检索结果-南通市图书馆

Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy

Chronic Diseases and Translational Medicine 2019年第4期5卷 258-266页

作者： Amin Zargar Samantha Chang Ankita Kothari Antoine M.Snijders Jian-Hua Mao Jessica Wang Amanda C.Hernandez Jay D.Keasling trever g.bivona Joint BioEnergy Institute Lawrence Berkeley National LaboratoryEmeryvilleCA 94608USA QB3 Institute University of California-Berkeley174 Stanley HallBerkeleyCA 94720USA Biological Systems and Engineering Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Chemical&Biomolecular Engineering Department of BioengineeringUniversity of CaliforniaBerkeleyCA 94720USA Helen Diller Family Comprehensive Cancer Center University of CaliforniaSan FranciscoCA 94143USA Department of Cellular and Molecular Pharmacology University o f CaliforniaSan FranciscoCA 94143USA

Despite tremendous efforts to fight cancer,it remains a major public health problem and a leading cause of death *** increased knowledge of cancer pathways and improved technological platforms,precision therapeutics that specifically target aberrant cancer pathways have improved patient ***,a primary cause of unsuccessful cancer therapy remains cancer drug *** this review,we summarize the broad classes of resistance to cancer therapy,particularly pharmacokinetics,the tumor microenvironment,and drug resistance ***,we describe how bacterial-mediated cancer therapy,a bygone mode of treatment,has been revitalized by synthetic biology and is uniquely suited to address the primary resistance mechanisms that confound traditional *** genetic engineering,we discuss how bacteria can be potent anticancer agents given their tumor targeting potential,anti-tumor activity,safety,and coordinated delivery of anti-cancer drugs.

关键词： Cancer therapy Synthetic biology Drug resistance Bacterial-mediated therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Physical activity and dietary behaviors of health clinic workers trying to lose weight

引用

Health 2012年第8期4卷 493-499页

作者： Tan Leng goh trever Ball Janet M. Shaw James C. Hannon Department of Exercise and Sport Science University of Utah Salt Lake City USA

Health clinic workers are potential agents of change for weight loss to patients, yet their behaviors are not well known. This study examined physical activity (PA) levels and dietary habits of health clinic workers who were and who were not trying to lose weight. Participants were 64 community health clinic workers (58 females and 6 males). Moderate-to-vigorous intensity (MVI) time spent in PA was assessed by triaxial accelerometry over 7 consecutive days. Dietary habits and weight loss efforts were determined by a food frequency questionnaire. Differences in MVI and nutrition variables were assessed by One-way ANOVA, comparing those trying to lose weight and those not trying to lose weight. 48 out of 64 health clinic workers (approximately 75%) indicated that they were currently trying to lose weight. There were significant differences (p gy (Kcal) and fat (g) intake between those trying to lose weight and those not trying to lose weight. There were no significant differences in MVI, daily sugar intake (g), vegetable and fruit servings, and daily fiber intake (g) between groups. Health clinic workers trying to lose weight appear to be engaging in some appropriate dietary but not PA behaviors.

关键词： Accelerometer Overweight Healthcare Nutrition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：