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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 49-49页

作者： Benhamou Y Fleury H. trimoulet p. 陈云茹(译) 史敏(校) Service d' Hép.to-Gastroentérologie Hopital Pitié Salpetri' ere 27 Boulevard de I'Hopital 75013 ParisFrance 不详

Tenofovir disop.oxil fumarate(TDF)has shown in vitro activity against both HIV and hep.titis B virus(HBV).We retrosp.ctively evaluated the efficacy of TDF(300 mg/d),administered as a p.rt of anti-retroviral therap.,in a large cohort of HIV/HBVcoinfected ***-five HIV/HBV-coinfected p.tients who received TDF for at least 6 months with serum HBV DNA levels above 2.3 log10 cop.es/mL at TDF initiation and who had stored serum samp.es before and during TDF therap. were *** HBV DNA was measured on stored *** median follow-up.p.riod was 12(Q1-Q3:8-17)*** hep.titis B e antigen(HBeAg)was p.sitive in 54 p.tients(83.1%).Fifty-two p.tients(80.0%)were receiving lamivudine(LAM)(150 mg twice a day),and 68.8%had documented LAM resistance at *** HBeAg p.sitive p.tients,the median reduction from baseline(8.17;Q1-Q3 = 7.30-8.30 log10cop.es/mL)of serum HBV DNA was 4.56 log10 cop.es/mL(Q1-Q3 = 3.33-5.55)(p.p.tients,serum HBV DNA decline from baseline(4.83;Q1-Q3 = 2.69-6.40 log10 cop.es/mL)was 2.53 log10 cop.es/mL(Q1-Q3 = 0.39-4.10).At the end of the study,HBV DNA became undetectable in 29.6%and 81.6%of the HBeAg p.sitive and HBeAg-negative p.tients,*** HBeAg became negative in 4 p.tients,2 of whom acquired serum hep.titis B e *** conclusion,this retrosp.ctive analysis demonstrates the efficacy of TDF against wild-typ.,p.esumed p.ecore mutants and LAM-resistant HBV when used as a p.rt of anti-retroviral therap. in HIV-coinfected p.tients.

关键词： HIV感染者抗HBV 替诺福韦酯富马酸抗逆转录病毒治疗 HBeAg阴性功效乙肝病毒e抗原

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Factors associated with DAA virological treatment failure and resistance-associated substitutions descrip.ion in HIV/HCV coinfected p.tients

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World Journal of Hep.tology 2018年第11期10卷 856-866页

作者： Dominique Salmon p.scale trimoulet Camille Gilbert Caroline Solas Eva Lafourcade Julie Chas Lionel p.roth Karine Lacombe Christine Katlama Gilles p.ytavin Hugues Aumaitre Laurent Alric Franoois Boué p.ilip.e Morlat Isabelle p.izot-Martin Eric Billaud Eric Rosenthal Alissa Naqvi p.trick Miailhes Firouzé Bani-Sadr Laure Esterle p.trizia Carrieri Franoois Dabis p.ilip.e Sogni Linda Wittkop.无 Assistance p.blique des Hop.taux de p.ris Hopitaux Universitaires Paris CentreHopital Hotel DieuUnitédes Maladies infectieuses et tropicalesParis 75004France Université p.ris Descartes Sorbonne Paris CitéParis 75006France trimoulet CHU de BordeauxHopital PellegrinLaboratoire de VirologieBordeaux 33000France trimoulet CNRS-UMR 5234Microbiologie fondamentale et PathogénicitéUniversitéde BordeauxBordeaux 3000France p.ilip.e Morlat Laure EsterleFrancois DabisLinda WittkopUniv.BordeauxISPEDInsermBordeaux Population Health Research Centerteam MORPH3EUSUMR 1219CIC-EC 1401Bordeaux F-33000France Ap.M Hopital La TimoneLaboratoire de Pharmacocinétique et ToxicologieMarseille 13005France Centre Hosp.talier Universitaire de Dijon Département d'InfectiologieDijon cedex 21079France INSERM-CIC 1342 Universitéde Bourgogne Dijon 21000France Assistance p.blique des Hop.taux de p.ris GHUEP site Saint-AntoineServices Maladies infectieuses et tropicalesParis 75011France Universitép.erre et Marie Curie UMR S1136Institut Pierre Louis d' Epidémiologie et de SantéPubliqueParis 75646France Universitép.ris-Sorbonne Paris 75005France Assistance p.blique des Hop.taux de p.ris Hop.tal p.tiéSalp.trière Services Maladies infectieuses et tropicalesParis 75013France Assistance p.blique des Hop.taux de p.ris Hopital Bichat-Claude BernardLaboratoire de PharmacologieParis 75877France IAME UMR 1137Sorbonne Paris CitéINSERMUniversitéParis DiderotParis 75890France Centre Hosp.talier de p.rp.gnan Service Maladies infectieuses et tropicalesPerpignan 66000Franc Centre Hosp.talier Universitaire de Toulouse Hopital PurpanService Médecine interne-Pole DigestifToulouse 31300France UMR 152 IRD UniversitéToulouseⅢ Paul SabatierToulouse 31330France Hop.tal Antoine-Béclère Assistance Publique des Hopitaux de ParisUniversitéParis SudService Médecine interne et immunologieClamart 92140France Centre Hosp.talier Universitaire de Bordeaux Service de médecine interneHopital Saint-AndréBordeaux 33000France Uni

AIMTo describe factors associated with treatment failure and frequency of resistance-associated substitutions （RAS）.METHODSHuman immunodefciency virus （HIV）/hep.titis C virus （HCV） coinfected p.tients starting a first direct-acting antiviral （DAA） regimen before February 2016 and included in the French ANRS CO13 HEp.VIH cohort were eligible. Failure was defned as：（1） non-resp.nse [HCV-RNA remained detectable during treatment, at end of treatment （EOT）]; and （2） relap.e （HCV-RNA sup.ressed at EOT but detectable thereafter）. Sequencing analysis was p.rformed to describe p.evalence of drug class-sp.cifc RAS. Factors associated with failure were determined using logistic regression *** 559 p.tients, 77% had sup.ressed p.asmaHIV-RNA 〈 50 cop.es/mL at DAA treatment initiation41% were cirrhotic, and 68% were HCV treatmentexp.rienced. Virological treatment failures occurred in22 p.tients and were mainly relap.es （17, 77%） thenundefined failures （3, 14%） and non-resp.nses （29%）. Mean treatment duration was 16 wk overall. p.sttreatment NS3, NS5A or NS5B RAS were detected in10/14 p.tients with samp.es available for sequencinganalysis. After adjustment for age, sex, ribavirin useHCV genotyp. and treatment duration, low p.atelecount was the only factor signifcantly associated with ahigher risk of failure （OR： 6.5; 95%CI： 1.8-22.6）. CONCLUSIONOnly 3.9% HIV-HCV coinfected p.tients failed DAAregimens and RAS were found in 70% of those failingLow p.atelet count was indep.ndently associated withvirological failure.

关键词： Human immunodeficiency virus Hep.titis C virus Direct-acting antiviral Treatment virological failure Resistant associated mutations

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