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Microbial phenolic metabolites are associated with better frontal lobe cognition

Food Science and Human Wellness 2024年

作者： Inés Domínguez-López Isabella Parilli-moser Anna Vallverdú-Queralt Anna Tresserra-Rimbau Cinta Valls-Pedret Zenaida Vázquez-Ruiz Olga Casta?er Ramon Estruch Emili Ros Rosa M.Lamuela-Raventós Lipid Clinic， Endocrinology and Nutrition Service， Institut d'Investigacions Biomèdiques August Pi i Sunyer， Hospital Clínic 08036 Barcelona， Spain Unit of Cardiovascular Risk and Nutrition， Institut Hospital del Mar de Investigaciones Médicas (IMIM) Department of Preventive Medicine and Public Health， University of Navarra Departament de Nutrició， Ciències de l'Alimentació i Gastronomía， Facultat de Farmacia， Universitat de Barcelon (UB)， Av.de Joan XXII Department of Endocrinology， Hospital Clinic IDIBAPS， Barcelona， Spain Department of Internal Medicine， Hospital Clinic， Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS)， University of Barcelona CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)， Instituto de Salud Carlos III Institut de Nutrició i Seguretat Alimentària (INSA)， Universitat de Barcelona (UB)

With increasing life expectancy， neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets， such as the Mediterranean diet， which is particularly rich in polyphenols， bioactive compounds with neuroprotective properties. The aim of this study was to assess the association of microbial phenolic metabolites (MPM) with cognition. This cross-sectional analysis was performed with 200 participants of the PREDIMED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM (protocatechuic acid， enterodiol glucuronide， enterolactone glucuronide， urolithin B glucuronide， and vanillic acid glucuronide)， and cognitive function was evaluated with neuropsychological tests. Multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM， and a score was calculated as the weighted sum of MPM. A higher MPM score was associated with better frontal lobe function. Among individual metabolites， vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multi-MPM was associated with better frontal cognitive performance in an older Mediterranean population.

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Engineering for problem solving in future: Eco-social market economy and eco-social tech

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Journal of Environmental Sciences 2001年第3期13卷 257-264页

作者： moser, Anton Institute of Biotechnology Group Eco-Tech A-8010 Graz Petersgasse 12 Austria. E-mail:

The paper differentiates approaches in technology (end-of-pipe, cleaner production, industrial ecology, zero emission and eco-social tech) and compares them in respect to the problem solving capacity on the ecological as well as social dimension by showing the eco-impact reduction and job creation. Eco-social-tech represents the approach with highest problem solution as it is based on "eco-social market economy", which will the replace free market economy. The deep background of these innovations is "ecosophy", the wisdom of nature, which serves as guideline for eco-restructuring the world.

关键词： Eco-social market economy and eco-social tech Engineering for problem solving in future In

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The epididymis, cytoplasmic droplets and male fertility

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Asian Journal of Andrology 2011年第1期13卷 130-138页

作者： trevor G Cooper Centre of Reproductive Medicine and Andrology University of MOnster MOnster D-48149 Germany

The potential of spermatozoa to become motile during post-testicular maturation, and the relationship between the cytoplasmic droplet and fertilizing capacity are reviewed. Post-testicular maturation of spermatozoa involves the autonomous induction of motility, which can occur in vivo in testes with occluded excurrent ducts and in vitro in testicular explants, and artefactual changes in morphology that appear to occur in the testis in vitro. Both modifications may reflect time-dependent oxidation of disulphide bonds of head and tail proteins. Regulatory volume decrease （RVD）, which counters sperm swelling at ejaculation, is discussed in relation to loss of cytoplasmic droplets and consequences for fertility. It is postulated that：（i） fertile males possess spermatozoa with sufficient osmolytes to drive RVD at ejaculation, permitting the droplet to round up and pinch off without membrane rupture; and （ii） infertile males possess spermatozoa with insufficient osmolytes so that RVD is inadequate, the droplet swells and the resulting flagellar angulation prevents droplet loss. Droplet retention at ejaculation is a harbinger of infertility caused by failure of the spermatozoon to negotiate the uterotubal junction or mucous and reach the egg. In this hypothesis, the epididymis regulates fertility indirectly by the extent of osmolyte provision to spermatozoa, which influences RVD and therefore droplet loss. Man is an exception, because ejaculated human spermatozoa retain their droplets. This may reflect their short midpiece, approximating head length, permitting a swollen droplet to extend along the entire midpiece; this not only obviates droplet migration and flagellar angulation but also hampers droplet loss.

关键词： epididymis fertility infertility sperm maturation

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Remembering Mike Bedford （21.5.1932-24.2.2018）

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Asian Journal of Andrology 2018年第4期20卷 420-424页

作者： trevor G Cooper .

John Michael Bedford （Figure 1） studied at Sidney Sussex College, Cambridge University （1952-1958）, and gained his BA （1955） and MA （1958） in Natural Sciences, with postgraduate training in Veterinary Medicine and Surgery （Vet MB 1958）. He had academic appointments as a Fellow at Bristol University （1958-1959）, a scientist with MC Chang at the Worcester Foundation in Shrewsbury, MA, USA （1959-1961）,and studied for a PhD in Physiology with Professor Amoroso at the University of London （1961-1965）. During this time, he was also a lecturer at the Royal Veterinary College （1961-1966） and a teacher at the University of London （1965）.

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Semen quality： variations among fathers and effects of moderate alcohol drinking

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Asian Journal of Andrology 2015年第1期17卷 46-47页

作者： trevor G Cooper Tuen Mun New Territories Hong Kong SAR China

Semen analysis results from over 750 fathers in the USA demonstrated marked differences in the quality of semen from men at different locations and of different ethnic groups. Another paper failed to demonstrate any effects of moderate alcohol consumption during the week before provision of an ejaculate on semen quality and few on serum hormones, of over 8300 men in Europe and the USA. While these observations are interesting, the reasons for regional and ethnic differences in semen quality of fathers are unclear. Although, there was no attempt to confirm the participant-provided level of alcohol consumption, an increase in serum testosterone in the men at the higher end of alcohol intake is compatible with an alcohol effect on liver metabolism, although whether alcohol intake was the cause of higher testosterone, or men with higher androgen levels consume more alcohol, is not known.

关键词： Semen quality variations among fathers

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Three thousand years in Tibet

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National Science Review 2020年第1期7卷 129-130页

作者： Bettina Harr trevor Price Max-Planck-Institut für Evolutionsbiologie Department of Ecology and Evolution University of Chicago

Humans have come to inhabit nearly every terrestrial environment. Their commensals have followed them and have consequently become some of the most abundant and widespread species on Earth, in the process becoming exposed to a variety of abiotic and biotic stressors. For example, the house sparrow was introduced from the UK to North America in the

关键词： Three thousand years in Tibet

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Sperm maturation in the epididymis： a new look at an old problem

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Asian Journal of Andrology 2007年第4期9卷 533-539页

作者： trevor G. Cooper Institute of Reproductive Medicine of the University Münster D-48129 Germany

The osmotic challenges facing maturing spermatozoa and their responses to them are discussed in relation to the concept of sperm maturation, defined as the increased ability of more distally recovered epididymal spermatozoa to fertilize eggs when inseminated into the female tract. One explanation could be that the more distal cells are better able to regulate their volume, and reach the oviducts, as a consequence of uptake of epididymal osmolytes. Increased motility, zona binding and oolemma fusion capacities are also acquired within the epididymis and are necessary for those cells that finally arrive at the site of fertilization. （Asian J Androl 2007 July; 9： 533-539）

关键词： epididymal function fertilization in vivo osmotic challenge sperm maturation

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Epididymal research： more warp than weft？

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Asian Journal of Andrology 2015年第5期17卷 699-703,I0005页

作者： trevor G Cooper Tuen Mun NTHong Kong SARChina

From a review of some aspects of epididymal structure, function and research done largely in my research area over the last 50 years, I conclude that more is known than is understood of sperm maturation and storage in the epididymis. Highly qualified technicians have not always applied sophisticated modern techniques in well-considered experiments to physiologically relevant and properly-prepared samples, so that our understanding of the biological problem of the nature of the epididymal epithelial influence on maturing epididymal spermatozoa has not kept pace with the outpouring of data generated, much of which is difficult to interpret. We stand at a crossroads of where to aim our limited resources and personnel： should we continue new technology-led studies in many directions, backtrack to test hypotheses and fill in gaps in our knowledge, or consider more biological directions to our research？

关键词：附睾精子扭曲现代技术技术人员数据生成十字路口多方向成熟

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Using LIDAR and ground truth for landslide recognition and characterization of geotechnical and morphological parameters in sedimentary rocks,a case study in Northern Bavaria (Germany)

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Journal of Mountain Science 2017年第8期14卷 1513-1525页

作者： WIEDENMANN Johannes ROHN Joachim moser Michael GeoZentrum Nordbayern Department of Applied GeologyUniversity of Erlangen-Nürnberg

The use of LIDAR-derived shaded relief maps led to the identification of all potential landslide areas in a hilly region in Northern Bavaria(1590 km^2), Germany. Every possible structure was investigated by field investigation which resulted in a detailed database of 1002 landslides within the study area. The analysis of geological, lithological, topographical and morphological properties(spatial ratio, lithological and geological setting, length/width distribution, material properties and slope angle) revealed characteristic appearances of the landslides and possible relationships between different aspects. Strong relations between the lithological setting, spatial ratio of the mapped landslides and distribution of slope angle could be observed. This study shows the value of high-resolution shaded relief maps for detecting and mapping landslides in a large area with comparatively little work and time in comparison to the traditional approach to mapping. It reveals that many landslides were not known before. Landslides are much more common in Northern Bavaria and have a higher influence on the denudation rate of the Franconian Alb than expected before.

关键词： Landslides LIDAR Appearance Spatialratio Material properties Bavaria

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An automated water dispensing system for controlling fires in coal yards

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International Journal of Coal Science & Technology 2022年第2期9卷 220-228页

作者： Jeevan Jayasuriya Irene moser Ravi de Mel University of Sri Jayewardenepura GangodawilaNugegodaSri Lanka Swinburne University of Technology MelbourneVICAustralia

In spite of recent moves to wean the world of fossil fuels,coal remains the main source of power in many *** yards are prone to spontaneous ignition,a problem faced in every country that stores or transports *** on the environment-temperature,ventilation,and the rank of the coal-heating and self-ignition can be a longer or shorter process,but the possibility can never be entirely dismissed.A plethora of studies have modelled this oxidation behavior and proposed *** often,human intervention is necessary,which is both slow and dangerous for the frefghters *** this study,we propose to build a complete frefghting solution which is mounted on a number of towers sufcient to cover the area of an open coal yard,complete with *** tower includes an inexpensive infrared detector,a water dispenser and a controller programmed to identify areas of elevated temperature,and actuate the *** heat direction algorithm calculates the parameters to position the water dispenser so that it covers the area.A prototype has been built from inexpensive components to demonstrate the efectiveness at detecting and extinguishing arising fres,and a solution has been costed for the coal yard in the case *** work has been conducted in collaboration with the managers of the coal yard of a power plant.

关键词： Coal yard fre Fire detection Internet of things Spontaneous combustion detection Infrared heat detection

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