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Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso

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Food Science and Human Wellness 2024年

作者： giles T.Hanley-Cook Yuri Bastos-Moreira Dries S.Martens trenton dailey-chwalibóg.laeticia celine toe Brenda de Kok Lionel Ouédraogo Alemayehu Argaw Kokeb Tesfamariam Patrick Kolsteren Lieven Huybregts Tim S.Nawrot Sarah De Saeger Marthe De Boevre Carl Lachat Department of Food Technology， Safety and Health， Faculty of Bioscience Engineering， ghent University Center of Excellence in Mycotoxicology and Public Health， MYTOXSOUTH~(?) Coordination Unit， Faculty of Pharmaceutical Sciences， ghent University Centre for Environmental Sciences， Hasselt University Unité Nutrition et Maladies Métaboliques， Institut de Recherche en Sciences de la Santé (IRSS) Centre Muraz Center of Excellence in Mycotoxicology and Public Health， MYTOXSOUTH? Coordination Unit， Faculty of Pharmaceutical Sciences， ghent University Nutrition， Diets， and Health Unit， Department of Food and Nutrition Policy， International Food Policy Research Institute (IFPRI) Department of Public Health & Primary Care， University of Leuven Department of Biotechnology and Food Technology， Faculty of Science， University of Johannesburg， Doornfontein Campus

Background: Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes. The effect on markers of health and disease， such as offspring telomere length (TL) and mitochondrial DNA content (mtDNAc) is unknown. Objectives: We assessed the efficacy of maternal multiple micronutrient (MMN)-fortified balanced-energy protein (BEP) and iron-folic acid (IFA) supplementation on newborn TL as a secondary outcome and mtDNAc as a non-declared outcome. Design: We conducted a randomized controlled trial in rural Burkina Faso， among pregnant females (15-40 years old) enrolled at gestation. Mothers received either MMN-fortified BEP and IFA (intervention) or IFA only (control) throughout pregnancy. Whole arterial blood samples were collected from the umbilical cord of 104 control and 90 intervention group infants， respectively. Average relative TL and mtDNAc were measured using quantitative polymerase chain reaction. Linear regression models were fitted to assess TL and mtDNAc differences across trial arms. Results: We found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn TL [β = -0.010 (95% CI: -0.057， 0.036); P = 0.662] or mtDNAc [β = 0.065 (95% CI: -0.203， 0.073); P = 0.354]， as compared to an IFA tablet alone. These findings were confirmed (P > 0.05) by adjusting the regression models for potential prognostic factors of study outcomes at enrollment. Exploratory analyses indicated higher， but non-significantly different mtDNAc among children born either small-for-gestational age， low birthweight， or preterm. Conclusions: Newborns from mothers who received daily nutritional supplements across gestation did not have different relative TL or mtDNAc.

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Subacute osteomyelitis due to Staphylococcus caprae in a teenager:A case report and review of the literature

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World Journal of Clinical Cases 2023年第20期11卷 4897-4902页

作者： Oscar Vazquez giacomo De Marco Nathaly gavira celine Habre Marcia Bartucz Christina N Steiger Romain Dayer Dimitri Ceroni Paediatric Orthopaedics Unit Geneva Children’s HospitalGeneva University HospitalsGeneva 1211Switzerland Paediatric Radiology Unit Geneva Children’s HospitalGeneva University HospitalsGeneva 1211Switzerland

BACKgROUND Staphylococcus caprae(***)is a human commensal bacterium which can be detected in the nose,nails,and *** can be responsible for heterogeneous infections such as bacteremia,endocarditis,pneumonia,acute otitis externa,peritonitis,and urinary tract *** and joint infections due to *** have also been reported,but most of them resulted from the infection of orthopedic devices,especially joint prostheses and internal osteosynthesis *** cases of primary osteoarticular infections caused by *** have been described,including osteitis,arthritis,or *** SUMMARY We report an unusual case of subacute osteomyelitis in a toe phalanx caused by *** in a 14.5-year-old *** Subacute *** osteomyelitis is a little-known and probably underestimated community-acquired infectious *** microorganism’s pathogenicity should be seen as more than a classic nosocomial orthopedic device infection.

关键词： Subacute Osteomyelitis Staphylococcus caprae Teenagers Case report

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