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Eco Friendly Passenger Car Motor Oil

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Eco Friendly Passenger Car Motor Oil

The epididymis, cytoplasmic droplets and male fertility

中国汽车工程学会燃料与润滑油分会第十四届年会

作者： Nobuo USHIODA trevor miller Chevron Japan Ltd. Chevron Oronite Co.LLC

Environmental protection is a key theme for any *** the automotive industry,the automobile makers have been working to develop new *** the same time,lubricant manufacturers and additive companies have been working on the development of"Eco Friendly"lubricants,which can play an important role in fuel economy performance and exhaust gas after-treatment system compatibility. One of the key"Eco Friendly"performance areas of automotive engine oil is fuel *** method of screening this performance is *** screen fuel economy performance,a motored friction torque test to evaluate additive formulations has been *** test was modeled after the SequenceⅥD engine test in the ILSAC GF-5 specification by incorporating both fresh and aged fuel economy measurements.A bench scale screener for predicting fuel economy degradation in SequenceⅥD was *** the screener,additive formulations that showed improved fuel economy performance have been developed. Emission system compatibility is also a key performance *** the ILSAC GF-5 specification, phosphorus volatility is also regulated with the same phosphorus content as in ILSAC GF-4 to secure wear protection.

关键词： Environmental Protection Fuel Economy ILSAC GF-5 SequenceⅥD Additive Formulation

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Asian Journal of Andrology 2011年第1期13卷 130-138页

作者： trevor G Cooper Centre of Reproductive Medicine and Andrology University of MOnster MOnster D-48149 Germany

The potential of spermatozoa to become motile during post-testicular maturation, and the relationship between the cytoplasmic droplet and fertilizing capacity are reviewed. Post-testicular maturation of spermatozoa involves the autonomous induction of motility, which can occur in vivo in testes with occluded excurrent ducts and in vitro in testicular explants, and artefactual changes in morphology that appear to occur in the testis in vitro. Both modifications may reflect time-dependent oxidation of disulphide bonds of head and tail proteins. Regulatory volume decrease （RVD）, which counters sperm swelling at ejaculation, is discussed in relation to loss of cytoplasmic droplets and consequences for fertility. It is postulated that：（i） fertile males possess spermatozoa with sufficient osmolytes to drive RVD at ejaculation, permitting the droplet to round up and pinch off without membrane rupture; and （ii） infertile males possess spermatozoa with insufficient osmolytes so that RVD is inadequate, the droplet swells and the resulting flagellar angulation prevents droplet loss. Droplet retention at ejaculation is a harbinger of infertility caused by failure of the spermatozoon to negotiate the uterotubal junction or mucous and reach the egg. In this hypothesis, the epididymis regulates fertility indirectly by the extent of osmolyte provision to spermatozoa, which influences RVD and therefore droplet loss. Man is an exception, because ejaculated human spermatozoa retain their droplets. This may reflect their short midpiece, approximating head length, permitting a swollen droplet to extend along the entire midpiece; this not only obviates droplet migration and flagellar angulation but also hampers droplet loss.

关键词： epididymis fertility infertility sperm maturation

Statin use and cognitive function in middle-aged adults with type 1 diabetes

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World Journal of Diabetes 2017年第6期8卷 286-296页

作者： Karen A Nunley trevor J Orchard Christopher M Ryan Rachel miller Tina Costacou Caterina Rosano Department of Epidemiology University of PittsburghPA 15213United States

AIM To test associations between statin use and cognitive impairment in adults with childhood-onset type 1 diabetes(T1D).METHODS In 2010-13, n = 108 middle-aged participants from ongoing observational Pittsburgh Epidemiology of Diabetes Complications Study underwent neurocognitive assessment(mean age and T1 D duration of 49 and 41 years, respectively). All were diagnosed with childhoodonset(i.e., prior to age 18) T1 D between 1950 and 1980 and were seen within one year of diagnosis at Children's Hospital of Pittsburgh. Self-reported statin use(yes/no and if yes, name of statin) was collected biennially from parent study baseline(1986-1988) to time of neurocognitive testing. Logistic regression models tested associations between statin use groups and cognitive impairment(defined as having two or more cognitive test scores 1.5SD or worse than published norms) while linear regression models tested associations between statin use groups and cognitive domain z-scores(domains: Verbal IQ, memory, executive function, psychomotor speed, and visuo-construction). All models controlled for education and age. To address confounding by indication, models were repeated using a propensity score for statin *** Of the 108 participants, 51 reported never using statins. Median duration of statin use among the 57 ever users was 6 years. These 57 ever statin users were split to create two groups(≤ or > median years of statin use): 1-6 years(n = 25), and 7-12 years(n = 32). Compared with never users, using statins 1-6 years tripled the odds of cognitive impairment(OR = 3.16; 95%CI: 0.93-10.72; P = 0.06) and using statins 7-12 years almost quintupled the odds of cognitive impairment(OR = 4.84; 95%CI: 1.63-14.44; P = 0.005). Compared with never users, using statins 1-6 or 7-12 years was related to worse performance in the memory domain(β =-0.52; P = 0.003, and-0.39; P = 0.014, respectively). Adjusting for coronary artery disease, low density lipoprotein cholesterol, and Apo E4 statu

关键词： Type 1 diabetes Cognitive impairment Memory Statin use Cohort study

Remembering Mike Bedford （21.5.1932-24.2.2018）

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Asian Journal of Andrology 2018年第4期20卷 420-424页

作者： trevor G Cooper Article notes Copyright and License information Disclaimer Correspondence: Dr. TG Cooper (moc.liamg@grovertc) Received 2018 Apr 7 Accepted 2018 Apr 25.Copyright : © The Author(s)(2018)This is an open access journal and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License which allows others to remix tweak and build upon the work non-commercially as long as appropriate credit is given and the new creations are licensed under the identical terms.<h2 class="head no_bottom_margin" id="idm***title"

John Michael Bedford （Figure 1） studied at Sidney Sussex College, Cambridge University （1952-1958）, and gained his BA （1955） and MA （1958） in Natural Sciences, with postgraduate training in Veterinary Medicine and Surgery （Vet MB 1958）. He had academic appointments as a Fellow at Bristol University （1958-1959）, a scientist with MC Chang at the Worcester Foundation in Shrewsbury, MA, USA （1959-1961）,and studied for a PhD in Physiology with Professor Amoroso at the University of London （1961-1965）. During this time, he was also a lecturer at the Royal Veterinary College （1961-1966） and a teacher at the University of London （1965）.

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Semen quality： variations among fathers and effects of moderate alcohol drinking

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Asian Journal of Andrology 2015年第1期17卷 46-47页

作者： trevor G Cooper Tuen Mun New Territories Hong Kong SAR China

Semen analysis results from over 750 fathers in the USA demonstrated marked differences in the quality of semen from men at different locations and of different ethnic groups. Another paper failed to demonstrate any effects of moderate alcohol consumption during the week before provision of an ejaculate on semen quality and few on serum hormones, of over 8300 men in Europe and the USA. While these observations are interesting, the reasons for regional and ethnic differences in semen quality of fathers are unclear. Although, there was no attempt to confirm the participant-provided level of alcohol consumption, an increase in serum testosterone in the men at the higher end of alcohol intake is compatible with an alcohol effect on liver metabolism, although whether alcohol intake was the cause of higher testosterone, or men with higher androgen levels consume more alcohol, is not known.

关键词： Semen quality variations among fathers

Three thousand years in Tibet

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National Science Review 2020年第1期7卷 129-130页

作者： Bettina Harr trevor Price Max-Planck-Institut für Evolutionsbiologie Department of Ecology and Evolution University of Chicago

Humans have come to inhabit nearly every terrestrial environment. Their commensals have followed them and have consequently become some of the most abundant and widespread species on Earth, in the process becoming exposed to a variety of abiotic and biotic stressors. For example, the house sparrow was introduced from the UK to North America in the

关键词： Three thousand years in Tibet

Epididymal research： more warp than weft？

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Asian Journal of Andrology 2015年第5期17卷 699-703,I0005页

作者： trevor G Cooper Tuen Mun NTHong Kong SARChina

From a review of some aspects of epididymal structure, function and research done largely in my research area over the last 50 years, I conclude that more is known than is understood of sperm maturation and storage in the epididymis. Highly qualified technicians have not always applied sophisticated modern techniques in well-considered experiments to physiologically relevant and properly-prepared samples, so that our understanding of the biological problem of the nature of the epididymal epithelial influence on maturing epididymal spermatozoa has not kept pace with the outpouring of data generated, much of which is difficult to interpret. We stand at a crossroads of where to aim our limited resources and personnel： should we continue new technology-led studies in many directions, backtrack to test hypotheses and fill in gaps in our knowledge, or consider more biological directions to our research？

关键词：附睾精子扭曲现代技术技术人员数据生成十字路口多方向成熟

Bacterial adhesion and biofilms on surfaces

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Progress in Natural Science:Materials International 2008年第9期18卷 1049-1056页

作者： trevor Roger Garrett Manmohan Bhakoo Department of Chemical Engineering School of Engineering The University of Birmingham Edgbaston Birmingham B15 2TT UK Unilever R&D Port Sunlight Quarry Road East Bebington Merseyside CH63 3JW UK

Bacterial adhesion has become a significant problem in industry and in the domicile, and much research has been done for deeper understanding of the processes involved. A generic biological model of bacterial adhesion and population growth called the bacterial biofilm growth cycle, has been described and modified many times. The biofilm growth cycle encompasses bacterial adhesion at all levels, starting with the initial physical attraction of bacteria to a substrate, and ending with the eventual liberation of cell clusters from the biofilm matrix. When describing bacterial adhesion one is simply describing one or more stages of biofilm development, neglecting the fact that the population may not reach maturity. This article provides an overview of bacterial adhesion, cites examples of how bac- terial adhesion afiects industry and summarises methods and instrumentation used to improve our understanding of the adhesive prop- erties of bacteria.

关键词： Adhesion Bacteria Biofilm Cleaning Micromanipulation

The Asian Journal of Andrology： view of an outsider coming in

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Asian Journal of Andrology 2014年第4期16卷 565-566页

作者： trevor G Cooper Tuen Mun New Territories Hong Kong SAR China.

My interest in science in China, .stimulated in 1980 by reading theabridged version of Joseph Needham＇s ＂Science and Civilization in China＂, continued when I was a Consultant to the National Family Planning Research Institute in Beijing in 1983, and to the Shandong Stem Cell Engineering Research Center, Yantai in 2009-2012. During that time, I have acted as reviewer of the Asian Journal of Andrology （AJA）, and I continue to be one of its editorial board members. What I can contribute as the second Deputy Editor-in-Chief for the journal will depend on the challenges faced by the journal in the coming years.

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