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Research of goal-directed fluid therapy on laparoscopic liver resection

实用休克杂志（中英文） 2024年第2期8卷 124-128页

作者： Wang le Luo Xuee Liu Xiehong Song Yinghui Zeng Qinghua Zhang Honghui Tang Hongying Hunan provincial people's Hospital(the First Affiliated Hospital of Hunan Normal University)

Objective To explore the application effect of goal-directed fluid therapy(GDFT)on laparoscopic liver *** From July 2023 to December 2023,48 patients who underwent laparoscopic liver resection were randomly divided into the GDFT group and the CLCVp(controlled low central venous pressure)*** patients in the GDFT group were guided by stroke volume variability(SVV)during surgery,while those in the CLCVp group were guided by a controlled low central venous pressure technique during fluid replacement *** bleeding volume,fluid replacement volume,urine output,liver blood flow obstruction time,postoperative exhaust time,length of hospital stays,and incidence of complications were recorded and compared between the two groups of *** There was a difference between the two groups in terms of crystal fluid,colloid fluid,total fluid volume,and urine volume(p>0.05).However,the bleeding volume in the GDFT group(515.61±246.71)mL was lower than that in the CLCVp group(389.37±187.35)mL(pp(46.33±7.26)min was shorter than that of the CLCVp group(41.84±6.24)min(ppostoperative exhaust time of patients in the GDFT group(4.86±1.24)d was shorter than that of patients in the CLCVp group(6.42±1.05)d(ppitalization days of patients in the GDFT group(9.21±2.15)d were fewer than those in the CLCVp group(11.04±4.29)d(ppostoperative complications between the two groups of patients(p>0.05).Conclusion GDFT guided by SVV can stabilize intraoperative hemodynamics in patients undergoing laparoscopic liver resection,reduce intraoperative bleeding,and reduce liver blood flow blockage *** is safer and more reliable than traditional fluid therapy.

关键词： Goal-directed fluid therapy Laparoscopic liver resection Stroke volume variability Controlled low central venous pressure

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Interpretation of Geological and Gravity Data from the Bamiléké plateau (West-Cameroon): Implication for the Understanding of Its Underground Lithotectonic Geometry

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Journal of Geoscience and Environment protection 2024年第9期12卷 283-314页

作者： Louis Christian Kamgang Chendjou Jean Victor Kenfack Jules Tcheumenak Kouémo Fidèle Koumetio Armand Kagou Dongmo Department of Earth Sciences Faculty of Science University of Dschang Dschang Cameroon Department of Earth Sciences Faculty of Sciences University of Douala Douala Cameroon Department of physics Faculty of Sciences University of Dschang Dschang Cameroon

The Bamiléké plateau represents a key domain in the understanding of the geodynamics associated with the central Cameroon shear. The study aimed to highlight the subsurface architecture of the plateaus basement setting with focus on high potential areas for hydrogeological and mining development projects. To this end, geological field observations were carried out. Since the structures sought were near-surface, a separation approach based on the upward continuation method was applied to the Bouguer anomaly grid. A set of processing techniques, including vertical derivative or DZ, analytical signal or SA and categorization of gravity signatures, was applied to generate the residual map. The synthesis geological model, obtained from analysis and interpretation of the various transformed maps and 2.5D modeling of two gravity profiles p1 and p2 highlights the following features: 1) intrusions of steep-sided granitic batholiths from Dschang to Bandjoun (profile p1), increasing in width from NW (Dschang) to SE (Bandjoun);2) larger volume batholiths with moderate sides located at Bafang and Bangangté (profile p1). These plutonic massifs were weakened by brittle deformation, which favored the emplacement of phonolite or anorthosite dykes within them. The emplacement of these dykes was accompanied by compressional faults with high dip between Dschang and Bandjoun and extensional faults with medium dip between Bafang and Bangangté. These fault zones (trending N85E to N95E) are ideal for hydrogeological investigations in a basement setting, as well as a series of dyke networks that could potentially be preferred zones for the circulation and accumulation of useful substances. The resulting geological sections p1 and p2 highlight the influence of granitic intrusions in the geological system of the study area, as well as the structural control associated with the various dyke intrusions. All the models obtained can serve as fundamental references for hydrogeological and mining e

关键词： Bamiléké plateau Gravity Measurement Gravity Anomalies Lineaments

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品种和养分管理影响冬小麦籽粒锌营养

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植物营养与肥料学报 2024年第6期30卷 1118-1129页

作者：常乐乐范子晗梁昊枫李哲张岁岐西北农林科技大学黄土高原土壤侵蚀与旱地农业国家重点实验室陕西杨凌712100 西北农林科技大学资源环境学院陕西杨凌712100

【目的】小麦籽粒中的锌含量对人类锌营养具有重要影响,研究品种特性、磷肥和丛枝菌根真菌(Arbuscular mycorrhizal fungal,AMF)对小麦籽粒锌含量的影响,为通过选择基因型育种和绿色养分管理最大化小麦锌营养提供理论依据。【方法】开... 详细信息

【目的】小麦籽粒中的锌含量对人类锌营养具有重要影响,研究品种特性、磷肥和丛枝菌根真菌(Arbuscular mycorrhizal fungal,AMF)对小麦籽粒锌含量的影响,为通过选择基因型育种和绿色养分管理最大化小麦锌营养提供理论依据。【方法】开展盆栽试验,供试小麦品种包括育成年代为1940s的蚂蚱麦(MZ)、1950s的碧蚂1号(BM)、1960s的丰产3号(FC)和2010s的长旱58号(CH),每个品种设置两个磷肥处理:施磷200 mg/kg(Hp)和不施磷(Lp);两个接菌处理:接种60 g Rhizophagus intraradices菌剂(A)和未接种(CK),每个品种均包括4个处理。在小麦开花期和成熟期,测定各部位锌含量和植株生物量、产量,分析菌根侵染率,计算菌根生长以及与菌根生长相关联的磷、锌吸收响应值(MGR、MpR、MZnR),以偏最小二乘路径模型分析锌吸收相关指标对籽粒锌含量的效应。【结果】冬小麦不同品种间籽粒产量存在显著差异,随品种的更替籽粒产量显著增加,而籽粒锌浓度随品种的更替呈降低趋势。Hp-CK处理冬小麦籽粒产量较Lp-CK处理显著增加36.73%~42.16%,籽粒锌浓度显著降低11.57%~27.07%,FC、CH的籽粒锌累积量分别显著增加25.75%、14.44%。Lp�A处理下4个冬小麦品种的根系菌根侵染率存在显著差异;施磷显著降低了冬小麦菌根侵染率(13.04%~23.63%)且导致品种间菌根侵染率无显著差异。与Lp-CK处理相比,Lp-A处理冬小麦籽粒锌浓度增加6.78%~9.37%,累积量显著提高23.75%~29.79%;Hp-A处理仅CH的籽粒锌累积量较Hp-CK处理显著提高。磷肥施用显著降低了4个冬小麦品种的MpR值(99.29%~140.76%),BM、FC和CH的MGR值(68.22%~71.77%)和MZnR值(56.47%~67.18%)。偏最小二乘路径分析结果显示,品种对籽粒锌浓度变化影响最大(−0.656),其次是磷肥(−0.557)、产量(−0.456)和AMF(0.191)。现代品种CH始终表现出较低的籽粒锌浓度和更高的产量及籽粒锌累积量。【结论】品种的产量潜力和养分管理是影响籽粒锌浓度最重要的因素。相比于育成年代较早的品种,当代品种小麦产量潜力高,对施肥(磷肥)和接种AMF的反应也高于育成年代较早的品种,因而进一步加剧了锌含量的稀释效应。因此,当代小麦品种需特别注意补充锌肥,以缓解稀释效应带来的籽粒低锌营养。

关键词：冬小麦产量潜力锌营养稀释效应养分管理丛枝菌根真菌菌根响应

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Multiomics analyses of two leonurus species illuminate leonurine biosynthesis and its evolution

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Molecular plant 2024年第1期17卷 158-177页

作者： peng Li Meng-Xiao Yan pan Liu Dan-Jie Yang Ze-Kun He Yun Gao Yan Jiang Yu Kong Xin Zhong Sheng Wu Jun Yang Hong-Xia Wang Yan-Bo Huang le Wang Xiao-Ya Chen Yong-Hong Hu Qing Zhao ping Xu shanghai Key Laboratory of plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChineseAcademy of SciencesShanghaiChina College of Life Sciences Shanghai Normal UniversityShanghai 200234China State Key Laboratory of plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghaiChina University of the Chinese Academy of Sciences Beijing 100049China The Research Center of Chiral Drugs Innovation Research Institute of Traditional Chinese MedicineShanghai University of Traditional Chinese Medicine1200 Cailun RoadShanghai 201203China College of Chemistry and Chemical Engineering Shanghai University of Engineering ScienceShanghai 201620China

The Lamiaceae family is renowned for its terpenoid-based medicinal components,but leonurus,which has traditional medicinal uses,stands out for its alkaloid-rich ***,the principal active compound found in leonurus,has demonstrated promising effects in reducing blood lipids and treating ***,the biosynthetic pathway of leonurine remains largely ***,we present the chromosome-level genome sequence assemblies of leonurus japonicus,known for its high leonurine production,and leonurus sibiricus,characterized by very limited leonurine *** integrating genomics,RNA sequencing,metabolomics,and enzyme activity assay data,we constructed the leonurine biosynthesis pathway and identified the arginine decarboxylase(ADC),uridine diphosphate glucosyltransferase(UGT),and serine carboxypeptidase-like(SCpL)acyltransferase enzymes that catalyze key reactions in this *** analyses revealed that the UGT–SCpL gene cluster evolved by gene duplication in the ancestor of leonurus and neofunctionalization of SCpL in ***,which contributed to the accumulation of leonurine specifically in ***,our comprehensive study illuminates leonurine biosynthesis and its evolution in leonurus.

关键词： Lamiaceae leonurus japonicus leonurus sibiricus genome sequence alkaloids leonurine gene cluster biosynthetic pathway evolution

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personality Trait Detection via Transfer learning

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Computers, Materials & Continua 2024年第2期78卷 1933-1956页

作者： Bashar Alshouha Jesus Serrano-Guerrero Francisco Chiclana Francisco p.Romero Jose A.Olivas Department of Information Technologies and Systems University of Castilla-La ManchaCiudad Real13071Spain Institute of Artificial Intelligence School of Computer Science and InformaticsDe Montfort UniversityThe GatewayLeicesterLE19BHUK

personality recognition plays a pivotal role when developing user-centric solutions such as recommender systems or decision support systems across various domains,including education,e-commerce,or human ***-ditional machine learning techniques have been broadly employed for personality trait identification;nevertheless,the development of new technologies based on deep learning has led to new opportunities to improve their *** study focuses on the capabilities of pre-trained language models such as BERT,RoBERTa,ALBERT,EleCTRA,ERNIE,or XLNet,to deal with the task of personality *** models are able to capture structural features from textual content and comprehend a multitude of language facets and complex features such as hierarchical relationships or long-term *** makes them suitable to classify multi-label personality traits from reviews while mitigating computational *** focus of this approach centers on developing an architecture based on different layers able to capture the semantic context and structural features from ***,it is able to fine-tune the previous models using the Mypersonality dataset,which comprises 9,917 status updates contributed by 250 Facebook *** status updates are categorized according to the well-known Big Five personality model,setting the stage for a comprehensive exploration of personality *** test the proposal,a set of experiments have been performed using different metrics such as the exact match ratio,hamming loss,zero-one-loss,precision,recall,F1-score,and weighted *** results reveal ERNIE is the top-performing model,achieving an exact match ratio of 72.32%,an accuracy rate of 87.17%,and 84.41%of *** findings demonstrate that the tested models substantially outperform other state-of-the-art studies,enhancing the accuracy by at least 3%and confirming them as powerful tools for personality *** findings represent substantial a

关键词： personality trait detection pre-trained language model big five model transfer learning

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超声药物渗透治疗的护理干预在消化道肿瘤患者术后快速康复中的应用

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中国实用护理杂志 2024年第3期40卷 161-166页

作者：王乐刘冰心大连医科大学附属第二医院采血室大连116023 大连医科大学附属第二医院关节与运动医学科大连116023

目的探讨消化道肿瘤患者手术后强化落实超声药物渗透治疗的护理干预对患者术后快速康复的影响,为消化道肿瘤患者术后快速康复干预方案的制订提供参考。方法采用随机对照试验方法,于2021年4—7月,选择大连医科大学附属第二医院收治的消... 详细信息

目的探讨消化道肿瘤患者手术后强化落实超声药物渗透治疗的护理干预对患者术后快速康复的影响,为消化道肿瘤患者术后快速康复干预方案的制订提供参考。方法采用随机对照试验方法,于2021年4—7月,选择大连医科大学附属第二医院收治的消化道肿瘤术后患者120例为研究对象,按照随机数字表法分为对照组、分散治疗组以及集中治疗组,每组40例。对照组主要采用常规加速康复外科护理,并辅以早期康复训练;分散治疗组在对照组的基础上接受了超声药物渗透治疗的护理干预,每天上午和下午各进行1次,每次持续30 min;集中治疗组在对照组的基础上采取了一次性60 min的超声药物渗透治疗的护理干预。采用单因素方差分析、LSD-t检验和χ^(2)检验比较各组患者的胃肠道反应、肠道功能恢复情况、住院情况、术后并发症及护理满意度。结果对照组男27例,女13例,年龄(61.85±16.85)岁;分散治疗组男23例,女17例,年龄(60.90±16.88)岁;集中治疗组男23例,女17例,年龄(59.80±13.58)岁。分散治疗组和集中治疗组患者术后恶心、呕吐及腹胀症状持续时间、肠鸣音恢复时间、排气恢复时间及首次进食时间分别为(38.58±2.74)、(17.45±1.92)、(38.76±3.34)、(50.04±2.57)h和(36.79±2.58)、(16.48±1.85)、(36.98±2.28)、(48.25±3.07)h,均低于对照组的(43.13±3.56)、(21.24±2.50)、(42.65±3.78)、(52.21±3.15)h,差异均有统计学意义(t值为3.38~9.68,均ppppp<0.05)。结论经过超声药物渗透治疗的护理干预,尤其是集中治疗方式的护理干预,可以显著改善消化道肿瘤患者术后肠道功能,减轻术后胃肠道反应,缩短住院时间,减少术后并发症的发生,加快患者康复,为临床提供有效的护理干预方案,值得推广应用。

关键词：胃肠肿瘤超声药物渗透治疗术后快速康复强化性护理干预

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基于《黄帝内经》五运六气理论分析吉林省延边地区呼吸系统疾病发病规律及高发主运时段与气象要素的相关性

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中华中医药杂志 2024年第1期39卷 425-428页

作者：张乐苏颖王焱长春中医药大学长春130117

目的:基于《黄帝内经》五运六气理论分析吉林省延边地区呼吸系统疾病发病规律及其高发主运时段与气象要素的相关性。方法:选取2007年1月20日至2017年1月19日10年间吉林省延边地区呼吸系统疾病入院病例资料与同期延边地区的气象要素资料... 详细信息

目的:基于《黄帝内经》五运六气理论分析吉林省延边地区呼吸系统疾病发病规律及其高发主运时段与气象要素的相关性。方法:选取2007年1月20日至2017年1月19日10年间吉林省延边地区呼吸系统疾病入院病例资料与同期延边地区的气象要素资料,应用SpSS 22.0统计学软件,采用卡方检验方法研究呼吸系统疾病在不同时段发病数是否具有统计学意义,进而探讨吉林省延边地区呼吸系统疾病的发病规律,继续选取发病数最高的主运时段的呼吸系统疾病病例数据及同期气象要素数据,采用主成分分析法提取与其呼吸系统疾病发病相关的主要气象要素因子得到成分矩阵,进行旋转分析,分析延边地区呼吸系统疾病高发主运时段与气象要素之间的相关性。结果:吉林省延边地区自2007年1月20日至2017年1月19日10年间呼吸系统疾病发病数在岁运、主运、主气、客气方面均具有统计学意义(p<0.05)。在2011年(岁运年水运不及之年)、在主运初之运时段(1月20日至4月3日)、在六气主气二之气(少阴君火)时段、在六气客气厥阴风木时段发病数较多,与气象要素中的日照、气温、气压、风速具有相关性。结论:吉林省延边地区呼吸系统疾病的发病受五运六气气候变化影响,温度低、日照时间短、气压高、风速大,易引发或加重呼吸系统疾病。

关键词：五运六气延边地区主成分分析呼吸系统疾病气象要素相关性

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脊椎侵袭性血管瘤^(18)F-FDG pET/CT表现

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中国医学影像技术 2024年第9期40卷 1400-1404页

作者：宋乐李慧张卫方北京大学第三医院核医学科北京100191

目的观察脊椎侵袭性血管瘤^(18)F-FDG pET/CT表现。方法回顾性收集24例脊椎侵袭性血管瘤患者,病变位于颈椎6例、胸椎14例、腰椎4例;观察其^(18)F-FDG pET/CT特点,比较具有不同CT表现病灶的最大标准摄取值(SUV_(max))。结果24例中,5例(5/... 详细信息

目的观察脊椎侵袭性血管瘤^(18)F-FDG pET/CT表现。方法回顾性收集24例脊椎侵袭性血管瘤患者,病变位于颈椎6例、胸椎14例、腰椎4例;观察其^(18)F-FDG pET/CT特点,比较具有不同CT表现病灶的最大标准摄取值(SUV_(max))。结果24例中,5例(5/24,20.83%)病变局限于椎体、19例(19/24,79.17%)病变累及椎体及附件;其中10例(10/24,41.67%)病变椎体见溶骨性破坏及内部残留骨质,6例(6/24,25.00%)伴单纯溶骨性破坏,4例(4/24,16.67%)伴骨小梁增粗、稀疏,4例(4/24,16.67%)骨质未见明显异常。相比邻近非病变椎体,12例(12/24,50.00%)病灶放射性摄取增高、9例(9/24,37.50%)接近、3例(3/24,12.50%)减低;14例(14/24,58.33%)放射性分布均匀、10例(10/24,41.67%)不均匀。24例血管瘤的SUV_(max)[2.50(1.53,4.13)]与肝脏SUV_(max)(2.79±0.53)差异无统计学意义(Z=0.261,p=0.794);其中,伴骨皮质破坏病灶的SUV_(max)高于无破坏病灶(pp<0.05)。结论脊椎侵袭性血管瘤CT表现多样,其^(18)F-FDG代谢接近肝脏,合并骨皮质破坏及骨折病灶的代谢较高。

关键词：脊柱血管瘤氟脱氧葡萄糖F18 正电子发射断层显像和计算机体层摄影术

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Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang Liu Junya Fujimoto Lingzhi Hong Alexandre Reuben Susan Varghese Carmen Behrens Tina McDowell Luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning le Natalie I Vokes Chao Cheng John V.Heymach Don L.Gibbons p.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:pulmonary sarcomatoid carcinoma(pSC)is a rare and aggressive subtype of non-small cell lung cancer(NSCLC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of pSC has not been well ***:Multiomics profiling of 21 pairs of pSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of pSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with Tp53 the most frequently mutated gene,followed by ***,most Tp53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most pSC *** identified two distinct molecular subtypes of pSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of pSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of pSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

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Comparison of Treatment Efficacy of Different Number of Botulinum Toxin Type A Injection Sites for Crow’s Feet Lines: A Single-Center Retrospective Clinical Study in Vietnam

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International Journal of Dermatology And Venereology 2024年第03期

作者： Quang Minh Nguyen le Thi Mai phuc Hieu Duong Vu Thai Ha le Huu Doanh Department of Stem Cell Research and Application National Hospital of Dermatology and Venereology Hanoi Vietnam Department of Healthcare Activity Direction National Hospital of Dermatology and Venereology Hanoi Vietnam Department of Dermatology Hanoi Medical University Hanoi Vietnam

Objective: Botulinum toxin type A is frequently used to treat crow’s feet lines. However, the optimal dose and injection sites are still controversial. The objective of this study was to compare the efficacy of different botulinum toxin type A injection patterns for the treatment of crow’s ***: This single-center, retrospective, clinical study was conducted at the National Hospital of Dermatology and Venereology from July 2020 to December 2020. Data on 60 patients with crow’s feet were collected and divided into 2 groups (3-or 4-point intramuscular injection) according to the intramuscular injection technique the patients received. The treatment efficacy was assessed based on the changes in the Crow’s Feet Grading Scale score at 1, 4, and 16 weeks after treatment. Repeated measures analysis of variance was used for the assessment of changes in scores over time between the two ***: After treatment, the average Crow’s Feet Grading Scale score was significantly decreased compared with the pretreatment score at all timepoints (1, 4, and 16 weeks) in both states (dynamic: For 3-point intramuscular injection technique, 1 week: 1.90 ± 0.71vs. 2.97 ± 0.56; 4 weeks: 1.87 ± 0.68vs. 2.97 ± 0.56; 16 weeks: 2.60 ± 0.67vs. 2.97 ± 0.56. For 4-point intramuscular injection technique, 1 week: 1.73 ± 0.83vs. 3.03 ± 0.49; 4 weeks: 1.73 ± 0.74vs. 3.03 ± 0.49; 16 weeks: 2.57 ± 0.68vs. 3.03 ± 0.49, allp point intramuscular injection technique, 1 week: 1.20 ± 0.89vs. 2.20 ± 0.85; 4 weeks:1.20 ± 0.89vs. 2.20 ± 0.85; 16 weeks: 1.87 ± 0.97vs. 2.20 ± 0.85; For 4-point intramuscular injection technique, 1 week: 1.50 ± 0.86vs. 2.30 ± 0.84; 4 weeks: 1.33 ± 0.84vs. 2.30 ± 0.84; 16 weeks: 1.87 ± 0.97vs. 2.30 ± 0.84. Allp patient-rated satisfaction scores after treatment were significantly higher in the 4-point injection group than in the 3-point injection group (p = 0.028). The adverse events were post-injection bruisi

关键词： botulinum toxin type A crow’s feet lines injection site dose

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