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Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-hsun Lin Ying-Yi Chen Yuan-ming tsai Ti-Hui Wu Hsu-Kai Huang tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

Improvement of fuel consumption and maintenance of heating furnaces using a modified heating pattern

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Journal of University of Science and Technology Beijing 2007年第1期14卷 27-32页

作者： hsun-Heng tsai Shiuh-ming Chang Department of Biomechatronics Engineering Pintung University of Science and TechnologyChina Taipei Department of Mechanical and Automation Engineering Kao Yuan UniversityChina Taipei

This article studies the transient heat conduction in a slab when passing through various sections of the furnace, and focuses on the thickness of the scale layer formed on the slab. The transient heat conduction behavior of a slab in various sections of the heating furnace is analyzed using the Laplace transformation method, including the pre-heating zone, the first heating zone, the second heating zone, and the soaking zone. The heating pattern of the furnace is then modified to reduce fuel consumption. The simulation results show that the scale layer formed on the slab significantly influences the quality of the hot rolled coil formed, and how the furnace parameters affect the efficiency of the furnace and the quality of the coil.

关键词： heating furnace heat conduction preheating zone heating zone soaking zone Laplace transformation

Rare solitary splenic metastasis from a thymic carcinoma detected on fluorodeoxyglucose-positron emission tomography:A case report

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World Journal of Clinical Cases 2022年第15期10卷 5072-5076页

作者： Yueh-hsun tsai Kuan-hsun Lin tsai-Wang Huang Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND Thymic carcinoma is a rare,aggressive tumor arising from the *** less than 7%of patients with thymic carcinoma,extrathoracic metastases occur in the extrathoracic lymph nodes,liver,and *** splenic metastasis can occur but is very *** date,only 2 cases of splenic metastases from thymic carcinoma have been *** SUMMARY A 45-year-old man presented with chronic cough,dyspnea,persistent hoarseness and unintentional weight loss 17 kgs in 6 *** magnetic resonance imaging revealed a large,lobulated,soft-tissue mass measuring 5.4 cm×6.6 cm×3.8 cm which involved the left superior mediastinum and supraclavicular *** computed tomography(CT)revealed a confluent and lobulated soft tissue mass encased the right brachiocephalic artery,right and left carotid arteries,and left subclavian artery in the mediastinum.A fluorodeoxyglucose-positron emission tomography was arranged for malignancy *** image revealed intense fluorodeoxyglucose avidity in a soft tissue lobulated mass occupying the superior mediastinum,over the cystic lesion in the spleen and in few enlarged nodules over the left supraclavicular ***-guided biopsy of the thymic mass and the ultrasound-guided biopsy of the splenic lesion were consistent with a thymic carcinoma with splenic *** patient was diagnosed of thymic carcinoma,cT2N2M1b,stage *** A fluorodeoxyglucose(FDG)-positron emission tomography(PET)scan can provide a useful diagnostic value in conjunction with pathological result in evaluating tumor *** case emphasizes the utility of FDG-PET for metastasis detection in thymic carcinoma.

关键词： Thymic carcinoma Splenic metastasis Positron emission tomography Extrathoracic metastases Mediastinal tumor Case report

Exosomes as promising frontier approaches in future cancer therapy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 28-33页

作者： Fatt-Yang Chew Chin-Hung tsai Kuang-Hsi Chang Yu-Kang Chang Ruey-Hwang Chou Yi-Jui Liu Department of Medical Imaging China Medical University HospitalTaichung 404TaiwanChina Department of Radiology School of MedicineChina Medical UniversityTaichung 404TaiwanChina Department of Cancer Center Tungs’Taichung MetroHarbor HospitalTaichung 435TaiwanChina Department of Chest Medicine Tungs’Taichung MetroHarbor HospitalTaichung 435TaiwanChina Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402TaiwanChina Department of Medical Research Tungs’Taichung MetroHarbor HospitalTaichung 435TaiwanChina Center for General Education China Medical UniversityTaichung 404TaiwanChina General Education Center Jen-Teh Junior College of MedicineNursing and ManagementMiaoli 356TaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoli 356TaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichung 404TaiwanChina Center for Molecular Medicine China Medical University HospitalTaichung 404TaiwanChina Department of Medical Laboratory and Biotechnology Asia UniversityTaichung 413TaiwanChina Department of Automatic Control Engineering Feng Chia UniversityTaichung 407TaiwanChina

In this editorial,we will discuss the article by Tang et al published in the recent issue of the World Journal of Gastrointestinal *** explored an innovative approach to enhancing gemcitabine(GEM)delivery and efficacy using human bone marrow mesenchymal stem cells(HU-BMSCs)-derived *** manufacture of GEM-loaded HU-BMSCs-derived exosomes(Exo-GEM)has been *** Tang et al’s study demonstrated that Exo-GEM exhibits enhanced cytotoxicity and apoptosis-inducing effects compared to free GEM,highlighting the potential of exosome-based drug delivery systems as a more effective and targeted approach to chemotherapy in pancreatic *** in vivo studies are required to confirm the safety and effectiveness of Exo-GEM before it can be considered for clinical use.

关键词： Mesenchymal stem cells Exosomes Gemcitabine Pancreatic cancer Apoptosis

Interface structure between epitaxial NiSi_2 and Si

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Journal of University of Science and Technology Beijing 2006年第6期13卷 558-563页

作者： Wei-Long Liu Wen-Jauh Chen Ting-Kan tsai hsun-Heng tsai Shu-Huei Hsieh Department of Materials Engineering Formosa University Yunlin China Taipei Graduate Institute of Materials Engineering Pingtung University of Science and Technology 1 Pingtung China Taipei Department of Biosystems Engineering Pingtung University of Science and Technology 1 Pingtung China Taipei

The interface structure between the Si and NiSi2 epitaxially grown on the （112） Si substrate was studied using high resolution transmission electron microscopy and computer image simulation. The results showed that the interface between Si and NiSi2 epitaxially grown on the （ 112 ） Si substrate has six different types： type A NiSi2 （111 ）/（ 111 ） Si, type A NiSi2 （001）/（001） Si, type B NiSi2 （ 111 ）/（ 111） Si, type B NiSi2 （ 112 ）/（ 1 12 ） Si, type B NiSi2 （ 271 ）/（001） Si, and type B NiSi2 （ 114 ）/（ 110 ） Si. And there are one or more different atomic structures for one type of interface.

关键词： nickel silicide interface high resolution image simulation atomic structure

Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling

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BIOCELL 2023年第8期47卷 1793-1802页

作者： FU-ming tsai PING-hsun LU LU-KAI WANG CHAN-YEN KUO MAO-LIANG CHEN CHUN-HUA WANG Department of Research Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan Department of Chinese Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan School of Post-Baccalaureate Chinese Medicine Tzu Chi UniversityHualien970Taiwan Department of Life Sciences National Science and Technology CouncilTaipei106Taiwan Department of Dermatology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan School of Medicine Tzu Chi UniversityHualien970Taiwan

Background:Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human *** often reduce the use of cisplatin due to its side effects,which in turn affects its *** study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for ***:Primary human follicle dermal papilla cells(HFDPCs)were used as target cells for cisplatininduced damage to hair *** blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs *** survival and cell cycle were analyzed by mitochondrial staining reagent WST-1 and propidium ***:Cisplatin could reduce the viability of HFDPCs without causing cell *** increased the level of phospho-Rad17 in HFDPCs and activated the Chk1/Cdc25C signaling to reduce the expression of Cdc2 protein,thereby arresting the cells in the G2/M *** combination of safflower extract and the flavonoids could effectively inhibit the signal transduction of Rad17/Chk1/Cdc25 in cisplatin-treated cells and reduce the cell population in the G2/M ***,we also confirmed that safflower extract could effectively inhibit the damage to HFDPCs caused by cisplatin,mainly at the level of reducing the DNA damage caused by ***:Safflower extract can be used as an adjuvant Chinese medicine for chemotherapy to reduce the damage caused by chemotherapy to normal hair follicle cells.

关键词： Safflower extract Cisplatin Human hair follicle dermal papilla cells Rad17 Hair loss Cell cycle

Tumor progression-dependent angiogenesis in gastric cancer and its potential application

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World Journal of Gastrointestinal Oncology 2019年第9期11卷 686-704页

作者： Hsi-Lung Hsieh ming-ming tsai Research Center for Chinese Herbal Medicine College of Human EcologyChang Gung University of Science and TechnologyTaoyuan 333Taiwan Department of Nursing Division of Basic Medical SciencesChang-Gung University of Science and TechnologyTaoyuan 333Taiwan Department of Neurology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of General Surgery Chang Gung Memorial HospitalChiayi 613Taiwan

Despite improvements in the early diagnosis,prognosis and therapeutic strategies for gastric cancer(GC),human GC remains one of the most frequently diagnosed malignant tumors in the world,and the survival rate of GC patients remains very ***,a suitable therapeutic strategy for GC is important for prolonging *** tumor cells themselves and the tumor microenvironment play an important role in tumorigenesis,including angiogenesis,inflammation,immunosuppression and ***,these cells contribute to gastric carcinogenesis by altering the angiogenic phenotype *** development,relapse and spreading of tumors depend on new vessels that provide the nutrition,growth factors and oxygen required for continuous tumor ***,a state of tumor dormancy could be induced by blocking tumor-associated ***,several antiangiogenic agents have been identified,and their potential for the clinical management of GC has been ***,we provide an up-to-date summary of angiogenesis and the angiogenic factors associated with tumor progression in *** also review antiangiogenic agents with a focus on the anti-vascular endothelial growth factor receptor(VEGFR)-mediated pathway for endothelial cell growth and their angiogenesis ability in ***,most antiangiogenic agents have reported no benefit to overall survival(OS)compared to chemotherapy alone in local or advanced *** phase III clinical trials,only ramucirumab(anti-VEGFR blocker)and apatinib(VEGFR-TKI blocker)have reported an improved median overall response rate and prolonged OS and progression-free survival outcomes as a 2 nd-line agent combined with chemotherapy treatment in advanced *** providing insights into the molecular mechanisms of angiogenesis associated with tumor progression in GC,this review will hopefully aid the optimization of antiangiogenesis strategies for GC therapy in combination with chemotherapy and adjuvant treatment.

关键词： Gastric cancer Angiogenesis Vascular endothelial cell Angiogenic phenotype switch Anti-angiogenesis Tumor dormancy

A new design of groundwater sampling device and its application

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Journal of Environmental Sciences 2005年第5期17卷 838-841页

作者： Yih-Jin tsai ming-Ching T. Kuo Department of Environmental Resources Engineering Diwan College of ManagementDepartment of Mineral and Petroleum Engineering "National" Cheng Kung University No. 87-1 Nansh Li Madou Tainan Taiwan ChinaTainan Taiwan China

Compounds in the atmosphere contaminate samples of groundwater. An inexpensive and simple method for collecting groundwater samples is developed to prevent contamination when the background concentration of contaminants is high. This new design of groundwater sampling device involves a glass sampling bottle with a Teflon-lined valve at each end. A cleaned and dried sampling bottle was connected to a low flow-rate peristaltic pump with Teflon tubing and was filled with water. No headspace volume was remained in the sampling bottle. The sample bottle was then packed in a PVC bag to prevent the target component from infiltrating into the water sample through the valves. In this study, groundwater was sampled at six wells using both the conventional method and the improved method. The analysis of trichlorofluoromethane（ CFC-11 ） concentrations at these six wells indicates that all the groundwater samples obtained by the conventional sampling method were contaminated by CFC-11 from the atmosphere. The improved sampling method greatly eliminated the problems of contamination, preservation and quantitative analysis of natural water.

关键词： groundwater sampling improved method conventional method tritium trichlorofluoromethane(CFC-11 )

Meditative Practices in the Context of Constructing and Understanding the Spatial World

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Fudan Journal of the Humanities and Social Sciences 2018年第4期11卷 515-531页

作者： Yao-ming tsai Department of Philosophy National Taiwan UniversityNo.1Sec.4Roosevelt Road Taipei 106TalwanROC

Major Buddhist traditions,especially Yogacara Buddhism,suggest that both mental activities and meditative practices play determinative roles in con- structing and understanding the spatial *** the spatial world,which is closely related to the temporal world,numerous passages in the Agama-sutras indicate that such a set of meditative practices as the "eight levels of liberation" (as..tau vimok4.8.h)can perform a pioneering function,on the one hand,in understating how the realm of desire of the spatial world is both constructed by and therefore confined by sentient beings'desire-infused mental activities,and on the other hand,in expanding the spatial world from the realm of desire to those of form and *** sixth chapter of the ***-nirmocana-sutra discusses in detail how and why a bodhisattva practices the meditation of quietude and *** the line of the quietude meditation,various discursive constructions of time and space can actually be *** the line of the insight meditation,the unreality of identity in relation to time and space can be clearly *** view of such reasoning,this study will investigate how the ***-nirmocana-sutra explicates the way in which mental activities and meditative practices are intrinsic in the construction and understanding of the spatial *** detailed exploration of the multiple roles played by meditative practices in shaping the spatial world,this study will conclude with a brief examination of the thematic consistency among these two texts.

关键词： Yogacaa Buddhism Meditation Space-time Liberation