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Wedelolactone from Eclipta prostrata(L)*** inflammation and improves insulin resistance

Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 253-258页

作者： trinh tat cuong Duong Duc Thien Hoang Hai Yen Nguyen Anh Duc trinh Quang Nam Do Viet Khanh Key Laboratory for Enzyme and Protein Technology Vietnam National University University of ScienceHanoiVietnam Faculty of Biology Vietnam National University University of ScienceHanoiVietnam Hanoi University of Pharmacy HanoiVietnam Vinschool HanoiVietnam

Objective:To evaluate the effects of wedelolactone,a major flavonoid from Vietnamese Eclipta prostrata(L)L.,on inflammation and insulin ***:Wedelolactone was extracted from the leaves of Vietnamese Eclipta prostrata(L.)*** methanol by *** effects of wedelolactone on lipopolysaccharide(LPS)-induced cytokine production,reactive oxygen species(ROS)generation,and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase activities in Raw 264.7 cells were measured by enzyme-linked immunosorbent assay(ELISA),specific immunofluorescent dyes and luminometric analysis,*** addition,its effects on glucose uptake and the protein expression of insulin receptor substrate 1(IRS1)and glucose transporter 4(GLUT4)were examined in 3T3-L1 cells by immunofluorescent dyes and Western ***:Wedelolactone at 30μg/mL significantly inhibited LPS-induced production of tumor necrosis factor-α,interleukin(IL)-6,and IL-8(P<0.01)with no noticeable effects on IL-10 *** also reduced ROS generation and NADPH oxidase activities in LPS-stimulated Raw 264.7 cells(P<0.01).Furthermore,wedelolactone showed anti-insulin resistance activity,as evidenced by improved glucose uptake and the upregulated expression of IRS1 and GLUT4 in 3T3-L1 cells(P<0.01).Conclusions:Wedelolactone exhibits anti-inflammation and anti-insulin resistance effects,which may be used for the treatment of diabetes and inflammation-associated diseases.

关键词： Wedelolactone Eclipta prostrata Inflammatory responses Anti-insulin resistance Diabetes IRS1 GLUT4

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An isogeometric approach to static and transient analysis of fluid-infiltrated porous metal foam piezoelectric nanoplates with flexoelectric effects and variable nonlocal parameters

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 461-489页

作者： Quoc-Hoa PHAM Van Ke Tran Phu-cuong Nguyen Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City 700000Vietnam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoi 100000Vietnam Advanced Structural Engineering Laboratory Department of Structural EngineeringFaculty of Civil EngineeringHo Chi Minh City Open UniversityHo Chi Minh City 700000Vietnam

In this work,a novel refined higher-order shear deformation plate theory is integrated with nonlocal elasticity theory for analyzing the free vibration,bending,and transient behaviors of fluid-infiltrated porous metal foam piezoelectric nanoplates resting on Pasternak elastic foundation with flexoelectric *** analysis(IGA)and the Navier solution are applied to the *** innovation in the present study is that the influence of the in-plane variation of the nonlocal parameter on the free and forced vibration of the piezoelectric nanoplates is investigated for the first *** nonlocal parameter and material characteristics are assumed to be material-dependent and vary gradually over the thickness of *** on Hamilton’s principle,equations of motion are built,then the IGA approach combined with the Navier solution is used to analyze the static and dynamic response of the ***,we investigate the effects of the porosity coefficients,flexoelectric parameters,elastic stiffness,thickness,and variation of the nonlocal parameters on the mechanical behaviors of the rectangular and elliptical piezoelectric nanoplates.

关键词： isogeometric analysis fluid-infiltrated porous piezoelectric nanoplates static and transient analysis flexoelectric effect variable nonlocal parameters

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Exact solution for thermal vibration of multi-directional functionally graded porous plates submerged in fluid medium

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Defence Technology（防务技术） 2024年第5期35卷 77-99页

作者： Quoc-Hoa Pham Van Ke Tran Phu-cuong Nguyen Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh CityViet Nam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoiViet Nam Advanced Structural Engineering Laboratory Department of Structural EngineeringFaculty of Civil EngineeringHo Chi Minh City Open UniversityHo Chi Minh CityViet Nam

An analytical method for analyzing the thermal vibration of multi-directional functionally graded porous rectangular plates in fluid media with novel porosity patterns is developed in this *** properties of MFG porous plates change according to the length,width,and thickness directions for various materials and the porosity distribution which can be widely applied in many fields of engineering and defence ***,new porous rules that depend on spatial coordinates and grading indexes are proposed in the present *** Hamilton's principle and the refined higher-order shear deformation plate theory,the governing equation of motion of an MFG porous rectangular plate in a fluid medium(the fluid-plate system)is *** fluid velocity potential is derived from the boundary conditions of the fluid-plate system and is used to compute the extra *** GalerkinVlasov solution is used to solve and give natural frequencies of MFG porous plates with various boundary conditions in a fluid *** validity and reliability of the suggested method are confirmed by comparing numerical results of the present work with those from available works in the *** effects of different parameters on the thermal vibration response of MFG porous rectangular plates are studied in *** findings demonstrate that the behavior of the structure within a liquid medium differs significantly from that within a vacuum ***,they offer appropriate operational approaches for the structure when employed in various mediums.

关键词： Plate-fluid contact Galerkin Vlasov's method Multi-directional functionally graded plate Novel porosity Thermal vibration Refined higher-order shear deformation theory

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DENSITY ESTIMATES FOR SOLUTIONS OF STOCHASTIC FUNCTIONAL DIFFERENTIAL EQUATIONS

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Acta Mathematica Scientia 2019年第4期39卷 955-970页

作者： Nguyen Tien DUNG Ta Cong SON Tran Manh cuong Nguyen Van TAN trinh Nhu QUYNH Department of Mathematics FPT University Hoa Lac High Tech Park Hanoi Vietnam Department of Mathematics VNU Hanoi University of Science 334 Nguyen Trai Thanh Xuan Hanoi Vietnam Department of Foundation Academy of Cryptography Techniques Hl Chien Thang Thanh Tri Hanoi Vietnam Military Information Technology Institute 17 Hoang Sam Cau Giay Hanoi Vietnam

In this article, we investigate the density of the solution to a class of stochastic functional differential equations by means of Malliavin calculus. Our aim is to provide upper and lower Gaussian estimates for the d... 详细信息

关键词： Stochastic functional differential equations density estimates Malliavin calculus

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A novel approach for synthesis of hierarchical mesoporous Nd2O3 nanomaterials

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Journal of Rare Earths 2017年第7期35卷 677-682页

作者： Le Huu trinh Dinh Quang Khieu Hoang Thai Long Tran Thai Hoa Duong Tuan Quang Nguyen Duc cuong College of Sciences Hue University 77 Nguyen Hue Hue City Viet Nam Faculty of Hospitality and Tourism Hue University 22 Lam Hoang Hue CityViet Nam College of Education Hue University 34 Le LoL Hue City Viet Nam

A novel route to the fabrication of hierarchical mesoporous Nd_2O_3 nanostructures including nanospheres and nanoporous network was described. Their structure and morphology evolution of the as-synthesized materials were determined by various techniques such as scanning electron microscopy, transmission electron microscopy, high-resolution transmission electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, Fourier transforminfrared spectra, nitrogen adsorption/desorption isotherm, and a formation mechanism was proposed. The results revealed that the Nd_2O_3 nanospheres had the diameter of 300 nm, which were composed of small primary nanoparticles（NPs） with the size of 10 nm. The nanoporous structure also formed the NPs of ca. 10 nm which were connected with each other to form a three-dimensional（3D） texture. This simple and mild approach to fabricate hierarchical mesoporous Nd_2O_3 nanostructures could be easily scaled up and potentially extended to synthesize other oxide hierarchical structures.

关键词： Nd2O3 hierarchical nanostructures nanospheres nanoporous network rare earths

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Facile synthesis of FeFe2O4 magnetic nanomaterial for removing methylene blue from aqueous solution

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Progress in Natural Science:Materials International 2019年第6期29卷 648-654页

作者： Van-Phuc Dinh Ngoc Quyen Tran Nguyen-Que-Tran Le Quang-Huy Tran trinh Duy Nguyen Gr EEN), Nguyen tat Thanh University Van Tan Le Dong Nai province Center of Excellence for Green Energy and Environmental Nanomaterials (CE Industrial University of Ho Chi Minh City Future Materials and Devices Laboratory Institute of Fundamental and Applied Sciences Duy Tan University Institute of Applied Materials Science VAST Graduate University of Science and Technology VAST Le Quy Don–LBT Highschool Bien Hoa City

A facile and simple chemical precipitation method was utilized to synthesize FeFe2O4magnetic nanomaterial for removing methylene blue（MB） from aqueous solution. Characterizations of this material were examined by using XRD, SEM, FT-IR, TGA-DTG and BET methods. Factors affecting the uptake of methylene blue, including p H, adsorption time, and MB initial concentration were also studied. The measured data were fitted by using four isotherm models including Langmuir, Freundlich, Sips and Temkin. Results showed that the Sips model offers the best fit to the data. In addition, the monolayer MB adsorption capacity obtained from the Langmuir model was 42.35 mg g-1under the optimal conditions of p H = 10 and adsorption time = 80 min. In particular, the uptake of MB onto FeFe2O4magnetic nanomaterial obtained from the kinetic and mechanism studies of the adsorption was in good agreement with prediction of the pseudo-first-order model, whereas the electrostatic interaction was found to play a primary mechanism.

关键词： FeFe2O4 magnetic nanomaterial Adsorption Methylene blue Adsorption mechanism

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Design and Manufacture an Elastic Neutron Scattering Spectrometer at the Dalat Nuclear Reactor

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Journal of Analytical Sciences, Methods and Instrumentation 2021年第3期11卷 23-28页

作者： Dang Hong Ngoc Quy Pham Ngoc Son Phan Bao Quoc Hieu trinh Van cuong Nuclear Research Institute Dalat Lam Dong Vietnam

The objective of this study is to design an elastic neutron scattering system according to the angle with a sample using thermal neutron beam at the Dalat Nuclear Reactor (DNR). The system is used for research and training in the field of material structure analysis by neutron scattering and diffraction techniques. It is designed on the basis of inheriting the neutron measurement spectrometer systems at the DNR and the scattered neutron measurement systems in the world. The measuring system, which was installed at the horizontal channel 4 of the DNR, consists of 5-helium-3 detectors and a fully electronic system to record the scatter counts and a mechanical system with the possibility of rotating at 15˚-75˚ angles. The constructed system is tested for evaluation of the accuracy, stability and reliability of the mechanical and electronic systems of moving detectors by angles.

关键词： Neutron Scattering Small-Angle Neutron Scattering (SANS) Elastic Neu-tron Cross Section

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Music Genre Classification Using DenseNet and Data Augmentation

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Computer Systems Science & Engineering 2023年第10期47卷 657-674页

作者： Dao Thi Le Thuy trinh Van Loan Chu Ba Thanh Nguyen Hieu cuong Faculty of Information Technology University of Transport and CommunicationsHanoi100000Vietnam School of Information and Communication Technology Hanoi University of Science and TechnologyHanoi100000Vietnam Faculty of Information Technology University of Technology and Education Hung Yen160000Vietnam

It can be said that the automatic classification of musical genres plays a very important role in the current digital technology world in which the creation,distribution,and enjoyment of musical works have undergone huge *** the number ofmusic products increases daily and themusic genres are extremely rich,storing,classifying,and searching these works manually becomes difficult,if not *** classification ofmusical genres will contribute to making this *** research presented in this paper proposes an appropriate deep learning model along with an effective data augmentation method to achieve high classification accuracy for music genre classification using Small Free Music Archive(FMA)data *** Small FMA,it is more efficient to augment the data by generating an echo rather than pitch *** research results show that the DenseNet121 model and data augmentation methods,such as noise addition and echo generation,have a classification accuracy of 98.97%for the Small FMA data set,while this data set lowered the sampling frequency to 16000 *** classification accuracy of this study outperforms that of the majority of the previous results on the same Small FMA data set.

关键词： Music genre classification Small FMA DenseNet CNN GRU data augmentation

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Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153

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Bone Research 2022年第4期10卷 799-815页

作者： Yi-Nan Li Chih-Wei Chen Thuong trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler Department of Internal Medicine 3–Rheumatology and Immunology Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum ErlangenErlangenGermany Deutsches Zentrum für Immuntherapie Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum ErlangenErlangenGermany Department of Rheumatology Xiangya HospitalCentral South UniversityChangshaHunanChina Core Facility Hohenheim University of HohenheimStuttgartGermany Graduate Institute of Anatomy and Cell biology National Taiwan University College of MedicineTaipeiTaiwan

Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone *** inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target *** O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically *** demonstrate that dynamic changes in O-GlcNAcylation are required for *** O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast *** the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell ***αfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory *** pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental *** of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits *** findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption.

关键词： osteoclast homeostasis maintained

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Optimization, equilibrium, adsorption behavior and role of surface functional groups on graphene oxide-based nanocomposite towards diclofenac drug

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Journal of Environmental Sciences 2020年第7期32卷 137-150页

作者： Thuan Van Tran Duyen Thi Cam Nguyen Hanh TNLe Dai-Viet NVo Sonil Nanda trinh Duy Nguyen Nguyen tat Thanh Hi-Tech Institute Nguyen Tat Thanh UniversityHo Chi Minh City 755414Viet Nam Center of Excellence for Green Energy and Environmental Nanomaterials(CE@GrEEN) Nguyen Tat Thanh UniversityHo Chi Minh City 755414Viet Nam Institute of Hygiene and Public Health Ho Chi Minh City 700000Viet Nam Department of Chemical and Biochemical Engineering University of Western OntarioLondonOntarioCanada

Aquatic contamination of diclofenac(DCF),an emergent non-steroidal anti-inflammatory drug(NSAIDs),can result in adverse effects to many ecosystems through ***,introducing effective remediation techniques to sequester the pharmaceutical wastes is highly fundamental to prevent their accumulation in the ***,adsorption has been presented as a green and efficient ***,we report the characterization and application of the novel magnetic nanocomposite(GO@CoFe2O4)derived from cobalt-based ferrite(CoFe2O4)and graphene oxide(GO)for DCF *** the optimization procedure,the response surface methodology(RSM)was adopted to investigate the impacts of DCF concentration(1.6-18.4 mg/L),DCF dosage(0.08-0.92 g/L),and solution pH(2.6-9.4)to find the optimum conditions for DCF removal,at 10.5 mg/L,0.74 g/L,and pH 4,*** the adsorption experiments,the kinetic,isotherm,thermodynamic,and intraparticle diffusion models were systematically ***,we have elucidated the role of functional groups on the surface of GO@CoFe2O4 in enhancing the adsorption of DCF *** good removal efficiency(up to 86.1%),high maximum adsorption capacity(32.4 mg/g),GO@CoFe2O4 can be a potential candidate to eliminate DCF drug from water.

关键词： Diclofenac sodium Graphene oxide Magnetic nanocomposite Response surface methodology Pharmaceuticals adsorption

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