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Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERKl/2 aggravates cancer-induced bone destruction

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Bone Research 2021年第4期9卷 557-570页

作者： Jungho Back Minh Nam nguyen Lu Li Saelim Lee Inkyu Lee Fancheng Chen Lauren Gillinov Yeon-Ho Chung Kareme D.Alder Hyuk-Kwon Kwon Kristin E.Yu Christopher M.Dussik Ziehen Hao Michael J.Flores Yoseph Kim Izuchukwu K.Ibe Alana M.Munger Sung Wook Seo Francis Y.Lee Department of Orthopaedics&Rehabilitation Yale UniversitySchool of MedicineNew HavenCTUSA Research Center for Genetics and Reproductive Health School of MedicineVietnam National University Ho Chi Minh CityLinh Trung WardThu Due DistrictHo Chi Minh CityVietnam Department of Rehabilitation Medicine Renji HospitalSchool of MedicineShanghai JiaoTong UniversityShanghaiChina College of Medicine Dankook UniversityCheonanRepublic of Korea Department of Life Science Chung-Ang UniversitySeoulRepublic of Korea Shanghai Medical College Fudan UniversityShanghai CityChina Department of Emergency&Trauma Changhai HospitalNavy Medical UniversityShanghaiChina Biomedical Engineering Johns Hopkins UniversityBaltimoreMDUSA Department of Orthopedic Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulGangnam-guRepublic of Korea

Disruption of bone homeostasis caused by metastatic osteolytic breast cancer cells increases inflammatory osteolysis and decreases bone formation,thereby predisposing patients to pathological fracture and cancer *** of osteoblast function induces skeletal diseases due to the disruption of bone *** observed increased activation of pERK1/2 in osteolytic breast cancer cells and osteoblasts in human pathological specimens with aggressive osteolytic breast cancer *** confirmed that osteolytic breast cancers with high expression of pERK1/2 disrupt bone homeostasis via osteoblastic ERK1/2 activation at the bone-breast cancer *** process of inflammatory osteolysis modulates ERK1/2 activation in osteoblasts and breast cancer cells through dominant-negative MEK1 expression and constitutively active MEK1 expression to promote cancer growth within ***,an FDA-approved MEK inhibitor,not only reduced breast cancer-induced bone destruction but also dramatically reduced cancer growth in bone by inhibiting the inflammatory skeletal *** together,these findings suggest that ERK1/2 activation in both breast cancer cells and osteoblasts is required for osteolytic breast cancer-induced inflammatory osteolysis and that ERK1/2 pathway inhibitors may represent a promising adjuvant therapy for patients with aggressive osteolytic breast cancers by altering the shared cancer and bone microenvironment.

关键词： pERK1/2 breast homeostasis

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Transparent and Conductive Properties of Nanocomposite Thin Film of MWCNTs and PEDOT-PSS for Applications in OLED

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材料科学与工程（中英文A版） 2015年第3期5卷 176-182页

作者： Khanh nguyen Duy Hoai Nam nguyen Phuong Laboratory for Nanotechnology Vietnam National University Community 6 Linh Trung Ward Thu Duc District Ho Chi Minh City Vietnam University of Engineering and Technology Vietnam National University 144 Xuan Thuy Cau Giay District Hanoi Vietnam

It is know that Multi-walled Carbon Nano Tubes (MWCNTs) are an excellent conduction nanomaterial while Poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT-PSS) is a conductive and transparent polymer. In this paper, we mix MWCNTs with PEDOT-PSS to create a new type of nanocomposite thin film which has both excellent conduction and transparency of each composition materials for applications in electronics and optoelectronics. The nanocomposite is synthesized by modifying MWCNTs in an acid solution then mix with PEDOT-PSS. The field emission scanning electron microscopy (FESEM) images of the fabricated thin film with 0.3 Wt% of MWCNTs show that the diameter and length of the MWCNTs are ca.10-30 nm and 300-500 nm, respectively. Electrical and optical properties of thin film are also investigated: the sheet resistance reaches the minimum value of 36.5 ?/sq with the transparency of ca.76% at the wave length of 600 nm. Furthermore, I-V characteristics of organic light emission diodes (OLEDs) made by the synthesized nanocomposite thin films are analyzed. The ITO/PEDOT-PSS: CNTs/PVK: MEH-PPV/Al multilayer OLED exhibits well improving performance with the work function of 0.8 V corresponding with the current of 0.4 mA while the ITO/PVK: MEH-PPV/Al simple OLED has the work function of 3 V and the current of only 0.01 mA.

关键词：多壁碳纳米管纳米复合薄膜导电性能 OLED 应用程序场发射扫描电子显微镜 MEH-PPV 有机发光二极管

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Enhanced Electrochemical and Physical Properties of Ag/AgCl Planar Reference Electrodesin Potentiometric Sensors by Graphite Oxide Layer

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材料科学与工程（中英文A版） 2019年第2期9卷 83-90页

作者： Tung Son Vinh nguyen Tien Minh Huynh Tin Chanh Duc Doan Chien Mau Dang Community 6 Linh Trung Ward Thu Duc District Ho Chi Minh City 800010 Vietnam

The most common reference electrode (RE) which is used in electrochemical measurements is the Ag/AgCl electrode. In this study, we present a novel solid-state Ag/AgCl planar electrode that was coated with a thin layer of Graphite Oxide (GO) as a protective layer. The Ag/AgCl planar electrode was fabricated by using the photolithography and lift-off method combined with the Ag[NH3]2Cl complex. The GO was produced by Hummer’s method and was deposited on top of the Ag/AgCl layer by drop-casting method. The layers of the fabricated reference electrode were characterized by micro Raman spectroscopy, Scanning Electron Microscopy (SEM) and Energy-dispersive X-ray spectroscopy (EDX). The responding time of the planar electrode was short and the signal was more stable in comparison to the plainAg/AgCl electrode. The Open Circuit Potential (OCP) measurement with the fabricated electrode as the RE and the platinum electrode as the working electrode in electrolyte solutions which had various pH values was performed with a linear response in pH ranges from pH 5 to pH 8 and the linear correlation coefficient (R^2 = 0.9899). Moreover, the coating of the GO layers also enhanced the durability of the modified electrode. The results showed that the modified Ag/AgCl electrode with a thin layer GO as the protective layer could be used as plana REs for the potentiometric sensors.

关键词： Graphite oxide potentiometric sensor Ag/AgCl reference electrode

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