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hepatocardiorenal syndrome in liver cirrhosis:Recognition of a new entity?

World Journal of Gastroenterology 2024年第2期30卷 128-136页

作者： henry h L Wu Amina Rakisheva Arvind Ponnusamy Rajkumar Chinnadurai Renal Research Kolling Institute of Medical ResearchRoyal North Shore Hospital&The University of SydneySt.Leonards(Sydney)2065New South WalesAustralia Department of Cardiology City Cardiological CenterAlmaty 050000Kazakhstan Department of Renal Medicine Royal Preston HospitalPreston PR29HTUnited Kingdom Donal O’Donoghue Renal Research Centre&Department of Renal Medicine Northern Care Alliance National Health Service Foundation TrustSalford M68HDUnited Kingdom

Emerging evidence and perspectives have pointed towards the heart playing an important role in hepatorenal syndrome(hRS),outside of conventional understanding that liver cirrhosis is traditionally considered the sole origin of a cascade of pathophysiological mechanisms directly affecting the kidneys in this *** the absence of established heart disease,cirrhotic cardiomyopathy may occur more frequently in those with liver cirrhosis and kidney *** is a specific form of cardiac dysfunction characterized by blunted contractile responsiveness to stress stimuli and altered diastolic relaxation with electrophysiological *** the clinical description of these potential cardiac-related complications of the liver,the role of the heart has traditionally been an overlooked aspect of circulatory dysfunction in *** from a physiological sense,temporality(prior onset)of cardiorenal interactions in hRS and positive effects stemming from portosystemic shunting demonstrated an important role of the heart in the development and progression of kidney dysfunction in cirrhotic *** this review,we discuss current concepts surrounding how the heart may influence the development and progression of hRS,and the role of systemic inflammation and endothelial dysfunction causing circulatory dysfunction within this *** temporality of heart and kidney dysfunction in hRS will be *** a subgroup of patients who receive portosystemic shunting,the dynamics of cardiorenal interactions following treatment is *** research to determine the unknowns in this topic is anticipated,hopefully to further clarify the intricacies surrounding the liver-heart-kidney connection and improve strategies for management.

关键词： hepatorenal syndrome Cardiorenal syndrome Cirrhosis Cardiac dysfunction Circulatory dysfunction

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Liouvillian Solutions of Algebraic Ordinary Differential Equations of Order One of Genus Zero

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Journal of Systems Science & Complexity 2023年第2期36卷 884-893页

作者： NGUYEN tri Dat NGO Lam Xuan Chau Faculty of Basic Science Ho Chi Minh City University of TransportHo Chi Minh CityVietnam Department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon CityVietnam

This paper considers the class of autonomous algebraic ordinary differential equations(AODEs)of order one,and studies their Liouvillian general *** particular,let F(y,w)=0 be a rational algebraic curve over *** authors give necessary and sufficient conditions for the autonomous first-order AODE F(y,y′)=0 to have a Liouvillian solution over ***,the authors show that a Liouvillian solutionαof this equation is either an algebraic function over C(x)or an algebraic function over C(exp(ax)).As a byproduct,these results lead to an algorithm for determining a Liouvillian general solution of an autonomous AODE of order one of genus *** parametrizations of rational algebraic curves play an important role on this method.

关键词： Algebraic ordinary differential equation autonomous differential equation Liouvillian solution rational algebraic curve rational parametrizations

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Pelleting and particle size reduction of corn increase net energy and digestibility of fiber,protein,and fat in corn-soybean meal diets fed to group-housed pigs

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1751-1760页

作者： Su A Lee Diego A.Rodriguez Chad B.Paulk hans h.Stein Department of Animal Sciences University of IllinoisUrbanaIL 61801USA Department of Grain Sciences and Industry Kansas State UniversityManhattanKS 66506USA

Background Reduction of the particle size of corn increases energy digestibility and concentrations of digestible and metabolizable *** may also reduce particle size of grain,but it is not known if there are interactions between particle size reduction and *** objective of this experiment was to test the hypothesis that particle size reduction and pelleting,separately or in combination,increase N balance,apparent total tract digestibility(ATTD)of fiber and fat,and net energy(NE)in corn-soybean meal diets fed to group-housed *** Six corn-soybean meal-based diets were used in a 3×2 factorial design with 3 particle sizes of corn(i.e.,700,500,or 300μm)and 2 diet forms(i.e.,meal or pelleted).Pigs were allowed ad libitum access to feed and ***-four castrated male pigs(initial weight:29.52 kg;standard diviation:1.40)were allotted to the 6 diets using a 6×6 Latin square design with 6 calorimeter chambers(i.e.,4 pigs/chamber)and 6 *** consumption and CO_(2)and Ch_(4)productions were measured during fed and fasting states and fecal and urine samples were *** Regardless of particle size of corn,the ATTD of gross energy(GE),N,and acid-hydrolyzed ether extract(AEE),and the concentration of NE were greater(Phan in meal *** of diet form,the ATTD of GE,N,and AEE,and the concentration of NE were increased(linear;Phe particle size of corn,but the increase was greater in meal diets than in pelleted diets(interaction;Ph pelleting and reduction of corn particle size increased nutrient digestibility and NE,but increases were greater in meal diets than in pelleted diets.

关键词： Corn Digestibility Feed technology Net energy Particle size Pelleting

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Search for production of dark fermion candidates in association with heavy neutral gauge boson decaying to dimuon in proton-proton collisions at√s=8 TeV using CMS open data

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Chinese Physics C 2024年第4期48卷 6-13页

作者： Y.Mahmoud h.Abdallah M.T.hussein S.Elgammal Centre for theoretical physics The British University in EgyptEgypt Physics Department Faculty of ScienceCairo UniversityEgypt

In this study,we conducted a search for dark matter using a part of the data recorded by the CMS experiment during run-I of the LhC in 2012 with a center of mass energy of 8 TeV and an integrated luminosity of 11.6 fb−*** data were gathered from the CMS open *** matter,in the framework of the simplified model(mono-Z′),can be produced from proton-proton collisions in association with a new hypothetical gauge boson,Z′.Thus,the search was conducted in the dimuon plus large missing transverse momentum *** benchmark scenario of mono-Z′,which is known as light vector,was used for interpreting the CMS open *** evidence of dark matter was observed,and exclusion limits were set on the masses of dark matter and Z′at 95%confidence level.

关键词： dark matter large hadron collider CMS open data search for new physics dark fermion

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Music as medicine for traumatic brain injury:a perspective on future research directions

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Neural Regeneration Research 2024年第10期19卷 2105-2106页

作者： Anthony E.Kline Eleni h.Moschonas Corina O.Bondi Department of Physical Medicine&Rehabilitation University of PittsburghPittsburghPAUSA Safar Center for Resuscitation Research University of PittsburghPittsburghPAUSA Center for Neuroscience University of PittsburghPittsburghPAUSA Department of Critical Care Medicine University of PittsburghPittsburghPAUSA Center for the Neural Basis of Cognition University of PittsburghPittsburghPAUSA Department of Psychology University of PittsburghPittsburghPAUSA Department of Neurobiology University of PittsburghPittsburghPAUSA

Traumatic brain injury(TBI) impacts 69 million individuals globally each year and is a leading cause of death and disability(Dewan et al.,2019).The majority of moderate-to-severe TBI survivors endure long-lasting disturbances in motor,cognitive,and affect that negatively impacts their *** a plethora of research on pharmacological interventions for TBI has been conducted,none has translated to the clinic,thus advocating for the evaluation of nonpharmacological therapeutic approaches that may increase translational success.

关键词： injury traumatic

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Integralinput-to-statestability ystemswithsmalldelays Integral input-to-state stability of systems with small delays

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Control Theory and Technology 2024年第3期22卷 455-467页

作者： R.h.harsha Nawarathna Yuandan Lin Yuan Wang Department of Mathematical Sciences Florida Atlantic UniversityBoca RatonFL 33431USA

We consider how small delays affect the integral-input-to-state stability(iss)property for a *** result is similar to the input-to-state stability(Iss)result obtained in[1]:the iss property will be preserved in a practical and semi-global manner if the delay interval is small ***,since the iss quantifies the robust stability in terms of a generalized Li norm of the inputs instead of a generalized Loo norm of the inputs for the Iss case,the techniques and proofs for the Iss case do not apply to the iss case *** the proofs in[1]are based on the Lyapunov-Razumikhin approach,our proofs are based on the iss-Lyapunov functions for the zero-delay *** addition to the interest by its own in showing how the iss property is affected by small delays,the result also serves to the study of the iss property for singularly perturbed systems.

关键词： Integral-input-to-state stability Nonlinear systems Small delays Lyapunov method

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Role of marine natural products in the development of antiviral agents against SARS‑CoV‑2:potential and prospects

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Marine Life Science & Technology 2024年第2期6卷 280-297页

作者： D.P.Nagahawatta N.M.Liyanage Thilina U.Jayawardena h.h.A.C.K.Jayawardhana Seong‑hun Jeong hyung‑Jun Kwon You‑Jin Jeon Department of Marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Department of Chemistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World health ***,the develop-ment of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic *** natural products(MNPs)have received increased attention in the development of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication mechanisms,including the function of the SARS-CoV-2 genome and ***,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing MNPs and predicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 Marine natural products Drug targets Inhibitors

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A vectorial model for the nonlinear gradient force exerted on metallic Rayleigh nanoparticles

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Chinese Optics Letters 2024年第2期22卷 207-213页

作者：朱政张聿全闵长俊 Aurèle J.LAdam h.Paul Urbach 袁小聪 Research Center for humanoid Sensing Research Institute of Intelligent SensingZhejiang LabHangzhou 311100China Nanophotonics Research Center Institute of Microscale Optoelectronics&State Key Laboratory of Radio Frequency Heterogeneous IntegrationShenzhen UniversityShenzhen 518060China Optics Research Group ImPhys DepartmentFaculty of Applied SciencesDelft University of TechnologyDelft 2628 CJThe Netherlands

Optical tweezers have proved to be a powerful tool with a wide range of *** gradient force plays a vital role in the stable optical trapping of *** scalar method is convenient and effective for analyzing the gradient force in traditional optical ***,when the third-order nonlinear effect of the nano-object is stimulated,the scalar method cannot adequately present the optical response of the metal nanoparticle to the external optical ***,we propose a theoretical model to interpret the nonlinear gradient force using the vector *** combining the optical Kerr effect,the polarizability vector of the metallic nanoparticle is derived.A quantitative analysis is obtained for the gradient force as well as for the optical potential *** vector method yields better agreement with reported experimental *** suggest that this method could lead to a deeper understanding of the physics relevant to nonlinear optical trapping and binding phenomena.

关键词： gradient forces nonlinear effect metallic nanoparticles

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不同结构AlGaN基深紫外发光二极管性能研究

不同结构AlGaN基深紫外发光二极管性能研究

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作者： ALMAZROI SALWA SAAD h 北京化工大学

学位级别：硕士

基于AlGaN材料的深紫外发光二极管(DUV LED)具有体积小、能耗低、工作电流小、亮度高和发光响应速度快等优点,发光具有很强的杀菌效果,是汞灯的理想替代品,广泛地用于生物研究和污水处理领域。同时也可以为生物实验室、实验用器具及医... 详细信息

基于AlGaN材料的深紫外发光二极管(DUV LED)具有体积小、能耗低、工作电流小、亮度高和发光响应速度快等优点,发光具有很强的杀菌效果,是汞灯的理想替代品,广泛地用于生物研究和污水处理领域。同时也可以为生物实验室、实验用器具及医院手术室、医疗器具等消毒,在微制造技术和环境科学领域也大有可为,而且还可以用于制造侦测有毒粒子的传感器。由于其很容易与晶体管和集成电路配套使用,是近几年来迅速崛起的半导体光电器件。然而由于材料极化特性、器件结构等一系列因素,导致器件的性能难以与同族材料制备的可见光LED比拟,严重阻碍了其产业化进程。针对上述难题,本论文设计构建了系列DUV LED器件结构,并采用APSYS软件,研究了有源区结构、电子阻挡层结构及p型区结构对器件性能的影响机理,并对器件结构进行了优化设计,获得了以下研究成果。(1)深入研究了有源区结构对器件性能的影响,研究发现在一定范围内增加量子阱(QW)和量子阱势垒(QB)层厚度可以提高载流子注入效率和辐射复合效率,提升内部量子效率(IQE)和总功率。然而,超过一定阈值后,由于量子限制stark效应,导致IQE下降。在本工作中,当QW和QB的厚度分别为3.50、10.00 nm时,器件性能最佳。I-V曲线显示,QW和QB厚度的增加,对器件开启电压几乎没有影响。该研究强调了材料组成、能带对齐和厚度在器件性能优化方面的重要性。优化QW和QB层的厚度可以极大地提高内部量子效率(IQE)和LED总功率。(2)探讨了超晶格电子阻挡层(SL-EBL)对AlGaN DUV LED性能的影响。深入研究了SL-EBL厚度对器件功能的影响,揭示了结构参数和LED性能之间微妙的关系。研究表明,SL-EBL厚度的变化对AlGaN DUV LED的效率有重大影响,随着SL-EBL厚度的增加,IQE和总LED功率均呈现出一致的降低。在所有结构中,较薄的SL-EBL厚度为1.00 nm时可实现最佳性能。此外,分析还探讨了SL-EBL结构和不同铝(Al)组分对SL-EBL性能的影响。对带隙能量的检查显示,较大的SL-EBL层导致导带和价带边缘发生显著变化,表明载流子限制增强,载流子迁移性降低。通过优化SL-EBL结构,可以达到更高的IQE,达到68.37%,强调了精心设计和组成在提高LED性能中的重要性。(3)研究探讨了p型层内Al化合物浓度的变化对器件特性的影响。审查了AlGaN DUV LED的Al比例与效率之间的相关性,以及它们各自的厚度。在优化Al浓度之后,确定了7).(6./7).(6.的配置,第一层厚度为10 nm,第二层厚度为10 nm,可以实现72.12%的内部量子效率(IQE)。该配置在注入电流为500 A/m时,还可实现144.24 W/m的输出功率。

关键词： AlGaN 发光二极管有源区 EBL AlGaN器件结

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Ballistic design and testing of a composite armour reinforced by CNTs suitable for armoured vehicles

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Defence Technology（防务技术） 2024年第2期32卷 173-195页

作者： Evangelos Ch.Tsirogiannis Evangelos Daskalakis Mohamed h.hassan Abdalla M.Omar Paulo Bartolo EODh SA Research and Development DepartmentLakkoma Chalkidikis63080Greece School of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchesterM139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological University639798Singapore

This paper is investigating the use of composite armour reinforced by nanomaterials, for the protection of light armoured(LAV) and medium armoured military vehicles(MAV), and the interaction between the composite materials and high-performance ballistic projectiles. Four armour materials, consisted of front hybrid fibre reinforced polymer cover layer, ceramic strike-face, fibre reinforced polymer intermediate layer and the metal matrix composite reinforced backplate, were manufactured and assembled by adhesive technology. The proposed laminated protection system is suitable for armoured ground vehicles;however, it could be used as armour on ground, air and naval platforms. The design of the protection system, including material selection and thickness, was elaborated depending on the performance requirements of Level 4 + STANAG 4569 military standard(projectile 14.5 mm × 114 mm API B32) and especially on a design philosophy which is analysed with the specifications. The backplate of this new composite is a hybrid material of Metal Matrix Composite(MMC) reinforced with carbon nanotubes(CNTs), manufactured with the use of powder metallurgy technique. The composite backplate material was morphologically, mechanically and chemically analysed. Results show that all plates are presenting high mechanical properties and ballistic characteristics, compared to commonly used armour plates. Real military ballistic tests according to AEP-STANAG 4569 were carried out for the total composite armour systems. After the ballistic tests, AA2024-CNT3 showed the best protection results, compared with the other plates(AA2024-CNT1 and AA2024-CNT2), with the projectile being unable to fully penetrate the composite plate.

关键词： Passive armour protection Protective armour Ballistic performance hybrid composites Vehicle protection

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