysics|Harvard&Smithsonian 60 Garden StreetMS 66CambridgeMA 02138USA

The Submillimeter Wave Astronomy Satellite(SWAS)was the first space telescope capable of high spectral resolution observations of terahertz spectral *** have investigated the integration ability of its two receivers and spectrometer during five and a half years of on-orbit *** CI,O_(2),H_(2)O,and^(13)CO spectra taken toward all observed Galactic sources were *** present results are based on spectra with a total integration time of up to 2.72×10~4hr(■10~8s).The noise in the spectra is generally consistent with that expected from the radiometer equation,without any sign of approaching a noise *** noise performance reflects the extremely stable performance of the passively cooled front end as well as other relevant components in the SWAS instrument throughout its mission lifetime.

关键词： telescopes space vehicles:instruments instrumentation:miscellaneous ISM:lines and bands

Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival

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World Journal of Gastroenterology 2024年第7期30卷 714-726页

作者： Pui-Yin Leung Wenjing Chen Anissa N Sari Poojitha Sitaram Pui-Kei wu Susan tsai Jong-In Park Department of Biochemistry Medical College of WisconsinMilwaukeeWI 53226United States Department of Surgery Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Pancreatic cancer is a leading cause of cancer-related *** activity of the epidermal growth factor receptor(EGFR)is often observed in pancreatic cancer,and the small molecule EGFR inhibitor erlotinib has been approved for pancreatic cancer therapy by the food and drug ***,erlotinib alone is ineffective and should be combined with other drugs to improve therapeutic *** previously showed that certain receptor tyrosine kinase inhibitors can increase mitochondrial membrane potential(Δψm),facilitate tumor cell uptake ofΔψm-sensitive agents,disrupt mitochondrial homeostasis,and subsequently trigger tumor cell *** has not been tested for this *** To determine whether erlotinib can elevateΔψm and increase tumor cell uptake ofΔψm-sensitive agents,subsequently triggering tumor cell ***Δψm-sensitive fluorescent dye was used to determine how erlotinib affectsΔψm in pancreatic adenocarcinoma(PDAC)cell *** viability of conventional and patient-derived primary PDAC cell lines in 2D-and 3D cultures was measured after treating cells sequentially with erlotinib and mitochondria-targeted ubiquinone(MitoQ),aΔψm-sensitive *** synergy between erlotinib and MitoQ was then analyzed using SynergyFinder *** preclinical efficacy of the twodrug combination was determined using immune-compromised nude mice bearing PDAC cell line *** Erlotinib elevatedΔψm in PDAC cells,facilitating tumor cell uptake and mitochondrial enrichment ofΔψm-sensitive *** triggered caspase-dependent apoptosis in PDAC cells in culture if used at high doses,while erlotinib pretreatment potentiated low doses of *** suggested that these drugs synergistically induced tumor cell *** with in vitro data,erlotinib and MitoQ combination suppressed human PDAC cell line xenografts in mice more effectively than single treatments of each *** Our findings suggest tha

关键词： Pancreatic cancer Erlotinib Mitochondria-targeted ubiquinone Mitochondria Combination therapy

Optical Extinctions of Inter-Arm Molecular Clouds in M31:A Pilot Study for the Upcoming CSST Observations

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Research in Astronomy and Astrophysics 2024年第6期24卷 323-333页

作者： Cailing Chen Zheng Zheng Chao-Wei tsai Sihan Jiao Jing Tang Jingwen wu Di Li Yun Zheng Linjing Feng Yujiao Yang Yuan Liang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Zhejiang Lab Hangzhou 311121China

Recent submillimeter dust thermal emission observations have unveiled a significant number of inter-arm massive molecular clouds in ***,the effectiveness of this technique is limited to its sensitivity,making it challenging to study more distant *** study introduces an alternative approach,utilizing optical extinctions derived from space-based telescopes,with a focus on the forthcoming China Space Station Telescope(CSST).We first demonstrate the capability of this method by constructing dust extinction maps for 17 inter-arm massive molecular clouds in M31 using the Panchromatic Hubble Andromeda Treasury *** analysis reveals that inter-arm massive molecular clouds with an optical extinction(A_(V)) greater than 1.6 mag exhibit a notable A_(V) excess,facilitating their *** majority of these inter-arm massive molecular clouds show an A_(V) around 1 mag,aligning with measurements from our JCMT *** validation using a mock CSST RGB star catalog confirms the method's *** show that the derived A_(V)values using CSST z and y photometries align more closely with the input *** clouds with A_(V)> 1.6 mag can also be identified using the CSST mock *** thus claim that future CSST observation clouds provide an effective way for the detection of inter-arm massive molecular clouds with significant optical extinction in nearby galaxies.

关键词： infrared:stars ISM:clouds Galaxy:structure

Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

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Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon Eom Dong-Hyeok Kwon Dae-Jin jung Dae-Hyun Kim Jun-Koo Yi Jae-jung Ha Ji-Hyun Lee Seong-Beom Lee Woo-Jae Son Soo-Young Yum Won-wu Lee Goo Jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7E1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MSTN PRNP

Identifying timing and risk factors for early recurrence of resectable rectal cancer: A single center retrospective study

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2842-2852页

作者： Tsung-jung tsai Kai-Jyun Syu Xuan-Yuan Huang Yu Shih Liu Chang-Wei Chen Yen-Hang wu Ching-Min Lin Yu-Yao Chang Division of Colon and Rectal Surgery Department of SurgeryChanghua Christian HospitalChanghua 50006Taiwan Department of Surgery Changhua Christian HospitalChanghua 50006Taiwan Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402202Taiwan

BACKGROUND Colorectal cancer is a common malignancy and various methods have been introduced to decrease the possibility of *** recurrence(ER)is related to worse *** date,few observational studies have reported on the analysis of rectal ***,we reported on the timing and risk factors for the ER of resectable rectal cancer at our *** To analyze a cohort of patients with local and/or distant recurrence following the radical resection of the primary *** Data were retrospectively collected from the institutional database from March 2011 to January *** data at diagnosis,perioperative and postoperative data,and first recurrence were collected and *** was defined via receiver operating characteristic *** factors were evaluated using the Kaplan–Meier method and Cox proportional hazards *** We included 131 *** optimal cut off value of recurrence-free survival(RFS)to differentiate between ER(n=55,41.9%)and late recurrence(LR)(n=76,58.1%)was 8 *** median post-recurrence survival(PRS)of ER and LR was 1.4 mo and 2.9 mo,respectively(P=0.008)but PRS was not strongly associated with RFS(R²=0.04).Risk factors included age≥70 years[hazard ratio(HR)=1.752,P=0.047],preoperative concurrent chemoradiotherapy(HR=3.683,P9 d(HR=0.441,P=0.006).CONCLUSION RFS of 8 mo was the optimal cut-off *** ER was not associated with PRS,it was still related to prognosis;thus,intense surveillance is recommended.

关键词： Rectal cancer Early recurrence Prognosis Post-recurrence survival

Assessment and Visualization of Ki67 Heterogeneity in Breast Cancers through Digital Image Analysis

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Advances in Breast Cancer Research 2024年第2期13卷 11-26页

作者： Chien-Hui wu Min-Hsiang Chang Hsin-Hsiu tsai Yi-Ting Peng Department of Anatomical Pathology Far Eastern Memorial Hospital New Taipei AI Lab Quanta Computer Inc. Taoyuan

The Ki67 index (KI) is a standard clinical marker for tumor proliferation;however, its application is hindered by intratumoral heterogeneity. In this study, we used digital image analysis to comprehensively analyze Ki67 heterogeneity and distribution patterns in breast carcinoma. Using Smart Pathology software, we digitized and analyzed 42 excised breast carcinoma Ki67 slides. Boxplots, histograms, and heat maps were generated to illustrate the KI distribution. We found that 30% of cases (13/42) exhibited discrepancies between global and hotspot KI when using a 14% KI threshold for classification. Patients with higher global or hotspot KI values displayed greater heterogenicity. Ki67 distribution patterns were categorized as randomly distributed (52%, 22/42), peripheral (43%, 18/42), and centered (5%, 2/42). Our sampling simulator indicated analyzing more than 10 high-power fields was typically required to accurately estimate global KI, with sampling size being correlated with heterogeneity. In conclusion, using digital image analysis in whole-slide images allows for comprehensive Ki67 profile assessment, shedding light on heterogeneity and distribution patterns. This spatial information can facilitate KI surveys of breast cancer and other malignancies.

关键词： Ki67 Heterogeneity Breast Cancer Digital Image Analysis