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High burden of hepatocellular carcinoma and viral hepatitis in Southern and Central Vietnam:Experience of a large tertiary referral center,2010 to 2016

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World Journal of Hepatology 2018年第1期10卷 116-123页

作者： Song-Huy Nguyen-Dinh Albert Do trang Ngoc Doan Pham Doan Y dao Trinh Nhu Nguy Moon S Chen Jr Liver Tumor DepartmentCho Ray HospitalHo Chi Minh City 700000Vietnam Department of Internal Medicine Yale UniversityNew HavenCT 06510United States School of Public Health University of IllinoisChicagoIL 60302United States Division of Digestive and Liver Diseases UT Southwestern Medical CenterDallasTX 75390United States Vietnam Viral Hepatitis Alliance Ho Chi Minh City 7000Vietnam Davis Comprehensive Cancer Center University of CaliforniaSacramentoCA 95817United States

AIM To examine the largest tertiary referral center in southern and central Vietnam from 2010 to 2016, evaluating epidemiological trends of hepatocellular carcinoma(HCC) and viral hepatitis B-C in this resource-limited *** We extracted data of patients receiving care from Cho Ray Hospital(Ho Chi Minh City), the largest oncology referral center in southern and central Vietnam, from 2010 to 2016. We collected information on patient age, gender, geographic distribution, and disease characteristics including disease stage, tumor biomarker levels [serum alpha-fetoprotein(AFP), AFP-L3 isoform percentage, and prothrombin induced by induced by vitamin K absence-Ⅱ], and serological testing for hepatitis B virus(HBV) and hepatitis C virus(HCV) *** Data from 24091 HCC patients were extracted, with sample demographics comprising mostly male(81.8%) and older age(however with 8.5% younger than 40 years old). This patient sample included a geographic catchment population of 56 million people(60% of the country's total population of 92.7 million), derived from 38 provinces and municipalities in Vietnam. Chronic HBV infection was found in 62.3% of cases, and chronic HCV infection in 26.0%. HBV and HCV co-infection was seen in 2.7%. Cirrhosis was found in an estimated 30% to 40% of cases. Nine percent of patients were not found to have chronic viral hepatitis. Twenty three point two percent of the patients had a normal AFP level. A total of 2199 patients were tested with AFP-L3 and PIVKA Ⅱ over two years, with 57.7% having elevated AFP-L3%, and 88.5% with elevated PIVKA Ⅱ levels. Over this 7-year period, the incidence of HCC increased, with a large proportion of cases(overall 40.8%) presenting initially an advanced stage, not amendable to surgical or locoregional *** HCC contributes significant health care burden in southern and central Vietnam, with increasing case volume over this seven-year period. Viral hepatitis likely explains this high

关键词： Hepatocellular carcinoma Hepatitis B virus Hepatitis C virus Alpha-fetoprotein

Hip Tuberculosis at Stage IV: Outcomes and Some Conditions for Total Hip Replacement

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Open Journal of Orthopedics 2022年第4期12卷 183-194页

作者： Do Dang Hoan dao Xuan Thanh Nguyen Khac trang Ngo Van Toan Department of General Surgery National Lung Hospital Hanoi Vietam Hanoi Medical University Hanoi Vietam Department of Orthopaedic Hanoi Medical University Hospital Hanoi Vietam Hanoi Medical University Hospital Hanoi Vietam

Background: Treatment of hip disorders during active hip tuberculosis has long been a controversial issue. Some authors have reported performing hip replacement with different strategies with very good outcomes. This study aimed to describe the surgical outcomes and necessary conditions for total hip replacement in active hip tuberculosis. Methods: We conducted a quasi-experimental study. The study enrolled 40 patients with 42 active tuberculosis hips at stage IV treated by total hip replacement from October 2016 to December 2019 at the National Lung Hospital. We followed up with the patients for at least 12 months, evaluated surgical outcomes, and investigated the factors associated with these outcomes by logistic regression analysis. Results: Surgical outcomes showed that 37 patients (88.1%) had excellent hip function, no abscesses, and no sinus tract formation. Four cases (9.5%) had sinus tract formations. One case (2.4%) had good hip function. Binary logistic regression models revealed that sinus tract formation was associated with preoperative tuberculosis infection syndrome. The average time to obtain antituberculosis drug treatment preoperatively was 4.6 weeks. Conclusion: Total hip replacement for active hip tuberculosis is a practical and promising treatment method. Surgeons should consider improving patients’ conditions before performing total hip replacement, administering antitubercular drugs, and arthrotomy to eliminate all abscesses, and decrease the risk of tuberculosis infection syndrome and the inflammatory response.

关键词： Active Hip Tuberculosis Stage IV Total Hip Replacement

Acetabular Defects of Hip Tuberculosis: Recommended Classification and Reconstruction in Hip Arthroplasty

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Open Journal of Orthopedics 2022年第11期12卷 407-419页

作者： Hoan Do Dang trang Nguyen Khac Thanh dao Xuan Toan Ngo Van Department of General Surgery National Lung Hospital Hanoi Vietnam Hanoi Medical University Hanoi Vietnam Department of Orthopaedic Hanoi Medical University Hospital Hanoi Vietnam Hanoi Medical University Hospital Hanoi Vietnam

Background: This study aimed to propose a classification of acetabular defects in advanced-stage hip tuberculosis based on preoperative radiographs and intraoperative evaluation, thereby providing options for reconstructing each type of defect in hip arthroplasty. Materials and Methods: We conducted a prospective study with 45 patients with active hip tuberculosis at stage IV who were treated with a total hip replacement strategy. We collected the patients’ acetabular defect data from preoperative radiographs and intraoperative observations. The defects were classified into types based on defect severity and reconstructive complexity. The hip replacement outcomes were evaluated at least 12 months after the operation. Results: The classification system includes three types: type I: localized or extensive defects inside the acetabulum, not affecting the acetabular rim, medial wall, or columns. Type II: extensive defects inside the acetabulum, affecting the acetabular rim or (and) medial wall. Type III: extensive defects inside the acetabulum, causing the medial wall and the acetabular column to lose function. Each type has a corresponding reconstruction. The outcome includes that 41/45 patients had excellent results;3/45 patients had good results. The patients had good results due to nerve and muscle damage caused by tuberculosis not related to the acetabular defects. Conclusion: This is a simple, practical classification system of acetabular defects in hip tuberculosis. The outcome of hip reconstruction using this classification was excellent without any cases of dislocation or protrusion.

关键词： Hip Tuberculosis Hip Arthroplasty Acetabular Defect Classification Reconstruction

Anti-inflammatory effects of alkaloid enriched extract from roots of Eurycoma longifolia Jack

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Asian Pacific Journal of Tropical Biomedicine 2019年第1期9卷 18-23页

作者： dao Thi Thanh Hien Tran Phi Long Tran Phuong Thao Jeong-Hyung Lee Duong Thu trang Nguyen Thi Thu Minh Pham Van Cuong Do Thi Ngoc Lan Nguyen Hai Dang Nguyen Tien Dat Deparment of Traditional Pharmacy Hanoi University of Pharmacy Department of Biochemistry College of Natural Sciences Kangwon National University Advanced Center for Bio-organic Chemistry Institute of Marine Biochemistry Vietnam Academy of Science and Technology National Institute of Drug Quality Control Center for Research and Technology Transfers

Objective: To examine the in vitro and in vivo anti-inflammatory effects of the alkaloid enriched extract(ELA) from the roots of Eurycoma longifolia. Methods: The in vitro antiinflammatory effects of ELA were evaluated by examining its inhibitory activities against nitric oxide(NO) production and inducible nitric oxide synthase(iN OS) and cyclooxygenase2(COX-2) expressions in lipopolysaccharide(LPS)-stimulated RAW264.7 cells. The level of NO produced in the culture media was determined by Griess method. The i NOS and COX-2 protein expressions were analyzed by Western blot. The in vivo effect of ELA was evaluated on LPS-induced septic shock in mice model. Mice mortality was monitored for5 days after injection of LPS. The chemical contents of the ELA were determined by using various chromatographic and spectroscopic techniques. Results: The ELA was found to exhibit a significant anti-inflammatory effect in both in vitro and in vivo models. The results demonstrated that ELA dose-dependently inhibited LPS-induced NO production as well as the protein iN OS and COX-2 expressions. In the septic shock model, ELA dose-dependently protected mice from LPS-induced mortality. Further study on the isolated components of ELA indicated that 9,10-dimethoxycanthin-6-one may contribute significantly to the antiinflammatory effects of the extract. Conclusions: These results suggest that ELA exhibits the anti-inflammatory activity via suppression of pro-inflammatory mediators such as NO, iN OS,and COX-2 and protects mice from LPS-induced mortality in septic shock model.

关键词： Eurycoma longifolia Anti-inflammation Alkaloid 9,10-dimethoxycanthin-6-one

The Effect of Hydraulic Retention Times and Loading Rates on the Removal of Pollutants from Fish Processing Wastewater by Anaerobic Process

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Journal of Food Science and Engineering 2018年第6期8卷 237-240页

作者： dao Khanh Chau Tran Thanh Dai Faculty of Health and Applied Sciences Dong Nai Technology UniversityNguyen Khuyen StreetTrang Dai ward 810000Bien Hoa cityDong Nai provinceVietnam

Anaerobic treatment model treats fish processing wastewater to be necessary for a small and medium factory that is very popular in Vietnam and other *** techniques have been ***,they are quite expensive and hard to operate,especially in remote *** this study,the hydraulic retention times(HRT)including 3,5,and 7 hours with a various organic loading rate of 1.5 to 6.5 kg COD/m3/day were *** concentration as mix-liquor volatile suspended solid(MLVSS)in the model is at 6,000 to 9,000 mg/*** the basis of the result the optimal HRT with a 4.0 kg COD/m3/day organic loading rate was 8 hours which BOD5,COD removal efficiency were 92.18,87.36 percent *** the end of the optimal hydraulic retention times,the total methane gas volume as a by-product was collected with 2.6 liters.

关键词： Wastewater treatment anaerobic process hydraulic retention time organic loading rate