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急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议（英文）

中华神经外科疾病研究杂志 2017年第6期16卷 529-529页

作者： Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC tsai ec Vaccaro A Wilson JR Yee A Harrop JS Toronto Western Hospital University Health Network University of Toronto University College Cork University of Maryland University of Wisconsin University of Kansas Medical Center The University of Kansas University of Utah Toronto Rehabilitation Institute University Health Network National Defense Medical College Spectrum Research Inc University of California at Los Angeles Christopher & Dana Reeve Foundation Ontario Neurotrauma Foundation University of Cambridge Medical College of Wisconsin University of British Columbia Thomas Jefferson University Hospital University of Sydney Nagoya University Keio University The University of Kansas Ottawa Hospital Research Institute Thomas Jefferson University Li Ka Shing Knowledge Institute St. Michael's Hospital Sunnybrook Health Sciences Centre

The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic *** review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI *** on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as " we recommend," whereas a weaker recommendation is indicated by "we suggest." Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) "We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making"(quality of evidence,very low) and(2) "We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome "(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI.

关键词：神经外科疾病医学研究患者

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Improvement of extraction efficiency for GaN-based light emitting diodes

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Science China(Technological Sciences) 2010年第2期53卷 322-325页

作者： SU YanKuin CHEN JianJhong KAO ChienChih tsai ChunFu Department of Electrical Engineering "National" Cheng-Kung University Department of Electrical Engineering Kun Shan University of Technology Institute of Microelectronics "National" Cheng-Kung University Advanced Optoelectronic Technology Center "National" Cheng Kung University

A simple, low cost method for mass production to enhance the light extraction efficiency of GaN-related LEDs was proposed. With appropriate process parameters, the nature lithography of nanosphere can be used to fabricate two-dimensional nanostructures, including the nanomesh ZnO layer, photonic crystal (PhC) patterned p-GaN, and patterned sapphire substrates. Based on preliminary results, the extraction efficiencies of LEDs with these nanostructures can thus be improved and the nature lithography is demonstrated to be a promising method to be widely exploited in the manufacture of all kinds of LED devices.

关键词： extraction efficiency light emitting diodes patterned sapphire substrate

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Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via PPAR-alpha/delta activations by prostacyclin released by sheared endothelial cells

Shear stress induces synthetic-to-contractile phenotypic mod...

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第七届海峡两岸心血管科学研讨会

作者： Min-Chien tsai Shu Chien Jeng-Jiann Chiu Division of Medical Engineering Research National Health Research InstitutesMiaoliTaiwan

Phenotypic modulation of smooth muscle cells(SMCs),which are located in close proximity to endothelial cells(ecs),is critical in regulating vascular *** investigated the role of flow-induced shear stress on ecs in modulating SMC phenotype and its underlying mechanism,using our newly developed ec/SMC co-culture flow system in which ecs and SMCs were separated by a porous *** of shear stress(12 dynes/ cm)to ec/SMC modulated SMC phenotype from synthetic to contractile state,with up-regulation of contractile markers,down-regulation of pro-inflammatory genes,and decreased percentage of cells in the synthetic phase. Treating SMCs with media from sheared ecs induced peroxisome proliferator-activated receptor(PPAR)-α,-δ, and-γligand binding activities;transfecting SMCs with specific small interfering RNAs(siRNAs)of PPAR-αand-δ, but not-γ,inhibited shear-induction of contractile *** exposed to shear stress released prostacyclin (PGI).Transfecting ecs with PGI synthase-specific siRNA inhibited shear-induced activation of PPAR-α/δ,up-regulation of contractile markers,down-regulation of pro-inflammatory genes,and decrease in percentage of SMCs in synthetic *** with PPAR-αdeficiency showed altered SMC phenotype toward a synthetic state,with increased arterial contractility in response to angiotensinⅡ,as compared with control *** results indicate that laminar shear stress induces synthetic-to-contractile phenotypic modulation in SMCs through the activation of PPAR-α/δby the ec-released *** findings provide insights into the mechanisms underlying the interplays of ecs with SMCs and the protective homeostatic function of laminar shear stress in modulating SMC phenotype.

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Stem cell involvement in the vascular remodelling

Stem cell involvement in the vascular remodelling

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2012国际生理学学术大会

作者： Yanhua Hu Tsung-Neng tsai John Paul Kirton Paola Campagnolo Qingbo Xu Cardiovascular Division King’s College London

To elucidate and quantify which cell types contribute to the developing neointima formation causing restenosis after vessel graft,we established a novel mouse model by grafting a decellularized vessel to the carotid ***,the graft developed neointimal lesions after 2 weeks,resulting in lumen closure within 4 weeks. Endothelial cells(ec) and smooth muscle cells(SMC),monocytes and stem/progenitor cells were detected 2 weeks *** lesional cells from neointimal tissue explant cultured in stem cell medium expressed a panel of stem/progenitor markers including c-kit,Sca-1 and *** showed clonogenic and multilineage differentiation *** Sca-1+ cells were able to differentiate into ecs and SMC in *** application of VEGF in vivo to the adventitial side of grafted vessel,increased re-endothelialization and reduced neointimal *** result indicate that a population of stem/progenitor cells exists within developing neointima,which display the ability to differentiate into both ec and SMC and can contribute to restenosis,drugs or cytokines directing cell differentiation to ecs may be effective in preventing or retarding restenosis.

关键词： stem cell restenosis decellularized vessel mouse model

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Improvement of extraction efficiency for GaN-based light emitting diodes

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中国科学:技术科学 2010年第2期 205-205页

作者： SU YanKuin HUANG ChunYuan CHEN JianJhong KAO ChienChih tsai ChunFu Department of Electrical Engineering “National” Cheng-Kung University Department of Electrical Engineering Kun Shan University of Technology Institute of Microelectronics “National” Cheng-Kung University Advanced Optoelectronic Technology Center “National” Cheng Kung University

A simple, low cost method for mass production to enhance the light extraction efficiency of GaN-related LEDs was proposed. With appropriate process parameters, the nature lithography of nanosphere can be used to fabricate two- dimensional nanostructures, including the nanomesh ZnO layer, photonic crystal (PhC) patterned p-GaN, and patterned sapphire substrates. Based on preliminary results, the extraction efficiencies of LEDs with these nanostructures can thus be improved and the nature lithography is demonstrated to be a promising method to be widely exploited in the manufacture of all kinds of LED devices.

关键词： extraction efficiency light emitting diodes patterned sapphire substrate

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Study on Welding-Bead Bonding Strength of Laser-Stacking Copper-Aluminum Heterogeneous Electrode Plates

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Journal of Mechanics Engineering and Automation 2021年第5期11卷 121-134页

作者： Shang-Wu tsai Shih-Kai Chien Kun-Tso Chen Tsung-Ying tsai Wen-Cheng Tseng Computer Aided Engineering Center Automotive Research and Testing Center(ARTC)Lukang TownshipChanghua County 50544Taiwan Laser and Additive Manufacturing Technology Center Industrial Technology Research Institute(ITRI)Tainan City 73445Taiwan Elite Crown Software and Consulting Co. Ltd.San Chung City Taipei County 24143Taiwan

In this paper,two types of copper-aluminum heterogeneous electrode plates are stacked and the finite element analysis(FEA)models of two different laser welding conditions are built by using SYSWELD welding simulation software to calculate the depth of the welding bead and the temperature distribution of the welding ***,the residual stress analysis data of the welded area are exported and the residual stress is applied to the welded specimen for CAE analysis to ensure that the welding bonding strength meets the design target of a shear force of 500 N or *** copper-aluminum laser-stacking simulation technique in this paper can be applied to the manufacturing of copper-aluminum heterogeneous laser-welded electrodes and series-connected electrodes of automotive lithium-ion power battery modules,providing an effective analysis method for welding bonding-strength.

关键词： Copper-aluminum heterogeneous laser welding simulation welding bonding strength analysis finite element method

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