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分析化学 1987年第12期 1076-1080页

作者：段群章中南工业大学化学系长沙

本文报道了用饱和法研究TnOA-H2SO4体系萃取铬（Ⅵ）的机理,测量了在不同pH和不同铬（Ⅵ）浓度下的铬（Ⅵ）萃取型体和TnOA对CrO42-和Cr2O72-的萃合比,给出了铬的萃取反应式,揭示了Deptuta等人对铬（Ⅵ）的萃取型体的不同结论。

关键词： VI TnOA-H2SO4 SO 萃取反应硫酸体系 Cr 酸度型体无水乙酸

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Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand nicolas Goudin Ivan nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre nadia Arzouk Veronique minard-Colin Caroline Chopinet michael Dussiot Denise mAdams tristan mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance InSERm U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UmR 5220 Villeurbanne 69100France Service de Radiologie mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France InSERm U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de médecine Vasculaire hôpital Européen Georges-PompidouParisFrance nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CnRS UmR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(mRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

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Clinical Safety of new tri-Phasic Oral Contraceptive Pill

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Journal of Reproduction and Contraception 1991年第1期3卷 25-30页

作者： n.mereuri G.Brilli A.C.mancini G.Botticelli G.Fabbri A.D.Genazzani F.Petraglia A.Volpe A.R.Genazzani Dept.Obst.Gynecol. UniversityofModenaViadelP02207141100ModenaItaly Dept.Obst.Gynecol. UniversityofCagliareItaly

The aim of our study was to evaluate the metabolic and clinical effects of a contraceptive treatment with a new tri-phasic formulation of ethynyl-estradiol (35μg) and norethisterone (0.5-1mg) in fertile *** this purpose 20 healthy fertile women (19-32years) volunteered to follow this ***-density lipoprotein cholesterol,low-density lipoprotion cholesterol,fibrinogen concentration and antithrombin Ⅲ were measured by enzymatic method and fibrinopeptides A,by *** patients were treated for 6 cycles and they were studied before and after 1,3, and 6 cycles of *** all patients both the length of the menstrual cycle,and bleeding,acne and seborrhea and side effects were *** contraceptive therapy with this new formulation resulted very effective,without significant metabolic changes and with very few side effects.

关键词：三相口服避孕药丸药物安全性临床试验药物代谢动力学育龄女性

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Adolescents’ perspectives on a school-based physical activity intervention:A mixed method study

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Journal of Sport and Health Science 2020年第1期9卷 28-40,F0003页

作者： Stephanie T.Jong Caroline H.D.Croxson Cornelia Guell Emma R.Lawlor Campbell Foubister Helen E.Brown Emma K.Wells Paul Wilkinson Anna Vignoles Esther m.F.van Sluijs Kirsten Corder mRC Epidemiology Unit and UKCRC Centre for Diet and Activity Research(CEDAR) University of Cambridge School of Clinical MedicineCambridgeCB2 OQQUK nuffield Department of Primary Care Health Sciences University of OxfordOxfordOX26GGU European Centre for Environment and Human Health University of Exeter Medical SchoolKnowledge SpaRoyal Cornwall HospitalTruroTRI 3HDUK Department of Psychiatry University of Cambridge and Cambridgeshire and Peterborough NHS Foundation TrustCambridgeCB215EFUK Faculty of Education University of CambridgeCambridgeCB28PQUK

Purpose'. To examine adolescent experiences and perspectives of the GoActive intervention (ISRCTn31583496) using mixed methods processevaluation to determine satisfaction with intervention components and interpret a*dolescents experiences of the intervention process in order toprovide insights for future intervention ***'. Participants (n = 1542;13.2 土 0.4 years, mean 土 SD) provided questionnaire data at baseline (shyness, activity level) and post-intervention(intervention acceptability, satisfaction with components). Between-group differences (boys vs. girls and shy/inactive vs. others) weretested with linear regression models, accounting for school clustering. Data from 16 individual interviews (shy/inactive) and 11 focus groupswith 48 participants (mean = 4;range 2—7) were thematically coded. Qualitative and quantitative data were merged in an integrative mixedmethods convergence matrix, which denoted convergence and dissonance across ***'. Effect sizes for quantitative results were small and may not represent substantial between-group differences. Boys (vs. girls) preferredclass-based sessions (0 = 0.2, 95% confidence interval (CI): 0.1—0.3);qualitative data suggested that this was because boys preferred competition,which was supported quantitatively (0 = 0.2, 95%CI: 0.1-0.3). Shy/inactive students did not enjoy the competition (0 = -0.3, 95%CI:—0.5 to —0.1). Boys enjoyed trying new activities more (0 = 0.1, 95%CI: 0.1 -0.2);qualitative data indicated a desire to try new activities acrossall subgroups but identified barriers to choosing unfamiliar activities with self-imposed choice restriction leading to boredom. Qualitative datahighlighted critique of mentorship;adolescents liked the idea, but older mentors did not meet ***. We interpreted adolescent perspectives of intervention components and implementation to provide insights into future complexinterventions aimed at increasing young people's physical activity in s

关键词： Adolescent Intervention mixed methods Physical activity Process evaluation

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核心价值观培育的文化心理建构

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浙江师范大学学报（社会科学版） 2017年第6期42卷 111-115页

作者：邱旭光张宏敏浙江工贸职业技术学院督导处浙江温州325003 浙江省社会科学院哲学研究所浙江杭州310007

核心价值观内化即价值观已经建构到文化心理层面,并形成相应的人格特征。为此,必须探索核心价值观与文化心理结构之间的复杂关系,明确文化心理的形成机制,寻找到建构核心价值观文化心理的路径。价值发生有其必然的文化心理动因,且是一... 详细信息

核心价值观内化即价值观已经建构到文化心理层面,并形成相应的人格特征。为此,必须探索核心价值观与文化心理结构之间的复杂关系,明确文化心理的形成机制,寻找到建构核心价值观文化心理的路径。价值发生有其必然的文化心理动因,且是一个不断积淀与重构的过程。价值内化和价值认知的文化心理过程、价值取向的文化心理动机以及文化心理的价值选择与价值判断共同构成价值观的文化心理机制。在明了当下文化心理的基础上,遵循心理认知规律,挖掘传统文化"有生"内涵,从而实现"现代中国文化心理"结构的重建。

关键词：核心价值观文化心理心理机制心理结构

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