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Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

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Oncology Research 2024年第1期32卷 19-47页

作者： ABHISHEK WAHI MAMTA BISHNOI NEHA RAINA MEGHNA AMRITA singh PIYUSH VERMA PIYUSH KUMAR GUPTA GINPREET KAUR HARDEEP singh TULI MADHU GUPTA Department of Pharmaceutics School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)Pushp ViharNew Delhi110017India Department of Pharmaceutical Sciences Gurugram UniversityHaryana122003India Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Graphic Era(Deemed to be University)DehradunUttarakhand248002India Department of Pharmacology Shobhaben Pratapbhai Patel School of Pharmacy&Technology ManagementSVKM’s NMIMSVile Parle(West)Mumbai400056India Department of Bio-Sciences and Technology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be University)MullanaAmbala133207India

Cancer is a leading cause of death globally,with limited treatment options and several *** agents often result in toxicity which long-term conventional *** are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the *** phytoconstituents act in several ways and deliver optimum effectiveness against ***,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and *** presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective *** holds significant potential for future advancements in cancer ***,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in ***,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo ***,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

关键词： Phyto-formulations Cancer Nanocarriers Nanotechnology Clinical development

Light correcting light with nonlinear optics

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Advanced Photonics 2024年第2期6卷 41-49页

作者： Sachleen singh Bereneice Sephton Wagner Tavares Buono Vincenzo D'Ambrosio Thomas Konrad Andrew Forbes University of the Witwatersrand School of Physics Università degli studi di Napoli “Federico Ⅱ” Dipartimento di Fisica “E.Pancini” University of Kwa Zulu-Natal School of Chemistry and Physics

Structured light, where complex optical fields are tailored in all their degrees of freedom, has become highly topical of late, advanced by a sophisticated toolkit comprising both linear and nonlinear *** undesired structure from light is far less developed, leveraging mostly on inverting the distortion,e.g., with adaptive optics or the inverse transmission matrix of a complex channel, both requiring that the distortion be fully characterized through appropriate measurement. We show that distortions in spatially structured light can be corrected through difference-frequency generation in a nonlinear crystal without any need for the distortion to be known. We demonstrate the versatility of our approach using a wide range of aberrations and structured light modes, including higher-order orbital angular momentum(OAM) beams,showing excellent recovery of the original undistorted field. To highlight the efficacy of this process, we deploy the system in a prepare-and-measure communications link with OAM, showing minimal cross talk even when the transmission channel is highly aberrated, and outline how the approach could be extended to alternative experimental modalities and nonlinear processes. Our demonstration of light-correcting light without the need for measurement opens an approach to measurement-free error correction for classical and quantum structured light, with direct applications in imaging, sensing, and communication.

关键词： phase conjugation aberration correction orbital angular momentum nonlinear optics

Nanozyme‑Engineered Hydrogels for Anti‑Inflammation and Skin Regeneration

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Nano-Micro Letters 2024年第6期16卷 127-179页

作者： Amal George Kurian Rajendra K.singh Varsha Sagar Jung‑Hwan Lee Hae‑Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science&BK21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Biomaterials Science School of DentistryDankook UniversityCheonan 31116Republic of Korea UCL Eastman‑Korea Dental Medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea Cell and Matter Institute Dankook UniversityCheonan 31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan 31116Republic of Korea

Inflammatory skin disorders can cause chronic scarring and functional impairments,posing a significant burden on patients and the healthcare *** therapies,such as corticosteroids and nonsteroidal anti-inflammatory drugs,are limited in efficacy and associated with adverse ***,nanozyme(NZ)-based hydrogels have shown great promise in addressing these ***-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of *** multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and *** review highlights the current state of the art in NZ-engineered hydrogels(NZ@hydrogels)for anti-inflammatory and skin regeneration *** also discusses the underlying chemo-mechano-biological mechanisms behind their ***,the challenges and future directions in this ground,particularly their clinical translation,are *** insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels,offering new possibilities for targeted and personalized skin-care therapies.

关键词： Nanozymes Hydrogels ROS scavenging Anti-inflammation Skin regeneration

Gas hydrate saturation from NGHP 02 LWD data in the Mahanadi Basin

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Energy Geoscience

Energy Geoscience 2024年第2期5卷 279-289页

作者： Uma Shankar Pradeep Kumar Yadav Sneha Devi Udham singh Yadav Department of Geophysics Institute of ScienceBHUVaranasi221005India Oil and Natural Gas Corporation Ltd. Gas Hydrate Research&Technology Centre(GHRTC)Panvel410221Navi MumbaiIndia

During the Indian National Gas Hydrate Program(NGHP)Expedition 02,Logging-while-drilling(LWD)logs were acquired at three sites(NGHP-02-11,NGHP-02-12,and NGHP-02-13)across the Mahanadi Basin in area *** applied rock physics theory to available sonic velocity logs to know the distribution of gas hydrate at site NGHP-02-11 and *** physics modeling using sonic velocity at well location shows that gas hydrate is distributed mainly within the depth intervals of 150-265 m and 100 -215 mbsf at site NGHP-02-11 and NGHP-02-13,respectively,with an average saturation of about 4%of the pore space and the maximum concentration of about 40%of the pore space at 250 m depth at site NGHP-02-11,and at site NGHP-02-13 an average saturation of about 2%of the pore space and the maximum concentration of about 20%of the pore space at 246 m depth,as gas hydrate is distributed mainly within 100-246 mbsf at this *** of gas hydrate estimated from the electrical resistivity method using density derived porosity and electrical resistivity logs from Archie's empirical formula shows high saturation compared to that from the sonic ***,estimates of hydrate saturation based on sonic P-wave velocity may differ significantly from that based on resistivity,because gas and hydrate have higher resistivity than conductive pore fluid and sonic P-wave velocity shows strong effect on gas hydrate as a small amount of gas reduces the velocity significantly while increasing velocity due to the presence of *** site NGHP-02-11,gas hydrate saturation is in the range of 15%e30%,in two zones between 150-180 and 245-265 *** NGHP-02-012 shows a gas hydrate saturation of 20%e30%in the zone between 100 and 207 *** NGHP-02-13 shows a gas hydrate saturation up to 30%in the zone between 215 and 246 *** observations from rock physics modeling and Archie’s approximation show the gas hydrate concentrations are relatively low(<4%of the pore space)at the sites of the

关键词： Mahanadi Basin Gas hydrate Sonic log Effective medium modeling Electrical resistivity log Archie’s analysis Gas hydrate saturation

Acoustical properties of a 3D printed honeycomb structure filled with nanofillers:Experimental analysis and optimization for emerging applications

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Defence Technology（防务技术） 2024年第5期35卷 248-258页

作者： Jeyanthi Subramanian Vinoth kumar Selvaraj Rohan singh Ilangovan S Naresh Kakur Ruban Whenish School of Mechanical Engineering Vellore Institute of TechnologyChennai600127Tamil NaduIndia Department of Mechanical Engineering SRM Institute of Science and TechnologyRamapuramChennai600089India Department of Chemical Engineering and Materials Science University of Southern CaliforniaLos Angeles90089USA Advanced Materials Research Centre Technology Innovation InstituteAbu Dhabi9639UAE Center for Biomaterials Cellular and Molecular TheranosticsVellore Institute of TechnologyVellore632014Tamil NaduIndia

The novelty of this research lies in the successful fabrication of a 3D-printed honeycomb structure filled with nanofillers for acoustic properties,utilizing an impedance tube setup in accordance with ASTM standard E *** Creality Ender-3,a 3D printer,was used for printing the honeycomb structures,and polylactic acid(PLA)material was employed for their *** organic,inorganic,and polymeric compounds within the composites were identified using fourier transformation infrared(FTIR)*** structure and homogeneity of the samples were examined using a field emission scanning electron microscope(FESEM).To determine the sound absorption coefficient of the 3D printed honeycomb structure,numerous samples were systematically developed using central composite design(CCD)and analysed using response surface methodology(RSM).The RSM mathematical model was established to predict the optimum values of each factor and noise reduction coefficient(NRC).The optimum values for an NRC of 0.377 were found to be 1.116 wt% carbon black,1.025 wt% aluminium powder,and 3.151 mm distance between parallel ***,the results demonstrate that a 3Dprinted honeycomb structure filled with nanofillers is an excellent material that can be utilized in various fields,including defence and aviation,where lightweight and acoustic properties are of great importance.

关键词： 3D printing Honeycomb structure Acoustics Field emission scanning electron microscope Response surface methodology

A Novel High-Efficiency Transaction Verification Scheme for Blockchain Systems

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1613-1633页

作者： Jingyu Zhang Pian Zhou Jin Wang Osama Alfarraj Saurabh singh Min Zhu School of Computer&Communication Engineering Changsha University of Science&TechnologyChangsha410015China Science and Technology on Information Systems Engineering Laboratory School of Systems EngineeringNational University of Defense TechnologyChangsha410073China Computer Science Department King Saud UniversityRiyadh11437Saudi Arabia Department of Artificial Intelligence and Big Data Woosong UniversityDaejeon34606South Korea College of Information Science and Technology Zhejiang Shuren UniversityHangzhou310015China

Blockchain can realize the reliable storage of a large amount of data that is chronologically related and verifiable within the *** technology has been widely used and has developed rapidly in big data systems across various *** increasing number of users are participating in application systems that use blockchain as their underlying *** the number of transactions and the capital involved in blockchain grow,ensuring information security becomes *** the verification of transactional information security and privacy has emerged as a critical ***-based verification methods can effectively eliminate the need for centralized third-party ***,the efficiency of nodes in storing and verifying blockchain data faces unprecedented *** address this issue,this paper introduces an efficient verification scheme for transaction ***,it presents a node evaluation module to estimate the activity level of user nodes participating in transactions,accompanied by a probabilistic analysis for all ***,this paper optimizes the conventional transaction organization form,introduces a heterogeneous Merkle tree storage structure,and designs algorithms for constructing these heterogeneous *** analyses and simulation experiments conclusively demonstrate the superior performance of this *** verifying the same number of transactions,the heterogeneous Merkle tree transmits less data and is more efficient than traditional *** findings indicate that the heterogeneous Merkle tree structure is suitable for various blockchain applications,including the Internet of *** scheme can markedly enhance the efficiency of information verification and bolster the security of distributed systems.

关键词： Blockchain architecture transaction verification information security heterogeneous Merkle tree distributed systems

Influence of edaphic factors on distribution and condition of Himalayan silver birch(Betula utilis ***)communities in the northwestern Indian Himalayas

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Journal of Mountain Science 2024年第2期21卷 590-606页

作者： Khashti DASILA Renu RAWAL Tanay BARMAN Sher singh SAMANT Anita PANDEY Veena PANDE G.B.Pant National Institute of Himalayan Environment Almora 263643India Centre of Excellence on Sustainable Land Management Indian Council of Forestry Research and EducationDehradun 248006India Uttarakhand State Council for Science&Technology Dehradun 248015India Department of Biotechnology Graphic Era(Deemed to be University)Dehradun 248002India Department of Biotechnology Kumaun UniversityNainital 263136India

The basic concept of phytosociology is crucial for the assessment of species composition and dynamic ecological succession of forests supporting ecological services,functions,disturbance,and resilience that lead to the development of integrated areas such as ecological niche modeling and contribute to identifying the valuable bio-indicators which can be used in framing conservation and management *** is one of the most dominant tree species of treeline ecotone in the Himalayan *** species is also considered as indicator species for monitoring the past and recent climate change *** current study was carried out in the natural populations of *** from the sub-alpine zone of North-western Indian *** birch dominated forest harbors a total of 305 plant species comprising Angiosperms(51 families,160 genera and 277 species),Gymnosperms(03 families,05 genera and 07 species)and Pteridophytes(07 families,11 genera and 21 species)with Asteraceae,Ranunculaceae and Rosaceae as dominant *** forests are found dominant in shady moist habitat and North West *** characteristics,anthropogenic and developmental activities affect the population structure of *** and associated ***,the species has fair regeneration status in the study *** acidic nature of soil pH and spatial variation in edaphic characteristics may be due to geographical differences,rooting patterns and litter accumulation of below and above-ground *** estimation of a representative population of *** from each site showed that TAGBD,TCD and TBD were found maximum in ST3(Hamta Pass II site).The CCA analysis determined that environmental variables such as altitude,organic matter,available phosphorous,organic carbon,available nitrogen,and electrical conductivity played a significant role in determining tree species composition and distribution in *** dominated forests.

关键词： Species composition Indicator species Biomass North-western Indian Himalaya Regeneration Environmental variables

Photon orbits and phase transition for Letelier AdS black holes immersed in perfect fluid dark matter

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Chinese Physics C 2024年第6期48卷 247-259页

作者： Ashima Sood Md Sabir Ali J.K.singh Sushant G.Ghosh Department of Mathematics Netaji Subhas University of TechnologyNew Delhi-110078India Centre for Theoretical Physics Jamia Millia IslamiaNew Delhi 110025India Department of Physics Mahishadal Raj CollegePurba MedinipurWest Bengal721628India Institute of Theoretical Physics&Research Center of Gravitation Lanzhou UniversityLanzhou 730000China Key Laboratory of Quantum Theory and Applications of MoE Lanzhou UniversityLanzhou 730000China Lanzhou Center for Theoretical Physics&Key Laboratory of Theoretical Physics of Gansu Province Lanzhou UniversityLanzhou 730000China Astrophysics and Cosmology Research Unit School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa

We obtain an exact solution for spherically symmetric Letelier AdS black holes immersed in perfect fluid dark matter(PFDM).Considering the cosmological constant as the positive pressure of the system and volume as its conjugate variable,we analyze the thermodynamics of our black holes in the extended phase *** to the background clouds of strings parameter(a)and the parameter endowed with PFDM(β),we analyze the Hawking temperature,entropy,and specific ***,we investigate the relationship between the photon sphere radius and phase transition for the Letelier AdS black holes immersed in *** the analysis,with a particular condition,non-monotonic behaviors are found between the photon sphere radius,impact parameter,PFDM parameter,temperature,and *** can regard the changes in both the photon sphere radius and impact parameter before and after phase transition as the order parameter;their critical exponents near the critical point are equal to the same value,1/2,similar to that in ordinary thermal *** indicates that a universal relation of gravity may exist near the critical point for a black hole thermodynamic system.

关键词： AdS black holes perfect fluid dark matter Letelier spacetime photon orbit extended phase space thermodynamics correlation of photon orbit and thermodynamics

Exploring Deep Learning Methods for Computer Vision Applications across Multiple Sectors:Challenges and Future Trends

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 103-141页

作者： Narayanan Ganesh Rajendran Shankar Miroslav Mahdal Janakiraman SenthilMurugan Jasgurpreet singh Chohan Kanak Kalita School of Computer Science and Engineering Vellore Institute of TechnologyChennai600127India Department of Computer Science and Engineering Koneru Lakshmaiah Education FoundationVaddeswaram522502India Department of Control Systems and Instrumentation Faculty of Mechanical EngineeringVSB-Technical University of OstravaOstrava70800Czech Republic Department of Computer Science and Engineering Vel Tech High Tech Dr.Rangarajan Dr.Sakunthala Engineering CollegeChennai600062India Department of Mechanical Engineering and University Centre for Research&Development Chandigarh UniversityMohali140413India Department of Mechanical Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyAvadi600062India

Computer vision(CV)was developed for computers and other systems to act or make recommendations based on visual inputs,such as digital photos,movies,and other *** learning(DL)methods are more successful than other traditional machine learning(ML)methods *** techniques can produce state-of-the-art results for difficult CV problems like picture categorization,object detection,and face *** this review,a structured discussion on the history,methods,and applications of DL methods to CV problems is *** sector-wise presentation of applications in this papermay be particularly useful for researchers in niche fields who have limited or introductory knowledge of DL methods and *** review will provide readers with context and examples of how these techniques can be applied to specific areas.A curated list of popular datasets and a brief description of them are also included for the benefit of readers.

关键词： Neural network machine vision classification object detection deep learning