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Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection

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World Journal of Gastroenterology 2008年第47期14卷 7149-7159页

作者： Juan R Larrubia Selma Benito-Martínez Miryam Calvino Eduardo Sanz-de-Villalobos trinidad parra-cid Department of Gastroenterology Guadalajara University HospitalUniversity of AlcaláDonante de Sangre st.19002 GuadalajaraSpain Guadalajara University Hospital University of AlcaláDonante de Sangre st.19002 GuadalajaraSpain

Chemokines produced in the liver during hepatitis C virus(HCV) infection induce migration of activated T cells from the periphery to infected *** milieu of chemokines secreted by infected hepatocytes is predominantly associated with the T-helper cell/Tc1 T cell(Th1/Tc1) *** chemokines consist of CCL3(macrophage inflammatory protein-1α;MIP-1α),CCL4(MIP-1β),CCL5(regulated on activation normal T cell expressed and secreted;RANTES),CXCL10(interferon-γ-inducible protein-10;IP-10),CXCL11(interferon-inducible T-cell α chemoattractant;I-TAC),and CXCL9(monokine induced by interferon γ;Mig) and they recruit T cells expressing either CCR5 or CXCR3 chemokine *** and peripheral blood levels of these chemokines are increased during chronic hepatitis *** interaction between chemokines and their receptors is essential in recruiting HCV-specific T cells to control the *** the adaptive immune response fails in this task,non-specific T cells without the capacity to control the infection are also recruited to the liver,and these are ultimately responsible for the persistent hepatic *** modulation of chemokine receptor expression and chemokine secretion could be a viral escape mechanism to avoid specific T cell migration to the liver during the early phase of infection,and to maintain liver viability during the chronic phase,by impairing non-specific T cell *** chemokines and their receptors correlate with liver damage,and CXCL10(IP-10) and CXCR3 levels have shown a clinical utility as predictors of treatment response *** regulation of chemokines and their receptors could be a future potential therapeutic target to decrease liver inflammation and to increase specific T cell migration to the infected liver.

关键词： Chemokines Chemokine receptors Hepatitis C virus Viral hepatitis pathogenesis Persistentinfection Viral escape mechanism

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Costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis C

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World Journal of Gastroenterology 2009年第41期15卷 5129-5140页

作者： Juan Ramón Larrubia Selma Benito-Martínez Joaquín Miquel Miryam Calvino Eduardo Sanz-de-Villalobos trinidad parra-cid Translational Hepatology Unit Guadalajara University Hospital University of Alcalá

Hepatitis C virus（HCV）-specific CD8^＋ T cells play an important role in the resolution of HCV infection. Nevertheless, during chronic hepatitis C these cells lack their effector functions and fail to control the virus. HCV has developed several mechanisms to escape immune control. One of these strategies is the upregulation of negative co-stimulatory molecules such us programmed death-1 （PD-1）. This molecule is upregulated on intrahepatic and peripheral HCV-specific cytotoxic T cells during acute and chronic phases of the disease, whereas PD-1 expression is low in resolved infection. PD-1 expressing HCV-specific CD8^＋ T cells are exhausted with impairment of several effector mechanisms, such as： type-1 cytokine production, expansion ability after antigen encounter and cytotoxic ability. However, PD-1 associated exhaustion can be restored by blocking the interaction between PD-1 and its ligand （PD-L1）. After this blockade, HCV-specific CD8^＋ T cells reacquire their functionality. Nevertheless, functional restoration depends on PD-1 expression level. High PD-l-expressing intrahepatic HCV-specific CD8^＋ T cells do not restore their effector abilities after PD-1/ PD-L1 blockade. The mechanisms by which HCV is able to induce PD-1 up-regulation to escape immune control are unknown. Persistent TCR stimulation by a high level of HCV antigens could favour early PD-1 induction, but the interaction between HCV core protein and gClq receptor could also participate in this process. The PD-1/PD-L1 pathway modulation could be a therapeutic strategy, in conjunction with the regulation of others co-stimulatory pathways, in order to restore immune response aclainst HCV to succeed in clearing the infection.

关键词： Chronic hepatitis Exhaustion Hepatitis C virus core Hepatitis C virus Programmed death-1 Programmed death-1 ligand

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Fate of polyphenols in pili(Canarium ovatum Engl.) pomace after in vitro simulated digestion

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Asian Pacific Journal of Tropical Biomedicine 2017年第1期7卷 53-58页

作者： Elizabeth Hashim Arenas trinidad Palad trinidad Department of Food Technology College of EducationUniversity of Santo TomasEspanaManila 1015Philippines The Graduate School University of Santo TomasEspanaManila 1015Philippines

Objective: To evaluate the stability and bioavailability of polyphenols in pili(Canarium ovatum Engl.) pomace during simulated in vitro ***: Freeze-dried pili pomace was subjected to in vitro digestion simulating conditions in the stomach, small intestine and colon. Total polyphenols, anthocyanins, fl avonoids and condensed tannins, and its antioxidant activity – 1,1-diphenyl-2-picrylhydrazyl, 2,20-azinobis-3-ethylbenzothiozoline-6-sulfonic acid, and ferric reducing antioxidant power were measured using standard spectrophotometric ***: In vitro digestion of pili pomace resulted in reduction of phenolic *** tannins and anthocyanins were released in the gastric and intestinal stages,while total polyphenols and flavonoids after fermentation simulating colonic *** values of the bioavailable fractions showed that more than 90% of activity was lost during simulated ***: Findings indicate that pili pomace is a promising functional ingredient for food and dietary supplements which can furnish potentially bioavailable phenolic antioxidants to the body.

关键词： Antioxidant In vitro digestion Phenolics Bioavailability Canarium ovatum Pili

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Preparation of Rod-like Aluminum Doped Zinc Oxide Powders by Sol-gel Technique Using Metal Chlorides and Acetylacetone Precursors

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Journal of Wuhan University of Technology(Materials Science) 2018年第6期33卷 1293-1297页

作者： KESHTKAR Javad VARGAS GARCIA Jorge Roberto GALAVIZ PEREZ Jorge MARTINEZ trinidad José Escuela Superior de Ingenieria Mecánica y Eléctrica Instituto Politécnico NacionalMéxico07738CDMXMéxico Escuela Superior de Ingenieria Quimica e Industrias Extractivas Instituto Politécnico NacionalMéxico07738CDMXMéxico Universidad Juárez Autònoma de Tabasco DivisiònAcadémica Multidisciplinaria de Jalpa de MéndezRibera AltaJalpa de MéndezTabasco86205México

Al-doped ZnO(AZO) powders were prepared by using metal chloride precursors and the sol-gel technique. IR peaks observed at 1590 cm-1 and 1620 cm-1indicated the formation of metal chelate as a consequence of the addition of acetylacetone to the metal chloride solution. TG-DSC analysis of the AZO gels confirmed the formation of metal chelate as evidenced by the development of several weight loss peaks accompanied by the introduction of new endothermic peaks. The resulting AZO gels were annealed at 500, 600, and 800 ℃ to study the effect of annealing temperature. XRD and SEM results showed that crystallization of AZO gels takes place around 600 ℃. Hexagonal wurtzite structure was identified as the main phase for all the samples. In addition, small shift of the XRD(002) peak coupled with XPS results from the AZO powders confirmed the successful doping of the ZnO powders. Micron sized rod-like AZO powders were uniform in dimension and morphology and remained stable even at 800 ℃.

关键词： aluminum doped ZnO rod-like metal chloride sol gel acetylacetone

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Clinical characteristics of a group of adults with nodular lymphoid hyperplasia:A single center experience

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World Journal of Gastroenterology 2006年第12期12卷 1945-1948页

作者： Alberto Rubio-Tapia Jorge Hernández-Calleros Luis Uscanga Sagrario trinidad-Hernández Department of Gastroenterology Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran(INNSZ)Mexico CityMexico Department of Pathology Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran(INNSZ)Mexico CityMexico

AIM： To describe the clinical and histological characteristics of a group of adults with small-bowel nodular lymphoid hyperplasia （NLH）. METHODS： Patients were searched for five years in pathology records of our institution. The biopsy material was reassessed using strict histopathological criteria. Clinical data were obtained from medical records. RESULTS： Small-bowel NLH was diagnosed in 18 cases. The female： male ratio was 2 ： 1. The most frequent symptoms were diarrhea （72%）, involuntary weight loss （72%） and abdominal pain （61%）. Nine patients （50%） had immunodeficiency. Small-bowel bacterial overgrowth was found in three （17%） cases. At small-bowel NLH diagnosis, three （17%） had associated lymphoma： two intestinal and one extra-intestinal lymphomas. In two patients with villous atrophy and anti-endomysial antibodies the diagnosis of celiac disease was established. Giardia larnblia infection was found in only one patient with hypogammaglobulinemia （Herman＇s syndrome）. CONCLUSIONS： NLH is uncommon in adult patients. Associated diseases are immunodeficiency and lymphoid tissue malignancies.

关键词： Nodular lymphoid hyperplasia Hypogammaglobulinemia Lymphoma

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Analysis of Pioneering Computable Biomedical Knowledge Repositories and their Emerging Governance Structures

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Data Intelligence 2022年第3期4卷 653-669页

作者： Philip Sahr Amara Marisa Conte Allen Flynn Jodyn Platt Marie Grace trinidad Department of Learning Health Sciences University of Michigan Medical SchoolMichigan 48109-0624USA Taubman Health Sciences Library University of Michigan Michigan 48109-1382USA School of Public Health University of MichiganMichigan 48109-2029USA

A growing interest in producing and sharing computable biomedical knowledge artifacts(CBKs) is increasing the demand for repositories that validate, catalog, and provide shared access to CBKs. However, there is a lack of evidence on how best to manage and sustain CBK repositories. In this paper, we present the results of interviews with several pioneering CBK repository owners. These interviews were informed by the Trusted Repositories Audit and Certification(TRAC) framework. Insights gained from these interviews suggest that the organizations operating CBK repositories are somewhat new, that their initial approaches to repository governance are informal, and that achieving economic sustainability for their CBK repositories is a major challenge. To enable a learning health system to make better use of its data intelligence, future approaches to CBK repository management will require enhanced governance and closer adherence to best practice frameworks to meet the needs of myriad biomedical science and health communities. More effort is needed to find sustainable funding models for accessible CBK artifact collections.

关键词： Computable Biomedical Knowledge Governance Repository Trust Sustainability

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Neurodevelopmental disorders:An innovative perspective via the response to intervention model

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World Journal of Psychiatry 2021年第11期11卷 1017-1026页

作者： Celestino Rodríguez Debora Areces trinidad García Marisol Cueli Paloma Gonzalez-Castro Department of Psychology University of OviedoOviedo 33003AsturiasSpain

Neurodevelopmental disorders are a group of conditions classified together by the most recent edition of the Diagnostic and Statistical Manual of Mental Disorders which include intellectual disability,communication disorders,autism spectrum disorder,attention-deficit/hyperactivity disorder,specific learning disorder(SLD),and motor *** is present in many students,who exhibit significant difficulties in the acquisition of reading,written expression,and mathematics,mostly due to problems with executive functions(EF).The present study is a review of the current situation of neurodevelopmental disorders and SLD focusing on the benefits of the response to intervention model(RtI),which allows the combination of evaluation and intervention *** also addresses the key role of *** importance of adapting RtI to new possibilities such as the use of virtual reality is discussed and a theoretical framework for carrying that out is provided.

关键词： Neurodevelopmental disorders Specific learning disorder Response to intervention model Virtual reality

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Hydration status,body composition,and anxiety status in aeronautical military personnel from Spain:a crosss-ectional study

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Military Medical Research 2022年第2期9卷 184-192页

作者： Alejandra Carretero-Krug Nataliaúbeda Carlos Velasco Juan Medina-Font trinidad Trujillo Laguna Gregorio Varela-Moreiras Ana Montero Departamento Ciencias Farmacéuticas y de la Salud Facultad de FarmaciaUniversidad San Pablo-CEUCEU UniversitiesUrbanización Montepríncipe28660 Boadilla del MonteSpain Centro de Instrucción de Medicina Aeroespacial Ejército del Aire28850 Torrejón de ArdozMadridSpain

Background: An adequate hydration status is critical to ensure efficiency during mental and physical *** goal was to assess the hydration status of a Spanish group of aeronautical military men and to determine the association of hydration status with body composition and ***: A total of 188 men were evaluated through a validated hydration questionnaire, anthropometric and biochemical parameters, and an anxiety questionnaire. Based on these methods, the criteria of hydration were ***: Of the total sample, 81% met the hydration criteria(urine color = well hydrated, water balance ≥0 ml, and total water intake/weight ≥35 ml/kg), and 19% did not meet the hydration criteria(urine color = not sufficiently hydrated or dehydrated, water balance <0 ml, and total water intake/weight <35 ml/kg). Subjects not meeting the hydration criteria had lower urine pH, negative water balance, and lower water intake. The latter also had higher anxiety status(score=4 vs. 3, P=0.026), weight [(84.7±10.5) kg vs.(80.5±10.2) kg], body mass index [(26.3±3.1) kg/m;vs.(25.2±2.8) kg/m;], body fat [(22.3±5.6)% vs.(18.3±6.5)%], urine specific gravity, and urine color. Using a logistic binary regression model, hydration status was related significantly with the percentage of body fat(P=0.004), but no relation was found with age, comorbidities, or medications. Furthermore, total water intake/weight was positively correlated with percentage of body water(r=0.357, P=0.000) and negatively with body fat(kg)(r=–0.427, P=0.000), percentage of body fat(r=–0.405, P=0.000), and waist/hip ratio(r=–0.223, P=0.002). Based on a linear regression model, total water intake/weight was related significantly with percentage of body fat(P=0.001) and percentage of body water content(P=0.035). No relation was found, however, with waist/hip ratio, age, comorbidities, or ***: These findings all suggest a relationship between hydration status and body composition but

关键词： Hydration status Military aeronautical personnel Body composition Anxiety status Water intake

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Mesenchymal stem cells and cell-free preparations for treating atopic dermatitis

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BIOCELL 2022年第11期46卷 2363-2367页

作者： trinidad MONTERO-VILCHEZ MANUEL SANCHEZ-DIAZ CAROLINA MONTERO-VILCHEZ ALVARO SIERRA-SANCHEZ SALVADOR ARIAS-SANTIAGO Dermatology Department Virgen de las Nieves University HospitalGranadaSpain Instituto de Investigación Biosanitaria Granada GranadaSpain Pharmacy Department Virgen de las Nieves University HospitalGranadaSpain Dermatology Department Faculty of MedicineUniversity of GranadaGranadaSpain

Atopic dermatitis(AD)is a chronic cutaneous inflammatory disease caused by an interaction between genetic,immune and epidermal barrier *** treatments can be used to treat this disease but there are patients that do not respond to actual ***,there is a need to develop effective therapies for *** stem cells(MSCs)are non-hematopoietic multipotent adult progenitor cells with immunomodulatory power and self-regenerating capacity to repair tissue damage,so they could be a potential effective treatment for ***-Conditioned Medium(CM)and MSCs-exosomes are cell-free preparation with molecules secreted by stem cells that could be also beneficial for *** viewpoint reviews the actual development of MSCs,MSCs-CM and MSCs-exosomes for treating patients with AD.

关键词： Atopic dermatitis Conditioned medium Dermatology Mesenchymal stem cells Stem cells

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Management of lung cancer in the COVID-19 pandemic:a review

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 145-157页

作者： Fernando Maroto Piñeiro Carmen trinidad López Javier de la Fuente Aguado Department of Internal Medicine Hospital Povisa Ribera Salud Salamanca 5 Vigo 36211Spain Radiology Service Hospital Povisa Ribera Salud Salamanca 5 Vigo 36211Spain.

Since its inception,the COVID-19 pandemic has affected health care as a *** patients in general and those suffering from lung cancer in particular are a vulnerable group because of their many intrinsic characteristics and care *** SARS-CoV-2(COVID-19)infection affects these patients regarding their risk of infection and outcome in this patient cohort is still to be *** this review,we tried to summarize our main concerns regarding COVID-19 in the context of cancer patients from a clinical and multidisciplinary *** types of lung cancer treatments(chemotherapy,radiation therapy and immunotherapy)may also influence the risk of infection and condition the patient´s risk of having a worse *** cancer patients require frequent radiologic study follow-ups,which may be affected by COVID-19 ***-19 related incidental radiologic findings can appear in routinely scheduled radiology tests,which may be difficult to *** cancer treatment induced pneumonitis may have similar radiologic features similar to those in acute SARS-CoV-2 pneumonia and lead to a wrong *** different health care needs,the requirement for continuous health care access and follow-ups,and the clinical traials in which this patient population might be enrrolled are all being affected by the current COVID-19 health *** COVID-19 pandemic has put health care providers and institutions in difficult situations and obliged them to face challenging ethical *** issues,in turn,have also affected the psychological well-being of health care workers.

关键词： COVID-19 cancer ethics CT thorax lung cancer cancer treatment chemotherapy immunotherapy

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